GREMLIN Database
Q97U07 - Uncharacterized protein
UniProt: Q97U07 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (280)
Sequences: 2608 (1973)
Seq/√Len: 117.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_T23_S5.0881.00
66_G98_V3.5201.00
171_K208_A3.3681.00
256_Y260_R3.2281.00
150_E222_N2.8351.00
118_S132_G2.5281.00
131_F234_L2.5001.00
108_P124_D2.4491.00
146_W223_A2.4491.00
151_A205_V2.3981.00
224_A228_A2.2911.00
166_T213_D2.2771.00
154_A215_I2.2441.00
18_Y282_L2.2211.00
124_D127_R2.1991.00
180_D183_D2.1741.00
71_D94_H2.1081.00
150_E153_R2.0801.00
8_G33_A2.0361.00
80_A84_R2.0281.00
28_G50_A1.9961.00
77_N81_E1.9901.00
146_W150_E1.9841.00
15_A50_A1.9481.00
147_I219_I1.9371.00
147_I249_M1.9131.00
120_I230_Y1.9061.00
275_H279_Q1.9051.00
112_V120_I1.9011.00
225_F262_Y1.8961.00
171_K207_E1.8961.00
26_G54_A1.8931.00
114_A227_L1.8841.00
16_I27_K1.8701.00
122_G238_I1.8251.00
144_A249_M1.8061.00
6_V65_V1.7901.00
147_I223_A1.7841.00
138_I156_G1.7811.00
96_G119_V1.7631.00
119_V130_R1.7621.00
155_F169_A1.7531.00
50_A54_A1.7331.00
151_A172_I1.7091.00
62_V89_N1.7051.00
206_D220_L1.6701.00
28_G54_A1.6701.00
228_A263_L1.6671.00
221_K258_F1.6431.00
8_G67_L1.6241.00
167_I213_D1.6211.00
188_A198_I1.5901.00
34_N68_A1.5811.00
170_D174_K1.5771.00
221_K262_Y1.5701.00
179_N183_D1.5621.00
158_M169_A1.5591.00
175_N207_E1.5421.00
249_M255_Y1.5411.00
262_Y265_N1.5361.00
144_A206_D1.5281.00
49_R53_L1.5281.00
152_L156_G1.5161.00
48_N52_L1.5141.00
112_V227_L1.5091.00
226_E229_S1.5051.00
70_V92_V1.5021.00
3_L20_C1.5011.00
136_W195_V1.4661.00
64_Y93_D1.4581.00
158_M166_T1.4541.00
5_G281_A1.4491.00
147_I205_V1.4151.00
31_G46_N1.3941.00
163_I215_I1.3671.00
108_P125_G1.3611.00
218_D222_N1.3611.00
103_E244_F1.3571.00
159_L181_V1.3551.00
112_V231_A1.3551.00
141_E153_R1.3471.00
99_A111_I1.3371.00
217_L221_K1.3311.00
44_V48_N1.3151.00
30_A50_A1.3021.00
12_K277_P1.3011.00
42_E45_K1.3001.00
245_L259_F1.2981.00
45_K49_R1.2951.00
14_S29_L1.2831.00
203_K207_E1.2640.99
16_I278_E1.2630.99
154_A219_I1.2600.99
120_I234_L1.2530.99
39_G42_E1.2430.99
40_V78_I1.2410.99
224_A258_F1.2210.99
110_V243_I1.2110.99
4_V51_I1.2110.99
15_A28_G1.2110.99
17_A58_M1.2040.99
24_F27_K1.2030.99
31_G50_A1.1960.99
5_G278_E1.1910.99
116_T199_A1.1830.99
76_Y80_A1.1810.99
53_L57_G1.1790.99
93_D97_F1.1790.99
176_L201_L1.1770.99
35_F75_D1.1680.99
281_A285_A1.1590.99
46_N49_R1.1520.99
113_I119_V1.1460.99
162_R233_Q1.1370.99
4_V17_A1.1340.99
154_A163_I1.1330.99
18_Y24_F1.1330.99
44_V85_S1.1280.99
136_W145_Y1.1280.99
229_S266_N1.1200.99
114_A142_G1.1180.99
171_K204_I1.1170.99
132_G230_Y1.1150.99
208_A216_A1.1140.99
112_V230_Y1.1140.99
11_S116_T1.1110.99
104_T244_F1.1100.99
232_V266_N1.1050.99
221_K261_N1.0970.98
209_A212_G1.0960.98
250_F259_F1.0900.98
145_Y198_I1.0850.98
149_R153_R1.0820.98
228_A262_Y1.0810.98
167_I208_A1.0810.98
99_A113_I1.0750.98
10_G34_N1.0700.98
155_F173_M1.0540.98
101_Y287_K1.0520.98
12_K29_L1.0500.98
223_A226_E1.0500.98
31_G34_N1.0460.98
202_A205_V1.0460.98
257_N261_N1.0430.98
155_F166_T1.0390.98
83_L87_A1.0380.98
134_L160_D1.0360.98
8_G13_T1.0330.98
205_V216_A1.0330.98
102_A273_A1.0310.98
46_N50_A1.0270.98
208_A212_G1.0170.97
175_N200_S1.0150.97
10_G68_A1.0080.97
209_A220_L1.0070.97
5_G282_L1.0070.97
172_I201_L1.0050.97
248_G251_N1.0030.97
11_S196_K0.9970.97
108_P126_N0.9960.97
260_R270_G0.9870.97
120_I131_F0.9770.97
66_G133_G0.9730.97
73_R77_N0.9710.97
42_E46_N0.9640.97
146_W226_E0.9640.97
33_A43_A0.9580.96
40_V81_E0.9540.96
36_H75_D0.9520.96
153_R157_K0.9500.96
110_V231_A0.9500.96
258_F262_Y0.9440.96
77_N80_A0.9410.96
197_D200_S0.9270.96
101_Y284_L0.9210.96
191_E197_D0.9160.95
222_N225_F0.9110.95
26_G57_G0.9010.95
104_T109_G0.8980.95
74_Y78_I0.8970.95
13_T33_A0.8930.95
175_N204_I0.8930.95
99_A246_K0.8820.94
224_A255_Y0.8820.94
232_V262_Y0.8710.94
120_I139_A0.8690.94
154_A218_D0.8690.94
17_A54_A0.8660.94
38_V43_A0.8660.94
19_T22_G0.8650.94
195_V198_I0.8650.94
152_L198_I0.8590.93
145_Y199_A0.8570.93
156_G160_D0.8570.93
98_V102_A0.8550.93
63_A87_A0.8550.93
145_Y195_V0.8510.93
224_A259_F0.8480.93
10_G15_A0.8430.93
100_L106_G0.8420.93
276_E279_Q0.8410.93
161_G233_Q0.8400.93
165_K169_A0.8340.92
53_L56_K0.8340.92
94_H119_V0.8310.92
122_G234_L0.8310.92
207_E210_N0.8290.92
144_A199_A0.8270.92
15_A54_A0.8230.92
242_K269_K0.8210.92
44_V82_A0.8210.92
168_I213_D0.8210.92
156_G159_L0.8170.92
112_V259_F0.8130.91
4_V63_A0.8050.91
118_S141_E0.8050.91
123_Y128_R0.8010.91
244_F271_V0.7990.91
10_G116_T0.7980.91
218_D221_K0.7960.91
101_Y106_G0.7960.91
141_E162_R0.7950.91
118_S143_S0.7930.90
82_A85_S0.7900.90
45_K218_D0.7870.90
134_L156_G0.7810.90
163_I166_T0.7800.90
243_I268_I0.7780.90
217_L261_N0.7770.90
11_S248_G0.7740.89
64_Y98_V0.7730.89
25_L58_M0.7710.89
256_Y272_I0.7670.89
167_I170_D0.7660.89
43_A47_V0.7650.89
187_W191_E0.7600.89
175_N201_L0.7550.88
222_N226_E0.7550.88
261_N265_N0.7540.88
136_W149_R0.7540.88
144_A148_G0.7530.88
15_A30_A0.7530.88
174_K177_N0.7520.88
114_A250_F0.7510.88
3_L62_V0.7500.88
177_N183_D0.7480.88
206_D249_M0.7480.88
48_N51_I0.7480.88
14_S27_K0.7470.88
64_Y101_Y0.7410.87
6_V15_A0.7400.87
155_F213_D0.7350.87
258_F261_N0.7350.87
200_S203_K0.7330.87
17_A55_T0.7320.87
36_H185_I0.7290.86
231_A259_F0.7260.86
55_T60_P0.7260.86
16_I279_Q0.7260.86
81_E85_S0.7230.86
34_N37_N0.7230.86
194_K197_D0.7220.86
221_K225_F0.7200.86
100_L123_Y0.7190.86
232_V236_V0.7180.86
231_A235_A0.7170.85
164_N214_W0.7160.85
26_G50_A0.7140.85
225_F266_N0.7080.85
114_A249_M0.7000.84
166_T170_D0.7000.84
9_G116_T0.6990.84
151_A216_A0.6990.84
157_K226_E0.6980.84
62_V91_Y0.6970.84
144_A202_A0.6970.84
99_A109_G0.6930.83
52_L56_K0.6890.83
220_L224_A0.6880.83
72_S75_D0.6880.83
155_F172_I0.6860.83
178_I184_L0.6820.83
132_G141_E0.6810.82
260_R264_D0.6810.82
70_V79_M0.6750.82
151_A208_A0.6720.82
114_A118_S0.6690.81
220_L254_V0.6690.81
43_A46_N0.6610.81
173_M181_V0.6600.80
36_H189_Y0.6590.80
114_A143_S0.6590.80
47_V287_K0.6580.80
135_G139_A0.6580.80
184_L198_I0.6520.80
150_E226_E0.6520.80
64_Y285_A0.6510.80
129_V237_K0.6480.79
16_I24_F0.6410.78
30_A46_N0.6380.78
131_F230_Y0.6380.78
45_K48_N0.6320.77
209_A216_A0.6320.77
110_V122_G0.6320.77
215_I218_D0.6310.77
137_L145_Y0.6290.77
85_S214_W0.6290.77
105_R283_L0.6290.77
68_A100_L0.6280.77
25_L60_P0.6260.77
186_K191_E0.6260.77
73_R76_Y0.6240.77
183_D219_I0.6220.76
137_L149_R0.6220.76
138_I188_A0.6210.76
49_R207_E0.6210.76
99_A273_A0.6210.76
61_D88_K0.6200.76
131_F233_Q0.6200.76
74_Y126_N0.6190.76
11_S199_A0.6170.76
54_A58_M0.6130.75
121_V127_R0.6100.75
122_G237_K0.6090.75
12_K113_I0.6080.75
8_G118_S0.6070.75
144_A220_L0.6040.74
223_A255_Y0.6020.74
101_Y111_I0.6020.74
41_E257_N0.6010.74
99_A277_P0.6000.74
28_G31_G0.6000.74
112_V245_L0.5970.73
221_K224_A0.5960.73
45_K264_D0.5950.73
102_A274_E0.5950.73
38_V42_E0.5900.73
118_S227_L0.5890.72
209_A258_F0.5880.72
47_V50_A0.5880.72
34_N195_V0.5860.72
230_Y234_L0.5850.72
14_S278_E0.5820.72
79_M82_A0.5810.71
5_G66_G0.5800.71
64_Y91_Y0.5770.71
209_A224_A0.5760.71
175_N203_K0.5750.71
141_E149_R0.5730.70
157_K162_R0.5720.70
138_I189_Y0.5710.70
250_F256_Y0.5710.70
83_L110_V0.5710.70
131_F160_D0.5710.70
77_N265_N0.5700.70
17_A60_P0.5690.70
172_I204_I0.5680.70
35_F148_G0.5660.69
119_V246_K0.5640.69
15_A26_G0.5640.69
102_A275_H0.5640.69
152_L157_K0.5630.69
196_K204_I0.5630.69
63_A90_V0.5620.69
263_L266_N0.5620.69
233_Q237_K0.5610.69
143_S146_W0.5580.68
168_I216_A0.5570.68
61_D89_N0.5570.68
66_G93_D0.5570.68
111_I246_K0.5570.68
224_A262_Y0.5550.68
67_L79_M0.5520.68
61_D126_N0.5500.67
202_A249_M0.5470.67
87_A267_N0.5470.67
98_V281_A0.5440.66
77_N84_R0.5410.66
222_N257_N0.5380.66
71_D130_R0.5380.66
93_D98_V0.5360.65
14_S249_M0.5330.65
20_C23_S0.5310.65
97_F123_Y0.5300.64
246_K277_P0.5290.64
217_L258_F0.5270.64
165_K170_D0.5260.64
263_L270_G0.5260.64
93_D284_L0.5230.63
228_A260_R0.5220.63
218_D225_F0.5220.63
23_S269_K0.5210.63
221_K265_N0.5200.63
103_E246_K0.5200.63
220_L258_F0.5140.62
12_K32_P0.5120.62
83_L86_I0.5120.62
202_A223_A0.5120.62
81_E177_N0.5110.62
35_F194_K0.5110.62
7_D12_K0.5100.61
49_R81_E0.5100.61
141_E157_K0.5090.61
260_R265_N0.5090.61
103_E111_I0.5090.61
151_A201_L0.5080.61
45_K86_I0.5080.61
224_A227_L0.5070.61
41_E56_K0.5070.61
245_L250_F0.5070.61
212_G287_K0.5070.61
105_R274_E0.5060.61
103_E273_A0.5060.61
136_W198_I0.5050.61
15_A65_V0.5040.61
3_L19_T0.5040.61
44_V86_I0.5020.60
122_G129_V0.5010.60
100_L104_T0.5010.60
282_L286_F0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e2oA 2 0.9966 100 0.478 Contact Map
2ch5A 2 0.9933 100 0.485 Contact Map
1zc6A 2 0.9295 100 0.512 Contact Map
1zbsA 2 0.9262 100 0.526 Contact Map
1zxoA 4 0.9228 100 0.527 Contact Map
2ap1A 2 0.906 100 0.642 Contact Map
2qm1A 2 0.9295 100 0.652 Contact Map
3r8eA 2 0.8826 99.9 0.655 Contact Map
2yhwA 2 0.896 99.9 0.662 Contact Map
3vglA 3 0.9128 99.9 0.663 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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