GREMLIN Database
Q97U05 - Amino acid transporter related protein
UniProt: Q97U05 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (412)
Sequences: 24624 (16170)
Seq/√Len: 796.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_S334_V4.2131.00
316_V328_N4.1991.00
379_K383_K3.2701.00
61_T239_G3.0441.00
319_K328_N3.0011.00
225_K229_R2.8931.00
20_G221_K2.7761.00
85_Y310_T2.6001.00
220_A226_T2.5931.00
394_V398_A2.5591.00
222_D225_K2.5231.00
308_S318_S2.4931.00
101_G307_M2.4871.00
175_F248_A2.4801.00
321_E327_T2.4531.00
316_V319_K2.3841.00
136_L338_F2.3661.00
25_V233_T2.3301.00
73_E381_S2.3271.00
21_F233_T2.3071.00
173_L177_S2.2471.00
218_G309_Y2.2101.00
402_S405_E2.2041.00
276_I280_F2.1081.00
219_E302_R2.0861.00
144_F148_M2.0691.00
331_I335_I2.0681.00
89_F97_G2.0531.00
21_F226_T2.0521.00
387_K391_Q2.0401.00
305_F309_Y2.0301.00
388_R391_Q2.0251.00
21_F25_V2.0151.00
24_I220_A2.0091.00
140_S338_F2.0041.00
267_H270_E1.9981.00
136_L341_S1.9671.00
143_S330_V1.9571.00
92_L379_K1.9361.00
147_I327_T1.9351.00
229_R233_T1.9281.00
151_K155_K1.9271.00
257_N271_N1.9151.00
70_V374_N1.8881.00
135_G341_S1.8881.00
162_L166_G1.8791.00
15_P320_F1.8731.00
184_Y189_F1.8651.00
387_K390_F1.8571.00
20_G23_D1.8421.00
105_V333_S1.8401.00
311_N315_K1.8251.00
89_F94_K1.8221.00
45_A53_A1.8061.00
428_G431_V1.7891.00
185_N189_F1.7881.00
62_L66_L1.7851.00
267_H271_N1.7791.00
317_F332_L1.7771.00
430_L434_T1.7661.00
405_E408_N1.7641.00
415_P418_V1.7491.00
254_L257_N1.7301.00
92_L375_F1.7221.00
395_G399_V1.7161.00
429_F433_E1.7131.00
321_E325_G1.6761.00
140_S334_V1.6711.00
23_D158_V1.6691.00
222_D226_T1.6591.00
88_A100_T1.6451.00
393_I397_S1.6381.00
388_R392_I1.6381.00
147_I331_I1.6311.00
111_Y337_Y1.6221.00
56_A199_A1.6091.00
398_A402_S1.6071.00
406_L409_S1.6061.00
232_I236_L1.6041.00
139_L337_Y1.5911.00
146_A294_L1.5821.00
379_K382_I1.5811.00
102_W428_G1.5801.00
323_Y327_T1.5771.00
405_E409_S1.5661.00
100_T372_A1.5581.00
19_L23_D1.5571.00
422_M426_I1.5541.00
166_G170_T1.5511.00
25_V237_L1.5481.00
423_S426_I1.5401.00
401_F405_E1.5291.00
28_S234_V1.5231.00
115_Y293_S1.5091.00
122_I134_V1.5041.00
389_L392_I1.4881.00
93_T96_L1.4871.00
130_N133_I1.4861.00
184_Y187_L1.4741.00
236_L240_L1.4701.00
371_V399_V1.4611.00
400_T404_F1.4381.00
180_G183_F1.4231.00
216_V298_I1.4091.00
176_L248_A1.4091.00
148_M323_Y1.4091.00
328_N332_L1.4061.00
304_I329_A1.4051.00
185_N188_S1.3981.00
315_K318_S1.3981.00
270_E278_F1.3901.00
95_R432_A1.3861.00
167_I284_A1.3821.00
300_T333_S1.3801.00
222_D229_R1.3791.00
129_I133_I1.3701.00
143_S331_I1.3641.00
118_G286_I1.3621.00
68_G235_I1.3591.00
136_L140_S1.3561.00
301_S330_V1.3551.00
88_A372_A1.3521.00
16_K324_K1.3461.00
60_G203_G1.3431.00
223_A228_S1.3421.00
305_F320_F1.3411.00
92_L96_L1.3391.00
115_Y139_L1.3291.00
15_P305_F1.3261.00
279_I283_F1.3231.00
375_F379_K1.3231.00
402_S406_L1.3181.00
401_F408_N1.3141.00
78_F90_Y1.3111.00
315_K319_K1.3081.00
416_I419_Y1.3081.00
67_N374_N1.3011.00
165_I169_T1.3011.00
396_I400_T1.3011.00
81_A218_G1.2991.00
420_I423_S1.2961.00
415_P419_Y1.2951.00
273_F277_T1.2941.00
424_F428_G1.2921.00
395_G398_A1.2911.00
118_G138_L1.2901.00
179_T251_D1.2901.00
404_F408_N1.2881.00
226_T229_R1.2841.00
319_K327_T1.2811.00
406_L410_L1.2731.00
270_E275_L1.2641.00
139_L334_V1.2531.00
395_G410_L1.2521.00
419_Y423_S1.2511.00
132_W136_L1.2501.00
23_D154_T1.2501.00
399_V402_S1.2491.00
261_N267_H1.2481.00
68_G231_I1.2471.00
172_A244_F1.2381.00
401_F410_L1.2341.00
393_I398_A1.2251.00
142_A293_S1.2231.00
382_I385_F1.2221.00
91_S376_S1.2191.00
54_P247_Y1.2171.00
21_F229_R1.2151.00
32_Q238_G1.2111.00
19_L154_T1.2061.00
19_L24_I1.2061.00
304_I313_L1.2001.00
69_L232_I1.1961.00
86_T90_Y1.1941.00
403_I407_I1.1931.00
240_L244_F1.1831.00
431_V435_L1.1811.00
398_A401_F1.1631.00
114_A292_G1.1591.00
52_L196_L1.1571.00
395_G409_S1.1551.00
399_V403_I1.1531.00
105_V304_I1.1511.00
255_F258_I1.1351.00
24_I230_A1.1301.00
22_I26_F1.1281.00
28_S213_I1.1171.00
175_F252_H1.1161.00
29_M237_L1.1101.00
145_F156_Y1.1061.00
186_P189_F1.1041.00
73_E76_K1.0961.00
405_E410_L1.0951.00
71_V84_Y1.0921.00
75_S87_Y1.0911.00
171_L175_F1.0861.00
328_N331_I1.0851.00
80_K86_T1.0811.00
221_K226_T1.0791.00
156_Y160_T1.0771.00
170_T174_V1.0741.00
309_Y318_S1.0661.00
88_A96_L1.0631.00
157_A294_L1.0611.00
184_Y188_S1.0511.00
401_F404_F1.0411.00
381_S385_F1.0391.00
155_K159_F1.0371.00
77_R387_K1.0281.00
98_F102_W1.0261.00
320_F324_K1.0261.00
143_S147_I1.0231.00
407_I410_L1.0231.00
399_V410_L1.0211.00
18_H221_K1.0201.00
27_L216_V1.0161.00
33_S36_L1.0111.00
58_I243_A0.9941.00
335_I339_I0.9931.00
85_Y306_A0.9901.00
419_Y422_M0.9831.00
254_L271_N0.9801.00
423_S427_I0.9801.00
133_I137_G0.9771.00
122_I126_I0.9721.00
169_T173_L0.9721.00
80_K90_Y0.9711.00
66_L397_S0.9691.00
90_Y384_K0.9651.00
150_I298_I0.9601.00
393_I396_I0.9591.00
95_R429_F0.9581.00
401_F409_S0.9571.00
414_S417_E0.9541.00
263_V267_H0.9541.00
387_K392_I0.9531.00
119_T134_V0.9531.00
208_T366_S0.9521.00
147_I325_G0.9511.00
62_L397_S0.9481.00
404_F407_I0.9461.00
426_I430_L0.9451.00
140_S144_F0.9431.00
395_G401_F0.9391.00
411_S414_S0.9381.00
431_V434_T0.9381.00
389_L395_G0.9381.00
137_G141_I0.9351.00
394_V397_S0.9341.00
29_M238_G0.9301.00
45_A49_A0.9281.00
371_V375_F0.9271.00
33_S38_I0.9251.00
160_T291_L0.9191.00
141_I290_I0.9131.00
364_F421_F0.9071.00
217_S227_I0.9041.00
122_I286_I0.9041.00
26_F158_V0.8961.00
239_G243_A0.8941.00
261_N264_D0.8901.00
375_F399_V0.8891.00
394_V409_S0.8861.00
398_A405_E0.8861.00
54_P250_G0.8851.00
142_A294_L0.8851.00
371_V403_I0.8841.00
113_V205_S0.8841.00
15_P302_R0.8811.00
297_I334_V0.8801.00
164_E288_D0.8791.00
211_G215_P0.8781.00
147_I321_E0.8771.00
401_F406_L0.8761.00
18_H151_K0.8761.00
189_F193_L0.8721.00
172_A248_A0.8721.00
96_L372_A0.8601.00
102_W313_L0.8591.00
198_Y202_F0.8581.00
172_A176_L0.8551.00
82_G86_T0.8551.00
61_T207_P0.8531.00
274_G277_T0.8521.00
334_V338_F0.8501.00
317_F328_N0.8501.00
15_P219_E0.8501.00
394_V401_F0.8461.00
23_D155_K0.8451.00
413_A417_E0.8421.00
171_L269_I0.8421.00
165_I241_L0.8421.00
416_I420_I0.8381.00
247_Y251_D0.8371.00
113_V359_G0.8361.00
70_V395_G0.8351.00
88_A376_S0.8341.00
402_S408_N0.8331.00
313_L317_F0.8281.00
119_T135_G0.8281.00
414_S418_V0.8281.00
34_P242_A0.8271.00
321_E324_K0.8251.00
118_G289_G0.8241.00
22_I158_V0.8231.00
399_V409_S0.8231.00
212_A299_A0.8221.00
233_T237_L0.8211.00
432_A436_S0.8201.00
413_A418_V0.8191.00
82_G85_Y0.8171.00
66_L70_V0.8131.00
394_V402_S0.8131.00
89_F310_T0.8111.00
192_N195_T0.8111.00
398_A409_S0.8091.00
18_H150_I0.8071.00
252_H268_L0.8061.00
155_K158_V0.8031.00
65_L69_L0.7941.00
123_L131_P0.7931.00
208_T370_H0.7931.00
361_I365_S0.7911.00
327_T331_I0.7901.00
144_F147_I0.7901.00
55_I196_L0.7901.00
65_L232_I0.7881.00
190_H193_L0.7851.00
402_S410_L0.7841.00
46_F53_A0.7811.00
34_P37_S0.7781.00
427_I431_V0.7781.00
39_L117_F0.7771.00
132_W341_S0.7731.00
402_S409_S0.7701.00
396_I399_V0.7691.00
179_T248_A0.7691.00
390_F393_I0.7651.00
38_I42_G0.7641.00
39_L42_G0.7631.00
395_G405_E0.7621.00
73_E392_I0.7611.00
399_V406_L0.7591.00
193_L196_L0.7571.00
58_I62_L0.7571.00
119_T131_P0.7561.00
51_F250_G0.7551.00
259_S264_D0.7541.00
390_F395_G0.7531.00
391_Q398_A0.7511.00
176_L244_F0.7511.00
377_L395_G0.7491.00
413_A416_I0.7481.00
21_F230_A0.7471.00
148_M152_I0.7461.00
422_M425_I0.7431.00
134_V137_G0.7421.00
260_A264_D0.7421.00
378_I382_I0.7391.00
139_L341_S0.7391.00
76_K388_R0.7321.00
118_G290_I0.7311.00
411_S416_I0.7311.00
335_I338_F0.7301.00
391_Q394_V0.7291.00
74_L377_L0.7271.00
423_S430_L0.7251.00
92_L376_S0.7251.00
228_S231_I0.7231.00
110_T362_A0.7191.00
30_G161_S0.7191.00
377_L381_S0.7181.00
55_I59_L0.7181.00
154_T158_V0.7181.00
374_N398_A0.7181.00
46_F49_A0.7111.00
427_I430_L0.7091.00
418_V421_F0.7091.00
222_D228_S0.7061.00
104_Y107_Y0.7051.00
269_I274_G0.7041.00
142_A297_I0.7031.00
420_I424_F0.7021.00
389_L394_V0.6991.00
172_A245_D0.6981.00
317_F329_A0.6981.00
425_I429_F0.6951.00
275_L279_I0.6931.00
401_F407_I0.6891.00
394_V405_E0.6891.00
22_I155_K0.6891.00
276_I279_I0.6881.00
77_R385_F0.6881.00
430_L433_E0.6841.00
391_Q395_G0.6841.00
322_N327_T0.6831.00
237_L241_L0.6821.00
132_W135_G0.6821.00
147_I323_Y0.6811.00
85_Y89_F0.6801.00
33_S164_E0.6791.00
112_G358_L0.6781.00
103_L369_V0.6781.00
15_P18_H0.6781.00
382_I386_R0.6771.00
421_F432_A0.6751.00
71_V373_A0.6731.00
146_A298_I0.6731.00
25_V230_A0.6721.00
376_S380_I0.6701.00
259_S263_V0.6701.00
32_Q234_V0.6701.00
390_F394_V0.6691.00
108_S336_L0.6691.00
74_L87_Y0.6681.00
81_A305_F0.6671.00
419_Y429_F0.6651.00
146_A330_V0.6651.00
264_D269_I0.6641.00
244_F248_A0.6641.00
18_H22_I0.6631.00
93_T433_E0.6631.00
316_V332_L0.6621.00
233_T236_L0.6621.00
365_S369_V0.6541.00
152_I155_K0.6521.00
53_A246_I0.6501.00
95_R433_E0.6491.00
308_S317_F0.6491.00
326_P329_A0.6481.00
110_T113_V0.6481.00
301_S329_A0.6471.00
25_V28_S0.6471.00
85_Y101_G0.6421.00
136_L342_L0.6411.00
31_S295_G0.6411.00
64_V210_Y0.6401.00
421_F425_I0.6401.00
174_V178_S0.6391.00
116_I358_L0.6391.00
214_A231_I0.6381.00
91_S379_K0.6371.00
37_S42_G0.6371.00
108_S333_S0.6351.00
378_I396_I0.6351.00
418_V422_M0.6341.00
91_S380_I0.6341.00
75_S227_I0.6321.00
354_A357_V0.6321.00
147_I330_V0.6311.00
49_A52_L0.6301.00
218_G305_F0.6291.00
122_I138_L0.6271.00
33_S37_S0.6241.00
142_A290_I0.6231.00
415_P422_M0.6231.00
138_L293_S0.6231.00
424_F427_I0.6221.00
54_P243_A0.6221.00
223_A226_T0.6211.00
121_Y285_A0.6181.00
304_I332_L0.6171.00
95_R99_E0.6171.00
57_I206_I0.6151.00
140_S143_S0.6141.00
115_Y119_T0.6141.00
417_E421_F0.6141.00
419_Y433_E0.6121.00
415_P424_F0.6121.00
85_Y97_G0.6111.00
150_I216_V0.6101.00
52_L188_S0.6081.00
397_S401_F0.6081.00
31_S296_F0.6071.00
395_G402_S0.6061.00
269_I277_T0.6051.00
297_I301_S0.6021.00
55_I58_I0.6021.00
259_S262_N0.6011.00
54_P58_I0.6011.00
174_V274_G0.6001.00
245_D249_I0.6001.00
302_R305_F0.5991.00
124_Y282_L0.5991.00
109_T361_I0.5981.00
433_E436_S0.5971.00
68_G210_Y0.5961.00
43_V356_G0.5961.00
356_G359_G0.5941.00
397_S400_T0.5931.00
404_F410_L0.5921.00
215_P299_A0.5891.00
72_Y76_K0.5881.00
163_L284_A0.5881.00
59_L200_I0.5871.00
154_T294_L0.5871.00
84_Y211_G0.5861.00
245_D265_I0.5841.00
52_L55_I0.5841.00
125_H283_F0.5831.00
179_T252_H0.5831.00
29_M161_S0.5831.00
149_G152_I0.5831.00
37_S41_Y0.5821.00
74_L91_S0.5811.00
220_A227_I0.5811.00
283_F287_N0.5801.00
75_S214_A0.5791.00
300_T304_I0.5791.00
195_T198_Y0.5781.00
425_I428_G0.5781.00
398_A408_N0.5781.00
163_L167_I0.5781.00
219_E326_P0.5771.00
114_A293_S0.5761.00
419_Y428_G0.5751.00
114_A117_F0.5751.00
208_T211_G0.5731.00
107_Y296_F0.5721.00
403_I406_L0.5721.00
31_S34_P0.5711.00
416_I423_S0.5711.00
125_H282_L0.5711.00
417_E425_I0.5691.00
190_H194_G0.5671.00
112_G340_T0.5661.00
248_A251_D0.5661.00
407_I411_S0.5661.00
380_I385_F0.5661.00
153_S298_I0.5661.00
420_I425_I0.5641.00
177_S181_F0.5631.00
143_S297_I0.5631.00
103_L368_F0.5621.00
237_L240_L0.5621.00
420_I432_A0.5611.00
404_F409_S0.5611.00
158_V162_L0.5601.00
339_I342_L0.5601.00
394_V408_N0.5581.00
422_M433_E0.5581.00
15_P81_A0.5571.00
40_T359_G0.5561.00
84_Y215_P0.5541.00
174_V273_F0.5531.00
380_I384_K0.5511.00
288_D291_L0.5511.00
237_L244_F0.5511.00
51_F54_P0.5501.00
51_F255_F0.5501.00
24_I216_V0.5491.00
139_L338_F0.5491.00
191_V194_G0.5481.00
338_F341_S0.5471.00
371_V402_S0.5471.00
141_I145_F0.5471.00
68_G72_Y0.5451.00
73_E77_R0.5451.00
31_S212_A0.5441.00
227_I231_I0.5441.00
208_T362_A0.5431.00
213_I227_I0.5401.00
138_L290_I0.5401.00
327_T330_V0.5401.00
36_L42_G0.5361.00
418_V424_F0.5361.00
60_G204_S0.5351.00
29_M33_S0.5351.00
421_F428_G0.5351.00
119_T122_I0.5341.00
366_S369_V0.5341.00
33_S241_L0.5331.00
166_G169_T0.5321.00
65_L236_L0.5301.00
302_R326_P0.5291.00
415_P428_G0.5281.00
220_A230_A0.5281.00
397_S402_S0.5271.00
29_M32_Q0.5271.00
263_V266_L0.5261.00
67_N211_G0.5261.00
137_G140_S0.5251.00
411_S418_V0.5241.00
34_P38_I0.5241.00
19_L150_I0.5211.00
193_L197_A0.5201.00
100_T369_V0.5201.00
39_L43_V0.5201.00
320_F323_Y0.5191.00
60_G207_P0.5181.00
38_I164_E0.5181.00
152_I156_Y0.5171.00
14_E17_R0.5171.00
63_L401_F0.5161.00
297_I330_V0.5121.00
424_F431_V0.5121.00
260_A263_V0.5111.00
355_F359_G0.5111.00
40_T43_V0.5111.00
54_P57_I0.5091.00
236_L239_G0.5091.00
22_I25_V0.5091.00
117_F121_Y0.5091.00
34_P164_E0.5071.00
35_F114_A0.5071.00
178_S181_F0.5071.00
112_G115_Y0.5071.00
70_V391_Q0.5071.00
80_K218_G0.5061.00
83_G214_A0.5061.00
385_F388_R0.5051.00
302_R320_F0.5051.00
138_L142_A0.5021.00
167_I280_F0.5011.00
331_I334_V0.5011.00
206_I242_A0.5011.00
416_I421_F0.5011.00
96_L99_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9327 100 0.27 Contact Map
3giaA 1 0.9439 100 0.317 Contact Map
4djkA 2 0.9103 100 0.361 Contact Map
3dh4A 3 0.9126 99.1 0.845 Contact Map
2xq2A 2 0.9193 99 0.851 Contact Map
2jlnA 1 0.9148 98.8 0.862 Contact Map
2a65A 2 0.926 97.8 0.895 Contact Map
4xp4A 1 0.9283 97.7 0.898 Contact Map
4wgvA 2 0.8117 97.3 0.905 Contact Map
4us3A 1 0.8677 96.8 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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