GREMLIN Database
GAPN - NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
UniProt: Q97U30 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 509 (458)
Sequences: 36260 (21800)
Seq/√Len: 1018.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_E415_K5.3641.00
314_E413_K3.3481.00
286_A323_L3.2901.00
317_Y413_K2.9831.00
394_L397_M2.8561.00
375_K383_E2.8501.00
281_S313_E2.8491.00
71_Y242_R2.8271.00
42_D54_K2.7861.00
350_V354_D2.7641.00
321_K411_L2.6641.00
361_K365_E2.6051.00
362_D398_Y2.5711.00
98_D131_L2.5421.00
209_M212_K2.5411.00
281_S315_E2.4971.00
100_F103_D2.4751.00
360_I382_I2.4221.00
71_Y244_Q2.3911.00
31_S72_R2.3181.00
437_G443_I2.2971.00
42_D51_I2.2811.00
59_N62_Q2.2701.00
102_E120_E2.2651.00
93_M214_M2.1941.00
215_E221_K2.1611.00
357_E361_K2.1531.00
101_K124_K2.1411.00
347_V356_W2.1261.00
357_E376_R2.1051.00
417_I442_K2.0701.00
163_E494_K2.0641.00
96_L216_L2.0241.00
362_D366_K2.0231.00
239_G261_N1.9901.00
290_Q328_L1.9831.00
325_I330_K1.9821.00
202_S349_D1.9781.00
371_L388_E1.9631.00
428_K475_D1.9591.00
89_I219_F1.9551.00
445_K449_F1.9271.00
277_A292_I1.9161.00
357_E382_I1.9081.00
319_T323_L1.8971.00
364_V370_I1.8951.00
103_D209_M1.8891.00
282_D442_K1.8801.00
417_I445_K1.8611.00
162_K488_Q1.8611.00
387_I399_F1.8301.00
162_K491_T1.8281.00
35_I65_D1.8201.00
68_E242_R1.8191.00
311_L420_A1.8111.00
451_E474_K1.8061.00
311_L423_I1.7981.00
257_E260_R1.7891.00
96_L217_A1.7891.00
256_E475_D1.7741.00
369_K388_E1.7561.00
96_L99_K1.7331.00
313_E414_V1.7301.00
100_F216_L1.7261.00
96_L213_V1.7241.00
75_R79_R1.7081.00
395_K423_I1.7041.00
400_Y412_I1.6951.00
64_D68_E1.6831.00
329_T386_L1.6791.00
325_I371_L1.6731.00
398_Y402_K1.6671.00
211_A226_I1.6621.00
419_E422_E1.6491.00
292_I320_L1.6461.00
107_V209_M1.6361.00
236_K239_G1.6241.00
285_L323_L1.6211.00
310_V409_A1.6171.00
91_K131_L1.6171.00
194_A223_S1.6161.00
322_D326_K1.6131.00
130_L186_V1.6001.00
317_Y321_K1.5921.00
64_D240_D1.5851.00
418_D449_F1.5721.00
95_S99_K1.5651.00
116_K120_E1.5631.00
318_D413_K1.5621.00
370_I387_I1.5611.00
415_K419_E1.5571.00
82_P85_K1.5561.00
297_I329_T1.5371.00
51_I54_K1.5301.00
358_K398_Y1.5301.00
95_S131_L1.5261.00
98_D127_I1.5211.00
317_Y388_E1.5121.00
281_S442_K1.5051.00
350_V380_T1.4941.00
323_L326_K1.4861.00
85_K88_D1.4771.00
91_K138_K1.4681.00
433_A452_V1.4671.00
49_L378_G1.4621.00
289_A323_L1.4561.00
212_K216_L1.4431.00
50_N378_G1.4371.00
280_L442_K1.4371.00
92_K95_S1.4341.00
102_E106_N1.4251.00
319_T322_D1.4241.00
291_R436_F1.4221.00
311_L414_V1.4181.00
62_Q65_D1.4081.00
33_Q221_K1.4071.00
136_D139_E1.4041.00
109_M119_A1.3981.00
361_K364_V1.3981.00
106_N110_I1.3971.00
292_I310_V1.3941.00
101_K120_E1.3941.00
94_A131_L1.3931.00
40_W54_K1.3841.00
130_L182_V1.3811.00
312_V320_L1.3801.00
80_D449_F1.3761.00
359_A404_V1.3631.00
333_K341_L1.3601.00
170_S195_I1.3511.00
280_L414_V1.3451.00
419_E423_I1.3421.00
106_N338_R1.3311.00
416_N419_E1.3291.00
259_V478_I1.3261.00
161_R448_R1.3191.00
44_I51_I1.3171.00
100_F209_M1.3151.00
356_W406_A1.3151.00
211_A224_F1.3121.00
353_V382_I1.3111.00
81_T85_K1.3101.00
326_K330_K1.3021.00
330_K372_F1.2991.00
414_V423_I1.2981.00
45_S48_D1.2971.00
354_D358_K1.2881.00
67_L240_D1.2861.00
353_V376_R1.2831.00
366_K398_Y1.2801.00
421_L446_L1.2791.00
104_F209_M1.2671.00
245_A268_I1.2651.00
353_V357_E1.2651.00
318_D322_D1.2621.00
280_L446_L1.2611.00
214_M224_F1.2611.00
368_G387_I1.2491.00
181_T197_I1.2491.00
321_K325_I1.2451.00
94_A98_D1.2401.00
313_E416_N1.2391.00
39_E57_K1.2391.00
363_A387_I1.2141.00
350_V353_V1.2081.00
67_L242_R1.2031.00
313_E316_V1.2001.00
231_G235_N1.2001.00
278_I420_A1.1911.00
401_N426_S1.1861.00
333_K343_T1.1751.00
162_K493_Y1.1741.00
321_K371_L1.1711.00
396_D401_N1.1701.00
159_V444_R1.1651.00
485_Y488_Q1.1631.00
321_K388_E1.1631.00
93_M213_V1.1631.00
395_K426_S1.1621.00
75_R194_A1.1591.00
335_G342_T1.1571.00
324_L409_A1.1571.00
109_M337_P1.1561.00
332_V344_V1.1531.00
68_E72_R1.1511.00
316_V319_T1.1501.00
81_T89_I1.1491.00
185_I224_F1.1471.00
93_M219_F1.1461.00
201_S232_R1.1461.00
320_L324_L1.1451.00
92_K96_L1.1411.00
433_A455_I1.1371.00
201_S230_P1.1361.00
254_T257_E1.1351.00
401_N428_K1.1291.00
57_K230_P1.1281.00
326_K331_S1.1251.00
484_G488_Q1.1241.00
93_M130_L1.1191.00
447_Q496_I1.1191.00
45_S336_D1.1121.00
418_D445_K1.1111.00
143_D484_G1.1071.00
278_I446_L1.1051.00
106_N116_K1.1001.00
143_D485_Y1.0991.00
358_K362_D1.0981.00
170_S247_S1.0961.00
443_I457_I1.0951.00
169_L237_V1.0931.00
67_L243_I1.0931.00
201_S231_G1.0911.00
257_E261_N1.0901.00
284_D438_K1.0831.00
377_L383_E1.0761.00
421_L449_F1.0761.00
100_F213_V1.0751.00
325_I372_F1.0701.00
256_E264_I1.0671.00
259_V267_F1.0641.00
373_G385_V1.0611.00
57_K233_D1.0591.00
366_K397_M1.0581.00
277_A307_V1.0571.00
47_I337_P1.0571.00
53_G205_L1.0571.00
330_K383_E1.0561.00
91_K135_L1.0561.00
99_K216_L1.0521.00
336_D339_D1.0521.00
222_D225_A1.0461.00
104_F213_V1.0401.00
485_Y493_Y1.0391.00
208_L228_T1.0381.00
417_I446_L1.0361.00
165_V245_A1.0351.00
41_Q57_K1.0341.00
253_E257_E1.0311.00
439_D442_K1.0301.00
353_V380_T1.0261.00
418_D422_E1.0251.00
208_L226_I1.0241.00
49_L380_T1.0221.00
356_W408_A1.0191.00
76_W80_D1.0171.00
230_P233_D1.0161.00
185_I195_I1.0151.00
176_Y303_R1.0131.00
169_L243_I1.0121.00
73_K194_A1.0111.00
278_I424_S1.0111.00
161_R496_I1.0051.00
464_G467_Y0.9961.00
276_P433_A0.9891.00
274_G308_K0.9861.00
259_V263_G0.9861.00
69_H225_A0.9851.00
318_D321_K0.9821.00
33_Q65_D0.9821.00
373_G383_E0.9761.00
414_V420_A0.9731.00
393_T397_M0.9701.00
77_S81_T0.9661.00
31_S69_H0.9651.00
374_G385_V0.9601.00
284_D287_W0.9591.00
286_A319_T0.9491.00
244_Q451_E0.9491.00
480_R492_A0.9481.00
388_E393_T0.9461.00
45_S110_I0.9441.00
359_A362_D0.9431.00
167_V243_I0.9431.00
473_R492_A0.9401.00
434_A460_Y0.9401.00
167_V194_A0.9351.00
165_V266_Q0.9291.00
87_L138_K0.9271.00
163_E448_R0.9271.00
100_F212_K0.9271.00
137_V190_V0.9271.00
105_V120_E0.9251.00
471_G480_R0.9231.00
289_A324_L0.9231.00
422_E426_S0.9181.00
295_G307_V0.9181.00
280_L417_I0.9171.00
126_A182_V0.9171.00
212_K215_E0.9091.00
364_V387_I0.9091.00
45_S50_N0.9091.00
110_I338_R0.9071.00
63_I169_L0.9071.00
363_A404_V0.9031.00
97_L126_A0.8981.00
420_A423_I0.8961.00
368_G397_M0.8951.00
251_S254_T0.8921.00
435_I446_L0.8911.00
79_R451_E0.8911.00
279_V320_L0.8891.00
412_I423_I0.8881.00
103_D106_N0.8881.00
414_V419_E0.8841.00
158_A468_F0.8841.00
91_K134_D0.8841.00
296_I308_K0.8801.00
354_D357_E0.8801.00
356_W404_V0.8801.00
362_D365_E0.8801.00
94_A134_D0.8781.00
287_W291_R0.8771.00
38_D65_D0.8771.00
359_A398_Y0.8761.00
87_L134_D0.8711.00
168_V245_A0.8691.00
288_A292_I0.8681.00
317_Y411_L0.8681.00
395_K412_I0.8661.00
112_N203_T0.8651.00
367_G397_M0.8641.00
165_V193_N0.8631.00
289_A320_L0.8611.00
114_K122_E0.8611.00
285_L289_A0.8611.00
277_A436_F0.8591.00
37_G62_Q0.8591.00
246_I258_V0.8591.00
73_K223_S0.8571.00
230_P234_M0.8561.00
358_K361_K0.8551.00
165_V492_A0.8521.00
83_G87_L0.8511.00
266_Q492_A0.8501.00
219_F224_F0.8501.00
60_W64_D0.8491.00
88_D92_K0.8481.00
289_A293_A0.8471.00
87_L91_K0.8461.00
163_E473_R0.8451.00
72_R76_W0.8441.00
76_W79_R0.8431.00
159_V498_Y0.8411.00
433_A450_L0.8381.00
38_D59_N0.8381.00
44_I380_T0.8321.00
37_G40_W0.8321.00
259_V262_A0.8291.00
280_L437_G0.8291.00
202_S351_K0.8281.00
289_A328_L0.8261.00
197_I207_I0.8251.00
126_A178_L0.8241.00
96_L100_F0.8221.00
421_L425_N0.8211.00
246_I262_A0.8211.00
388_E413_K0.8171.00
61_N64_D0.8171.00
80_D448_R0.8161.00
360_I408_A0.8131.00
65_D69_H0.8111.00
47_I381_Y0.8101.00
259_V264_I0.8081.00
97_L127_I0.8061.00
444_R448_R0.8051.00
288_A320_L0.8031.00
238_V258_V0.8021.00
169_L246_I0.7981.00
181_T185_I0.7981.00
90_Y190_V0.7951.00
41_Q230_P0.7951.00
468_F495_S0.7951.00
293_A324_L0.7911.00
77_S80_D0.7901.00
31_S221_K0.7861.00
256_E260_R0.7811.00
34_W215_E0.7801.00
211_A215_E0.7771.00
61_N65_D0.7761.00
187_Y486_T0.7751.00
69_H222_D0.7741.00
324_L386_L0.7741.00
120_E340_P0.7721.00
92_K217_A0.7691.00
76_W422_E0.7691.00
440_I443_I0.7671.00
78_I223_S0.7651.00
38_D61_N0.7631.00
188_T195_I0.7631.00
191_I491_T0.7631.00
112_N348_I0.7621.00
109_M116_K0.7611.00
353_V377_L0.7601.00
334_V377_L0.7591.00
70_I225_A0.7581.00
238_V261_N0.7571.00
322_D325_I0.7571.00
276_P424_S0.7551.00
356_W382_I0.7551.00
255_G271_L0.7541.00
52_I110_I0.7541.00
58_L62_Q0.7531.00
84_E138_K0.7531.00
255_G269_M0.7531.00
37_G56_P0.7511.00
91_K95_S0.7491.00
105_V109_M0.7481.00
35_I62_Q0.7461.00
260_R263_G0.7451.00
275_D308_K0.7451.00
117_S343_T0.7431.00
208_L212_K0.7431.00
65_D68_E0.7411.00
199_P228_T0.7401.00
452_V455_I0.7391.00
170_S184_K0.7381.00
182_V210_L0.7381.00
60_W236_K0.7321.00
280_L313_E0.7301.00
236_K257_E0.7291.00
313_E417_I0.7291.00
332_V343_T0.7291.00
63_I67_L0.7281.00
105_V116_K0.7271.00
285_L316_V0.7251.00
312_V316_V0.7241.00
416_N422_E0.7231.00
329_T372_F0.7221.00
193_N491_T0.7171.00
350_V376_R0.7161.00
178_L206_P0.7141.00
248_L254_T0.7141.00
359_A402_K0.7131.00
323_L328_L0.7121.00
38_D62_Q0.7111.00
262_A267_F0.7111.00
219_F223_S0.7101.00
60_W233_D0.7091.00
360_I387_I0.7081.00
336_D342_T0.7071.00
104_F178_L0.7071.00
114_K118_A0.7071.00
339_D342_T0.7061.00
440_I498_Y0.7051.00
252_T475_D0.7041.00
325_I329_T0.7031.00
116_K338_R0.7021.00
238_V246_I0.7011.00
417_I421_L0.6991.00
372_F386_L0.6951.00
197_I224_F0.6931.00
351_K354_D0.6881.00
158_A495_S0.6881.00
110_I205_L0.6871.00
229_I234_M0.6871.00
457_I498_Y0.6851.00
58_L227_I0.6841.00
236_K261_N0.6831.00
98_D124_K0.6831.00
282_D437_G0.6831.00
357_E360_I0.6821.00
44_I49_L0.6811.00
108_L111_N0.6801.00
181_T207_I0.6801.00
64_D242_R0.6801.00
196_I225_A0.6801.00
374_G383_E0.6751.00
438_K441_N0.6741.00
107_V205_L0.6731.00
71_Y76_W0.6721.00
364_V375_K0.6721.00
98_D101_K0.6711.00
393_T399_F0.6701.00
58_L66_T0.6691.00
395_K400_Y0.6681.00
310_V320_L0.6671.00
329_T332_V0.6661.00
214_M219_F0.6651.00
89_I217_A0.6651.00
63_I234_M0.6651.00
311_L395_K0.6621.00
393_T400_Y0.6621.00
447_Q457_I0.6611.00
300_T344_V0.6601.00
352_T355_E0.6581.00
109_M338_R0.6581.00
334_V344_V0.6581.00
49_L350_V0.6571.00
324_L411_L0.6561.00
165_V244_Q0.6561.00
70_I194_A0.6541.00
73_K77_S0.6531.00
201_S355_E0.6521.00
83_G137_V0.6521.00
293_A328_L0.6521.00
202_S348_I0.6481.00
31_S225_A0.6471.00
266_Q489_Y0.6471.00
437_G442_K0.6471.00
95_S98_D0.6461.00
56_P228_T0.6431.00
311_L400_Y0.6421.00
349_D352_T0.6411.00
423_I426_S0.6401.00
382_I385_V0.6401.00
78_I89_I0.6391.00
209_M213_V0.6351.00
376_R383_E0.6351.00
79_R449_F0.6351.00
194_A225_A0.6331.00
293_A332_V0.6321.00
55_I204_P0.6321.00
292_I324_L0.6311.00
172_V181_T0.6301.00
325_I386_L0.6291.00
31_S65_D0.6291.00
79_R164_P0.6291.00
45_S338_R0.6261.00
79_R163_E0.6251.00
351_K355_E0.6251.00
334_V343_T0.6241.00
157_E444_R0.6231.00
282_D438_K0.6211.00
68_E71_Y0.6211.00
279_V288_A0.6211.00
94_A127_I0.6151.00
140_T491_T0.6151.00
159_V496_I0.6151.00
387_I393_T0.6141.00
185_I197_I0.6131.00
451_E473_R0.6121.00
32_G215_E0.6121.00
259_V269_M0.6121.00
440_I444_R0.6121.00
285_L319_T0.6111.00
355_E358_K0.6101.00
123_V127_I0.6101.00
140_T487_I0.6091.00
97_L210_L0.6091.00
443_I447_Q0.6091.00
370_I385_V0.6081.00
158_A497_V0.6071.00
89_I218_S0.6071.00
103_D212_K0.6061.00
347_V352_T0.6051.00
404_V408_A0.6051.00
30_L66_T0.6051.00
435_I443_I0.6021.00
268_I489_Y0.6011.00
181_T210_L0.6001.00
96_L218_S0.6001.00
366_K396_D0.5991.00
444_R498_Y0.5991.00
34_W212_K0.5981.00
421_L445_K0.5981.00
178_L210_L0.5961.00
488_Q491_T0.5951.00
114_K176_Y0.5951.00
78_I189_T0.5931.00
40_W56_P0.5921.00
161_R494_K0.5921.00
201_S257_E0.5911.00
314_E317_Y0.5901.00
97_L178_L0.5881.00
184_K247_S0.5881.00
184_K481_E0.5871.00
43_V111_N0.5861.00
455_I494_K0.5851.00
168_V193_N0.5851.00
102_E116_K0.5851.00
89_I93_M0.5851.00
232_R235_N0.5851.00
106_N109_M0.5841.00
108_L206_P0.5841.00
282_D439_D0.5841.00
287_W290_Q0.5831.00
488_Q493_Y0.5831.00
83_G190_V0.5821.00
287_W438_K0.5811.00
43_V53_G0.5811.00
123_V178_L0.5791.00
277_A310_V0.5771.00
441_N445_K0.5761.00
60_W239_G0.5761.00
43_V204_P0.5761.00
283_A288_A0.5751.00
235_N239_G0.5751.00
85_K89_I0.5751.00
108_L122_E0.5731.00
281_S414_V0.5731.00
305_D464_G0.5731.00
312_V411_L0.5721.00
101_K105_V0.5711.00
97_L104_F0.5691.00
245_A489_Y0.5641.00
169_L196_I0.5641.00
421_L450_L0.5631.00
370_I373_G0.5601.00
231_G234_M0.5601.00
170_S185_I0.5601.00
72_R77_S0.5591.00
303_R306_S0.5591.00
230_P235_N0.5581.00
108_L119_A0.5581.00
97_L130_L0.5571.00
66_T227_I0.5571.00
441_N444_R0.5551.00
94_A130_L0.5541.00
347_V382_I0.5521.00
400_Y423_I0.5521.00
333_K339_D0.5511.00
210_L214_M0.5511.00
104_F123_V0.5491.00
93_M96_L0.5481.00
77_S194_A0.5471.00
295_G460_Y0.5471.00
297_I332_V0.5461.00
395_K422_E0.5451.00
69_H221_K0.5451.00
253_E351_K0.5441.00
168_V195_I0.5431.00
71_Y167_V0.5411.00
276_P452_V0.5401.00
135_L138_K0.5401.00
310_V411_L0.5391.00
101_K127_I0.5391.00
454_A463_H0.5371.00
357_E364_V0.5361.00
360_I385_V0.5351.00
70_I196_I0.5351.00
328_L331_S0.5341.00
132_R136_D0.5331.00
277_A434_A0.5321.00
275_D432_D0.5311.00
76_W449_F0.5311.00
122_E176_Y0.5301.00
71_Y75_R0.5291.00
366_K394_L0.5281.00
76_W81_T0.5281.00
105_V123_V0.5281.00
363_A398_Y0.5281.00
450_L455_I0.5271.00
316_V414_V0.5271.00
179_F183_N0.5261.00
133_A187_Y0.5261.00
191_I487_I0.5261.00
196_I227_I0.5251.00
296_I409_A0.5251.00
52_I205_L0.5241.00
252_T256_E0.5241.00
167_V244_Q0.5231.00
92_K218_S0.5231.00
307_V434_A0.5221.00
169_L238_V0.5221.00
70_I167_V0.5211.00
285_L288_A0.5201.00
125_A179_F0.5201.00
424_S450_L0.5191.00
30_L35_I0.5171.00
368_G393_T0.5161.00
451_E492_A0.5161.00
55_I205_L0.5161.00
395_K401_N0.5151.00
359_A399_F0.5131.00
321_K386_L0.5131.00
83_G141_R0.5111.00
399_F404_V0.5101.00
289_A316_V0.5101.00
420_A424_S0.5081.00
39_E59_N0.5071.00
112_N299_Y0.5071.00
201_S253_E0.5061.00
39_E233_D0.5061.00
247_S490_V0.5061.00
66_T196_I0.5041.00
215_E222_D0.5041.00
124_K127_I0.5031.00
267_F478_I0.5031.00
34_W211_A0.5031.00
417_I449_F0.5031.00
232_R236_K0.5031.00
183_N482_G0.5031.00
456_Y459_D0.5021.00
168_V247_S0.5021.00
435_I457_I0.5011.00
215_E218_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uxtA 4 0.9725 100 0.064 Contact Map
4yweA 5 0.9116 100 0.07 Contact Map
4pxlA 4 0.9332 100 0.073 Contact Map
3ek1A 5 0.943 100 0.073 Contact Map
4pz2A 4 0.9312 100 0.074 Contact Map
4qf6A 4 0.945 100 0.074 Contact Map
1a4sA 4 0.9627 100 0.075 Contact Map
4o5hA 4 0.9627 100 0.075 Contact Map
4lihA 5 0.943 100 0.076 Contact Map
4wj9A 4 0.945 100 0.077 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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