GREMLIN Database
Q97U31 - Uncharacterized protein
UniProt: Q97U31 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (299)
Sequences: 2484 (1504)
Seq/√Len: 87.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
255_G258_Q7.4681.00
143_Y294_L4.5421.00
255_G260_V3.8421.00
166_I170_A3.6681.00
120_L123_A3.2561.00
135_L139_S2.9271.00
91_Y98_N2.8391.00
258_Q261_S2.8161.00
258_Q264_P2.7311.00
6_I10_I2.6571.00
194_A204_L2.5641.00
285_D292_E2.5331.00
132_Y305_A2.5051.00
63_G260_V2.4911.00
255_G261_S2.3891.00
152_Y156_L2.3761.00
16_V20_A2.3711.00
257_S260_V2.3121.00
97_S287_N2.3051.00
255_G259_T2.2431.00
258_Q262_L2.1771.00
123_A126_Y2.1471.00
31_E40_G2.1471.00
136_F298_G2.1321.00
50_L54_I2.1321.00
7_L11_V2.1151.00
209_T213_A2.0961.00
217_E242_S2.0961.00
20_A23_M2.0921.00
95_Y228_S2.0911.00
170_A174_I2.0601.00
18_F22_L2.0201.00
49_A214_E1.9961.00
188_S191_S1.9141.00
158_N161_N1.9131.00
157_K160_K1.8731.00
93_L96_K1.8491.00
246_N250_L1.8401.00
34_F38_I1.8231.00
52_E217_E1.8221.00
140_P298_G1.8151.00
248_T252_S1.7991.00
224_L234_T1.7761.00
110_Y118_I1.7551.00
220_T224_L1.7511.00
31_E36_K1.7001.00
261_S264_P1.6881.00
255_G262_L1.6721.00
239_F243_K1.6431.00
256_I259_T1.6141.00
119_I123_A1.6021.00
41_G45_G1.5991.00
30_L165_A1.5711.00
257_S261_S1.5651.00
81_T275_T1.5171.00
75_G214_E1.5081.00
95_Y98_N1.5061.00
122_I128_K1.5061.00
121_G125_V1.5041.00
260_V264_P1.4780.99
146_Y150_K1.4780.99
293_G296_L1.4610.99
30_L34_F1.4520.99
152_Y155_I1.4480.99
221_A239_F1.4460.99
79_L242_S1.4310.99
46_F245_E1.4270.99
86_L297_F1.4160.99
214_E218_N1.4150.99
55_I71_S1.4130.99
180_I184_K1.3960.99
256_I260_V1.3760.99
157_K162_K1.3640.99
89_I297_F1.3620.99
64_F201_P1.3610.99
167_K170_A1.3600.99
75_G79_L1.3590.99
12_L185_Y1.3540.99
140_P295_S1.3400.99
53_T79_L1.3400.99
260_V263_R1.3180.99
89_I143_Y1.3110.99
43_I54_I1.3100.99
18_F21_T1.3000.99
214_E246_N1.2940.99
259_T264_P1.2930.99
48_N214_E1.2910.99
24_A186_L1.2800.98
44_L47_I1.2690.98
165_A169_L1.2580.98
27_T44_L1.2530.98
79_L214_E1.2510.98
102_L105_D1.2480.98
120_L299_I1.2290.98
98_N228_S1.2210.98
121_G138_L1.2180.98
163_G167_K1.2130.98
189_T192_S1.2130.98
206_I307_L1.2110.98
243_K246_N1.2100.98
66_D69_L1.2090.98
78_L214_E1.2020.98
94_K226_S1.2000.98
16_V21_T1.1980.98
64_F191_S1.1930.98
147_R152_Y1.1890.97
142_I146_Y1.1810.97
123_A127_G1.1810.97
92_Y98_N1.1770.97
171_Y174_I1.1660.97
255_G264_P1.1490.97
124_I269_L1.1480.97
108_I121_G1.1470.97
83_G214_E1.1410.97
120_L127_G1.1270.97
143_Y290_V1.1220.96
74_G81_T1.1200.96
13_L20_A1.1150.96
267_L306_I1.1140.96
10_I14_I1.1100.96
57_I61_L1.1060.96
41_G183_S1.1020.96
256_I261_S1.0990.96
122_I306_I1.0940.96
88_S292_E1.0890.96
136_F140_P1.0850.96
268_Y271_L1.0820.96
72_A209_T1.0770.96
24_A218_N1.0770.96
122_I301_A1.0750.95
121_G272_I1.0690.95
131_Y135_L1.0650.95
68_A72_A1.0640.95
193_I197_F1.0610.95
116_A247_M1.0580.95
147_R290_V1.0420.95
71_S187_I1.0420.95
195_S201_P1.0410.95
177_L181_F1.0410.95
207_L304_I1.0390.95
207_L210_P1.0380.95
89_I93_L1.0290.94
91_Y228_S1.0280.94
184_K188_S1.0260.94
108_I112_S1.0240.94
272_I275_T1.0130.94
149_Y152_Y1.0090.94
72_A251_L0.9970.93
147_R151_N0.9940.93
85_G91_Y0.9880.93
113_F119_I0.9860.93
259_T263_R0.9850.93
245_E252_S0.9800.93
304_I308_L0.9790.93
101_T104_S0.9790.93
162_K200_Q0.9770.93
164_N167_K0.9750.92
211_I215_L0.9740.92
121_G128_K0.9710.92
45_G52_E0.9710.92
24_A214_E0.9710.92
23_M47_I0.9670.92
16_V23_M0.9670.92
209_T244_L0.9660.92
127_G199_V0.9650.92
26_G47_I0.9630.92
99_I102_L0.9580.92
76_N247_M0.9560.92
142_I145_I0.9560.92
19_S178_P0.9540.92
32_R161_N0.9460.91
148_R237_M0.9440.91
209_T212_A0.9420.91
12_L182_I0.9400.91
28_R31_E0.9320.91
72_A171_Y0.9310.91
20_A43_I0.9290.91
90_F226_S0.9270.90
108_I114_L0.9250.90
242_S246_N0.9200.90
242_S250_L0.9170.90
62_N135_L0.9140.90
67_I71_S0.9120.90
121_G126_Y0.9120.90
189_T196_V0.9110.90
266_L273_L0.9060.89
84_I279_A0.9060.89
135_L298_G0.9030.89
32_R159_E0.9020.89
158_N162_K0.8960.89
115_L122_I0.8910.89
86_L90_F0.8820.88
118_I299_I0.8810.88
128_K158_N0.8800.88
18_F23_M0.8780.88
253_I261_S0.8520.86
284_K299_I0.8500.86
142_I161_N0.8480.86
151_N156_L0.8460.86
220_T238_N0.8450.86
34_F43_I0.8410.86
109_E112_S0.8400.86
76_N246_N0.8370.85
72_A203_I0.8330.85
13_L21_T0.8310.85
117_V123_A0.8300.85
33_S183_S0.8280.85
144_Y148_R0.8260.85
154_G173_M0.8240.84
44_L48_N0.8210.84
100_I288_I0.8180.84
141_Y144_Y0.8140.84
26_G172_V0.8080.83
48_N213_A0.8070.83
241_G247_M0.8060.83
134_G137_L0.8060.83
7_L15_L0.7990.83
33_S165_A0.7980.82
49_A242_S0.7970.82
214_E245_E0.7960.82
174_I178_P0.7960.82
255_G263_R0.7940.82
98_N288_I0.7930.82
302_I306_I0.7920.82
162_K165_A0.7920.82
182_I244_L0.7900.82
242_S245_E0.7860.81
143_Y147_R0.7820.81
70_G205_A0.7790.81
85_G92_Y0.7790.81
76_N243_K0.7780.81
87_I91_Y0.7740.80
97_S103_D0.7740.80
264_P305_A0.7720.80
267_L279_A0.7710.80
127_G174_I0.7700.80
179_L194_A0.7690.80
143_Y153_R0.7680.80
301_A305_A0.7650.80
79_L243_K0.7650.80
73_L206_I0.7640.80
109_E114_L0.7610.79
111_S126_Y0.7590.79
211_I218_N0.7590.79
179_L216_E0.7580.79
107_N125_V0.7570.79
90_F222_I0.7550.79
58_Q183_S0.7530.79
14_I140_P0.7500.78
119_I126_Y0.7500.78
20_A28_R0.7500.78
74_G300_Y0.7460.78
199_V271_L0.7450.78
22_L26_G0.7430.78
47_I50_L0.7410.78
289_K292_E0.7390.77
65_Y262_L0.7370.77
176_G180_I0.7340.77
108_I111_S0.7340.77
163_G177_L0.7330.77
26_G175_G0.7310.77
34_F244_L0.7290.76
50_L179_L0.7270.76
183_S249_L0.7230.76
10_I169_L0.7220.76
297_F301_A0.7210.76
88_S92_Y0.7210.76
29_E87_I0.7180.75
259_T262_L0.7140.75
131_Y236_L0.7140.75
155_I290_V0.7130.75
87_I235_A0.7130.75
280_L284_K0.7120.75
58_Q187_I0.7120.75
223_K226_S0.7090.74
276_S280_L0.7050.74
17_A275_T0.7050.74
150_K153_R0.7030.74
153_R156_L0.7000.73
158_N257_S0.6980.73
205_A210_P0.6980.73
208_I211_I0.6970.73
12_L15_L0.6960.73
194_A223_K0.6960.73
92_Y293_G0.6930.73
272_I279_A0.6890.72
89_I157_K0.6880.72
235_A242_S0.6870.72
173_M257_S0.6860.72
43_I223_K0.6860.72
88_S288_I0.6830.72
91_Y97_S0.6830.72
154_G157_K0.6800.71
168_G172_V0.6730.70
77_I271_L0.6720.70
28_R50_L0.6670.70
24_A221_A0.6660.70
34_F37_G0.6630.69
183_S243_K0.6610.69
88_S131_Y0.6610.69
27_T250_L0.6600.69
173_M302_I0.6590.69
31_E42_L0.6580.69
91_Y95_Y0.6580.69
127_G295_S0.6570.69
132_Y136_F0.6570.69
46_F49_A0.6540.68
158_N170_A0.6510.68
64_F67_I0.6500.68
206_I299_I0.6490.68
11_V99_I0.6490.68
125_V129_L0.6480.68
49_A246_N0.6470.67
60_V293_G0.6460.67
186_L212_A0.6440.67
109_E117_V0.6430.67
142_I174_I0.6430.67
67_I190_I0.6430.67
41_G46_F0.6420.67
49_A79_L0.6390.67
50_L234_T0.6380.66
133_I137_L0.6380.66
41_G48_N0.6350.66
71_S218_N0.6350.66
105_D282_I0.6340.66
255_G295_S0.6340.66
190_I193_I0.6330.66
27_T49_A0.6310.66
245_E248_T0.6310.66
44_L238_N0.6300.65
293_G297_F0.6270.65
146_Y277_L0.6220.64
99_I139_S0.6200.64
216_E238_N0.6150.64
295_S298_G0.6140.63
101_T118_I0.6130.63
211_I214_E0.6130.63
79_L213_A0.6130.63
137_L141_Y0.6120.63
56_V233_T0.6100.63
41_G44_L0.6080.63
20_A27_T0.6080.63
155_I298_G0.6070.63
114_L277_L0.6070.63
75_G242_S0.6020.62
147_R153_R0.6020.62
194_A205_A0.5960.61
60_V63_G0.5960.61
131_Y256_I0.5940.61
99_I161_N0.5930.61
261_S266_L0.5930.61
186_L218_N0.5920.61
78_L300_Y0.5910.61
205_A229_P0.5880.60
45_G56_V0.5880.60
147_R156_L0.5880.60
156_L287_N0.5870.60
17_A141_Y0.5860.60
78_L217_E0.5840.60
49_A53_T0.5830.59
87_I190_I0.5820.59
281_G284_K0.5820.59
233_T237_M0.5800.59
20_A225_I0.5800.59
100_I105_D0.5800.59
135_L192_S0.5790.59
214_E243_K0.5790.59
75_G83_G0.5790.59
8_Q11_V0.5740.58
49_A83_G0.5720.58
83_G133_I0.5710.58
48_N242_S0.5690.58
132_Y162_K0.5690.58
71_S213_A0.5680.58
294_L306_I0.5670.57
305_A308_L0.5670.57
120_L128_K0.5660.57
115_L215_L0.5640.57
160_K287_N0.5630.57
21_T209_T0.5630.57
20_A137_L0.5620.57
125_V139_S0.5610.57
114_L281_G0.5610.57
53_T246_N0.5610.57
273_L277_L0.5600.56
51_P183_S0.5590.56
68_A254_I0.5580.56
223_K227_D0.5580.56
16_V49_A0.5560.56
40_G141_Y0.5560.56
297_F308_L0.5550.56
154_G159_E0.5550.56
114_L178_P0.5540.56
16_V26_G0.5530.56
157_K161_N0.5520.55
212_A216_E0.5520.55
86_L174_I0.5520.55
139_S294_L0.5520.55
203_I292_E0.5500.55
224_L238_N0.5480.55
111_S117_V0.5470.55
186_L201_P0.5470.55
139_S161_N0.5460.55
34_F305_A0.5450.54
80_L186_L0.5440.54
70_G73_L0.5430.54
246_N252_S0.5410.54
92_Y97_S0.5390.54
20_A217_E0.5390.54
146_Y236_L0.5380.54
29_E32_R0.5360.53
75_G218_N0.5360.53
257_S263_R0.5360.53
71_S184_K0.5340.53
73_L251_L0.5320.53
10_I120_L0.5310.53
52_E242_S0.5300.52
118_I128_K0.5300.52
66_D263_R0.5280.52
31_E52_E0.5250.52
190_I279_A0.5240.52
81_T296_L0.5240.52
237_M245_E0.5230.51
84_I286_R0.5220.51
45_G242_S0.5220.51
270_L287_N0.5210.51
40_G241_G0.5210.51
42_L145_I0.5200.51
260_V266_L0.5190.51
6_I169_L0.5180.51
112_S123_A0.5160.51
48_N246_N0.5130.50
31_E224_L0.5120.50
199_V210_P0.5120.50
146_Y154_G0.5100.50
16_V220_T0.5090.50
11_V198_N0.5070.49
245_E250_L0.5060.49
147_R155_I0.5060.49
244_L251_L0.5050.49
40_G183_S0.5050.49
132_Y284_K0.5040.49
204_L212_A0.5020.49
190_I194_A0.5010.49
166_I177_L0.5010.49
110_Y275_T0.5010.49
41_G56_V0.5000.48
252_S293_G0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k1cA 4 0.9872 100 0.184 Contact Map
4kjrA 3 0.9295 100 0.24 Contact Map
3v5uA 1 0.9423 100 0.261 Contact Map
4kppA 1 0.984 100 0.304 Contact Map
3l1lA 2 0.484 14 0.956 Contact Map
3j1zP 8 0.6154 12.2 0.957 Contact Map
2kncA 1 0.1603 10.5 0.958 Contact Map
3zuxA 1 0.2917 9.7 0.959 Contact Map
3o7qA 1 0.4679 8.9 0.96 Contact Map
4pgrA 1 0.4391 8.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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