GREMLIN Database
Q97U17 - Oxidoreductase, aldo/keto reductase family
UniProt: Q97U17 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (248)
Sequences: 32268 (20526)
Seq/√Len: 1303.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_Y244_D3.1111.00
96_K136_I2.9601.00
30_D65_K2.8611.00
68_E103_N2.7781.00
215_Y258_D2.6591.00
255_S258_D2.4421.00
95_A131_L2.4371.00
34_I69_N2.4221.00
92_I130_E2.3671.00
92_I134_Q2.3361.00
39_Y43_K2.2771.00
214_K261_R2.1571.00
34_I65_K2.0091.00
97_N101_R1.9911.00
209_E213_R1.9861.00
129_E133_D1.9591.00
214_K258_D1.9501.00
229_R259_Y1.9371.00
256_D260_E1.9241.00
106_Y138_N1.9201.00
130_E134_Q1.9181.00
183_F187_N1.9161.00
71_D74_K1.8651.00
210_E261_R1.8391.00
240_K244_D1.8341.00
184_C191_V1.8281.00
88_Y130_E1.7801.00
77_I104_A1.7681.00
12_G47_V1.7601.00
230_R263_S1.7281.00
111_L164_A1.7251.00
39_Y240_K1.7181.00
58_H61_E1.7061.00
151_E155_S1.6971.00
217_K252_W1.6881.00
130_E133_D1.6831.00
79_T107_I1.6811.00
43_K244_D1.6801.00
40_V45_I1.6311.00
190_K232_I1.6141.00
225_N252_W1.6041.00
61_E101_R1.5991.00
88_Y92_I1.5991.00
79_T98_S1.5961.00
29_K32_H1.5921.00
218_T245_E1.5911.00
43_K247_L1.5771.00
34_I66_A1.5771.00
81_V110_Y1.5641.00
151_E183_F1.5471.00
34_I38_K1.5411.00
38_K69_N1.5401.00
81_V91_L1.5401.00
207_I210_E1.5401.00
92_I96_K1.5371.00
39_Y42_S1.5361.00
95_A110_Y1.5131.00
78_I111_L1.5021.00
248_G251_G1.4951.00
127_A130_E1.4781.00
15_T48_I1.4711.00
6_K139_C1.4371.00
52_E94_S1.4341.00
182_P186_R1.4241.00
129_E160_Y1.4201.00
93_R97_N1.4171.00
185_E231_S1.4021.00
41_I75_I1.3991.00
111_L192_I1.3971.00
217_K221_Q1.3911.00
107_I137_V1.3841.00
96_K100_K1.3751.00
179_D182_P1.3561.00
30_D34_I1.3451.00
32_H35_E1.3451.00
37_L66_A1.3431.00
139_C163_T1.3421.00
146_D149_L1.3341.00
132_V160_Y1.3341.00
6_K76_F1.3291.00
244_D248_G1.3281.00
154_M187_N1.3241.00
167_I191_V1.3211.00
225_N229_R1.3001.00
88_Y126_R1.2771.00
97_N100_K1.2621.00
237_A242_H1.2601.00
38_K42_S1.2571.00
131_L137_V1.2481.00
35_E39_Y1.2401.00
92_I127_A1.2391.00
88_Y127_A1.2381.00
217_K222_V1.2371.00
154_M183_F1.2311.00
76_F109_L1.2251.00
237_A243_I1.2001.00
137_V140_I1.1931.00
60_E98_S1.1921.00
147_I183_F1.1871.00
210_E214_K1.1831.00
65_K103_N1.1811.00
218_T221_Q1.1771.00
102_L107_I1.1701.00
72_R104_A1.1651.00
122_E156_I1.1641.00
133_D158_K1.1571.00
207_I261_R1.1561.00
64_G103_N1.1551.00
109_L164_A1.1551.00
181_I185_E1.1521.00
72_R106_Y1.1441.00
48_I63_V1.1421.00
172_E205_N1.1381.00
87_K90_D1.1311.00
169_Y230_R1.1271.00
241_D244_D1.1271.00
4_C139_C1.1081.00
209_E219_S1.1021.00
95_A107_I1.1011.00
89_D93_R1.0971.00
61_E65_K1.0961.00
151_E186_R1.0951.00
211_I222_V1.0941.00
115_P149_L1.0931.00
132_V163_T1.0861.00
90_D93_R1.0811.00
123_E126_R1.0771.00
47_V192_I1.0671.00
36_I243_I1.0611.00
129_E132_V1.0591.00
227_L233_P1.0571.00
31_S35_E1.0491.00
128_M140_I1.0451.00
47_V78_I1.0411.00
96_K134_Q1.0401.00
112_I128_M1.0321.00
38_K66_A1.0291.00
86_L112_I1.0291.00
151_E187_N1.0241.00
171_V262_I1.0201.00
210_E213_R1.0181.00
206_K210_E1.0141.00
131_L136_I1.0031.00
228_L249_A1.0031.00
35_E240_K1.0021.00
15_T63_V0.9991.00
46_N76_F0.9981.00
208_L219_S0.9951.00
221_Q248_G0.9941.00
147_I151_E0.9931.00
206_K209_E0.9821.00
152_E156_I0.9751.00
9_S46_N0.9721.00
171_V223_A0.9711.00
243_I247_L0.9701.00
164_A192_I0.9611.00
122_E152_E0.9581.00
176_A191_V0.9491.00
65_K69_N0.9471.00
9_S45_I0.9451.00
60_E101_R0.9421.00
4_C163_T0.9391.00
142_V162_I0.9341.00
192_I232_I0.9291.00
182_P185_E0.9271.00
88_Y123_E0.9201.00
178_K182_P0.9191.00
10_Q228_L0.9141.00
61_E100_K0.9131.00
108_D138_N0.9111.00
92_I95_A0.9061.00
67_I75_I0.8951.00
131_L134_Q0.8931.00
126_R130_E0.8891.00
52_E90_D0.8871.00
221_Q245_E0.8871.00
241_D245_E0.8841.00
245_E248_G0.8821.00
85_H90_D0.8771.00
127_A131_L0.8751.00
41_I71_D0.8671.00
37_L48_I0.8641.00
78_I192_I0.8621.00
129_E158_K0.8611.00
211_I215_Y0.8601.00
10_Q250_L0.8591.00
165_N184_C0.8561.00
142_V150_L0.8541.00
224_L249_A0.8531.00
93_R96_K0.8431.00
140_I162_I0.8431.00
260_E263_S0.8371.00
229_R253_N0.8341.00
214_K255_S0.8331.00
52_E85_H0.8301.00
30_D58_H0.8301.00
239_S242_H0.8271.00
183_F186_R0.8251.00
257_E261_R0.8251.00
35_E38_K0.8221.00
230_R259_Y0.8171.00
257_E260_E0.8141.00
126_R129_E0.8131.00
129_E140_I0.8101.00
4_C132_V0.8051.00
152_E155_S0.7991.00
78_I109_L0.7971.00
215_Y255_S0.7941.00
223_A227_L0.7931.00
169_Y181_I0.7891.00
158_K161_E0.7871.00
52_E101_R0.7871.00
92_I131_L0.7801.00
144_N194_Y0.7781.00
13_F40_V0.7761.00
225_N249_A0.7751.00
15_T59_S0.7711.00
150_L189_I0.7601.00
99_L136_I0.7591.00
79_T110_Y0.7591.00
229_R256_D0.7471.00
147_I180_V0.7461.00
193_A196_P0.7431.00
181_I191_V0.7421.00
177_E182_P0.7411.00
217_K251_G0.7381.00
196_P235_P0.7371.00
50_T63_V0.7371.00
39_Y243_I0.7341.00
52_E97_N0.7231.00
238_S242_H0.7151.00
43_K248_G0.7151.00
125_L162_I0.7141.00
180_V184_C0.7131.00
193_A233_P0.7041.00
125_L153_T0.7021.00
95_A136_I0.6961.00
38_K71_D0.6941.00
13_F18_I0.6931.00
129_E157_T0.6871.00
36_I240_K0.6861.00
125_L140_I0.6861.00
12_G235_P0.6841.00
154_M161_E0.6831.00
86_L124_S0.6821.00
181_I230_R0.6821.00
114_W144_N0.6791.00
45_I247_L0.6781.00
99_L104_A0.6761.00
98_S110_Y0.6751.00
142_V165_N0.6731.00
41_I48_I0.6691.00
147_I179_D0.6671.00
184_C189_I0.6661.00
215_Y222_V0.6601.00
33_Y62_L0.6601.00
222_V252_W0.6571.00
220_V245_E0.6531.00
211_I261_R0.6531.00
73_D106_Y0.6531.00
6_K138_N0.6521.00
17_K199_R0.6521.00
94_S97_N0.6521.00
111_L141_G0.6521.00
212_G222_V0.6511.00
37_L41_I0.6501.00
142_V145_F0.6501.00
11_I228_L0.6481.00
91_L131_L0.6471.00
254_L259_Y0.6461.00
242_H245_E0.6451.00
208_L262_I0.6451.00
213_R216_N0.6441.00
196_P227_L0.6411.00
91_L124_S0.6411.00
107_I110_Y0.6401.00
132_V139_C0.6391.00
31_S34_I0.6391.00
43_K243_I0.6371.00
46_N74_K0.6341.00
226_Y263_S0.6341.00
169_Y227_L0.6321.00
217_K225_N0.6321.00
211_I258_D0.6271.00
124_S127_A0.6261.00
87_K124_S0.6211.00
121_L156_I0.6201.00
222_V254_L0.6151.00
16_W195_S0.6131.00
128_M132_V0.6101.00
208_L223_A0.6101.00
53_M82_W0.6091.00
132_V137_V0.6091.00
205_N209_E0.6091.00
217_K248_G0.6071.00
71_D75_I0.6031.00
91_L127_A0.6031.00
18_I33_Y0.6011.00
169_Y177_E0.5951.00
169_Y191_V0.5951.00
8_V232_I0.5891.00
151_E154_M0.5891.00
32_H240_K0.5891.00
36_I237_A0.5861.00
99_L106_Y0.5851.00
70_F75_I0.5851.00
254_L258_D0.5841.00
95_A99_L0.5831.00
120_P152_E0.5821.00
201_N205_N0.5811.00
12_G232_I0.5811.00
41_I46_N0.5771.00
99_L105_K0.5771.00
212_G219_S0.5761.00
19_G59_S0.5721.00
99_L107_I0.5681.00
92_I136_I0.5681.00
8_V47_V0.5681.00
58_H62_L0.5671.00
172_E201_N0.5651.00
258_D261_R0.5641.00
202_A223_A0.5621.00
121_L124_S0.5621.00
171_V226_Y0.5611.00
221_Q252_W0.5611.00
116_N119_V0.5601.00
52_E82_W0.5581.00
222_V258_D0.5561.00
42_S240_K0.5551.00
30_D62_L0.5541.00
110_Y128_M0.5531.00
20_G62_L0.5531.00
49_D166_E0.5521.00
72_R108_D0.5521.00
149_L152_E0.5511.00
81_V86_L0.5511.00
228_L233_P0.5481.00
18_I36_I0.5481.00
237_A246_I0.5471.00
195_S199_R0.5451.00
50_T59_S0.5431.00
83_S86_L0.5411.00
81_V94_S0.5391.00
41_I74_K0.5361.00
142_V153_T0.5351.00
175_S178_K0.5351.00
13_F36_I0.5341.00
212_G215_Y0.5331.00
110_Y137_V0.5321.00
240_K243_I0.5301.00
148_K151_E0.5291.00
11_I250_L0.5271.00
122_E126_R0.5241.00
47_V76_F0.5211.00
211_I214_K0.5191.00
112_I124_S0.5191.00
48_I67_I0.5181.00
60_E79_T0.5181.00
37_L63_V0.5141.00
215_Y252_W0.5121.00
12_G234_I0.5111.00
88_Y91_L0.5101.00
154_M189_I0.5101.00
55_G58_H0.5101.00
121_L149_L0.5091.00
63_V66_A0.5081.00
121_L152_E0.5071.00
157_T162_I0.5051.00
249_A252_W0.5031.00
225_N253_N0.5031.00
222_V262_I0.5011.00
125_L157_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.9849 100 0.08 Contact Map
3v0sA 1 0.9321 100 0.085 Contact Map
4xk2A 5 0.9547 100 0.089 Contact Map
3n2tA 1 0.9774 100 0.092 Contact Map
1pz1A 1 0.9811 100 0.096 Contact Map
4r9oA 5 0.9774 100 0.097 Contact Map
5c7hA 1 0.9736 100 0.1 Contact Map
4wghA 1 0.9736 100 0.106 Contact Map
3lutA 3 0.9774 100 0.108 Contact Map
3erpA 6 0.9774 100 0.109 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.