GREMLIN Database
Q97U32 - Formate dehydrogenase (Amino end)
UniProt: Q97U32 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 370 (362)
Sequences: 9115 (5257)
Seq/√Len: 276.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_S56_L5.8911.00
203_R245_E3.1581.00
197_I217_L3.0081.00
144_W193_A2.9991.00
195_G229_I2.9961.00
199_R203_R2.9821.00
227_E237_S2.9471.00
198_K202_E2.9001.00
208_L212_D2.8681.00
52_I65_L2.7791.00
58_N61_E2.7581.00
197_I279_L2.6991.00
180_K242_E2.6841.00
230_E237_S2.6681.00
192_L233_T2.5731.00
237_S241_D2.5721.00
52_I57_S2.5671.00
166_T178_S2.4851.00
139_E252_P2.4111.00
239_K242_E2.4071.00
225_N228_E2.3851.00
236_D239_K2.3841.00
140_S246_L2.3251.00
206_A211_L2.3081.00
70_I329_F2.3051.00
204_N208_L2.2901.00
328_T355_R2.2721.00
331_F361_H2.1971.00
66_I359_V2.1941.00
180_K239_K2.1621.00
242_E246_L2.1611.00
182_Y243_L2.1451.00
137_K283_K2.1341.00
65_L69_E2.1211.00
138_Y141_F2.0381.00
209_S213_E2.0301.00
57_S65_L2.0251.00
140_S165_A2.0051.00
182_Y235_L1.9331.00
192_L240_I1.9191.00
201_F218_R1.8911.00
198_K226_D1.8901.00
77_E328_T1.8881.00
199_R241_D1.8571.00
180_K246_L1.8471.00
52_I55_K1.8171.00
356_L359_V1.8151.00
50_V59_I1.7941.00
73_R328_T1.7861.00
205_W248_Y1.7831.00
348_Y352_K1.7701.00
200_L248_Y1.7521.00
202_E222_Y1.7321.00
320_K346_R1.7251.00
247_Y280_I1.7141.00
139_E250_R1.7111.00
203_R241_D1.6931.00
245_E249_Y1.6841.00
188_S232_A1.6651.00
163_Y179_N1.6641.00
219_N222_Y1.6551.00
167_I192_L1.6501.00
354_V358_L1.6481.00
229_I240_I1.6451.00
64_D68_K1.6351.00
199_R245_E1.6161.00
200_L206_A1.5921.00
349_D352_K1.5891.00
80_H99_W1.5821.00
323_E346_R1.5801.00
218_R222_Y1.5751.00
199_R226_D1.5691.00
180_K243_L1.5621.00
140_S243_L1.5351.00
57_S61_E1.5311.00
188_S233_T1.5281.00
142_V243_L1.5241.00
247_Y253_L1.5161.00
74_K77_E1.5141.00
199_R202_E1.5121.00
216_E219_N1.5041.00
61_E65_L1.5031.00
230_E236_D1.4981.00
14_I25_F1.4951.00
205_W245_E1.4891.00
99_W104_A1.4821.00
169_V181_Y1.4821.00
191_Y232_A1.4791.00
230_E240_I1.4741.00
196_I243_L1.4701.00
142_V167_I1.4651.00
79_L327_I1.4361.00
201_F221_V1.4301.00
166_T175_A1.4041.00
51_Y56_L1.3951.00
209_S212_D1.3871.00
227_E241_D1.3771.00
332_V358_L1.3771.00
182_Y239_K1.3611.00
224_F229_I1.3611.00
139_E251_R1.3491.00
201_F206_A1.3471.00
224_F228_E1.3411.00
65_L356_L1.3331.00
198_K222_Y1.3271.00
140_S250_R1.3201.00
192_L243_L1.3141.00
217_L221_V1.3141.00
317_E320_K1.3081.00
79_L318_V1.2951.00
260_L273_I1.2861.00
70_I359_V1.2841.00
228_E231_E1.2791.00
134_D137_K1.2771.00
224_F232_A1.2711.00
163_Y177_R1.2671.00
196_I244_A1.2611.00
184_V188_S1.2451.00
160_R163_Y1.2391.00
202_E241_D1.2251.00
250_R253_L1.2221.00
338_L344_S1.2221.00
69_E355_R1.2191.00
200_L280_I1.2131.00
171_I176_K1.2061.00
196_I247_Y1.2031.00
329_F356_L1.1981.00
141_F162_K1.1951.00
197_I221_V1.1901.00
343_M346_R1.1901.00
223_S228_E1.1891.00
329_F359_V1.1891.00
78_I329_F1.1871.00
321_E326_K1.1801.00
318_V327_I1.1741.00
322_I354_V1.1701.00
205_W249_Y1.1671.00
193_A273_I1.1561.00
282_M285_G1.1561.00
142_V196_I1.1551.00
143_I146_S1.1531.00
144_W167_I1.1531.00
119_A270_I1.1481.00
66_I356_L1.1461.00
73_R77_E1.1401.00
346_R349_D1.1381.00
199_R205_W1.1211.00
23_D49_S1.1201.00
190_V269_A1.1171.00
165_A243_L1.1131.00
199_R240_I1.1071.00
70_I102_I1.1041.00
193_A272_L1.0991.00
255_I277_P1.0951.00
228_E232_A1.0941.00
169_V183_I1.0911.00
323_E353_E1.0871.00
123_H271_S1.0851.00
17_D20_K1.0801.00
286_F289_A1.0731.00
199_R244_A1.0721.00
18_N42_N1.0711.00
208_L218_R1.0621.00
67_V71_R1.0561.00
338_L348_Y1.0541.00
194_I220_Y1.0521.00
196_I276_I1.0501.00
229_I233_T1.0431.00
314_R317_E1.0411.00
184_V235_L1.0361.00
76_E310_F1.0361.00
197_I276_I1.0341.00
349_D353_E1.0311.00
78_I102_I1.0271.00
148_L159_I1.0261.00
206_A279_L1.0211.00
247_Y255_I1.0191.00
167_I184_V1.0151.00
330_M354_V1.0141.00
238_S241_D1.0131.00
135_F254_T1.0101.00
165_A246_L1.0071.00
167_I182_Y1.0061.00
230_E233_T1.0011.00
241_D245_E0.9971.00
195_G240_I0.9951.00
323_E349_D0.9951.00
161_D164_K0.9941.00
319_G322_I0.9941.00
196_I200_L0.9871.00
194_I224_F0.9861.00
69_E356_L0.9811.00
66_I69_E0.9761.00
76_E105_A0.9731.00
52_I61_E0.9711.00
226_D241_D0.9691.00
51_Y365_C0.9691.00
11_D154_H0.9691.00
217_L279_L0.9661.00
136_L158_L0.9651.00
253_L282_M0.9641.00
70_I331_F0.9581.00
215_E218_R0.9561.00
184_V192_L0.9521.00
141_F159_I0.9521.00
48_D56_L0.9501.00
345_D349_D0.9491.00
55_K61_E0.9451.00
207_D210_L0.9441.00
168_D172_S0.9421.00
185_K234_G0.9401.00
220_Y223_S0.9361.00
210_L214_P0.9321.00
192_L196_I0.9311.00
242_E245_E0.9271.00
136_L161_D0.9271.00
124_Y274_S0.9251.00
238_S242_E0.9251.00
171_I183_I0.9241.00
226_D229_I0.9241.00
122_L271_S0.9231.00
171_I181_Y0.9231.00
167_I243_L0.9221.00
258_F262_R0.9211.00
239_K246_L0.9201.00
149_V174_T0.9141.00
165_A180_K0.9141.00
320_K324_E0.9121.00
332_V368_L0.9091.00
140_S253_L0.9081.00
260_L269_A0.9061.00
50_V58_N0.8981.00
317_E321_E0.8951.00
15_F31_T0.8931.00
175_A181_Y0.8861.00
200_L276_I0.8851.00
65_L68_K0.8781.00
225_N229_I0.8771.00
318_V322_I0.8751.00
194_I221_V0.8741.00
283_K286_F0.8721.00
193_A276_I0.8711.00
22_I39_L0.8661.00
235_L240_I0.8631.00
226_D230_E0.8601.00
87_Q333_W0.8551.00
235_L239_K0.8541.00
304_T307_I0.8531.00
91_T94_Y0.8531.00
79_L330_M0.8521.00
49_S58_N0.8501.00
252_P285_G0.8491.00
57_S62_A0.8481.00
199_R237_S0.8441.00
73_R355_R0.8431.00
190_V272_L0.8421.00
48_D51_Y0.8391.00
119_A274_S0.8381.00
63_L67_V0.8371.00
69_E329_F0.8361.00
17_D22_I0.8361.00
198_K225_N0.8361.00
203_R248_Y0.8331.00
143_I174_T0.8331.00
88_G91_T0.8260.99
215_E219_N0.8240.99
195_G199_R0.8220.99
230_E238_S0.8190.99
246_L250_R0.8180.99
220_Y224_F0.8180.99
268_D271_S0.8160.99
311_K314_R0.8130.99
150_F173_E0.8120.99
54_G57_S0.8110.99
201_F279_L0.8060.99
83_Y107_T0.8050.99
76_E104_A0.8020.99
322_I330_M0.8010.99
184_V233_T0.8010.99
244_A248_Y0.7960.99
202_E226_D0.7960.99
19_H22_I0.7930.99
313_C321_E0.7900.99
252_P283_K0.7890.99
182_Y192_L0.7870.99
157_N161_D0.7850.99
338_L351_V0.7840.99
198_K221_V0.7830.99
190_V265_N0.7790.99
51_Y54_G0.7780.99
226_D237_S0.7780.99
140_S247_Y0.7750.99
217_L220_Y0.7730.99
43_S364_Y0.7690.99
328_T354_V0.7690.99
66_I331_F0.7660.99
195_G226_D0.7630.99
245_E248_Y0.7620.99
243_L246_L0.7610.99
150_F170_R0.7610.99
195_G244_A0.7590.99
143_I148_L0.7580.99
237_S240_I0.7560.99
30_F157_N0.7560.99
131_L134_D0.7550.99
18_N21_P0.7540.99
194_I272_L0.7540.99
137_K252_P0.7520.99
197_I275_L0.7510.99
119_A123_H0.7490.99
332_V360_V0.7490.99
142_V255_I0.7490.99
147_E150_F0.7460.99
192_L235_L0.7420.99
171_I175_A0.7410.99
28_N161_D0.7390.99
227_E230_E0.7380.99
68_K71_R0.7350.99
97_R100_N0.7350.99
138_Y253_L0.7340.99
32_C35_G0.7310.99
256_I287_F0.7310.99
218_R221_V0.7270.99
33_S37_A0.7220.99
244_A276_I0.7210.99
60_D64_D0.7190.99
331_F359_V0.7180.99
188_S191_Y0.7160.99
65_L329_F0.7150.99
62_A66_I0.7140.99
16_D20_K0.7130.99
123_H274_S0.7130.99
198_K229_I0.7120.99
19_H39_L0.7080.98
120_I274_S0.7060.98
260_L270_I0.7050.98
191_Y229_I0.7050.98
195_G231_E0.7040.98
247_Y277_P0.7030.98
332_V337_P0.7030.98
277_P287_F0.7010.98
63_L66_I0.6980.98
247_Y276_I0.6940.98
5_C13_C0.6940.98
75_K103_G0.6940.98
319_G347_I0.6910.98
130_A134_D0.6900.98
81_V335_S0.6900.98
47_V365_C0.6890.98
230_E235_L0.6880.98
16_D22_I0.6870.98
252_P282_M0.6860.98
144_W273_I0.6840.98
146_S290_N0.6820.98
195_G228_E0.6790.98
362_D366_Q0.6780.98
322_I350_A0.6770.98
191_Y228_E0.6760.98
113_S117_H0.6740.98
345_D348_Y0.6710.98
64_D67_V0.6690.98
37_A40_K0.6680.98
315_Y341_L0.6670.98
138_Y252_P0.6630.98
322_I353_E0.6600.98
299_K302_P0.6590.98
321_E324_E0.6580.98
123_H275_L0.6580.98
202_E218_R0.6570.97
39_L42_N0.6540.97
130_A254_T0.6530.97
286_F292_Q0.6500.97
306_Q309_S0.6480.97
160_R177_R0.6480.97
211_L279_L0.6480.97
191_Y195_G0.6480.97
168_D181_Y0.6470.97
344_S348_Y0.6440.97
255_I273_I0.6440.97
289_A292_Q0.6440.97
146_S257_G0.6430.97
80_H95_P0.6430.97
195_G225_N0.6420.97
206_A218_R0.6390.97
137_K284_K0.6340.97
166_T174_T0.6340.97
110_S114_S0.6300.97
24_T28_N0.6290.97
168_D175_A0.6270.97
201_F211_L0.6260.97
330_M358_L0.6250.97
329_F354_V0.6250.97
195_G230_E0.6250.97
116_G256_I0.6230.97
139_E253_L0.6210.96
190_V193_A0.6200.96
74_K328_T0.6170.96
168_D174_T0.6160.96
18_N22_I0.6150.96
10_Y13_C0.6150.96
129_G288_Y0.6130.96
148_L174_T0.6100.96
49_S57_S0.6100.96
360_V366_Q0.6070.96
70_I356_L0.6070.96
116_G270_I0.6060.96
195_G198_K0.6060.96
197_I272_L0.6060.96
29_G53_E0.6050.96
326_K353_E0.6050.96
133_E137_K0.6040.96
297_D300_Y0.6040.96
143_I166_T0.6040.96
118_E267_G0.6020.96
52_I66_I0.5990.96
183_I239_K0.5970.96
148_L290_N0.5960.96
113_S116_G0.5960.96
200_L204_N0.5950.96
320_K323_E0.5940.95
36_I40_K0.5920.95
265_N269_A0.5860.95
200_L205_W0.5840.95
198_K228_E0.5820.95
147_E168_D0.5820.95
61_E64_D0.5820.95
124_Y287_F0.5820.95
13_C32_C0.5810.95
198_K223_S0.5800.95
336_N368_L0.5800.95
300_Y303_R0.5800.95
200_L279_L0.5800.95
119_A267_G0.5800.95
99_W107_T0.5790.95
236_D241_D0.5790.95
330_M351_V0.5790.95
240_I244_A0.5780.95
132_P135_F0.5780.95
335_S341_L0.5770.95
298_F301_L0.5760.95
183_I186_P0.5750.95
227_E231_E0.5740.95
72_K328_T0.5720.94
256_I270_I0.5720.94
84_D87_Q0.5720.94
318_V330_M0.5660.94
138_Y254_T0.5660.94
319_G341_L0.5650.94
199_R248_Y0.5640.94
152_F155_G0.5630.94
247_Y282_M0.5630.94
96_A100_N0.5620.94
291_S294_L0.5620.94
305_S308_L0.5620.94
31_T36_I0.5600.94
322_I327_I0.5590.94
70_I98_L0.5560.94
196_I245_E0.5560.94
5_C35_G0.5560.94
277_P282_M0.5550.94
360_V368_L0.5550.94
120_I124_Y0.5530.93
308_L314_R0.5520.93
55_K65_L0.5520.93
111_I341_L0.5500.93
99_W102_I0.5490.93
288_Y291_S0.5490.93
195_G237_S0.5480.93
15_F38_D0.5480.93
70_I78_I0.5470.93
238_S245_E0.5470.93
47_V54_G0.5470.93
263_S269_A0.5460.93
358_L368_L0.5450.93
274_S287_F0.5440.93
212_D215_E0.5440.93
142_V276_I0.5440.93
277_P280_I0.5430.93
144_W276_I0.5420.93
351_V358_L0.5420.93
158_L161_D0.5410.93
266_G270_I0.5390.93
330_M337_P0.5390.93
115_E261_G0.5390.93
313_C327_I0.5380.92
158_L162_K0.5380.92
151_S257_G0.5350.92
72_K355_R0.5340.92
275_L278_A0.5340.92
200_L244_A0.5330.92
5_C32_C0.5320.92
295_G298_F0.5310.92
269_A273_I0.5310.92
15_F22_I0.5300.92
188_S229_I0.5300.92
4_A12_T0.5300.92
304_T309_S0.5290.92
113_S291_S0.5290.92
147_E259_A0.5290.92
313_C326_K0.5280.92
225_N231_E0.5280.92
203_R226_D0.5270.92
211_L214_P0.5260.92
258_F261_G0.5250.92
77_E326_K0.5240.92
157_N162_K0.5230.91
239_K243_L0.5230.91
289_A294_L0.5230.91
145_G169_V0.5220.91
134_D254_T0.5220.91
54_G365_C0.5210.91
40_K44_L0.5210.91
266_G269_A0.5200.91
337_P368_L0.5200.91
81_V315_Y0.5190.91
347_I351_V0.5190.91
271_S275_L0.5180.91
160_R164_K0.5170.91
194_I217_L0.5170.91
172_S175_A0.5160.91
77_E329_F0.5160.91
7_R10_Y0.5150.91
113_S258_F0.5150.91
93_Y97_R0.5150.91
34_R352_K0.5130.91
140_S180_K0.5130.91
229_I232_A0.5110.90
246_L249_Y0.5100.90
198_K224_F0.5100.90
333_W361_H0.5100.90
147_E173_E0.5080.90
140_S252_P0.5060.90
332_V351_V0.5040.90
114_S118_E0.5030.90
23_D28_N0.5020.90
13_C35_G0.5020.90
25_F29_G0.5010.90
217_L275_L0.5010.90
169_V184_V0.5010.90
57_S63_L0.5000.90
321_E327_I0.5000.90
255_I276_I0.5000.90
296_I300_Y0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h0hA 1 0.9892 100 0.2 Contact Map
1kqfA 3 0.9892 100 0.202 Contact Map
2iv2X 1 0.9892 100 0.22 Contact Map
3ml1A 1 0.9919 100 0.223 Contact Map
2napA 1 0.9919 100 0.225 Contact Map
2e7zA 1 0.9811 100 0.237 Contact Map
2ivfA 1 0.9919 100 0.246 Contact Map
2vpzA 1 0.9784 100 0.256 Contact Map
1q16A 2 0.9892 100 0.265 Contact Map
1ti6A 3 0.9946 100 0.282 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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