GREMLIN Database
Q97U25 - Uncharacterized protein
UniProt: Q97U25 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 128 (110)
Sequences: 318 (284)
Seq/√Len: 27.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_D104_A4.4141.00
80_K101_D4.3791.00
80_K104_A4.3201.00
5_I31_A3.8981.00
8_I63_T3.7801.00
83_A109_F3.6891.00
5_I33_V2.3580.99
18_T21_K2.2510.98
21_K25_I2.2080.98
6_L59_I2.0380.96
49_N52_K2.0130.96
96_F108_L1.9360.95
33_V109_F1.8740.94
104_A107_H1.8710.94
55_Y64_K1.8510.94
59_I63_T1.8290.93
101_D107_H1.7720.92
13_D27_K1.6980.91
62_L108_L1.6070.88
19_K25_I1.5740.87
10_C30_Y1.5720.87
80_K107_H1.5530.86
20_S50_K1.5500.86
6_L63_T1.5330.85
18_T25_I1.5210.85
10_C25_I1.5030.84
19_K61_Y1.4670.83
45_S49_N1.4520.82
37_G77_V1.4490.82
86_F109_F1.3290.76
10_C14_T1.2850.73
11_K14_T1.2320.70
18_T23_F1.1830.67
23_F93_I1.1750.66
13_D24_L1.1720.66
17_R20_S1.1230.63
52_K63_T1.1180.62
3_S37_G1.1120.62
82_L90_N1.1090.62
96_F106_S1.0960.61
19_K99_S1.0600.58
90_N111_V1.0400.57
94_E98_S1.0330.56
88_K92_F1.0170.55
72_F99_S1.0080.54
7_L14_T1.0030.54
7_L29_V0.9930.53
92_F98_S0.9920.53
26_R92_F0.9860.53
12_T82_L0.9720.52
3_S82_L0.9710.52
46_R80_K0.9640.51
33_V37_G0.9630.51
62_L95_E0.9480.50
15_T22_K0.9400.49
29_V111_V0.9390.49
33_V83_A0.9360.49
19_K104_A0.9330.49
12_T84_L0.9260.48
9_K29_V0.9060.47
8_I59_I0.9050.47
48_F63_T0.8960.46
11_K85_L0.8830.45
6_L36_C0.8750.44
83_A107_H0.8620.43
10_C68_P0.8580.43
74_M82_L0.8530.43
48_F90_N0.8420.42
38_R42_R0.8280.41
33_V86_F0.8260.41
44_V112_N0.8230.41
20_S41_G0.8220.40
38_R56_H0.8160.40
12_T105_K0.7980.39
86_F92_F0.7970.39
44_V95_E0.7950.38
18_T61_Y0.7890.38
33_V63_T0.7860.38
45_S65_A0.7800.37
36_C40_C0.7680.37
56_H85_L0.7680.37
27_K84_L0.7600.36
21_K61_Y0.7590.36
31_A111_V0.7590.36
19_K107_H0.7530.36
38_R41_G0.7530.36
51_E67_E0.7480.35
9_K69_I0.7420.35
16_I72_F0.7290.34
39_S77_V0.7230.33
39_S111_V0.7200.33
8_I68_P0.7050.32
70_G110_I0.7000.32
10_C65_A0.6950.32
8_I16_I0.6870.31
91_A98_S0.6860.31
25_I61_Y0.6820.31
12_T24_L0.6760.30
36_C101_D0.6740.30
30_Y55_Y0.6730.30
65_A70_G0.6690.30
69_I84_L0.6620.30
29_V110_I0.6600.29
92_F106_S0.6580.29
9_K67_E0.6550.29
7_L16_I0.6420.28
14_T65_A0.6390.28
40_C52_K0.6380.28
5_I86_F0.6350.28
41_G111_V0.6280.27
78_G82_L0.6260.27
40_C49_N0.6260.27
25_I80_K0.6150.27
40_C111_V0.6150.27
87_S106_S0.6080.26
8_I67_E0.6050.26
62_L83_A0.6010.26
66_C73_V0.5980.26
19_K101_D0.5870.25
67_E74_M0.5870.25
26_R110_I0.5850.25
68_P71_V0.5840.25
76_H88_K0.5840.25
67_E93_I0.5830.25
9_K94_E0.5810.25
50_K56_H0.5810.25
85_L88_K0.5760.24
74_M84_L0.5740.24
33_V84_L0.5680.24
12_T112_N0.5590.23
74_M86_F0.5580.23
36_C104_A0.5570.23
46_R82_L0.5570.23
45_S75_N0.5550.23
83_A93_I0.5520.23
11_K67_E0.5490.23
88_K106_S0.5460.23
25_I107_H0.5400.22
59_I83_A0.5390.22
11_K81_E0.5380.22
3_S13_D0.5350.22
41_G44_V0.5260.22
50_K54_N0.5240.22
68_P82_L0.5230.22
109_F113_D0.5230.22
30_Y98_S0.5230.22
66_C70_G0.5220.22
75_N86_F0.5170.21
25_I76_H0.5160.21
21_K104_A0.5150.21
25_I104_A0.5150.21
17_R103_D0.5140.21
88_K105_K0.5110.21
32_Y58_H0.5000.20
58_H97_G0.5000.20
32_Y79_E0.5000.20
32_Y60_D0.5000.20
58_H79_E0.5000.20
32_Y43_R0.5000.20
43_R58_H0.5000.20
43_R60_D0.5000.20
79_E100_D0.5000.20
43_R79_E0.5000.20
43_R97_G0.5000.20
43_R100_D0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mk0A 1 0.6328 65.2 0.919 Contact Map
1yd6A 5 0.6797 58.5 0.922 Contact Map
1yd0A 1 0.6406 57.6 0.923 Contact Map
2wshA 4 0.7188 20.2 0.94 Contact Map
3clwA 1 0.375 18.4 0.941 Contact Map
2c1wA 1 0.3438 13.7 0.945 Contact Map
2wnwA 2 0.4609 13.6 0.945 Contact Map
3og6A 1 0.2812 12.1 0.946 Contact Map
4ccdA 1 0.375 10 0.948 Contact Map
2b3yA 1 0.9297 7.5 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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