GREMLIN Database
KDGK - 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase
UniProt: Q97U29 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (280)
Sequences: 22457 (16713)
Seq/√Len: 998.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_L266_S3.3041.00
66_I81_V2.6871.00
227_L233_I2.6391.00
51_S75_D2.6291.00
234_A278_L2.5371.00
5_I129_S2.5221.00
267_L272_K2.4731.00
273_D276_Y2.2761.00
232_A260_M2.2431.00
154_E186_K2.2381.00
241_A275_E2.1121.00
216_K235_Y2.0851.00
63_K81_V2.0711.00
196_P227_L2.0481.00
95_G99_P2.0121.00
58_N83_N2.0101.00
267_L280_H2.0061.00
55_R82_D1.9931.00
70_R76_T1.9821.00
41_I72_Q1.9521.00
300_T303_D1.9311.00
55_R120_D1.8721.00
45_R72_Q1.8621.00
6_A40_C1.8601.00
233_I242_F1.8571.00
212_Y235_Y1.8511.00
209_D240_K1.8471.00
43_V48_L1.8441.00
259_A284_A1.8241.00
272_K276_Y1.7881.00
193_I261_A1.7701.00
150_I182_S1.7671.00
133_H164_N1.7661.00
42_A262_G1.7491.00
123_E155_L1.7341.00
68_Y71_A1.7241.00
270_Q301_L1.7151.00
164_N265_V1.7151.00
232_A282_I1.6941.00
222_V236_K1.6671.00
66_I70_R1.6661.00
188_D221_K1.6641.00
234_A241_A1.6621.00
189_I222_V1.6241.00
264_F277_S1.6191.00
263_T284_A1.6141.00
224_L264_F1.6121.00
275_E279_A1.6031.00
153_F163_T1.6001.00
155_L159_R1.5971.00
227_L230_K1.5961.00
246_Y283_A1.5911.00
285_S289_I1.5731.00
67_E71_A1.5631.00
150_I154_E1.5521.00
256_A289_I1.5501.00
227_L242_F1.5331.00
234_A274_I1.5171.00
85_S115_R1.5151.00
162_D188_D1.5131.00
131_L162_D1.5121.00
291_V303_D1.5011.00
4_V43_V1.5011.00
30_K64_N1.4921.00
43_V266_S1.4911.00
10_P54_A1.4911.00
151_K154_E1.4621.00
131_L265_V1.4551.00
151_K155_L1.4461.00
214_K217_E1.4281.00
236_K239_V1.4261.00
32_V65_I1.4151.00
243_K278_L1.4061.00
263_T280_H1.4001.00
58_N81_V1.3991.00
127_R159_R1.3951.00
58_N63_K1.3901.00
243_K282_I1.3731.00
207_D210_E1.3721.00
266_S270_Q1.3711.00
155_L158_S1.3681.00
63_K67_E1.3661.00
68_Y72_Q1.3641.00
205_V214_K1.3581.00
246_Y279_A1.3481.00
49_S75_D1.3401.00
37_L69_S1.3311.00
252_D293_G1.3241.00
209_D213_R1.3011.00
157_K186_K1.2881.00
14_F28_F1.2711.00
12_I64_N1.2681.00
213_R235_Y1.2661.00
157_K188_D1.2641.00
117_S120_D1.2641.00
248_V290_T1.2631.00
64_N67_E1.2521.00
222_V274_I1.2471.00
267_L277_S1.2361.00
156_A161_L1.2341.00
213_R217_E1.2311.00
222_V268_Y1.2251.00
267_L270_Q1.2221.00
118_P151_K1.2201.00
32_V68_Y1.2091.00
232_A278_L1.2071.00
235_Y240_K1.1981.00
187_Y192_L1.1941.00
66_I79_I1.1831.00
131_L164_N1.1821.00
132_V156_A1.1811.00
48_L269_L1.1761.00
264_F281_G1.1681.00
63_K66_I1.1681.00
162_D166_R1.1671.00
82_D85_S1.1671.00
250_V289_I1.1601.00
62_G87_T1.1511.00
287_L290_T1.1471.00
287_L291_V1.1451.00
48_L270_Q1.1451.00
166_R226_K1.1441.00
133_H265_V1.1361.00
213_R240_K1.1361.00
276_Y279_A1.1351.00
222_V264_F1.1331.00
40_C50_C1.1311.00
246_Y286_T1.1221.00
263_T281_G1.1161.00
51_S129_S1.1141.00
250_V253_P1.1121.00
181_L218_L1.1081.00
189_I268_Y1.1031.00
227_L231_G1.0991.00
14_F30_K1.0981.00
205_V210_E1.0961.00
44_V74_I1.0941.00
222_V234_A1.0931.00
264_F268_Y1.0891.00
64_N68_Y1.0871.00
193_I226_K1.0841.00
39_F133_H1.0821.00
246_Y282_I1.0821.00
199_T225_Y1.0781.00
43_V50_C1.0741.00
46_N263_T1.0661.00
10_P65_I1.0601.00
248_V289_I1.0561.00
41_I45_R1.0471.00
160_S166_R1.0411.00
60_E63_K1.0401.00
226_K260_M1.0391.00
210_E213_R1.0371.00
196_P230_K1.0341.00
212_Y225_Y1.0301.00
214_K218_L1.0291.00
122_N151_K1.0261.00
154_E158_S1.0201.00
103_E106_Y1.0191.00
243_K279_A1.0181.00
44_V73_G1.0161.00
189_I264_F1.0151.00
51_S78_H1.0131.00
67_E70_R1.0101.00
259_A288_V1.0091.00
162_D221_K1.0091.00
162_D189_I1.0091.00
199_T211_A1.0071.00
66_I76_T1.0061.00
51_S125_Y0.9961.00
32_V64_N0.9901.00
14_F89_I0.9861.00
134_S153_F0.9831.00
133_H261_A0.9761.00
264_F274_I0.9751.00
42_A259_A0.9671.00
82_D115_R0.9651.00
279_A283_A0.9611.00
123_E159_R0.9591.00
7_L132_V0.9531.00
43_V262_G0.9531.00
10_P37_L0.9391.00
56_V66_I0.9371.00
56_V62_G0.9351.00
10_P52_L0.9321.00
193_I264_F0.9291.00
147_E151_K0.9281.00
251_E292_R0.9271.00
245_A282_I0.9231.00
132_V161_L0.9181.00
277_S281_G0.9171.00
76_T79_I0.9151.00
272_K280_H0.9151.00
266_S301_L0.9121.00
14_F61_F0.9121.00
282_I285_S0.9111.00
4_V269_L0.9051.00
185_K219_G0.9041.00
266_S280_H0.9011.00
268_Y277_S0.9011.00
126_V129_S0.9001.00
55_R80_K0.8971.00
166_R170_W0.8971.00
236_K274_I0.8961.00
5_I53_I0.8961.00
102_S106_Y0.8961.00
56_V79_I0.8911.00
182_S185_K0.8911.00
46_N284_A0.8901.00
203_L211_A0.8821.00
239_V275_E0.8801.00
167_P194_T0.8801.00
250_V290_T0.8751.00
134_S163_T0.8741.00
44_V49_S0.8741.00
196_P200_K0.8701.00
124_N127_R0.8601.00
6_A36_E0.8601.00
25_V105_V0.8571.00
243_K275_E0.8561.00
210_E214_K0.8531.00
51_S77_S0.8521.00
66_I80_K0.8481.00
233_I240_K0.8461.00
263_T267_L0.8411.00
7_L152_A0.8401.00
213_R216_K0.8391.00
44_V50_C0.8381.00
154_E182_S0.8381.00
273_D277_S0.8381.00
15_N31_H0.8381.00
30_K61_F0.8381.00
57_G87_T0.8331.00
134_S149_V0.8271.00
5_I51_S0.8151.00
12_I30_K0.8021.00
260_M282_I0.8011.00
93_Q103_E0.8011.00
113_G116_L0.7961.00
249_P290_T0.7961.00
150_I186_K0.7961.00
11_L88_G0.7961.00
184_L187_Y0.7951.00
231_G245_A0.7941.00
56_V81_V0.7931.00
212_Y223_L0.7901.00
65_I87_T0.7861.00
212_Y216_K0.7861.00
59_D87_T0.7831.00
216_K237_D0.7781.00
148_A152_A0.7761.00
230_K242_F0.7731.00
160_S164_N0.7681.00
39_F261_A0.7661.00
132_V152_A0.7651.00
103_E107_Y0.7651.00
236_K241_A0.7631.00
248_V286_T0.7611.00
40_C52_L0.7571.00
131_L269_L0.7571.00
37_L295_N0.7561.00
46_N280_H0.7561.00
194_T199_T0.7541.00
283_A287_L0.7501.00
241_A278_L0.7471.00
88_G93_Q0.7441.00
123_E158_S0.7411.00
41_I295_N0.7391.00
259_A285_S0.7381.00
282_I286_T0.7321.00
12_I61_F0.7321.00
259_A263_T0.7201.00
80_K120_D0.7161.00
104_L107_Y0.7131.00
224_L234_A0.7121.00
68_Y295_N0.7121.00
229_S247_K0.7111.00
195_D198_D0.7071.00
165_I187_Y0.7041.00
93_Q105_V0.7011.00
260_M281_G0.7011.00
209_D235_Y0.7001.00
209_D242_F0.7001.00
92_I104_L0.6981.00
95_G101_K0.6971.00
78_H125_Y0.6971.00
216_K236_K0.6951.00
199_T215_Y0.6891.00
118_P147_E0.6881.00
101_K105_V0.6881.00
61_F89_I0.6851.00
260_M285_S0.6841.00
147_E150_I0.6831.00
60_E64_N0.6831.00
161_L166_R0.6811.00
208_P227_L0.6811.00
236_K240_K0.6761.00
285_S288_V0.6711.00
46_N304_A0.6661.00
161_L164_N0.6651.00
129_S161_L0.6651.00
40_C74_I0.6641.00
231_G242_F0.6641.00
4_V131_L0.6641.00
29_E292_R0.6591.00
211_A215_Y0.6561.00
46_N266_S0.6541.00
5_I125_Y0.6471.00
280_H301_L0.6451.00
101_K107_Y0.6451.00
209_D233_I0.6451.00
232_A243_K0.6431.00
212_Y240_K0.6391.00
116_L120_D0.6391.00
181_L185_K0.6391.00
166_R194_T0.6371.00
205_V211_A0.6361.00
123_E127_R0.6361.00
153_F186_K0.6351.00
125_Y129_S0.6321.00
280_H304_A0.6311.00
78_H81_V0.6311.00
208_P211_A0.6281.00
102_S105_V0.6281.00
164_N193_I0.6261.00
102_S107_Y0.6251.00
72_Q300_T0.6251.00
260_M278_L0.6201.00
133_H160_S0.6161.00
272_K277_S0.6161.00
150_I153_F0.6111.00
278_L282_I0.6091.00
118_P148_A0.6061.00
19_P101_K0.6051.00
77_S125_Y0.6041.00
49_S269_L0.6031.00
116_L121_I0.6011.00
193_I224_L0.6011.00
287_L303_D0.6001.00
58_N82_D0.5991.00
54_A79_I0.5991.00
274_I277_S0.5971.00
101_K104_L0.5931.00
126_V161_L0.5851.00
197_D201_I0.5841.00
92_I254_T0.5841.00
224_L260_M0.5841.00
196_P228_G0.5841.00
271_G277_S0.5831.00
136_G165_I0.5811.00
164_N168_K0.5811.00
119_E122_N0.5781.00
209_D212_Y0.5771.00
185_K218_L0.5741.00
59_D62_G0.5731.00
150_I179_T0.5721.00
276_Y280_H0.5721.00
165_I168_K0.5721.00
90_Y93_Q0.5701.00
17_F27_Y0.5681.00
4_V48_L0.5651.00
44_V72_Q0.5631.00
118_P122_N0.5621.00
224_L278_L0.5621.00
166_R193_I0.5571.00
16_S19_P0.5541.00
77_S80_K0.5531.00
164_N268_Y0.5511.00
287_L304_A0.5511.00
153_F183_I0.5501.00
101_K106_Y0.5441.00
69_S74_I0.5441.00
85_S112_A0.5441.00
6_A50_C0.5421.00
188_D222_V0.5421.00
130_R161_L0.5411.00
86_F89_I0.5411.00
125_Y128_N0.5401.00
156_A163_T0.5401.00
69_S76_T0.5371.00
82_D120_D0.5371.00
229_S250_V0.5331.00
14_F91_F0.5321.00
21_P24_F0.5321.00
152_A155_L0.5311.00
192_L223_L0.5301.00
131_L268_Y0.5301.00
221_K236_K0.5301.00
216_K223_L0.5291.00
267_L271_G0.5291.00
216_K219_G0.5281.00
163_T169_L0.5271.00
37_L52_L0.5271.00
150_I180_I0.5261.00
216_K238_N0.5251.00
31_H296_E0.5251.00
63_K70_R0.5231.00
6_A43_V0.5231.00
110_G114_S0.5231.00
90_Y106_Y0.5221.00
208_P212_Y0.5221.00
243_K246_Y0.5221.00
267_L301_L0.5221.00
43_V265_V0.5221.00
199_T208_P0.5221.00
33_A38_N0.5211.00
203_L214_K0.5201.00
39_F265_V0.5201.00
88_G113_G0.5181.00
92_I102_S0.5151.00
262_G266_S0.5131.00
13_Q33_A0.5121.00
123_E151_K0.5101.00
187_Y220_V0.5101.00
163_T166_R0.5101.00
220_V223_L0.5061.00
200_K206_T0.5041.00
169_L172_S0.5031.00
100_M103_E0.5021.00
49_S130_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v78A 5 0.9744 100 0.165 Contact Map
2rbcA 2 0.9425 100 0.171 Contact Map
2dcnA 5 0.9681 100 0.173 Contact Map
3iq0A 2 0.9744 100 0.174 Contact Map
3ljsA 2 0.9744 100 0.179 Contact Map
1v1aA 5 0.9457 100 0.188 Contact Map
4du5A 2 0.9297 100 0.188 Contact Map
1tyyA 2 0.9265 100 0.189 Contact Map
3hj6A 2 0.8722 100 0.193 Contact Map
1rkdA 2 0.9393 100 0.195 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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