GREMLIN Database
Q97U24 - Uncharacterized protein
UniProt: Q97U24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (178)
Sequences: 4103 (2355)
Seq/√Len: 176.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_R123_L3.7541.00
47_T50_E3.4031.00
80_P83_L3.3101.00
41_E89_K3.1661.00
58_E77_E3.0761.00
37_S158_E3.0571.00
37_S156_E3.0221.00
41_E91_K2.9331.00
99_F157_I2.6911.00
54_L87_M2.5841.00
100_Y156_E2.5641.00
33_R45_S2.4601.00
77_E124_F2.4561.00
35_K45_S2.3201.00
121_V138_A2.2211.00
44_L88_A2.1481.00
86_E115_L2.1371.00
98_M160_I2.1311.00
83_L86_E2.1031.00
85_I159_F2.0761.00
63_F147_A2.0511.00
58_E75_K2.0341.00
28_N31_T2.0241.00
39_E161_K1.9981.00
75_K127_G1.9701.00
74_V125_M1.9631.00
97_V159_F1.9141.00
109_I142_I1.8801.00
84_L121_V1.8801.00
60_V75_K1.8721.00
82_K86_E1.8411.00
39_E91_K1.8241.00
122_A141_I1.7261.00
56_R77_E1.7261.00
93_K161_K1.6951.00
102_L155_T1.6921.00
57_K80_P1.6901.00
49_E53_K1.6251.00
100_Y158_E1.6121.00
81_F114_L1.6081.00
42_N89_K1.5751.00
98_M158_E1.5581.00
16_F74_V1.5261.00
40_V43_S1.5211.00
79_I84_L1.5111.00
99_F154_L1.5071.00
35_K156_E1.5041.00
62_D73_S1.4931.00
52_M123_L1.4831.00
121_V154_L1.4621.00
94_V159_F1.4541.00
48_Y52_M1.4531.00
46_F87_M1.4391.00
99_F140_P1.4041.00
44_L87_M1.3891.00
56_R124_F1.3861.00
39_E93_K1.3611.00
30_E49_E1.3231.00
119_V142_I1.3081.00
97_V114_L1.2641.00
63_F150_S1.2531.00
124_F129_K1.2501.00
116_K119_V1.2251.00
32_Y48_Y1.2091.00
165_D170_E1.1691.00
77_E123_L1.1631.00
10_Q60_V1.1461.00
54_L79_I1.1261.00
55_P83_L1.1091.00
82_K117_D1.1081.00
166_G169_E1.1011.00
59_I120_I1.0861.00
16_F125_M1.0841.00
51_L138_A1.0711.00
13_I131_P1.0491.00
81_F157_I1.0451.00
101_S151_A1.0431.00
107_S151_A1.0310.99
165_D169_E1.0110.99
111_F159_F1.0100.99
107_S148_W1.0000.99
39_E94_V0.9970.99
95_N161_K0.9950.99
113_D145_L0.9790.99
142_I150_S0.9780.99
55_P80_P0.9720.99
29_L48_Y0.9690.99
90_V159_F0.9650.99
40_V159_F0.9560.99
20_A24_I0.9500.99
52_M124_F0.9480.99
176_R183_E0.9460.99
16_F72_K0.9410.99
49_E52_M0.9390.99
63_F74_V0.9160.99
34_L138_A0.9140.99
75_K126_N0.9140.99
113_D144_H0.9120.99
57_K83_L0.9110.99
38_G43_S0.9030.99
32_Y138_A0.8990.99
125_M134_H0.8970.99
113_D176_R0.8930.98
79_I123_L0.8830.98
36_V40_V0.8820.98
13_I74_V0.8820.98
110_P113_D0.8810.98
97_V157_I0.8770.98
46_F88_A0.8690.98
85_I90_V0.8680.98
54_L83_L0.8670.98
107_S149_K0.8650.98
50_E53_K0.8440.98
10_Q125_M0.8320.98
125_M131_P0.8270.97
26_E132_L0.8260.97
30_E48_Y0.8230.97
66_V148_W0.8060.97
140_P151_A0.8040.97
74_V126_N0.7930.97
56_R79_I0.7880.97
81_F140_P0.7870.97
37_S43_S0.7840.97
40_V88_A0.7800.96
27_V102_L0.7750.96
36_V44_L0.7690.96
123_L129_K0.7670.96
158_E164_V0.7660.96
64_H71_I0.7580.96
98_M169_E0.7520.96
40_V94_V0.7470.95
121_V140_P0.7470.95
80_P120_I0.7430.95
90_V111_F0.7400.95
57_K120_I0.7370.95
83_L87_M0.7360.95
168_W177_G0.7350.95
79_I83_L0.7310.95
131_P134_H0.7290.95
141_I150_S0.7270.95
46_F50_E0.7240.95
140_P154_L0.7230.95
40_V44_L0.7130.94
20_A153_W0.7040.94
35_K43_S0.7030.94
13_I128_E0.6920.93
114_L119_V0.6920.93
85_I88_A0.6860.93
36_V46_F0.6840.93
167_Y171_R0.6820.93
51_L79_I0.6800.93
122_A140_P0.6770.92
100_Y106_T0.6770.92
19_Y69_W0.6740.92
123_L138_A0.6700.92
116_K144_H0.6670.92
64_H107_S0.6670.92
24_I133_K0.6660.92
13_I125_M0.6610.92
107_S169_E0.6520.91
148_W169_E0.6500.91
29_L136_F0.6490.91
24_I132_L0.6460.91
23_G26_E0.6430.90
98_M164_V0.6420.90
120_I141_I0.6350.90
87_M90_V0.6350.90
140_P157_I0.6340.90
79_I121_V0.6320.90
96_W164_V0.6300.90
105_Y148_W0.6260.89
66_V69_W0.6250.89
68_G180_W0.6240.89
122_A138_A0.6190.89
85_I115_L0.6170.89
98_M165_D0.6170.89
52_M129_K0.6160.88
44_L50_E0.6160.88
66_V146_Y0.6120.88
44_L89_K0.6080.88
95_N111_F0.6060.88
37_S100_Y0.6050.88
51_L123_L0.6040.87
12_Y15_N0.6040.87
160_I164_V0.6040.87
38_G94_V0.6030.87
81_F159_F0.6020.87
18_V133_K0.6010.87
108_I163_Y0.5980.87
77_E80_P0.5960.87
98_M106_T0.5940.87
55_P79_I0.5920.86
89_K159_F0.5900.86
63_F141_I0.5850.86
74_V141_I0.5840.86
81_F85_I0.5830.86
72_K147_A0.5830.86
37_S40_V0.5810.85
34_L46_F0.5810.85
182_E185_F0.5800.85
162_D165_D0.5800.85
71_I74_V0.5790.85
67_T70_S0.5780.85
67_T148_W0.5770.85
122_A130_L0.5760.85
95_N162_D0.5760.85
39_E160_I0.5750.85
167_Y170_E0.5740.85
17_I71_I0.5730.85
8_P15_N0.5710.84
113_D116_K0.5710.84
76_W122_A0.5680.84
53_K86_E0.5660.84
9_N60_V0.5650.84
81_F119_V0.5640.84
84_L138_A0.5640.84
34_L48_Y0.5620.83
21_E24_I0.5620.83
71_I182_E0.5610.83
19_Y67_T0.5600.83
113_D119_V0.5580.83
29_L52_M0.5550.83
10_Q75_K0.5540.83
16_F76_W0.5480.82
81_F142_I0.5470.82
79_I120_I0.5470.82
64_H182_E0.5460.82
96_W108_I0.5460.82
106_T170_E0.5450.82
97_V111_F0.5420.81
79_I138_A0.5410.81
166_G170_E0.5400.81
11_K68_G0.5400.81
46_F54_L0.5400.81
128_E131_P0.5390.81
39_E43_S0.5390.81
145_L149_K0.5360.81
168_W172_G0.5350.80
16_F168_W0.5310.80
82_K116_K0.5300.80
43_S46_F0.5300.80
171_R174_H0.5280.80
90_V115_L0.5270.79
27_V34_L0.5270.79
76_W142_I0.5270.79
163_Y175_E0.5270.79
41_E44_L0.5260.79
20_A101_S0.5220.79
27_V103_D0.5210.79
169_E172_G0.5210.79
146_Y149_K0.5200.79
118_N144_H0.5180.78
105_Y149_K0.5170.78
36_V84_L0.5160.78
167_Y172_G0.5160.78
33_R47_T0.5130.78
25_P150_S0.5110.77
149_K168_W0.5100.77
60_V72_K0.5100.77
9_N12_Y0.5080.77
96_W163_Y0.5070.77
84_L88_A0.5070.77
109_I145_L0.5050.76
66_V149_K0.5040.76
70_S107_S0.5040.76
98_M108_I0.5030.76
38_G41_E0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ogpA 4 1 100 0.181 Contact Map
2a9dA 2 1 100 0.181 Contact Map
1soxA 2 1 100 0.182 Contact Map
2blfA 1 0.995 100 0.205 Contact Map
2bihA 2 1 100 0.215 Contact Map
2biiA 2 1 100 0.218 Contact Map
1xdyA 3 0.995 100 0.218 Contact Map
2xtsA 2 0.995 100 0.225 Contact Map
4pw3A 2 0.9648 100 0.229 Contact Map
2nptA 1 0.4623 16.8 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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