GREMLIN Database
Q97U20 - Uncharacterized protein
UniProt: Q97U20 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (217)
Sequences: 1202 (803)
Seq/√Len: 54.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_I173_V4.4681.00
87_V110_V4.1591.00
175_D179_K3.3981.00
137_F141_V3.1031.00
236_V239_I2.8651.00
159_A171_L2.8631.00
121_V142_F2.6901.00
214_M217_N2.6851.00
51_L54_T2.4541.00
226_S229_R2.4221.00
210_V213_V2.3681.00
221_I225_A2.3081.00
94_F136_I2.2631.00
219_V224_L2.2571.00
215_V219_V2.2241.00
96_A100_M2.2071.00
198_D201_D2.1731.00
154_V158_Q2.1371.00
98_N102_T2.1251.00
217_N221_I2.1091.00
96_A121_V2.0991.00
216_T225_A2.0591.00
217_N225_A2.0471.00
46_L58_Y2.0411.00
92_D95_T2.0341.00
87_V91_S2.0001.00
91_S95_T1.9571.00
88_Y91_S1.9061.00
94_F98_N1.8890.99
196_A199_K1.8580.99
87_V139_V1.7780.99
230_A233_E1.7290.99
201_D204_Y1.7020.99
204_Y207_G1.6730.99
93_E137_F1.6670.99
111_V115_D1.6630.99
231_A235_I1.6620.99
215_V221_I1.6350.99
110_V139_V1.5770.98
109_P180_V1.5630.98
216_T219_V1.5620.98
178_N181_V1.5340.98
89_N118_V1.5260.98
148_Q166_R1.5150.98
97_I126_F1.5040.97
150_I154_V1.4710.97
151_Y176_D1.4590.97
123_E127_L1.4300.96
195_K198_D1.4040.96
223_E229_R1.3910.96
217_N222_D1.3690.95
252_R256_T1.3600.95
87_V96_A1.3550.95
214_M225_A1.3490.95
227_V235_I1.3370.95
222_D225_A1.3270.95
91_S110_V1.3150.94
80_M173_V1.3020.94
223_E226_S1.2980.94
211_K216_T1.2730.93
228_N232_A1.2710.93
216_T224_L1.2620.93
44_G47_T1.2500.93
207_G210_V1.2500.93
231_A238_R1.2470.93
202_P207_G1.2450.93
169_R186_V1.2440.93
209_V212_D1.2380.92
231_A236_V1.2370.92
242_L246_N1.2310.92
216_T223_E1.2220.92
217_N223_E1.2040.91
253_G256_T1.1940.91
220_T223_E1.1850.91
198_D202_P1.1760.90
215_V224_L1.1620.90
195_K203_D1.1560.89
58_Y72_S1.1460.89
214_M221_I1.1420.89
220_T224_L1.1250.88
195_K199_K1.1230.88
138_P141_V1.1210.88
139_V146_K1.1120.88
121_V189_A1.0810.86
152_K181_V1.0790.86
215_V223_E1.0640.85
196_A200_L1.0550.85
55_V58_Y1.0550.85
210_V221_I1.0540.85
216_T221_I1.0540.85
219_V222_D1.0530.85
197_V200_L1.0420.84
218_L224_L1.0350.84
182_G257_E1.0320.83
245_L256_T1.0310.83
147_V172_P1.0280.83
203_D207_G1.0270.83
150_I172_P1.0170.82
113_I179_K1.0170.82
49_R55_V1.0160.82
47_T55_V1.0130.82
215_V225_A1.0120.82
97_I101_V1.0110.82
202_P206_Y1.0100.82
151_Y154_V1.0050.82
219_V225_A0.9970.81
227_V231_A0.9970.81
195_K201_D0.9920.81
224_L236_V0.9900.81
229_R247_K0.9900.81
54_T58_Y0.9870.80
41_K44_G0.9860.80
214_M219_V0.9850.80
229_R236_V0.9800.80
246_N250_T0.9790.80
247_K258_R0.9790.80
217_N224_L0.9790.80
221_I224_L0.9710.79
85_V108_L0.9670.79
215_V220_T0.9580.78
199_K203_D0.9540.78
93_E142_F0.9490.78
76_I173_V0.9480.78
235_I240_G0.9450.77
233_E237_K0.9360.77
253_G257_E0.9320.77
42_I47_T0.9300.76
57_S112_D0.9230.76
78_D192_Q0.9190.75
203_D206_Y0.9170.75
152_K175_D0.9160.75
100_M171_L0.9150.75
228_N233_E0.9100.75
116_K179_K0.9100.75
250_T253_G0.9080.75
246_N252_R0.9020.74
127_L168_F0.9020.74
216_T222_D0.8980.74
198_D203_D0.8940.73
99_I103_R0.8880.73
90_T113_I0.8840.73
57_S126_F0.8750.72
52_L58_Y0.8700.71
96_A126_F0.8700.71
90_T138_P0.8670.71
168_F188_N0.8600.71
234_M238_R0.8580.70
210_V214_M0.8560.70
198_D204_Y0.8530.70
93_E133_L0.8520.70
223_E236_V0.8510.70
72_S162_L0.8490.70
215_V222_D0.8430.69
134_D137_F0.8420.69
140_K145_T0.8390.69
248_D256_T0.8350.68
88_Y111_V0.8330.68
248_D253_G0.8330.68
100_M108_L0.8240.67
125_E163_M0.8220.67
85_V103_R0.8200.67
93_E135_E0.8160.66
91_S139_V0.8150.66
220_T237_K0.8100.66
197_V204_Y0.8060.66
216_T220_T0.8050.65
214_M224_L0.7980.65
150_I189_A0.7940.64
200_L203_D0.7900.64
195_K200_L0.7860.64
51_L57_S0.7850.63
41_K47_T0.7820.63
78_D122_T0.7770.63
98_N136_I0.7770.63
40_E85_V0.7710.62
95_T98_N0.7710.62
41_K45_L0.7700.62
100_M189_A0.7670.62
97_I163_M0.7670.62
172_P180_V0.7640.61
158_Q161_K0.7600.61
54_T57_S0.7600.61
210_V225_A0.7600.61
214_M223_E0.7590.61
99_I104_N0.7580.61
144_S147_V0.7550.60
96_A108_L0.7550.60
71_I108_L0.7530.60
249_N256_T0.7510.60
57_S102_T0.7470.60
113_I118_V0.7460.59
245_L253_G0.7450.59
132_D137_F0.7430.59
38_A41_K0.7410.59
197_V206_Y0.7410.59
53_S57_S0.7370.59
207_G212_D0.7350.58
44_G52_L0.7350.58
224_L229_R0.7340.58
220_T231_A0.7310.58
160_V163_M0.7300.58
170_R240_G0.7300.58
186_V190_I0.7290.58
39_N76_I0.7280.58
50_D55_V0.7260.57
95_T108_L0.7240.57
89_N140_K0.7220.57
210_V215_V0.7220.57
38_A42_I0.7210.57
95_T99_I0.7200.57
154_V173_V0.7180.57
71_I76_I0.7120.56
211_K214_M0.7090.56
233_E238_R0.7070.55
91_S108_L0.7040.55
196_A201_D0.7030.55
120_I159_A0.7030.55
246_N257_E0.7030.55
239_I242_L0.6970.54
80_M86_T0.6950.54
104_N181_V0.6950.54
229_R237_K0.6900.54
70_H74_T0.6900.54
214_M220_T0.6890.54
204_Y213_V0.6770.52
103_R181_V0.6760.52
156_L189_A0.6750.52
95_T178_N0.6740.52
246_N258_R0.6730.52
207_G211_K0.6710.52
170_R184_V0.6710.52
98_N101_V0.6700.51
249_N252_R0.6690.51
228_N231_A0.6680.51
43_E51_L0.6660.51
211_K215_V0.6640.51
247_K250_T0.6610.51
121_V186_V0.6600.50
50_D58_Y0.6600.50
42_I45_L0.6580.50
139_V145_T0.6560.50
224_L231_A0.6540.50
199_K207_G0.6530.50
106_G186_V0.6450.49
227_V232_A0.6420.48
208_K212_D0.6380.48
120_I147_V0.6340.48
247_K252_R0.6320.47
88_Y113_I0.6300.47
71_I181_V0.6280.47
247_K257_E0.6270.47
88_Y133_L0.6230.46
142_F190_I0.6190.46
252_R258_R0.6170.46
51_L56_E0.6140.46
201_D205_F0.6130.45
229_R235_I0.6130.45
40_E160_V0.6130.45
153_E176_D0.6120.45
88_Y192_Q0.6120.45
89_N112_D0.6090.45
39_N173_V0.6050.45
253_G258_R0.6040.44
201_D206_Y0.6030.44
76_I150_I0.6020.44
171_L234_M0.5990.44
85_V105_F0.5980.44
98_N115_D0.5960.44
159_A170_R0.5960.44
196_A213_V0.5920.43
117_P174_I0.5900.43
195_K207_G0.5900.43
190_I193_L0.5890.43
118_V142_F0.5860.43
235_I238_R0.5840.42
80_M186_V0.5840.42
82_P85_V0.5840.42
232_A236_V0.5810.42
229_R232_A0.5800.42
220_T232_A0.5760.42
250_T257_E0.5740.41
170_R244_I0.5710.41
171_L241_S0.5700.41
224_L247_K0.5680.41
182_G258_R0.5670.41
109_P251_I0.5660.40
220_T228_N0.5660.40
93_E124_R0.5650.40
166_R173_V0.5630.40
150_I167_G0.5600.40
76_I184_V0.5590.40
126_F176_D0.5580.40
107_S170_R0.5560.39
233_E236_V0.5560.39
237_K240_G0.5530.39
40_E51_L0.5500.39
147_V156_L0.5500.39
57_S98_N0.5460.38
84_P191_K0.5440.38
160_V194_A0.5430.38
249_N253_G0.5380.38
39_N172_P0.5380.38
88_Y114_N0.5350.37
93_E178_N0.5350.37
165_R177_D0.5330.37
87_V126_F0.5330.37
86_T139_V0.5320.37
39_N44_G0.5280.37
47_T54_T0.5280.37
156_L186_V0.5270.37
125_E144_S0.5260.36
52_L55_V0.5240.36
44_G48_T0.5210.36
247_K253_G0.5190.36
92_D97_I0.5190.36
47_T50_D0.5180.36
121_V127_L0.5170.36
105_F123_E0.5170.36
40_E43_E0.5160.35
71_I152_K0.5090.35
106_G187_V0.5090.35
46_L54_T0.5060.34
252_R257_E0.5040.34
81_T180_V0.5020.34
64_S75_P0.5010.34
250_T258_R0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ddjA 1 0.9856 100 0.552 Contact Map
2yzqA 2 0.7906 100 0.58 Contact Map
3kh5A 1 0.9531 100 0.592 Contact Map
2qrdG 1 0.8014 100 0.594 Contact Map
3t4nC 1 0.7906 100 0.6 Contact Map
2v8qE 1 0.9531 99.9 0.621 Contact Map
3l2bA 2 0.4224 99.9 0.642 Contact Map
1vrdA 3 0.5199 99.9 0.649 Contact Map
4af0A 3 0.5054 99.9 0.656 Contact Map
1jcnA 6 0.769 99.9 0.658 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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