GREMLIN Database
KDGA - 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
UniProt: Q97U28 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (280)
Sequences: 10303 (6805)
Seq/√Len: 406.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
232_K235_E3.8281.00
42_E79_V3.3651.00
27_T31_R3.2111.00
127_V161_E3.1321.00
266_F290_I2.9111.00
38_K79_V2.7891.00
34_K71_E2.6941.00
34_K75_A2.6361.00
87_V99_A2.5781.00
103_K138_P2.5721.00
38_K75_A2.5061.00
201_V206_L2.4921.00
227_L235_E2.4441.00
70_L101_L2.4351.00
99_A110_I2.2581.00
235_E238_K2.1861.00
19_I51_K2.0721.00
226_K230_E2.0461.00
123_E158_V2.0281.00
92_L129_Y2.0261.00
123_E155_D2.0051.00
202_A228_A1.9861.00
222_V226_K1.9561.00
227_L232_K1.9541.00
42_E82_K1.9511.00
50_D226_K1.9331.00
43_N47_K1.9291.00
71_E74_K1.9061.00
33_D36_K1.8961.00
42_E46_R1.8831.00
290_I294_E1.8761.00
153_D177_H1.8621.00
66_P94_D1.8361.00
131_K135_E1.8201.00
38_K78_D1.8141.00
124_K128_K1.8091.00
127_V131_K1.8031.00
262_L286_E1.7701.00
124_K161_E1.7541.00
220_V242_L1.7501.00
74_K78_D1.7341.00
47_K219_E1.7081.00
41_A76_V1.7061.00
77_Y83_I1.7001.00
142_Y167_G1.6791.00
20_T214_S1.6661.00
37_L76_V1.6601.00
128_K131_K1.6541.00
71_E75_A1.6441.00
68_E275_R1.6251.00
160_K184_L1.6211.00
287_R290_I1.6201.00
36_K39_I1.6111.00
112_S133_L1.5881.00
25_P37_L1.5781.00
99_A137_S1.5381.00
155_D158_V1.5171.00
265_Y272_G1.5111.00
75_A79_V1.5091.00
54_V76_V1.5071.00
159_A168_V1.4911.00
238_K242_L1.4861.00
73_L85_F1.4731.00
37_L72_N1.4561.00
283_D287_R1.3921.00
95_A133_L1.3881.00
50_D222_V1.3811.00
223_T235_E1.3781.00
45_I82_K1.3641.00
283_D286_E1.3631.00
287_R291_K1.3631.00
128_K132_T1.3601.00
89_G95_A1.3571.00
103_K137_S1.3551.00
223_T227_L1.3451.00
252_I288_Q1.3371.00
19_I53_F1.3351.00
262_L266_F1.3251.00
66_P97_R1.3221.00
103_K139_H1.3141.00
23_I264_K1.3101.00
60_L261_V1.3041.00
101_L104_D1.3021.00
18_I49_I1.2991.00
142_Y210_V1.2911.00
291_K295_G1.2711.00
70_L97_R1.2711.00
282_D285_E1.2671.00
75_A78_D1.2621.00
219_E223_T1.2611.00
84_I109_G1.2481.00
110_I137_S1.2371.00
16_P229_M1.2351.00
91_N94_D1.2291.00
96_I132_T1.2251.00
182_K190_V1.2241.00
70_L74_K1.2151.00
199_A236_A1.2141.00
228_A233_I1.2141.00
43_N269_Y1.2111.00
55_N72_N1.2081.00
73_L102_S1.2021.00
66_P101_L1.2001.00
134_C164_C1.1951.00
100_K104_D1.1821.00
67_E71_E1.1821.00
265_Y270_D1.1741.00
31_R93_D1.1701.00
20_T44_L1.1551.00
132_T276_P1.1521.00
77_Y108_V1.1501.00
74_K101_L1.1461.00
132_T135_E1.1381.00
263_T293_V1.1351.00
157_K184_L1.1321.00
80_T83_I1.1321.00
35_E38_K1.1251.00
27_T33_D1.1201.00
223_T226_K1.1171.00
180_D184_L1.1161.00
233_I237_L1.1141.00
53_F111_A1.1091.00
234_D237_L1.1031.00
26_F64_L1.1011.00
225_K229_M1.1011.00
41_A80_T1.0991.00
291_K294_E1.0931.00
70_L104_D1.0921.00
262_L290_I1.0921.00
41_A79_V1.0881.00
189_L207_D1.0811.00
262_L265_Y1.0701.00
84_I142_Y1.0651.00
87_V102_S1.0551.00
34_K38_K1.0541.00
110_I139_H1.0541.00
20_T49_I1.0481.00
124_K127_V1.0371.00
132_T136_V1.0311.00
18_I222_V1.0311.00
100_K136_V1.0281.00
36_K271_L1.0271.00
74_K105_F1.0181.00
96_I100_K1.0181.00
124_K282_D1.0151.00
28_K273_Y1.0151.00
101_L105_F1.0121.00
88_G113_Y1.0041.00
281_L289_L1.0011.00
16_P207_D0.9981.00
180_D248_E0.9961.00
203_S233_I0.9921.00
36_K270_D0.9911.00
281_L285_E0.9901.00
38_K42_E0.9841.00
66_P98_L0.9801.00
85_F107_I0.9741.00
286_E290_I0.9731.00
143_L159_A0.9701.00
235_E239_L0.9621.00
237_L241_F0.9601.00
178_T201_V0.9561.00
77_Y107_I0.9451.00
45_I80_T0.9441.00
22_I44_L0.9421.00
145_N153_D0.9411.00
288_Q291_K0.9321.00
69_K98_L0.9321.00
96_I136_V0.9301.00
41_A75_A0.9291.00
67_E97_R0.9291.00
50_D225_K0.9271.00
134_C141_V0.9261.00
126_L152_K0.9241.00
40_H264_K0.9231.00
127_V158_V0.9211.00
83_I107_I0.9201.00
89_G94_D0.9161.00
265_Y286_E0.9151.00
110_I141_V0.9151.00
285_E288_Q0.9111.00
97_R101_L0.9091.00
213_G247_I0.9071.00
77_Y105_F0.9061.00
87_V110_I0.9031.00
156_A184_L0.9021.00
26_F275_R0.9011.00
97_R100_K0.8941.00
191_Y208_G0.8921.00
128_K279_F0.8901.00
114_A152_K0.8881.00
30_N93_D0.8851.00
18_I225_K0.8841.00
234_D238_K0.8811.00
134_C165_F0.8811.00
202_A225_K0.8791.00
30_N276_P0.8761.00
224_I239_L0.8731.00
203_S228_A0.8731.00
217_L246_V0.8721.00
227_L239_L0.8711.00
284_E287_R0.8701.00
211_A214_S0.8671.00
292_K295_G0.8661.00
100_K103_K0.8661.00
123_E161_E0.8561.00
49_I218_P0.8541.00
54_V72_N0.8531.00
57_T117_Y0.8501.00
203_S237_L0.8471.00
249_A292_K0.8461.00
73_L107_I0.8461.00
28_K271_L0.8441.00
18_I209_N0.8441.00
22_I52_L0.8431.00
198_I209_N0.8421.00
112_S141_V0.8371.00
272_G286_E0.8371.00
245_E295_G0.8361.00
55_N85_F0.8321.00
92_L96_I0.8321.00
18_I214_S0.8291.00
284_E288_Q0.8211.00
73_L105_F0.8131.00
217_L243_H0.8111.00
192_S201_V0.8091.00
266_F294_E0.8051.00
37_L41_A0.8051.00
231_R234_D0.8001.00
265_Y271_L0.7831.00
146_Y150_T0.7811.00
180_D183_R0.7811.00
41_A52_L0.7791.00
39_I269_Y0.7791.00
131_K161_E0.7791.00
67_E70_L0.7771.00
27_T273_Y0.7771.00
200_T203_S0.7761.00
266_F286_E0.7721.00
156_A160_K0.7711.00
272_G280_P0.7681.00
154_I159_A0.7671.00
35_E39_I0.7661.00
102_S107_I0.7651.00
240_Q244_D0.7641.00
162_I165_F0.7641.00
52_L80_T0.7621.00
93_D97_R0.7581.00
106_D139_H0.7581.00
95_A112_S0.7571.00
156_A177_H0.7561.00
27_T35_E0.7481.00
22_I37_L0.7431.00
199_A228_A0.7411.00
185_N188_M0.7411.00
230_E235_E0.7391.00
217_L220_V0.7371.00
114_A154_I0.7371.00
144_Y169_K0.7361.00
51_K84_I0.7311.00
47_K218_P0.7271.00
64_L72_N0.7201.00
244_D248_E0.7201.00
178_T190_V0.7181.00
44_L49_I0.7141.00
45_I79_V0.7131.00
32_I37_L0.7121.00
156_A180_D0.7101.00
15_M109_G0.7091.00
159_A181_Y0.7081.00
70_L98_L0.7071.00
92_L132_T0.7061.00
128_K276_P0.7061.00
178_T182_K0.7051.00
220_V223_T0.7031.00
224_I228_A0.6981.00
33_D270_D0.6981.00
219_E267_Q0.6971.00
74_K104_D0.6961.00
55_N64_L0.6911.00
70_L105_F0.6891.00
19_I84_I0.6891.00
87_V112_S0.6861.00
145_N170_D0.6861.00
66_P70_L0.6841.00
73_L77_Y0.6801.00
70_L102_S0.6801.00
125_H279_F0.6801.00
22_I76_V0.6791.00
123_E157_K0.6760.99
143_L154_I0.6760.99
57_T144_Y0.6730.99
223_T239_L0.6710.99
200_T204_T0.6700.99
43_N267_Q0.6690.99
157_K180_D0.6640.99
287_R294_E0.6590.99
40_H44_L0.6590.99
153_D174_N0.6570.99
176_I196_M0.6560.99
61_G86_Q0.6550.99
273_Y280_P0.6520.99
138_P164_C0.6520.99
179_L183_R0.6500.99
30_N273_Y0.6490.99
264_K269_Y0.6480.99
65_S93_D0.6450.99
264_K267_Q0.6440.99
183_R241_F0.6440.99
44_L47_K0.6430.99
292_K296_I0.6410.99
77_Y81_N0.6400.99
202_A229_M0.6380.99
274_P278_I0.6380.99
253_F285_E0.6360.99
32_I72_N0.6350.99
157_K160_K0.6330.99
94_D97_R0.6330.99
199_A233_I0.6290.99
27_T30_N0.6270.99
266_F293_V0.6270.99
281_L286_E0.6270.99
122_S253_F0.6250.99
198_I224_I0.6230.99
21_P211_A0.6230.99
42_E45_I0.6210.99
16_P50_D0.6210.99
170_D178_T0.6210.99
54_V83_I0.6200.99
142_Y166_T0.6160.99
200_T240_Q0.6160.99
288_Q292_K0.6150.99
55_N69_K0.6090.99
179_L240_Q0.6090.99
160_K185_N0.6080.99
135_E164_C0.6060.99
120_R148_T0.6030.99
179_L204_T0.6030.99
199_A240_Q0.6020.99
158_V161_E0.6000.99
166_T189_L0.5990.99
21_P195_D0.5970.99
182_K207_D0.5970.99
53_F84_I0.5960.99
32_I75_A0.5950.99
21_P212_A0.5940.99
226_K229_M0.5900.99
179_L200_T0.5890.99
49_I222_V0.5880.99
78_D81_N0.5880.99
122_S125_H0.5860.99
23_I260_Y0.5850.99
227_L230_E0.5840.99
167_G189_L0.5840.99
216_Y263_T0.5830.98
84_I111_A0.5800.98
262_L274_P0.5760.98
274_P279_F0.5740.98
34_K79_V0.5710.98
18_I44_L0.5710.98
107_I139_H0.5710.98
67_E101_L0.5700.98
144_Y171_T0.5690.98
48_G222_V0.5680.98
215_N218_P0.5660.98
263_T289_L0.5640.98
198_I221_T0.5580.98
194_S197_L0.5570.98
238_K241_F0.5570.98
177_H181_Y0.5560.98
183_R245_E0.5560.98
228_A236_A0.5550.98
31_R71_E0.5540.98
26_F68_E0.5530.98
124_K279_F0.5510.98
252_I285_E0.5480.98
99_A133_L0.5450.98
174_N177_H0.5430.98
154_I158_V0.5420.98
263_T266_F0.5410.98
86_Q111_A0.5410.98
167_G188_M0.5390.97
103_K136_V0.5380.97
55_N73_L0.5370.97
190_V201_V0.5340.97
227_L236_A0.5330.97
95_A99_A0.5290.97
283_D290_I0.5270.97
142_Y189_L0.5270.97
63_S92_L0.5260.97
175_I197_L0.5260.97
24_T55_N0.5240.97
250_S260_Y0.5240.97
199_A203_S0.5220.97
212_A260_Y0.5200.97
47_K222_V0.5200.97
114_A130_F0.5200.97
77_Y80_T0.5190.97
129_Y132_T0.5190.97
193_G210_V0.5170.97
216_Y260_Y0.5170.97
262_L281_L0.5130.97
213_G217_L0.5130.97
216_Y264_K0.5110.97
93_D132_T0.5100.97
69_K94_D0.5090.96
43_N218_P0.5090.96
181_Y190_V0.5080.96
137_S164_C0.5080.96
239_L242_L0.5060.96
172_I177_H0.5060.96
98_L102_S0.5050.96
112_S130_F0.5050.96
40_H43_N0.5040.96
77_Y82_K0.5030.96
40_H269_Y0.5030.96
246_V250_S0.5030.96
130_F165_F0.5010.96
37_L75_A0.5000.96
249_A288_Q0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3si9A 3 0.9286 100 0.124 Contact Map
1w3iA 3 0.9351 100 0.127 Contact Map
2r91A 3 0.9221 100 0.128 Contact Map
3na8A 3 0.9188 100 0.128 Contact Map
3cprA 3 0.9513 100 0.13 Contact Map
4oe7A 3 0.9286 100 0.131 Contact Map
2nuwA 3 0.9286 100 0.132 Contact Map
3l21A 5 0.9416 100 0.132 Contact Map
3eb2A 3 0.9221 100 0.135 Contact Map
3a5fA 3 0.9188 100 0.136 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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