GLCD3 - SULSO - GREMLIN Contacts

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GLCD3 - Glucose 1-dehydrogenase 3

UniProt:	Q97U21	Sequences: MKAIVVNPPNKGVHVKEINDIHRSLTADEVLVKTIANGICGTDRGIVSGLLKFSRPPNGKNDLVLGHENLGQVIDKGPEVHGLGKGDYVVSIVRRGCGKCSNCLAGRQDFCETGEFVEAGIRGLDGFMREFYIDNASYLVKIPDEIVDIAVLLEPLSNVVKAYSELMLVQRRMTWWCKDGSYNCRNVAIVGSGPIGLMFSLMFSIQGFNAFVLNKRDPFPIEAEIVEKSNAKFINTNKDRLPNTIDLLIDTSGYPSAFIPLMSRLNKNSAIILFGTTGGEKFEVNADLITYLVENNILLFGSVNASKKDFENGVNYLTIWKYRYPSVLNRMITRVIKPEQAPEVLYTKPKGEIKTVISWV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (291)
Sequences:	51806 (35185)
Seq/√Len:	2062.6

ECOLI - YAHK YBDR YGGP AHR YDJL FRMA YPHC RSPB ADHP GATD YJJN TDH IDND YDJJ YCJQ QOR1 ACUI CURA
BACSU - ADHB YJMD ADHA YOGA DHSO YYCR TDH BDHA YHFP YFMJ
HALSA - Q9HMB6 Q9HP38 GLCDH Q9HR85 Q9HQS8
SULSO - GLCD3 GLCD1 Q97YT7 Q7LXK1 GLCD2 Q97VW0 Q97VV5 Q97ZV3 ADH Q97XR4 Q97WA1 Q97V32 Q97YM2 Q97TZ4 Q97W06 Q97UW5 Q97VB8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_I	147_V	3.138	1.00
33_K	74_I	3.043	1.00
35_I	72_Q	2.958	1.00
340_Q	343_E	2.798	1.00
7_N	16_K	2.728	1.00
31_L	74_I	2.618	1.00
84_G	87_D	2.557	1.00
88_Y	142_I	2.466	1.00
87_D	141_K	2.447	1.00
30_V	139_L	2.388	1.00
186_N	209_N	2.380	1.00
336_I	347_T	2.350	1.00
20_D	131_F	2.327	1.00
204_S	232_K	2.293	1.00
182_Y	185_R	2.280	1.00
33_K	72_Q	2.255	1.00
33_K	131_F	2.252	1.00
69_N	127_F	2.247	1.00
334_R	347_T	2.209	1.00
7_N	14_H	2.209	1.00
148_D	335_V	2.203	1.00
335_V	358_S	2.196	1.00
187_V	203_F	2.183	1.00
5_V	16_K	2.124	1.00
26_T	29_E	2.121	1.00
27_A	78_P	2.104	1.00
167_M	206_Q	2.085	1.00
223_A	227_E	2.074	1.00
69_N	91_S	2.047	1.00
27_A	79_E	2.047	1.00
200_S	231_A	2.041	1.00
82_G	136_A	2.020	1.00
31_L	133_I	1.998	1.00
145_E	318_T	1.984	1.00
74_I	131_F	1.979	1.00
48_S	349_P	1.952	1.00
28_D	79_E	1.938	1.00
315_N	319_I	1.912	1.00
88_Y	147_V	1.890	1.00
70_L	147_V	1.854	1.00
337_K	340_Q	1.826	1.00
159_V	198_M	1.819	1.00
224_E	227_E	1.816	1.00
224_E	228_K	1.805	1.00
246_D	266_N	1.788	1.00
346_Y	350_K	1.776	1.00
167_M	312_N	1.760	1.00
188_A	245_I	1.751	1.00
270_A	298_L	1.747	1.00
223_A	234_I	1.747	1.00
142_I	147_V	1.743	1.00
205_I	321_K	1.730	1.00
225_I	228_K	1.698	1.00
343_E	346_Y	1.653	1.00
270_A	300_F	1.628	1.00
343_E	347_T	1.627	1.00
142_I	150_A	1.622	1.00
4_I	341_A	1.614	1.00
31_L	131_F	1.603	1.00
24_S	75_D	1.589	1.00
336_I	344_V	1.588	1.00
72_Q	88_Y	1.583	1.00
190_V	261_L	1.568	1.00
265_L	271_I	1.553	1.00
75_D	85_K	1.534	1.00
76_K	85_K	1.512	1.00
239_D	242_P	1.512	1.00
248_L	265_L	1.502	1.00
220_P	224_E	1.501	1.00
128_M	345_L	1.486	1.00
342_P	346_Y	1.485	1.00
83_L	87_D	1.482	1.00
31_L	75_D	1.470	1.00
29_E	135_N	1.469	1.00
265_L	269_S	1.468	1.00
77_G	80_V	1.464	1.00
83_L	141_K	1.463	1.00
34_T	69_N	1.462	1.00
149_I	329_N	1.459	1.00
265_L	297_I	1.443	1.00
28_D	135_N	1.438	1.00
220_P	236_T	1.429	1.00
25_L	133_I	1.420	1.00
333_T	347_T	1.408	1.00
29_E	133_I	1.396	1.00
148_D	358_S	1.386	1.00
248_L	261_L	1.384	1.00
88_Y	144_D	1.382	1.00
3_A	18_I	1.375	1.00
185_R	270_A	1.366	1.00
209_N	233_F	1.361	1.00
72_Q	147_V	1.354	1.00
36_A	148_D	1.352	1.00
30_V	83_L	1.342	1.00
181_S	185_R	1.335	1.00
220_P	223_A	1.329	1.00
315_N	318_T	1.328	1.00
210_A	214_N	1.327	1.00
47_V	345_L	1.316	1.00
205_I	316_Y	1.306	1.00
25_L	31_L	1.301	1.00
73_V	83_L	1.294	1.00
209_N	232_K	1.285	1.00
199_F	249_I	1.270	1.00
4_I	15_V	1.269	1.00
35_I	88_Y	1.261	1.00
163_Y	167_M	1.255	1.00
34_T	132_Y	1.234	1.00
337_K	358_S	1.213	1.00
228_K	330_R	1.209	1.00
215_K	237_N	1.209	1.00
214_N	223_A	1.204	1.00
210_A	233_F	1.196	1.00
223_A	236_T	1.191	1.00
211_F	245_I	1.185	1.00
186_N	246_D	1.185	1.00
36_A	358_S	1.184	1.00
307_K	311_E	1.170	1.00
20_D	31_L	1.167	1.00
83_L	139_L	1.160	1.00
316_Y	321_K	1.160	1.00
28_D	136_A	1.156	1.00
186_N	210_A	1.148	1.00
186_N	211_F	1.147	1.00
185_R	246_D	1.132	1.00
263_S	291_Y	1.126	1.00
312_N	315_N	1.123	1.00
153_L	317_L	1.115	1.00
164_S	309_D	1.103	1.00
188_A	213_L	1.101	1.00
227_E	234_I	1.099	1.00
134_D	139_L	1.095	1.00
181_S	208_F	1.084	1.00
5_V	18_I	1.084	1.00
9_P	12_G	1.078	1.00
203_F	208_F	1.078	1.00
32_V	89_V	1.049	1.00
36_A	147_V	1.041	1.00
162_A	199_F	1.040	1.00
341_A	357_I	1.032	1.00
347_T	355_T	1.031	1.00
32_V	71_G	1.030	1.00
252_S	257_A	1.026	1.00
346_Y	349_P	1.016	1.00
39_I	344_V	1.015	1.00
25_L	29_E	1.014	1.00
80_V	136_A	1.013	1.00
47_V	349_P	1.010	1.00
15_V	339_E	1.010	1.00
74_I	85_K	1.002	1.00
311_E	315_N	0.996	1.00
167_M	309_D	0.995	1.00
192_S	213_L	0.993	1.00
163_Y	312_N	0.985	1.00
37_N	128_M	0.985	1.00
20_D	24_S	0.980	1.00
165_E	274_F	0.978	1.00
9_P	61_N	0.976	1.00
4_I	338_P	0.974	1.00
170_Q	247_L	0.972	1.00
336_I	340_Q	0.964	1.00
227_E	233_F	0.964	1.00
312_N	316_Y	0.959	1.00
162_A	202_M	0.945	1.00
36_A	356_V	0.945	1.00
260_P	263_S	0.935	1.00
44_R	348_K	0.934	1.00
40_C	68_E	0.931	1.00
90_V	314_V	0.927	1.00
165_E	249_I	0.927	1.00
81_H	136_A	0.921	1.00
197_L	225_I	0.921	1.00
259_I	263_S	0.920	1.00
37_N	127_F	0.920	1.00
185_R	247_L	0.904	1.00
221_I	224_E	0.903	1.00
250_D	253_G	0.900	1.00
146_I	150_A	0.899	1.00
188_A	264_R	0.899	1.00
35_I	70_L	0.897	1.00
76_K	84_G	0.889	1.00
128_M	341_A	0.889	1.00
292_L	299_L	0.876	1.00
308_K	312_N	0.875	1.00
21_I	24_S	0.872	1.00
190_V	213_L	0.870	1.00
159_V	313_G	0.866	1.00
291_Y	295_N	0.864	1.00
5_V	64_V	0.863	1.00
33_K	130_E	0.860	1.00
4_I	13_V	0.859	1.00
76_K	80_V	0.856	1.00
40_C	67_H	0.853	1.00
211_F	233_F	0.852	1.00
3_A	64_V	0.851	1.00
190_V	248_L	0.848	1.00
186_N	245_I	0.836	1.00
160_V	309_D	0.835	1.00
128_M	357_I	0.831	1.00
191_G	212_V	0.829	1.00
189_I	203_F	0.829	1.00
20_D	75_D	0.826	1.00
251_T	274_F	0.823	1.00
222_E	352_E	0.822	1.00
24_S	31_L	0.822	1.00
20_D	74_I	0.816	1.00
268_N	296_N	0.815	1.00
226_V	231_A	0.815	1.00
287_D	291_Y	0.814	1.00
336_I	355_T	0.814	1.00
200_S	212_V	0.810	1.00
280_E	283_E	0.808	1.00
140_V	311_E	0.808	1.00
38_G	68_E	0.805	1.00
192_S	226_V	0.805	1.00
248_L	271_I	0.804	1.00
18_I	125_D	0.803	1.00
187_V	208_F	0.803	1.00
69_N	132_Y	0.794	1.00
63_L	125_D	0.794	1.00
30_V	136_A	0.794	1.00
7_N	12_G	0.792	1.00
210_A	232_K	0.792	1.00
314_V	318_T	0.792	1.00
308_K	311_E	0.792	1.00
261_L	271_I	0.788	1.00
144_D	318_T	0.786	1.00
202_M	313_G	0.785	1.00
189_I	199_F	0.783	1.00
316_Y	320_W	0.780	1.00
292_L	301_G	0.778	1.00
210_A	213_L	0.773	1.00
127_F	132_Y	0.772	1.00
316_Y	319_I	0.771	1.00
84_G	141_K	0.770	1.00
166_L	203_F	0.768	1.00
215_K	238_K	0.768	1.00
334_R	343_E	0.765	1.00
39_I	348_K	0.762	1.00
206_Q	312_N	0.758	1.00
40_C	43_D	0.757	1.00
26_T	133_I	0.754	1.00
203_F	210_A	0.753	1.00
188_A	214_N	0.750	1.00
210_A	215_K	0.750	1.00
186_N	243_N	0.749	1.00
332_I	335_V	0.744	1.00
310_F	314_V	0.744	1.00
273_L	299_L	0.743	1.00
42_T	67_H	0.741	1.00
192_S	200_S	0.739	1.00
190_V	257_A	0.736	1.00
336_I	357_I	0.735	1.00
18_I	64_V	0.727	1.00
89_V	139_L	0.726	1.00
162_A	198_M	0.721	1.00
70_L	151_V	0.720	1.00
197_L	331_M	0.720	1.00
348_K	355_T	0.719	1.00
28_D	78_P	0.718	1.00
292_L	297_I	0.717	1.00
212_V	231_A	0.715	1.00
181_S	247_L	0.709	1.00
28_D	77_G	0.708	1.00
212_V	245_I	0.701	1.00
44_R	349_P	0.700	1.00
15_V	338_P	0.698	1.00
146_I	317_L	0.695	1.00
225_I	229_S	0.694	1.00
202_M	316_Y	0.694	1.00
165_E	199_F	0.693	1.00
82_G	307_K	0.691	1.00
347_T	350_K	0.690	1.00
4_I	342_P	0.688	1.00
247_L	272_I	0.688	1.00
60_K	63_L	0.687	1.00
170_Q	272_I	0.684	1.00
140_V	310_F	0.679	1.00
90_V	142_I	0.678	1.00
169_V	247_L	0.678	1.00
208_F	247_L	0.677	1.00
170_Q	182_Y	0.676	1.00
143_P	318_T	0.675	1.00
225_I	352_E	0.673	1.00
245_I	264_R	0.672	1.00
164_S	296_N	0.669	1.00
225_I	331_M	0.669	1.00
245_I	248_L	0.667	1.00
291_Y	294_E	0.666	1.00
28_D	137_S	0.666	1.00
25_L	77_G	0.665	1.00
25_L	75_D	0.665	1.00
91_S	134_D	0.663	1.00
30_V	73_V	0.663	1.00
163_Y	316_Y	0.660	1.00
250_D	271_I	0.659	1.00
45_G	50_L	0.657	1.00
87_D	144_D	0.653	1.00
254_Y	257_A	0.652	1.00
163_Y	313_G	0.652	1.00
223_A	226_V	0.652	1.00
243_N	266_N	0.650	1.00
167_M	202_M	0.647	1.00
59_G	63_L	0.647	1.00
201_L	229_S	0.645	1.00
192_S	212_V	0.645	1.00
345_L	349_P	0.644	1.00
34_T	37_N	0.644	1.00
200_S	229_S	0.643	1.00
161_K	195_I	0.642	1.00
259_I	291_Y	0.641	1.00
70_L	88_Y	0.637	1.00
70_L	142_I	0.635	1.00
267_K	295_N	0.634	1.00
162_A	195_I	0.633	1.00
280_E	285_N	0.633	1.00
36_A	70_L	0.631	1.00
211_F	235_N	0.631	1.00
233_F	236_T	0.626	1.00
42_T	46_I	0.625	1.00
334_R	355_T	0.624	1.00
258_F	271_I	0.621	1.00
21_I	133_I	0.620	1.00
255_P	259_I	0.620	1.00
40_C	158_N	0.620	1.00
228_K	331_M	0.619	1.00
36_A	335_V	0.619	1.00
136_A	139_L	0.619	1.00
37_N	357_I	0.617	1.00
184_C	209_N	0.616	1.00
162_A	166_L	0.613	1.00
164_S	168_L	0.612	1.00
168_L	309_D	0.612	1.00
247_L	270_A	0.612	1.00
44_R	48_S	0.611	1.00
285_N	291_Y	0.611	1.00
232_K	235_N	0.610	1.00
309_D	312_N	0.610	1.00
88_Y	145_E	0.609	1.00
163_Y	309_D	0.607	1.00
199_F	274_F	0.606	1.00
291_Y	297_I	0.605	1.00
296_N	306_S	0.605	1.00
165_E	272_I	0.605	1.00
213_L	237_N	0.604	1.00
158_N	198_M	0.603	1.00
170_Q	270_A	0.602	1.00
183_N	207_G	0.601	1.00
158_N	194_P	0.601	1.00
212_V	226_V	0.597	1.00
66_G	128_M	0.596	1.00
35_I	358_S	0.593	1.00
187_V	247_L	0.593	1.00
140_V	314_V	0.592	1.00
231_A	234_I	0.587	1.00
200_S	210_A	0.584	1.00
186_N	244_T	0.584	1.00
214_N	234_I	0.583	1.00
188_A	248_L	0.582	1.00
40_C	354_K	0.581	1.00
202_M	206_Q	0.578	1.00
215_K	223_A	0.577	1.00
32_V	139_L	0.577	1.00
212_V	215_K	0.577	1.00
282_F	286_A	0.576	1.00
83_L	136_A	0.575	1.00
311_E	314_V	0.575	1.00
200_S	226_V	0.575	1.00
152_L	356_V	0.574	1.00
76_K	87_D	0.572	1.00
41_G	45_G	0.571	1.00
39_I	128_M	0.571	1.00
135_N	138_Y	0.571	1.00
140_V	307_K	0.568	1.00
248_L	264_R	0.565	1.00
82_G	85_K	0.562	1.00
42_T	45_G	0.561	1.00
91_S	139_L	0.560	1.00
32_V	91_S	0.559	1.00
92_I	140_V	0.558	1.00
81_H	84_G	0.553	1.00
147_V	150_A	0.552	1.00
197_L	229_S	0.552	1.00
149_I	153_L	0.547	1.00
153_L	313_G	0.546	1.00
235_N	238_K	0.544	1.00
21_I	131_F	0.543	1.00
334_R	352_E	0.542	1.00
158_N	354_K	0.541	1.00
70_L	150_A	0.539	1.00
29_E	124_L	0.536	1.00
183_N	206_Q	0.532	1.00
169_V	300_F	0.532	1.00
166_L	202_M	0.532	1.00
165_E	302_S	0.532	1.00
169_V	272_I	0.530	1.00
201_L	329_N	0.530	1.00
228_K	329_N	0.530	1.00
336_I	343_E	0.530	1.00
294_E	303_V	0.530	1.00
198_M	202_M	0.530	1.00
21_I	31_L	0.530	1.00
161_K	274_F	0.529	1.00
189_I	200_S	0.529	1.00
11_K	346_Y	0.528	1.00
244_T	266_N	0.528	1.00
302_S	305_A	0.525	1.00
257_A	260_P	0.525	1.00
214_N	226_V	0.524	1.00
257_A	261_L	0.524	1.00
170_Q	185_R	0.522	1.00
226_V	234_I	0.521	1.00
168_L	298_L	0.521	1.00
259_I	285_N	0.521	1.00
214_N	237_N	0.521	1.00
204_S	231_A	0.520	1.00
258_F	273_L	0.520	1.00
334_R	340_Q	0.520	1.00
10_N	47_V	0.519	1.00
41_G	193_G	0.517	1.00
82_G	141_K	0.516	1.00
250_D	275_G	0.516	1.00
13_V	345_L	0.515	1.00
223_A	237_N	0.514	1.00
163_Y	206_Q	0.512	1.00
199_F	251_T	0.509	1.00
303_V	306_S	0.508	1.00
186_N	233_F	0.506	1.00
76_K	83_L	0.506	1.00
6_V	47_V	0.505	1.00
259_I	283_E	0.504	1.00
146_I	318_T	0.504	1.00
355_T	358_S	0.504	1.00
6_V	9_P	0.503	1.00
90_V	140_V	0.502	1.00
198_M	201_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3widA	4	0.9611	100	0.184	Contact Map
1h2bA	4	0.9028	100	0.196	Contact Map
4gi2A	2	0.9222	100	0.205	Contact Map
2b5wA	2	0.9417	100	0.206	Contact Map
1cdoA	2	0.9167	100	0.206	Contact Map
4c4oA	4	0.9	100	0.208	Contact Map
1e3iA	2	0.9111	100	0.208	Contact Map
2cdcA	3	0.9306	100	0.209	Contact Map
1vj0A	4	0.9139	100	0.211	Contact Map
4cpdA	2	0.9083	100	0.212	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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