GREMLIN Database
Q97U09 - Second ORF in transposon ISC1316
UniProt: Q97U09 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (206)
Sequences: 4764 (2896)
Seq/√Len: 201.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_D103_K4.6771.00
173_A203_N3.8141.00
121_H124_Q3.3321.00
153_L160_L3.1571.00
146_R162_L2.7741.00
116_V212_A2.6511.00
144_E148_V2.6341.00
106_K110_E2.5561.00
117_M149_L2.4511.00
40_L145_L2.4391.00
126_V138_S2.3881.00
183_S186_D2.2611.00
171_T178_V2.1961.00
150_K162_L2.1691.00
211_G214_S2.1021.00
59_L135_R2.0811.00
109_A153_L2.0361.00
167_Y170_K2.0301.00
102_M151_Y1.9491.00
168_T208_I1.9451.00
190_V197_I1.9361.00
102_M148_V1.9331.00
58_A96_L1.8981.00
144_E147_D1.8561.00
115_V153_L1.8301.00
163_V208_I1.8131.00
131_R134_R1.8031.00
98_T144_E1.8031.00
170_K182_L1.7541.00
102_M152_Q1.7011.00
101_Y148_V1.6911.00
33_I41_L1.6851.00
65_L82_A1.6811.00
145_L149_L1.6741.00
174_R196_W1.6681.00
105_G148_V1.6551.00
117_M160_L1.6531.00
101_Y144_E1.6121.00
102_M105_G1.5991.00
40_L100_L1.5961.00
175_C194_C1.5851.00
113_D158_K1.5831.00
172_C175_C1.5411.00
187_R200_R1.5011.00
117_M162_L1.4891.00
191_C194_C1.4871.00
175_C191_C1.4681.00
118_E165_P1.4481.00
69_L83_K1.4421.00
150_K154_E1.4411.00
117_M146_R1.4341.00
179_K189_F1.3911.00
172_C191_C1.3901.00
82_A86_L1.3591.00
91_E95_N1.3561.00
43_T47_E1.3471.00
172_C194_C1.3371.00
189_F198_A1.3371.00
77_N80_F1.3331.00
119_G162_L1.3291.00
30_V209_L1.3261.00
6_T9_E1.3211.00
189_F196_W1.3171.00
72_K82_A1.3141.00
61_K65_L1.2891.00
173_A206_L1.2821.00
68_E72_K1.2811.00
206_L210_K1.2721.00
10_R91_E1.2711.00
42_V202_Y1.2701.00
39_K42_V1.2631.00
179_K192_P1.2571.00
80_F83_K1.2461.00
105_G151_Y1.2271.00
179_K182_L1.2241.00
109_A156_Y1.2181.00
30_V114_V1.2171.00
107_W111_H1.2051.00
75_L79_W1.1811.00
177_Y192_P1.1781.00
137_L142_F1.1761.00
65_L68_E1.1731.00
8_S91_E1.1671.00
105_G152_Q1.1641.00
188_V197_I1.1501.00
121_H165_P1.1431.00
148_V151_Y1.1311.00
31_V43_T1.1311.00
33_I43_T1.1281.00
32_A209_L1.1201.00
66_H70_S1.1101.00
65_L89_A1.0981.00
105_G145_L1.0801.00
35_V142_F1.0781.00
30_V213_G1.0741.00
182_L186_D1.0721.00
35_V146_R1.0691.00
6_T10_R1.0411.00
110_E156_Y1.0391.00
170_K180_N1.0341.00
98_T148_V1.0281.00
150_K160_L1.0251.00
163_V212_A1.0221.00
37_V140_V1.0221.00
173_A198_A1.0201.00
62_V90_Y1.0191.00
171_T211_G1.0111.00
101_Y145_L1.0101.00
42_V48_Y1.0071.00
58_A93_L1.0061.00
44_S48_Y0.9951.00
184_L187_R0.9941.00
109_A158_K0.9861.00
152_Q155_K0.9781.00
202_Y206_L0.9711.00
163_V211_G0.9560.99
69_L82_A0.9390.99
177_Y193_N0.9340.99
69_L86_L0.9290.99
31_V112_Y0.9290.99
168_T211_G0.9250.99
101_Y105_G0.9240.99
153_L158_K0.9220.99
54_P96_L0.9210.99
198_A206_L0.9150.99
106_K156_Y0.9100.99
27_T113_D0.8990.99
147_D150_K0.8980.99
6_T91_E0.8940.99
92_Y96_L0.8920.99
10_R95_N0.8880.99
62_V86_L0.8860.99
184_L200_R0.8800.99
30_V116_V0.8770.99
44_S205_S0.8660.99
29_K113_D0.8590.99
143_G147_D0.8580.99
179_K183_S0.8580.99
170_K181_D0.8570.99
165_P168_T0.8530.99
114_V161_I0.8530.99
51_N54_P0.8500.99
31_V115_V0.8480.99
131_R138_S0.8480.99
198_A202_Y0.8450.99
37_V136_R0.8440.99
126_V134_R0.8340.98
94_K98_T0.8280.98
79_W83_K0.8240.98
203_N207_N0.8200.98
45_D112_Y0.8190.98
167_Y211_G0.8150.98
109_A115_V0.8030.98
101_Y141_G0.8030.98
55_Y59_L0.8020.98
116_V208_I0.7980.98
62_V70_S0.7960.98
39_K48_Y0.7960.98
170_K178_V0.7910.98
119_G165_P0.7880.98
85_K88_R0.7880.98
202_Y205_S0.7840.98
116_V161_I0.7830.98
48_Y199_D0.7810.98
114_V159_K0.7800.98
64_H68_E0.7770.98
49_F52_L0.7710.97
182_L189_F0.7660.97
65_L85_K0.7630.97
26_N29_K0.7620.97
100_L104_L0.7610.97
75_L80_F0.7570.97
62_V93_L0.7540.97
173_A204_A0.7430.97
151_Y155_K0.7390.97
183_S187_R0.7380.97
183_S200_R0.7370.97
83_K87_A0.7370.97
24_L158_K0.7340.97
72_K78_N0.7330.97
66_H90_Y0.7300.96
42_V49_F0.7300.96
187_R199_D0.7300.96
51_N140_V0.7260.96
119_G146_R0.7250.96
66_H86_L0.7220.96
104_L107_W0.7170.96
105_G149_L0.7100.96
106_K152_Q0.7100.96
39_K50_P0.7040.96
58_A62_V0.7020.96
37_V126_V0.7000.96
161_I212_A0.6970.95
122_A142_F0.6940.95
89_A93_L0.6930.95
62_V66_H0.6890.95
36_G42_V0.6860.95
186_D200_R0.6850.95
116_V209_L0.6840.95
98_T102_M0.6830.95
108_F115_V0.6800.95
186_D189_F0.6780.95
69_L79_W0.6760.95
24_L27_T0.6740.95
173_A196_W0.6730.94
63_K67_R0.6720.94
133_L137_L0.6720.94
126_V131_R0.6700.94
41_L104_L0.6660.94
21_F154_E0.6660.94
110_E114_V0.6640.94
54_P58_A0.6600.94
173_A210_K0.6580.94
29_K112_Y0.6570.94
65_L86_L0.6550.94
171_T207_N0.6530.94
122_A143_G0.6510.93
95_N99_D0.6420.93
78_N81_K0.6330.93
63_K66_H0.6320.92
58_A89_A0.6320.92
148_V152_Q0.6300.92
32_A116_V0.6290.92
170_K179_K0.6260.92
55_Y58_A0.6240.92
35_V41_L0.6230.92
103_K106_K0.6220.92
38_E42_V0.6210.92
93_L139_D0.6210.92
189_F200_R0.6200.92
21_F155_K0.6200.92
188_V198_A0.6190.92
90_Y97_R0.6180.92
40_L105_G0.6160.91
44_S202_Y0.6160.91
204_A207_N0.6120.91
208_I211_G0.6120.91
63_K70_S0.6090.91
9_E91_E0.6060.91
146_R150_K0.6050.91
57_K60_W0.6050.91
39_K199_D0.6030.91
47_E107_W0.5990.90
134_R138_S0.5900.90
48_Y202_Y0.5890.90
40_L140_V0.5880.90
181_D186_D0.5870.89
97_R139_D0.5860.89
169_S182_L0.5850.89
31_V44_S0.5850.89
61_K89_A0.5840.89
120_I165_P0.5820.89
68_E71_R0.5800.89
133_L136_R0.5790.89
126_V132_S0.5770.89
41_L145_L0.5750.88
43_T48_Y0.5720.88
19_H22_P0.5710.88
206_L209_L0.5710.88
68_E85_K0.5680.88
28_G113_D0.5680.88
56_E136_R0.5670.88
102_M106_K0.5670.88
86_L90_Y0.5650.88
64_H67_R0.5560.87
170_K183_S0.5550.87
210_K213_G0.5520.86
167_Y178_V0.5510.86
171_T189_F0.5510.86
167_Y171_T0.5490.86
67_R70_S0.5470.86
198_A203_N0.5470.86
76_S79_W0.5450.86
23_K26_N0.5440.86
49_F104_L0.5420.85
70_S86_L0.5400.85
56_E59_L0.5400.85
67_R71_R0.5390.85
190_V196_W0.5370.85
184_L199_D0.5330.84
95_N98_T0.5330.84
104_L145_L0.5320.84
80_F84_V0.5320.84
124_Q137_L0.5310.84
143_G146_R0.5310.84
38_E199_D0.5300.84
29_K45_D0.5290.84
73_K76_S0.5290.84
171_T176_G0.5290.84
149_L160_L0.5270.84
112_Y158_K0.5270.84
179_K200_R0.5260.84
43_T108_F0.5260.84
125_L137_L0.5220.83
146_R160_L0.5210.83
174_R206_L0.5160.82
34_D201_D0.5140.82
79_W82_A0.5120.82
59_L63_K0.5120.82
32_A44_S0.5110.82
164_N167_Y0.5070.81
141_G144_E0.5070.81
52_L100_L0.5070.81
93_L97_R0.5040.81
12_Y91_E0.5020.81
58_A92_Y0.5020.81
166_A170_K0.5020.81
63_K131_R0.5010.81
69_L72_K0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.5966 94.2 0.899 Contact Map
1nu0A 1 0.5579 93.8 0.901 Contact Map
1iv0A 1 0.4163 88.9 0.913 Contact Map
4aybP 1 0.1845 88.7 0.913 Contact Map
3j20Y 1 0.2146 86.2 0.917 Contact Map
1vq8Z 1 0.2961 85.1 0.918 Contact Map
1qypA 1 0.1974 83.3 0.92 Contact Map
2k4xA 1 0.2361 82.4 0.92 Contact Map
1ffkW 1 0.2876 81.1 0.922 Contact Map
1vd4A 1 0.2403 80.4 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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