GREMLIN Database
GLCD3 - Glucose 1-dehydrogenase 3
UniProt: Q97U21 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (291)
Sequences: 51806 (35185)
Seq/√Len: 2062.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_I147_V3.1381.00
33_K74_I3.0431.00
35_I72_Q2.9581.00
340_Q343_E2.7981.00
7_N16_K2.7281.00
31_L74_I2.6181.00
84_G87_D2.5571.00
88_Y142_I2.4661.00
87_D141_K2.4471.00
30_V139_L2.3881.00
186_N209_N2.3801.00
336_I347_T2.3501.00
20_D131_F2.3271.00
204_S232_K2.2931.00
182_Y185_R2.2801.00
33_K72_Q2.2551.00
33_K131_F2.2521.00
69_N127_F2.2471.00
334_R347_T2.2091.00
7_N14_H2.2091.00
148_D335_V2.2031.00
335_V358_S2.1961.00
187_V203_F2.1831.00
5_V16_K2.1241.00
26_T29_E2.1211.00
27_A78_P2.1041.00
167_M206_Q2.0851.00
223_A227_E2.0741.00
69_N91_S2.0471.00
27_A79_E2.0471.00
200_S231_A2.0411.00
82_G136_A2.0201.00
31_L133_I1.9981.00
145_E318_T1.9841.00
74_I131_F1.9791.00
48_S349_P1.9521.00
28_D79_E1.9381.00
315_N319_I1.9121.00
88_Y147_V1.8901.00
70_L147_V1.8541.00
337_K340_Q1.8261.00
159_V198_M1.8191.00
224_E227_E1.8161.00
224_E228_K1.8051.00
246_D266_N1.7881.00
346_Y350_K1.7761.00
167_M312_N1.7601.00
188_A245_I1.7511.00
270_A298_L1.7471.00
223_A234_I1.7471.00
142_I147_V1.7431.00
205_I321_K1.7301.00
225_I228_K1.6981.00
343_E346_Y1.6531.00
270_A300_F1.6281.00
343_E347_T1.6271.00
142_I150_A1.6221.00
4_I341_A1.6141.00
31_L131_F1.6031.00
24_S75_D1.5891.00
336_I344_V1.5881.00
72_Q88_Y1.5831.00
190_V261_L1.5681.00
265_L271_I1.5531.00
75_D85_K1.5341.00
76_K85_K1.5121.00
239_D242_P1.5121.00
248_L265_L1.5021.00
220_P224_E1.5011.00
128_M345_L1.4861.00
342_P346_Y1.4851.00
83_L87_D1.4821.00
31_L75_D1.4701.00
29_E135_N1.4691.00
265_L269_S1.4681.00
77_G80_V1.4641.00
83_L141_K1.4631.00
34_T69_N1.4621.00
149_I329_N1.4591.00
265_L297_I1.4431.00
28_D135_N1.4381.00
220_P236_T1.4291.00
25_L133_I1.4201.00
333_T347_T1.4081.00
29_E133_I1.3961.00
148_D358_S1.3861.00
248_L261_L1.3841.00
88_Y144_D1.3821.00
3_A18_I1.3751.00
185_R270_A1.3661.00
209_N233_F1.3611.00
72_Q147_V1.3541.00
36_A148_D1.3521.00
30_V83_L1.3421.00
181_S185_R1.3351.00
220_P223_A1.3291.00
315_N318_T1.3281.00
210_A214_N1.3271.00
47_V345_L1.3161.00
205_I316_Y1.3061.00
25_L31_L1.3011.00
73_V83_L1.2941.00
209_N232_K1.2851.00
199_F249_I1.2701.00
4_I15_V1.2691.00
35_I88_Y1.2611.00
163_Y167_M1.2551.00
34_T132_Y1.2341.00
337_K358_S1.2131.00
228_K330_R1.2091.00
215_K237_N1.2091.00
214_N223_A1.2041.00
210_A233_F1.1961.00
223_A236_T1.1911.00
211_F245_I1.1851.00
186_N246_D1.1851.00
36_A358_S1.1841.00
307_K311_E1.1701.00
20_D31_L1.1671.00
83_L139_L1.1601.00
316_Y321_K1.1601.00
28_D136_A1.1561.00
186_N210_A1.1481.00
186_N211_F1.1471.00
185_R246_D1.1321.00
263_S291_Y1.1261.00
312_N315_N1.1231.00
153_L317_L1.1151.00
164_S309_D1.1031.00
188_A213_L1.1011.00
227_E234_I1.0991.00
134_D139_L1.0951.00
181_S208_F1.0841.00
5_V18_I1.0841.00
9_P12_G1.0781.00
203_F208_F1.0781.00
32_V89_V1.0491.00
36_A147_V1.0411.00
162_A199_F1.0401.00
341_A357_I1.0321.00
347_T355_T1.0311.00
32_V71_G1.0301.00
252_S257_A1.0261.00
346_Y349_P1.0161.00
39_I344_V1.0151.00
25_L29_E1.0141.00
80_V136_A1.0131.00
47_V349_P1.0101.00
15_V339_E1.0101.00
74_I85_K1.0021.00
311_E315_N0.9961.00
167_M309_D0.9951.00
192_S213_L0.9931.00
163_Y312_N0.9851.00
37_N128_M0.9851.00
20_D24_S0.9801.00
165_E274_F0.9781.00
9_P61_N0.9761.00
4_I338_P0.9741.00
170_Q247_L0.9721.00
336_I340_Q0.9641.00
227_E233_F0.9641.00
312_N316_Y0.9591.00
162_A202_M0.9451.00
36_A356_V0.9451.00
260_P263_S0.9351.00
44_R348_K0.9341.00
40_C68_E0.9311.00
90_V314_V0.9271.00
165_E249_I0.9271.00
81_H136_A0.9211.00
197_L225_I0.9211.00
259_I263_S0.9201.00
37_N127_F0.9201.00
185_R247_L0.9041.00
221_I224_E0.9031.00
250_D253_G0.9001.00
146_I150_A0.8991.00
188_A264_R0.8991.00
35_I70_L0.8971.00
76_K84_G0.8891.00
128_M341_A0.8891.00
292_L299_L0.8761.00
308_K312_N0.8751.00
21_I24_S0.8721.00
190_V213_L0.8701.00
159_V313_G0.8661.00
291_Y295_N0.8641.00
5_V64_V0.8631.00
33_K130_E0.8601.00
4_I13_V0.8591.00
76_K80_V0.8561.00
40_C67_H0.8531.00
211_F233_F0.8521.00
3_A64_V0.8511.00
190_V248_L0.8481.00
186_N245_I0.8361.00
160_V309_D0.8351.00
128_M357_I0.8311.00
191_G212_V0.8291.00
189_I203_F0.8291.00
20_D75_D0.8261.00
251_T274_F0.8231.00
222_E352_E0.8221.00
24_S31_L0.8221.00
20_D74_I0.8161.00
268_N296_N0.8151.00
226_V231_A0.8151.00
287_D291_Y0.8141.00
336_I355_T0.8141.00
200_S212_V0.8101.00
280_E283_E0.8081.00
140_V311_E0.8081.00
38_G68_E0.8051.00
192_S226_V0.8051.00
248_L271_I0.8041.00
18_I125_D0.8031.00
187_V208_F0.8031.00
69_N132_Y0.7941.00
63_L125_D0.7941.00
30_V136_A0.7941.00
7_N12_G0.7921.00
210_A232_K0.7921.00
314_V318_T0.7921.00
308_K311_E0.7921.00
261_L271_I0.7881.00
144_D318_T0.7861.00
202_M313_G0.7851.00
189_I199_F0.7831.00
316_Y320_W0.7801.00
292_L301_G0.7781.00
210_A213_L0.7731.00
127_F132_Y0.7721.00
316_Y319_I0.7711.00
84_G141_K0.7701.00
166_L203_F0.7681.00
215_K238_K0.7681.00
334_R343_E0.7651.00
39_I348_K0.7621.00
206_Q312_N0.7581.00
40_C43_D0.7571.00
26_T133_I0.7541.00
203_F210_A0.7531.00
188_A214_N0.7501.00
210_A215_K0.7501.00
186_N243_N0.7491.00
332_I335_V0.7441.00
310_F314_V0.7441.00
273_L299_L0.7431.00
42_T67_H0.7411.00
192_S200_S0.7391.00
190_V257_A0.7361.00
336_I357_I0.7351.00
18_I64_V0.7271.00
89_V139_L0.7261.00
162_A198_M0.7211.00
70_L151_V0.7201.00
197_L331_M0.7201.00
348_K355_T0.7191.00
28_D78_P0.7181.00
292_L297_I0.7171.00
212_V231_A0.7151.00
181_S247_L0.7091.00
28_D77_G0.7081.00
212_V245_I0.7011.00
44_R349_P0.7001.00
15_V338_P0.6981.00
146_I317_L0.6951.00
225_I229_S0.6941.00
202_M316_Y0.6941.00
165_E199_F0.6931.00
82_G307_K0.6911.00
347_T350_K0.6901.00
4_I342_P0.6881.00
247_L272_I0.6881.00
60_K63_L0.6871.00
170_Q272_I0.6841.00
140_V310_F0.6791.00
90_V142_I0.6781.00
169_V247_L0.6781.00
208_F247_L0.6771.00
170_Q182_Y0.6761.00
143_P318_T0.6751.00
225_I352_E0.6731.00
245_I264_R0.6721.00
164_S296_N0.6691.00
225_I331_M0.6691.00
245_I248_L0.6671.00
291_Y294_E0.6661.00
28_D137_S0.6661.00
25_L77_G0.6651.00
25_L75_D0.6651.00
91_S134_D0.6631.00
30_V73_V0.6631.00
163_Y316_Y0.6601.00
250_D271_I0.6591.00
45_G50_L0.6571.00
87_D144_D0.6531.00
254_Y257_A0.6521.00
163_Y313_G0.6521.00
223_A226_V0.6521.00
243_N266_N0.6501.00
167_M202_M0.6471.00
59_G63_L0.6471.00
201_L229_S0.6451.00
192_S212_V0.6451.00
345_L349_P0.6441.00
34_T37_N0.6441.00
200_S229_S0.6431.00
161_K195_I0.6421.00
259_I291_Y0.6411.00
70_L88_Y0.6371.00
70_L142_I0.6351.00
267_K295_N0.6341.00
162_A195_I0.6331.00
280_E285_N0.6331.00
36_A70_L0.6311.00
211_F235_N0.6311.00
233_F236_T0.6261.00
42_T46_I0.6251.00
334_R355_T0.6241.00
258_F271_I0.6211.00
21_I133_I0.6201.00
255_P259_I0.6201.00
40_C158_N0.6201.00
228_K331_M0.6191.00
36_A335_V0.6191.00
136_A139_L0.6191.00
37_N357_I0.6171.00
184_C209_N0.6161.00
162_A166_L0.6131.00
164_S168_L0.6121.00
168_L309_D0.6121.00
247_L270_A0.6121.00
44_R48_S0.6111.00
285_N291_Y0.6111.00
232_K235_N0.6101.00
309_D312_N0.6101.00
88_Y145_E0.6091.00
163_Y309_D0.6071.00
199_F274_F0.6061.00
291_Y297_I0.6051.00
296_N306_S0.6051.00
165_E272_I0.6051.00
213_L237_N0.6041.00
158_N198_M0.6031.00
170_Q270_A0.6021.00
183_N207_G0.6011.00
158_N194_P0.6011.00
212_V226_V0.5971.00
66_G128_M0.5961.00
35_I358_S0.5931.00
187_V247_L0.5931.00
140_V314_V0.5921.00
231_A234_I0.5871.00
200_S210_A0.5841.00
186_N244_T0.5841.00
214_N234_I0.5831.00
188_A248_L0.5821.00
40_C354_K0.5811.00
202_M206_Q0.5781.00
215_K223_A0.5771.00
32_V139_L0.5771.00
212_V215_K0.5771.00
282_F286_A0.5761.00
83_L136_A0.5751.00
311_E314_V0.5751.00
200_S226_V0.5751.00
152_L356_V0.5741.00
76_K87_D0.5721.00
41_G45_G0.5711.00
39_I128_M0.5711.00
135_N138_Y0.5711.00
140_V307_K0.5681.00
248_L264_R0.5651.00
82_G85_K0.5621.00
42_T45_G0.5611.00
91_S139_L0.5601.00
32_V91_S0.5591.00
92_I140_V0.5581.00
81_H84_G0.5531.00
147_V150_A0.5521.00
197_L229_S0.5521.00
149_I153_L0.5471.00
153_L313_G0.5461.00
235_N238_K0.5441.00
21_I131_F0.5431.00
334_R352_E0.5421.00
158_N354_K0.5411.00
70_L150_A0.5391.00
29_E124_L0.5361.00
183_N206_Q0.5321.00
169_V300_F0.5321.00
166_L202_M0.5321.00
165_E302_S0.5321.00
169_V272_I0.5301.00
201_L329_N0.5301.00
228_K329_N0.5301.00
336_I343_E0.5301.00
294_E303_V0.5301.00
198_M202_M0.5301.00
21_I31_L0.5301.00
161_K274_F0.5291.00
189_I200_S0.5291.00
11_K346_Y0.5281.00
244_T266_N0.5281.00
302_S305_A0.5251.00
257_A260_P0.5251.00
214_N226_V0.5241.00
257_A261_L0.5241.00
170_Q185_R0.5221.00
226_V234_I0.5211.00
168_L298_L0.5211.00
259_I285_N0.5211.00
214_N237_N0.5211.00
204_S231_A0.5201.00
258_F273_L0.5201.00
334_R340_Q0.5201.00
10_N47_V0.5191.00
41_G193_G0.5171.00
82_G141_K0.5161.00
250_D275_G0.5161.00
13_V345_L0.5151.00
223_A237_N0.5141.00
163_Y206_Q0.5121.00
199_F251_T0.5091.00
303_V306_S0.5081.00
186_N233_F0.5061.00
76_K83_L0.5061.00
6_V47_V0.5051.00
259_I283_E0.5041.00
146_I318_T0.5041.00
355_T358_S0.5041.00
6_V9_P0.5031.00
90_V140_V0.5021.00
198_M201_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3widA 4 0.9611 100 0.184 Contact Map
1h2bA 4 0.9028 100 0.196 Contact Map
4gi2A 2 0.9222 100 0.205 Contact Map
2b5wA 2 0.9417 100 0.206 Contact Map
1cdoA 2 0.9167 100 0.206 Contact Map
4c4oA 4 0.9 100 0.208 Contact Map
1e3iA 2 0.9111 100 0.208 Contact Map
2cdcA 3 0.9306 100 0.209 Contact Map
1vj0A 4 0.9139 100 0.211 Contact Map
4cpdA 2 0.9083 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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