GREMLIN Database
GAD - D-gluconate/D-galactonate dehydratase
UniProt: Q97U27 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (341)
Sequences: 11662 (6651)
Seq/√Len: 360.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_K76_E3.5271.00
124_R348_H3.3271.00
238_K267_N3.1941.00
259_F263_E3.0521.00
203_N206_S2.9481.00
235_R239_A2.9081.00
69_E72_K2.7401.00
230_D233_G2.6921.00
28_T96_A2.6821.00
36_E104_I2.6411.00
258_A262_E2.5641.00
52_Y56_K2.5141.00
7_E29_R2.4341.00
31_I37_V2.4301.00
5_E31_I2.3751.00
32_T104_I2.3541.00
236_K239_A2.3271.00
29_R37_V2.3151.00
7_E31_I2.2911.00
212_K215_E2.2461.00
147_K187_A2.2461.00
71_E284_S2.1631.00
32_T36_E2.1051.00
254_E281_V2.1001.00
261_V294_V2.0941.00
339_Y360_S2.0901.00
211_A222_M2.0881.00
212_K240_S2.0741.00
235_R263_E2.0551.00
98_D280_T2.0261.00
236_K240_S2.0181.00
232_I263_E1.9721.00
211_A241_T1.9551.00
9_I29_R1.9501.00
5_E59_S1.9441.00
147_K151_K1.9421.00
276_I285_V1.9291.00
179_E182_K1.9241.00
36_E108_E1.9221.00
11_L41_E1.8941.00
106_G113_I1.8901.00
126_P155_K1.8671.00
139_P143_A1.8621.00
208_I240_S1.8531.00
29_R39_Y1.8371.00
268_I295_E1.8321.00
34_N108_E1.8311.00
148_D152_M1.7931.00
210_I214_L1.7911.00
257_T285_V1.7751.00
213_R216_K1.7461.00
345_E350_K1.7411.00
193_D220_G1.7341.00
4_R31_I1.7341.00
182_K217_Y1.7301.00
138_T141_E1.7211.00
73_N101_S1.7131.00
65_K72_K1.7071.00
262_E292_N1.7041.00
42_A96_A1.6901.00
226_V237_Y1.6891.00
6_I30_V1.6501.00
30_V101_S1.6501.00
84_L255_K1.6061.00
215_E242_H1.5981.00
260_Y266_V1.5911.00
150_V192_V1.5901.00
112_P115_K1.5811.00
288_I292_N1.5721.00
36_E107_K1.5611.00
287_K290_E1.5531.00
111_A115_K1.5521.00
145_K148_D1.5371.00
261_V288_I1.5261.00
204_A236_K1.5131.00
205_N236_K1.5121.00
182_K186_E1.5081.00
143_A187_A1.5071.00
315_A351_V1.4901.00
53_N57_Q1.4891.00
204_A237_Y1.4861.00
124_R350_K1.4751.00
283_R287_K1.4681.00
183_A186_E1.4621.00
59_S63_I1.4591.00
4_R33_E1.4551.00
178_E213_R1.4481.00
107_K360_S1.4451.00
176_E179_E1.4421.00
113_I357_L1.4091.00
173_G176_E1.3681.00
68_E108_E1.3641.00
98_D102_W1.3631.00
6_I59_S1.3631.00
208_I236_K1.3511.00
65_K73_N1.3441.00
153_G192_V1.3411.00
286_I317_T1.3371.00
57_Q88_F1.3331.00
132_W177_A1.3271.00
120_K123_D1.3231.00
259_F262_E1.3141.00
27_V39_Y1.3121.00
157_L192_V1.3091.00
147_K150_V1.3081.00
226_V233_G1.3041.00
261_V292_N1.3011.00
111_A116_L1.2741.00
182_K216_K1.2741.00
12_T22_A1.2731.00
195_L221_F1.2691.00
103_D107_K1.2571.00
77_W94_V1.2471.00
188_V194_I1.2451.00
282_G313_L1.2381.00
209_M212_K1.2371.00
72_K76_E1.2341.00
105_I109_L1.2331.00
179_E183_A1.2331.00
195_L220_G1.2311.00
75_H79_K1.2311.00
32_T108_E1.2241.00
99_I279_V1.2231.00
208_I237_Y1.2161.00
258_A288_I1.2091.00
257_T269_L1.2071.00
281_V284_S1.2011.00
185_R189_G1.2001.00
340_N354_K1.1971.00
56_K59_S1.1941.00
209_M213_R1.1941.00
146_A157_L1.1921.00
103_D309_V1.1901.00
126_P348_H1.1841.00
204_A233_G1.1811.00
141_E144_E1.1791.00
287_K291_A1.1711.00
229_E256_E1.1651.00
246_A268_I1.1561.00
196_I219_P1.1511.00
106_G116_L1.1461.00
215_E243_L1.1461.00
238_K264_G1.1381.00
283_R317_T1.1361.00
99_I309_V1.1271.00
137_V141_E1.1161.00
235_R265_L1.1151.00
160_D199_H1.1141.00
144_E147_K1.1101.00
256_E259_F1.1031.00
198_H222_M1.1001.00
254_E288_I1.0971.00
68_E105_I1.0971.00
225_P237_Y1.0911.00
225_P245_V1.0901.00
237_Y245_V1.0891.00
212_K242_H1.0851.00
206_S209_M1.0841.00
66_E69_E1.0841.00
284_S290_E1.0751.00
71_E283_R1.0731.00
65_K69_E1.0661.00
68_E109_L1.0641.00
56_K60_K1.0631.00
269_L289_A1.0621.00
159_F184_V1.0621.00
150_V157_L1.0531.00
146_A188_V1.0511.00
175_R179_E1.0471.00
148_D151_K1.0451.00
6_I62_Y1.0431.00
247_L260_Y1.0421.00
264_G294_V1.0391.00
273_L282_G1.0371.00
202_F207_A1.0361.00
284_S287_K1.0351.00
178_E217_Y1.0311.00
207_A211_A1.0281.00
187_A190_D1.0241.00
244_R321_Y1.0231.00
102_W280_T1.0151.00
33_E67_V1.0151.00
8_P56_K1.0081.00
27_V305_I0.9861.00
9_I39_Y0.9861.00
246_A270_Q0.9861.00
115_K353_Y0.9841.00
61_A76_E0.9761.00
185_R194_I0.9721.00
144_E148_D0.9721.00
224_E270_Q0.9661.00
272_D299_H0.9641.00
276_I282_G0.9641.00
178_E182_K0.9621.00
261_V269_L0.9571.00
202_F210_I0.9531.00
219_P243_L0.9531.00
309_V357_L0.9511.00
290_E318_Q0.9491.00
70_V105_I0.9491.00
58_V97_I0.9471.00
9_I27_V0.9421.00
143_A188_V0.9391.00
140_E144_E0.9371.00
73_N76_E0.9261.00
232_I259_F0.9231.00
109_L116_L0.9211.00
41_E305_I0.9161.00
266_V269_L0.9161.00
183_A187_A0.9101.00
178_E216_K0.9081.00
139_P179_E0.9071.00
149_V152_M0.9021.00
283_R316_V0.9001.00
52_Y55_I0.8991.00
184_V188_V0.8941.00
273_L310_E0.8861.00
226_V234_L0.8851.00
154_Y326_F0.8841.00
253_S256_E0.8811.00
113_I279_V0.8811.00
105_I116_L0.8781.00
139_P183_A0.8781.00
354_K360_S0.8781.00
252_I256_E0.8761.00
174_L210_I0.8731.00
181_V196_I0.8711.00
74_Y98_D0.8701.00
102_W279_V0.8681.00
174_L178_E0.8671.00
181_V217_Y0.8661.00
55_I59_S0.8591.00
215_E241_T0.8581.00
8_P55_I0.8561.00
185_R191_N0.8551.00
154_Y328_D0.8511.00
231_V265_L0.8511.00
251_L257_T0.8481.00
156_A195_L0.8471.00
73_N77_W0.8461.00
207_A226_V0.8361.00
279_V309_V0.8331.00
288_I291_A0.8331.00
234_L247_L0.8321.00
181_V214_L0.8321.00
295_E321_Y0.8311.00
130_N150_V0.8301.00
114_H312_Q0.8301.00
239_A264_G0.8291.00
205_N209_M0.8281.00
258_A292_N0.8231.00
58_V77_W0.8201.00
188_V192_V0.8121.00
298_F314_S0.8101.00
67_V105_I0.8091.00
190_D218_N0.8081.00
67_V101_S0.8071.00
114_H351_V0.8061.00
286_I296_V0.8061.00
74_Y78_Y0.8051.00
163_G177_A0.8031.00
238_K245_V0.8031.00
231_V260_Y0.8001.00
74_Y280_T0.7991.00
143_A186_E0.7991.00
248_G272_D0.7981.00
78_Y281_V0.7951.00
198_H202_F0.7941.00
279_V283_R0.7921.00
298_F319_N0.7901.00
85_A88_F0.7891.00
350_K353_Y0.7881.00
117_L283_R0.7881.00
286_I298_F0.7851.00
202_F222_M0.7851.00
271_P282_G0.7841.00
30_V62_Y0.7821.00
143_A147_K0.7791.00
286_I290_E0.7791.00
30_V38_G0.7751.00
204_A226_V0.7721.00
234_L245_V0.7701.00
110_G355_P0.7651.00
140_E143_A0.7651.00
198_H211_A0.7631.00
39_Y305_I0.7581.00
54_A93_A0.7581.00
109_L112_P0.7561.00
254_E284_S0.7561.00
251_L256_E0.7531.00
232_I235_R0.7511.00
247_L266_V0.7481.00
50_S53_N0.7461.00
204_A208_I0.7451.00
208_I241_T0.7431.00
175_R213_R0.7421.00
231_V259_F0.7411.00
237_Y241_T0.7411.00
49_I53_N0.7381.00
76_E79_K0.7361.00
120_K353_Y0.7341.00
75_H284_S0.7341.00
273_L313_L0.7341.00
345_E348_H0.7331.00
51_V55_I0.7321.00
57_Q60_K0.7321.00
62_Y65_K0.7301.00
67_V108_E0.7251.00
185_R218_N0.7241.00
236_K264_G0.7231.00
271_P286_I0.7220.99
38_G107_K0.7220.99
233_G236_K0.7210.99
311_I351_V0.7180.99
255_K258_A0.7180.99
8_P52_Y0.7150.99
31_I39_Y0.7120.99
61_A65_K0.7100.99
344_V349_V0.7100.99
208_I226_V0.7080.99
146_A184_V0.7060.99
257_T289_A0.7030.99
129_A149_V0.7000.99
290_E319_N0.6990.99
143_A183_A0.6970.99
254_E285_V0.6970.99
55_I60_K0.6960.99
4_R34_N0.6960.99
124_R346_G0.6960.99
49_I57_Q0.6930.99
49_I52_Y0.6880.99
314_S323_L0.6880.99
207_A237_Y0.6840.99
145_K149_V0.6840.99
157_L188_V0.6840.99
127_V130_N0.6830.99
269_L294_V0.6820.99
129_A154_Y0.6810.99
327_Y330_F0.6800.99
231_V263_E0.6780.99
117_L279_V0.6770.99
146_A150_V0.6770.99
117_L316_V0.6770.99
178_E188_V0.6760.99
177_A202_F0.6760.99
311_I349_V0.6740.99
69_E115_K0.6730.99
12_T24_I0.6700.99
71_E280_T0.6700.99
10_V52_Y0.6660.99
143_A146_A0.6650.99
156_A193_D0.6640.99
113_I117_L0.6640.99
271_P296_V0.6620.99
37_V107_K0.6610.99
315_A352_P0.6610.99
122_R125_V0.6610.99
10_V24_I0.6600.99
31_I35_G0.6590.99
53_N56_K0.6580.99
74_Y77_W0.6580.99
289_A294_V0.6580.99
37_V360_S0.6560.99
181_V188_V0.6540.99
211_A243_L0.6540.99
38_G103_D0.6510.99
176_E180_R0.6500.99
257_T294_V0.6490.99
102_W113_I0.6490.99
38_G100_A0.6470.99
234_L237_Y0.6470.99
32_T67_V0.6450.99
115_K120_K0.6450.99
343_P350_K0.6450.99
106_G355_P0.6440.99
255_K259_F0.6400.99
340_N360_S0.6380.99
67_V104_I0.6380.99
113_I116_L0.6370.99
257_T271_P0.6360.99
105_I108_E0.6360.99
182_K187_A0.6350.99
102_W117_L0.6340.99
251_L260_Y0.6310.99
106_G111_A0.6300.99
73_N97_I0.6260.99
266_V294_V0.6250.99
61_A80_Q0.6240.99
71_E75_H0.6230.99
161_P202_F0.6230.99
161_P196_I0.6220.99
3_I30_V0.6200.98
283_R313_L0.6200.98
62_Y73_N0.6200.98
270_Q299_H0.6200.98
66_E115_K0.6200.98
78_Y94_V0.6180.98
104_I108_E0.6170.98
94_V278_G0.6160.98
55_I97_I0.6130.98
4_R32_T0.6120.98
161_P198_H0.6120.98
181_V194_I0.6110.98
300_N307_N0.6110.98
155_K346_G0.6080.98
329_W332_Q0.6060.98
50_S57_Q0.6050.98
101_S105_I0.6020.98
221_F297_A0.6000.98
289_A296_V0.5990.98
40_G96_A0.5990.98
254_E258_A0.5980.98
70_V280_T0.5980.98
106_G109_L0.5970.98
279_V313_L0.5970.98
34_N67_V0.5960.98
209_M240_S0.5950.98
6_I97_I0.5940.98
224_E250_R0.5870.98
50_S54_A0.5860.98
60_K63_I0.5830.98
50_S55_I0.5830.98
308_A359_V0.5800.98
282_G298_F0.5800.98
10_V49_I0.5780.98
146_A183_A0.5780.98
241_T245_V0.5770.98
208_I212_K0.5750.98
70_V116_L0.5750.98
178_E181_V0.5750.98
62_Y97_I0.5740.98
175_R190_D0.5720.97
256_E265_L0.5700.97
144_E187_A0.5700.97
71_E123_D0.5690.97
146_A187_A0.5680.97
189_G192_V0.5680.97
224_E249_E0.5670.97
159_F181_V0.5660.97
70_V73_N0.5650.97
75_H78_Y0.5640.97
26_I52_Y0.5600.97
296_V319_N0.5600.97
62_Y101_S0.5590.97
309_V313_L0.5590.97
113_I312_Q0.5580.97
150_V188_V0.5550.97
114_H353_Y0.5550.97
220_G244_R0.5540.97
124_R345_E0.5530.97
314_S320_L0.5510.97
175_R182_K0.5500.97
304_S338_V0.5500.97
224_E248_G0.5450.97
147_K188_V0.5440.97
273_L279_V0.5420.96
83_Y88_F0.5420.96
269_L285_V0.5420.96
290_E296_V0.5420.96
6_I28_T0.5410.96
107_K354_K0.5400.96
119_G123_D0.5400.96
274_T301_A0.5400.96
20_T23_S0.5370.96
42_A92_T0.5360.96
121_T318_Q0.5360.96
77_W278_G0.5350.96
107_K110_G0.5330.96
126_P193_D0.5330.96
207_A222_M0.5290.96
70_V101_S0.5290.96
58_V81_D0.5280.96
328_D331_P0.5260.96
54_A89_E0.5250.96
200_G250_R0.5240.96
181_V219_P0.5240.96
234_L265_L0.5230.96
98_D278_G0.5230.96
286_I319_N0.5230.96
114_H120_K0.5220.96
82_F89_E0.5190.96
311_I352_P0.5190.96
296_V317_T0.5190.96
120_K124_R0.5180.95
26_I51_V0.5180.95
150_V187_A0.5180.95
127_V349_V0.5160.95
38_G104_I0.5150.95
194_I219_P0.5150.95
84_L87_S0.5140.95
8_P26_I0.5130.95
219_P222_M0.5130.95
122_R126_P0.5130.95
238_K265_L0.5120.95
43_V274_T0.5110.95
155_K191_N0.5110.95
211_A237_Y0.5100.95
57_Q61_A0.5090.95
244_R268_I0.5080.95
139_P142_F0.5070.95
234_L266_V0.5070.95
128_Y299_H0.5070.95
235_R264_G0.5060.95
11_L25_M0.5060.95
265_L294_V0.5060.95
196_I214_L0.5060.95
160_D163_G0.5050.95
51_V54_A0.5050.95
308_A312_Q0.5040.95
211_A214_L0.5020.95
32_T35_G0.5020.95
112_P116_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rcyA 5 0.962 100 0.195 Contact Map
3s5sA 2 0.881 100 0.211 Contact Map
3stpA 5 0.9139 100 0.213 Contact Map
3t6cA 5 0.9544 100 0.216 Contact Map
4dwdA 5 0.9316 100 0.218 Contact Map
3vdgA 2 0.957 100 0.219 Contact Map
3bjsA 5 0.9165 100 0.219 Contact Map
3vc5A 2 0.9544 100 0.22 Contact Map
2qdeA 5 0.9038 100 0.22 Contact Map
2qddA 5 0.9114 100 0.221 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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