GREMLIN Database
Q97U06 - Sugar phosphate nucleotydyl transferase
UniProt: Q97U06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (226)
Sequences: 22387 (13933)
Seq/√Len: 926.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_R49_D3.8871.00
98_E196_R3.4131.00
150_T166_I2.6271.00
150_T167_D2.6041.00
131_P223_Y2.6001.00
4_K58_K2.5881.00
45_D73_Y2.5271.00
139_R178_N2.5261.00
88_K92_D2.5201.00
67_G71_M2.5131.00
152_Q164_R2.3891.00
58_K78_T2.2771.00
139_R226_E2.2651.00
58_K80_T2.1771.00
105_P188_K2.1751.00
137_V224_A2.1601.00
194_A214_N2.1001.00
5_A56_V2.0841.00
227_M231_E2.0601.00
213_H217_L2.0571.00
152_Q166_I2.0371.00
131_P221_E2.0101.00
5_A51_L1.9881.00
48_M59_F1.9131.00
126_F134_V1.9121.00
63_V67_G1.8961.00
210_Y213_H1.8771.00
95_L98_E1.8721.00
67_G83_F1.8551.00
82_V96_R1.8541.00
164_R223_Y1.8441.00
68_M72_Q1.8141.00
125_L225_L1.7961.00
105_P127_N1.7451.00
6_V97_A1.7211.00
94_V108_V1.7081.00
179_L226_E1.7031.00
9_S61_I1.7001.00
17_K21_N1.6941.00
129_I223_Y1.6881.00
51_L109_H1.6801.00
150_T177_S1.6781.00
45_D49_D1.6661.00
69_L72_Q1.6611.00
167_D213_H1.6421.00
142_N145_R1.6071.00
214_N217_L1.6021.00
194_A219_G1.5951.00
120_D124_L1.5771.00
171_K175_P1.5751.00
23_L29_P1.5531.00
234_L244_D1.5471.00
132_D188_K1.5191.00
60_C100_F1.5111.00
151_V179_L1.5061.00
71_M83_F1.4881.00
52_N77_R1.4791.00
23_L69_L1.4701.00
42_P45_D1.4641.00
80_T100_F1.4481.00
165_V224_A1.4401.00
154_K164_R1.4391.00
39_V46_L1.4301.00
60_C82_V1.4081.00
118_G121_S1.4081.00
92_D96_R1.3821.00
125_L129_I1.3561.00
121_S124_L1.3501.00
27_L69_L1.3501.00
137_V149_V1.3361.00
59_F77_R1.3291.00
101_S106_F1.3291.00
149_V165_V1.3231.00
242_Y246_L1.3191.00
152_Q155_G1.3051.00
98_E192_F1.3031.00
104_E189_P1.2991.00
211_G214_N1.2871.00
12_K87_P1.2791.00
165_V222_V1.2601.00
41_R46_L1.2471.00
243_L247_N1.2181.00
214_N219_G1.2091.00
194_A211_G1.2081.00
105_P189_P1.2031.00
133_G187_F1.1931.00
238_D241_S1.1721.00
197_Q214_N1.1721.00
190_S193_S1.1721.00
60_C97_A1.1621.00
63_V83_F1.1611.00
121_S125_L1.1571.00
63_V71_M1.1511.00
110_A183_A1.1461.00
151_V224_A1.1381.00
92_D95_L1.1361.00
232_K248_Y1.1271.00
95_L196_R1.1251.00
132_D221_E1.1221.00
106_F189_P1.1151.00
137_V179_L1.1131.00
132_D220_K1.1021.00
164_R221_E1.1001.00
16_M28_L1.0931.00
241_S244_D1.0911.00
150_T169_E1.0841.00
169_E176_K1.0821.00
124_L128_E1.0781.00
105_P186_I1.0731.00
63_V81_F1.0651.00
236_V245_A1.0571.00
116_T120_D1.0541.00
144_S171_K1.0491.00
107_F186_I1.0321.00
4_K104_E1.0311.00
194_A197_Q1.0311.00
68_M71_M1.0281.00
56_V107_F1.0211.00
27_L73_Y1.0151.00
122_L136_L1.0081.00
60_C80_T1.0041.00
187_F212_I1.0011.00
76_D79_P0.9891.00
44_I61_I0.9831.00
95_L195_L0.9801.00
43_V236_V0.9771.00
122_L186_I0.9761.00
71_M81_F0.9711.00
108_V187_F0.9691.00
193_S196_R0.9611.00
66_N69_L0.9551.00
44_I74_L0.9521.00
29_P40_T0.9391.00
181_I185_Y0.9351.00
17_K20_T0.9321.00
210_Y214_N0.9281.00
147_G170_E0.9261.00
189_P192_F0.9231.00
44_I70_L0.9211.00
234_L248_Y0.9181.00
41_R45_D0.9101.00
10_A62_V0.9061.00
63_V70_L0.9031.00
7_I111_D0.9011.00
49_D75_F0.8961.00
244_D247_N0.8941.00
145_R241_S0.8911.00
4_K60_C0.8911.00
107_F123_K0.8791.00
243_L246_L0.8771.00
29_P42_P0.8751.00
54_I120_D0.8721.00
16_M20_T0.8721.00
124_L127_N0.8711.00
205_E209_T0.8661.00
53_K116_T0.8641.00
49_D52_N0.8531.00
77_R81_F0.8531.00
190_S194_A0.8501.00
4_K102_T0.8411.00
6_V106_F0.8371.00
240_K244_D0.8291.00
175_P178_N0.8251.00
52_N59_F0.8241.00
244_D248_Y0.8221.00
223_Y226_E0.8131.00
193_S197_Q0.8111.00
148_V180_A0.8081.00
212_I215_L0.8061.00
234_L245_A0.8021.00
201_E204_K0.8021.00
48_M79_P0.7991.00
145_R171_K0.7961.00
82_V100_F0.7951.00
42_P73_Y0.7921.00
52_N57_E0.7871.00
166_I169_E0.7851.00
48_M74_L0.7821.00
215_L220_K0.7801.00
94_V191_I0.7771.00
70_L73_Y0.7751.00
155_G166_I0.7691.00
125_L223_Y0.7651.00
133_G222_V0.7651.00
26_A111_D0.7641.00
8_T110_A0.7571.00
61_I79_P0.7541.00
123_K127_N0.7501.00
113_G233_W0.7471.00
28_L242_Y0.7401.00
212_I216_L0.7401.00
43_V47_I0.7381.00
82_V97_A0.7371.00
67_G70_L0.7341.00
212_I222_V0.7331.00
126_F188_K0.7311.00
144_S173_L0.7271.00
90_F110_A0.7261.00
52_N76_D0.7201.00
50_S54_I0.7111.00
134_V223_Y0.7101.00
167_D174_H0.7071.00
132_D190_S0.7071.00
20_T28_L0.7001.00
98_E193_S0.6981.00
42_P46_L0.6981.00
56_V123_K0.6971.00
130_S188_K0.6971.00
209_T213_H0.6921.00
102_T189_P0.6891.00
57_E78_T0.6891.00
109_H119_Y0.6851.00
194_A215_L0.6831.00
39_V246_L0.6811.00
126_F186_I0.6781.00
191_I195_L0.6711.00
190_S220_K0.6711.00
6_V62_V0.6691.00
24_P69_L0.6661.00
114_V245_A0.6661.00
168_A181_I0.6621.00
122_L225_L0.6611.00
89_G207_E0.6611.00
52_N78_T0.6571.00
155_G164_R0.6561.00
117_K120_D0.6561.00
13_G25_K0.6531.00
139_R179_L0.6521.00
131_P164_R0.6521.00
133_G215_L0.6521.00
213_H216_L0.6511.00
61_I74_L0.6511.00
6_V60_C0.6501.00
199_K210_Y0.6501.00
46_L49_D0.6491.00
121_S225_L0.6461.00
77_R80_T0.6461.00
7_I109_H0.6441.00
190_S221_E0.6431.00
150_T176_K0.6391.00
179_L224_A0.6391.00
64_G87_P0.6361.00
137_V140_V0.6351.00
198_I214_N0.6351.00
53_K120_D0.6351.00
19_I23_L0.6341.00
100_F103_N0.6331.00
69_L73_Y0.6311.00
134_V138_R0.6231.00
45_D74_L0.6231.00
153_D164_R0.6231.00
145_R238_D0.6201.00
87_P92_D0.6191.00
62_V93_A0.6191.00
80_T83_F0.6171.00
125_L128_E0.6151.00
239_P243_L0.6151.00
4_K101_S0.6151.00
137_V226_E0.6101.00
135_L149_V0.6101.00
62_V97_A0.6101.00
19_I239_P0.6091.00
165_V168_A0.6071.00
8_T90_F0.6021.00
48_M61_I0.6011.00
190_S219_G0.5991.00
5_A59_F0.5981.00
198_I206_L0.5981.00
95_L206_L0.5951.00
4_K106_F0.5921.00
101_S192_F0.5901.00
123_K186_I0.5881.00
122_L134_V0.5841.00
202_E206_L0.5811.00
50_S116_T0.5781.00
138_R180_A0.5751.00
155_G223_Y0.5741.00
74_L79_P0.5731.00
50_S184_V0.5711.00
115_L182_A0.5711.00
143_P146_Y0.5681.00
9_S44_I0.5671.00
129_I132_D0.5661.00
149_V224_A0.5651.00
86_M92_D0.5631.00
202_E205_E0.5591.00
120_D123_K0.5561.00
62_V82_V0.5541.00
168_A209_T0.5521.00
235_N241_S0.5501.00
203_G207_E0.5491.00
84_Q93_A0.5491.00
50_S53_K0.5471.00
109_H184_V0.5451.00
99_D102_T0.5441.00
135_L140_V0.5431.00
49_D53_K0.5431.00
75_F79_P0.5431.00
151_V154_K0.5421.00
19_I28_L0.5411.00
140_V143_P0.5411.00
15_R25_K0.5401.00
89_G210_Y0.5401.00
51_L107_F0.5391.00
110_A113_G0.5381.00
174_H177_S0.5361.00
143_P148_V0.5351.00
103_N192_F0.5341.00
187_F191_I0.5321.00
67_G74_L0.5311.00
30_L246_L0.5291.00
208_L212_I0.5271.00
216_L219_G0.5261.00
133_G212_I0.5261.00
142_N146_Y0.5251.00
63_V68_M0.5251.00
48_M77_R0.5211.00
228_N231_E0.5211.00
47_I50_S0.5211.00
137_V165_V0.5191.00
155_G226_E0.5191.00
195_L198_I0.5181.00
98_E106_F0.5181.00
196_R200_V0.5171.00
199_K206_L0.5151.00
67_G73_Y0.5151.00
198_I211_G0.5151.00
212_I217_L0.5131.00
7_I47_I0.5121.00
194_A220_K0.5111.00
200_V206_L0.5101.00
28_L246_L0.5091.00
187_F208_L0.5081.00
133_G137_V0.5071.00
76_D81_F0.5061.00
90_F181_I0.5051.00
61_I81_F0.5051.00
45_D75_F0.5041.00
12_K21_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lvwA 3 0.9328 100 0.283 Contact Map
3jukA 3 0.9289 100 0.287 Contact Map
1iimA 3 0.9328 100 0.289 Contact Map
1mc3A 3 0.9289 100 0.293 Contact Map
4ho4A 3 0.9249 100 0.295 Contact Map
2e3dA 3 0.9209 100 0.297 Contact Map
2ux8A 4 0.9328 100 0.305 Contact Map
2pa4A 3 0.9486 100 0.317 Contact Map
4ecmA 3 0.917 100 0.324 Contact Map
1tzfA 4 0.8577 100 0.331 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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