GREMLIN Database
Q97U15 - 4-aminobutyrate aminotransferase (GabT-2)
UniProt: Q97U15 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 418 (379)
Sequences: 20797 (12162)
Seq/√Len: 624.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_K72_D4.4731.00
230_N234_K4.1791.00
379_R413_E4.0991.00
35_I43_E3.6981.00
331_K405_M3.3931.00
30_H37_Y3.1911.00
93_R316_E3.1841.00
320_K323_D2.9811.00
254_K260_H2.9401.00
331_K401_E2.8701.00
341_S412_K2.8261.00
187_L228_K2.8071.00
324_H328_I2.7211.00
400_S403_L2.6711.00
65_N69_E2.6451.00
47_F407_G2.5041.00
313_V316_E2.4931.00
62_K313_V2.3751.00
228_K231_N2.3621.00
62_K317_E2.3451.00
335_E408_T2.3401.00
60_N317_E2.3031.00
35_I403_L2.2871.00
29_D39_I2.2741.00
231_N235_K2.2741.00
327_S401_E2.2101.00
37_Y43_E2.1441.00
375_N378_R2.1201.00
93_R312_N2.1011.00
191_E235_K2.0851.00
335_E405_M2.0821.00
129_W203_E2.0301.00
90_V311_A2.0211.00
169_P189_F1.9281.00
64_I68_K1.9231.00
381_V410_I1.9001.00
375_N379_R1.8971.00
406_K410_I1.8871.00
333_I337_T1.8861.00
103_K287_K1.8851.00
208_I241_I1.8661.00
38_D42_N1.8571.00
330_K334_E1.8501.00
42_N380_G1.8221.00
102_A287_K1.8101.00
29_D73_K1.7911.00
85_E89_E1.7821.00
107_A281_G1.7811.00
190_I229_L1.7681.00
35_I406_K1.7431.00
287_K291_D1.7341.00
335_E338_D1.7321.00
67_V310_A1.7221.00
92_K96_S1.7201.00
333_I349_G1.7201.00
345_Y359_R1.7061.00
191_E195_F1.6991.00
114_V269_C1.6781.00
207_F233_L1.6771.00
209_A229_L1.6481.00
67_V71_M1.6371.00
129_W166_Y1.6241.00
32_F61_E1.6211.00
270_L282_A1.6181.00
278_L307_A1.6161.00
254_K326_S1.6101.00
173_R228_K1.6031.00
275_G280_L1.5931.00
194_V238_I1.5871.00
134_I169_P1.5631.00
328_I331_K1.5441.00
34_A403_L1.5441.00
133_F225_F1.5341.00
43_E406_K1.5191.00
333_I354_I1.5191.00
69_E73_K1.5141.00
124_H289_I1.5091.00
375_N414_E1.5001.00
89_E312_N1.4961.00
328_I404_A1.4961.00
224_D227_Y1.4951.00
242_L258_F1.4921.00
98_M284_V1.4821.00
324_H327_S1.4581.00
34_A398_I1.4451.00
270_L284_V1.4451.00
116_A283_V1.4431.00
230_N233_L1.4391.00
376_S383_A1.4371.00
379_R414_E1.4341.00
130_I206_A1.4321.00
131_I204_V1.4311.00
171_P222_P1.4261.00
91_A106_Y1.4231.00
230_N240_L1.4201.00
191_E228_K1.4181.00
313_V317_E1.4121.00
132_G167_L1.4081.00
335_E409_K1.4071.00
312_N316_E1.3951.00
38_D44_Y1.3811.00
118_I130_I1.3701.00
195_F236_F1.3701.00
104_V284_V1.3651.00
61_E65_N1.3651.00
255_M259_E1.3581.00
254_K259_E1.3511.00
93_R96_S1.3511.00
339_T408_T1.3451.00
280_L308_L1.3451.00
335_E412_K1.3451.00
117_A269_C1.3361.00
339_T412_K1.3331.00
331_K335_E1.3301.00
328_I401_E1.3251.00
95_S104_V1.3221.00
209_A226_F1.3181.00
15_Y95_S1.3101.00
65_N68_K1.3101.00
114_V208_I1.3071.00
174_R345_Y1.3071.00
412_K416_E1.3051.00
399_I404_A1.3041.00
121_A241_I1.2991.00
28_I36_V1.2991.00
267_L285_G1.2981.00
32_F59_K1.2951.00
323_D327_S1.2901.00
89_E316_E1.2891.00
207_F229_L1.2871.00
274_L280_L1.2791.00
258_F268_V1.2771.00
30_H73_K1.2771.00
56_L317_E1.2751.00
341_S416_E1.2681.00
224_D261_F1.2631.00
147_F165_T1.2611.00
260_H350_L1.2551.00
67_V306_L1.2401.00
188_G192_D1.2351.00
191_E232_L1.2221.00
261_F350_L1.2181.00
60_N319_P1.2171.00
227_Y231_N1.2161.00
64_I71_M1.2141.00
274_L282_A1.2141.00
264_T286_R1.2121.00
280_L311_A1.2061.00
59_K64_I1.2061.00
403_L406_K1.2001.00
107_A283_V1.1871.00
64_I72_D1.1821.00
103_K291_D1.1811.00
66_A313_V1.1791.00
15_Y92_K1.1711.00
376_S410_I1.1591.00
326_S330_K1.1571.00
106_Y308_L1.1531.00
409_K413_E1.1521.00
147_F208_I1.1441.00
239_L289_I1.1431.00
227_Y262_N1.1361.00
242_L263_V1.1311.00
35_I45_I1.1301.00
168_I193_W1.1281.00
68_K71_M1.1221.00
250_G322_L1.1211.00
187_L232_L1.1181.00
256_F270_L1.1161.00
376_S414_E1.1091.00
379_R410_I1.1071.00
334_E338_D1.1061.00
111_T144_S1.0971.00
381_V407_G1.0921.00
406_K409_K1.0841.00
267_L283_V1.0821.00
191_E231_N1.0751.00
233_L238_I1.0731.00
34_A45_I1.0721.00
276_G314_I1.0621.00
32_F43_E1.0621.00
401_E405_M1.0601.00
29_D85_E1.0541.00
405_M409_K1.0461.00
322_L325_V1.0411.00
90_V312_N1.0371.00
191_E236_F1.0341.00
29_D41_G1.0261.00
376_S381_V1.0251.00
97_L255_M1.0221.00
371_K375_N1.0211.00
27_V39_I1.0161.00
253_G259_E1.0141.00
120_I283_V1.0081.00
113_S269_C1.0041.00
189_F192_D0.9931.00
32_F37_Y0.9931.00
55_A273_A0.9901.00
56_L314_I0.9891.00
231_N234_K0.9831.00
118_I147_F0.9791.00
127_R237_G0.9761.00
318_V321_L0.9741.00
132_G208_I0.9741.00
211_P242_L0.9661.00
93_R97_L0.9601.00
54_V276_G0.9591.00
29_D37_Y0.9581.00
100_F268_V0.9581.00
173_R186_L0.9571.00
206_A241_I0.9561.00
323_D326_S0.9551.00
133_F221_P0.9511.00
223_K227_Y0.9471.00
169_P172_D0.9451.00
128_Q203_E0.9451.00
324_H401_E0.9441.00
65_N72_D0.9431.00
63_I310_A0.9351.00
146_A162_L0.9341.00
45_I403_L0.9341.00
402_E405_M0.9291.00
249_I318_V0.9291.00
62_K65_N0.9241.00
194_V204_V0.9211.00
226_F261_F0.9201.00
357_E389_S0.9181.00
345_Y357_E0.9181.00
337_T340_R0.9181.00
229_L240_L0.9161.00
101_S264_T0.9061.00
309_A313_V0.9051.00
318_V322_L0.9041.00
99_P258_F0.9041.00
45_I406_K0.8971.00
56_L63_I0.8931.00
27_V88_I0.8871.00
117_A241_I0.8861.00
220_V350_L0.8851.00
224_D228_K0.8851.00
201_P236_F0.8851.00
124_H239_L0.8831.00
111_T141_T0.8831.00
355_G390_V0.8811.00
129_W204_V0.8801.00
69_E309_A0.8771.00
374_Y378_R0.8751.00
47_F399_I0.8741.00
129_W195_F0.8731.00
321_L325_V0.8721.00
133_F170_Y0.8721.00
232_L236_F0.8701.00
69_E72_D0.8651.00
39_I85_E0.8641.00
34_A400_S0.8641.00
97_L315_L0.8621.00
120_I285_G0.8551.00
329_G333_I0.8551.00
214_G246_Q0.8541.00
260_H326_S0.8541.00
212_I350_L0.8531.00
170_Y221_P0.8531.00
62_K316_E0.8481.00
255_M322_L0.8451.00
334_E337_T0.8411.00
234_K264_T0.8371.00
399_I407_G0.8371.00
346_D357_E0.8351.00
62_K66_A0.8301.00
247_T353_L0.8281.00
338_D412_K0.8261.00
353_L394_E0.8231.00
108_N112_E0.8221.00
121_A206_A0.8181.00
89_E93_R0.8171.00
86_V309_A0.8171.00
121_A239_L0.8161.00
335_E404_A0.8151.00
352_L399_I0.8041.00
370_E374_Y0.7991.00
249_I315_L0.7981.00
299_N302_G0.7961.00
278_L306_L0.7941.00
45_I407_G0.7941.00
52_G394_E0.7911.00
348_R357_E0.7861.00
194_V232_L0.7841.00
237_G288_E0.7841.00
393_I411_L0.7821.00
230_N263_V0.7801.00
258_F263_V0.7771.00
256_F268_V0.7751.00
327_S331_K0.7751.00
228_K232_L0.7741.00
94_L284_V0.7731.00
104_V282_A0.7721.00
200_D203_E0.7701.00
188_G191_E0.7671.00
233_L240_L0.7671.00
322_L326_S0.7671.00
207_F238_I0.7661.00
107_A113_S0.7661.00
47_F381_V0.7661.00
186_L189_F0.7651.00
33_G398_I0.7641.00
249_I274_L0.7621.00
331_K334_E0.7591.00
34_A396_P0.7591.00
166_Y193_W0.7561.00
90_V308_L0.7561.00
349_G354_I0.7551.00
249_I270_L0.7511.00
123_G296_S0.7511.00
189_F193_W0.7501.00
372_V411_L0.7481.00
86_V312_N0.7471.00
373_L385_G0.7461.00
211_P226_F0.7441.00
168_I190_I0.7401.00
347_V354_I0.7351.00
221_P224_D0.7351.00
249_I255_M0.7321.00
48_N384_I0.7311.00
190_I207_F0.7301.00
63_I276_G0.7291.00
252_T260_H0.7261.00
171_P174_R0.7251.00
212_I252_T0.7241.00
121_A267_L0.7241.00
220_V349_G0.7231.00
126_G203_E0.7231.00
109_S112_E0.7181.00
66_A310_A0.7171.00
86_V89_E0.7151.00
288_E291_D0.7141.00
128_Q164_S0.7141.00
328_I352_L0.7131.00
120_I292_L0.7131.00
28_I31_G0.7121.00
143_G162_L0.7121.00
204_V238_I0.7111.00
338_D341_S0.7101.00
293_P296_S0.7061.00
270_L274_L0.7051.00
114_V144_S0.7041.00
137_F140_R0.7021.00
118_I208_I0.7021.00
325_V329_G0.7011.00
93_R315_L0.7001.00
214_G353_L0.6991.00
86_V308_L0.6991.00
286_R289_I0.6981.00
16_L91_A0.6961.00
327_S330_K0.6961.00
87_A91_A0.6951.00
97_L256_F0.6951.00
45_I381_V0.6941.00
227_Y261_F0.6941.00
271_A281_G0.6921.00
119_K297_H0.6901.00
357_E390_V0.6881.00
358_L372_V0.6881.00
86_V90_V0.6881.00
75_F278_L0.6871.00
234_K240_L0.6861.00
49_A394_E0.6861.00
209_A240_L0.6851.00
71_M306_L0.6851.00
73_K85_E0.6851.00
83_Y88_I0.6841.00
407_G410_I0.6821.00
74_F77_Y0.6811.00
285_G290_M0.6791.00
84_Y87_A0.6781.00
372_V414_E0.6761.00
116_A297_H0.6761.00
250_G318_V0.6741.00
174_R359_R0.6701.00
42_N378_R0.6701.00
402_E406_K0.6691.00
117_A267_L0.6681.00
372_V376_S0.6681.00
376_S411_L0.6671.00
393_I407_G0.6641.00
90_V280_L0.6621.00
70_Q73_K0.6561.00
100_F258_F0.6551.00
131_I190_I0.6551.00
226_F242_L0.6541.00
329_G349_G0.6531.00
59_K71_M0.6511.00
174_R191_E0.6511.00
371_K374_Y0.6491.00
241_I267_L0.6471.00
56_L321_L0.6471.00
331_K404_A0.6451.00
324_H400_S0.6441.00
107_A112_E0.6431.00
98_M268_V0.6421.00
240_L263_V0.6411.00
356_A411_L0.6411.00
213_Q216_G0.6381.00
194_V236_F0.6381.00
347_V356_A0.6381.00
124_H288_E0.6371.00
100_F264_T0.6361.00
110_G245_V0.6341.00
31_G74_F0.6331.00
36_V382_L0.6321.00
99_P259_E0.6281.00
213_Q219_I0.6271.00
223_K350_L0.6271.00
192_D195_F0.6261.00
70_Q86_V0.6261.00
408_T412_K0.6251.00
127_R238_I0.6231.00
245_V269_C0.6231.00
223_K261_F0.6231.00
43_E410_I0.6221.00
134_I167_L0.6221.00
372_V391_V0.6211.00
120_I267_L0.6201.00
88_I92_K0.6191.00
95_S102_A0.6181.00
358_L415_I0.6181.00
328_I399_I0.6171.00
97_L254_K0.6171.00
249_I256_F0.6161.00
90_V106_Y0.6151.00
258_F265_P0.6141.00
34_A399_I0.6141.00
343_Y359_R0.6141.00
98_M256_F0.6121.00
49_A396_P0.6111.00
133_F168_I0.6101.00
381_V406_K0.6081.00
168_I189_F0.6081.00
27_V83_Y0.6071.00
330_K333_I0.6071.00
131_I193_W0.6051.00
410_I414_E0.6041.00
31_G36_V0.6031.00
374_Y377_F0.6001.00
71_M310_A0.5981.00
325_V397_L0.5971.00
368_G371_K0.5971.00
122_R142_L0.5971.00
190_I232_L0.5921.00
122_R160_P0.5911.00
66_A69_E0.5911.00
26_F29_D0.5911.00
399_I403_L0.5911.00
332_I408_T0.5901.00
310_A313_V0.5861.00
55_A397_L0.5861.00
344_L415_I0.5841.00
127_R203_E0.5831.00
160_P164_S0.5831.00
73_K86_V0.5831.00
133_F229_L0.5821.00
99_P264_T0.5811.00
328_I400_S0.5791.00
391_V411_L0.5781.00
55_A318_V0.5771.00
325_V352_L0.5771.00
332_I354_I0.5771.00
48_N382_L0.5771.00
232_L235_K0.5751.00
125_T205_A0.5751.00
15_Y88_I0.5741.00
133_F209_A0.5741.00
324_H404_A0.5721.00
212_I353_L0.5721.00
17_M285_G0.5691.00
98_M270_L0.5681.00
367_E371_K0.5671.00
246_Q353_L0.5671.00
190_I228_K0.5671.00
66_A316_E0.5661.00
271_A301_F0.5641.00
188_G228_K0.5631.00
28_I82_F0.5631.00
335_E339_T0.5621.00
332_I404_A0.5611.00
211_P247_T0.5611.00
358_L368_G0.5601.00
71_M75_F0.5591.00
234_K288_E0.5561.00
410_I413_E0.5551.00
95_S284_V0.5521.00
151_K156_K0.5501.00
326_S329_G0.5491.00
16_L87_A0.5491.00
29_D32_F0.5481.00
31_G54_V0.5481.00
63_I314_I0.5471.00
132_G165_T0.5471.00
369_L385_G0.5471.00
411_L415_I0.5461.00
28_I74_F0.5450.99
255_M318_V0.5440.99
82_F382_L0.5440.99
32_F35_I0.5440.99
61_E72_D0.5430.99
129_W200_D0.5410.99
140_R298_A0.5410.99
267_L289_I0.5410.99
348_R355_G0.5400.99
229_L238_I0.5390.99
215_E392_R0.5380.99
67_V75_F0.5380.99
56_L60_N0.5370.99
396_P399_I0.5360.99
101_S286_R0.5360.99
64_I276_G0.5350.99
70_Q74_F0.5340.99
118_I143_G0.5330.99
69_E313_V0.5320.99
304_N307_A0.5310.99
98_M104_V0.5310.99
45_I399_I0.5310.99
211_P258_F0.5300.99
63_I313_V0.5300.99
131_I168_I0.5280.99
348_R390_V0.5280.99
331_K408_T0.5280.99
321_L324_H0.5270.99
244_E257_A0.5270.99
95_S100_F0.5260.99
27_V85_E0.5260.99
227_Y230_N0.5260.99
129_W164_S0.5250.99
339_T409_K0.5250.99
380_G410_I0.5250.99
404_A407_G0.5210.99
149_S167_L0.5200.99
89_E92_K0.5200.99
255_M315_L0.5200.99
220_V261_F0.5200.99
118_I165_T0.5190.99
223_K262_N0.5180.99
344_L356_A0.5170.99
209_A242_L0.5170.99
26_F377_F0.5160.99
141_T144_S0.5150.99
246_Q392_R0.5150.99
16_L19_S0.5140.99
273_A276_G0.5140.99
195_F203_E0.5130.99
195_F235_K0.5130.99
407_G411_L0.5120.99
133_F207_F0.5110.99
404_A408_T0.5110.99
343_Y415_I0.5100.99
377_F382_L0.5090.99
30_H43_E0.5090.99
62_K319_P0.5090.99
405_M408_T0.5080.99
381_V414_E0.5080.99
384_I387_G0.5080.99
135_N216_G0.5070.99
356_A393_I0.5070.99
406_K413_E0.5070.99
95_S98_M0.5040.99
103_K290_M0.5040.99
239_L267_L0.5030.99
225_F229_L0.5010.99
367_E370_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4atqA 7 0.9928 100 0.361 Contact Map
3oksA 2 0.9952 100 0.366 Contact Map
4ffcA 4 0.988 100 0.379 Contact Map
4uoxA 3 0.9498 100 0.379 Contact Map
4e3qA 3 0.9833 100 0.384 Contact Map
1z7dA 2 0.8732 100 0.387 Contact Map
4a0gA 2 0.9689 100 0.389 Contact Map
2epjA 2 0.9258 100 0.392 Contact Map
3hmuA 2 0.9833 100 0.394 Contact Map
1sffA 3 0.9785 100 0.396 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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