GREMLIN Database
Q97U04 - Uncharacterized protein
UniProt: Q97U04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 372 (334)
Sequences: 1744 (1291)
Seq/√Len: 70.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_G355_A4.3181.00
50_L89_A4.0701.00
109_L163_F4.0341.00
167_L183_A3.9281.00
21_Y114_L3.8981.00
134_A358_V3.3681.00
110_G152_H3.3611.00
22_T111_D3.2921.00
90_V94_F3.1341.00
243_A247_A3.1181.00
26_V111_D3.0081.00
116_V167_L2.9261.00
118_Y139_A2.9131.00
121_G138_T2.9121.00
142_I148_V2.8641.00
122_K135_G2.7441.00
244_W247_A2.7361.00
120_L173_L2.7261.00
112_L163_F2.7121.00
244_W248_T2.5651.00
123_K174_N2.5171.00
171_F179_W2.4841.00
84_A157_L2.4581.00
26_V104_I2.4201.00
109_L160_Y2.3871.00
83_L186_L2.3371.00
120_L170_Y2.3341.00
170_Y174_N2.3161.00
95_V104_I2.3011.00
87_I164_F2.1431.00
83_L189_L2.0921.00
227_Y231_S2.0751.00
46_A89_A2.0701.00
43_P155_A2.0341.00
39_E103_R2.0181.00
23_Y27_I2.0111.00
18_I115_I1.9871.00
137_L358_V1.9411.00
161_V187_A1.9331.00
355_A358_V1.9111.00
45_A76_I1.8811.00
243_A246_D1.8801.00
45_A77_N1.8601.00
91_F101_V1.8571.00
307_L310_I1.8491.00
121_G135_G1.8321.00
232_T236_A1.8201.00
29_F107_W1.7961.00
164_F190_S1.7911.00
22_T26_V1.7901.00
113_M166_F1.7481.00
83_L190_S1.7031.00
138_T358_V1.7011.00
106_S160_Y1.6981.00
13_S136_I1.6851.00
293_T298_L1.6801.00
354_D358_V1.6721.00
202_L205_L1.6701.00
14_L118_Y1.6691.00
113_M148_V1.6651.00
253_A257_V1.6530.99
189_L230_F1.6510.99
242_K246_D1.6240.99
168_S184_L1.6130.99
231_S234_L1.6070.99
297_V301_W1.5980.99
28_T31_P1.5900.99
50_L93_Y1.5870.99
42_Y157_L1.5840.99
223_P231_S1.5750.99
231_S235_I1.5540.99
120_L166_F1.5540.99
223_P227_Y1.5450.99
42_Y345_Y1.5170.99
301_W304_T1.4980.99
242_K245_L1.4630.99
95_V101_V1.4510.99
207_E211_N1.4460.99
246_D250_I1.4140.98
125_V359_V1.4140.98
140_L144_L1.4040.98
124_L173_L1.3930.98
108_I112_L1.3880.98
80_H85_K1.3840.98
165_S348_D1.3770.98
152_H159_I1.3560.98
12_L16_V1.3520.98
296_Y300_L1.3360.98
181_S202_L1.3260.98
199_F202_L1.3230.97
117_G142_I1.3190.97
255_W259_N1.3180.97
163_F183_A1.3140.97
141_L357_V1.3030.97
254_L258_T1.2940.97
186_L190_S1.2920.97
243_A248_T1.2910.97
197_L329_G1.2840.97
37_G267_T1.2780.97
135_G139_A1.2750.97
256_D259_N1.2720.97
235_I239_G1.2690.97
116_V120_L1.2600.97
118_Y135_G1.2530.97
298_L303_I1.2520.97
242_K247_A1.2430.96
297_V303_I1.2410.96
88_M155_A1.2380.96
116_V170_Y1.2350.96
26_V107_W1.2310.96
181_S223_P1.1950.95
254_L257_V1.1940.95
83_L164_F1.1870.95
69_E72_I1.1850.95
171_F183_A1.1810.95
269_Q284_Y1.1770.95
230_F234_L1.1730.95
44_T47_Y1.1720.95
90_V93_Y1.1660.95
303_I310_I1.1530.94
290_Y293_T1.1520.94
327_W352_V1.1510.94
294_N297_V1.1460.94
219_G230_F1.1450.94
100_I104_I1.1380.94
219_G223_P1.1290.94
340_T345_Y1.1020.93
137_L141_L1.1010.93
42_Y77_N1.1000.93
113_M162_S1.0990.93
122_K128_G1.0930.93
47_Y51_K1.0920.93
17_L21_Y1.0850.92
43_P97_Y1.0790.92
44_T48_N1.0780.92
237_Y240_G1.0750.92
245_L248_T1.0750.92
113_M163_F1.0590.91
227_Y235_I1.0440.91
224_A228_I1.0440.91
246_D251_H1.0420.91
182_I186_L1.0420.91
279_N343_S1.0420.91
301_W306_P1.0350.91
227_Y230_F1.0320.90
346_V349_F1.0320.90
293_T299_I1.0320.90
323_A356_Y1.0280.90
331_V335_I1.0220.90
95_V100_I1.0130.90
342_F346_V1.0110.89
340_T344_F1.0080.89
292_S299_I1.0070.89
235_I240_G1.0020.89
49_M52_L1.0010.89
329_G349_F0.9990.89
41_W44_T0.9960.89
306_P309_F0.9940.89
92_I102_W0.9930.89
307_L363_K0.9900.88
227_Y234_L0.9890.88
242_K248_T0.9860.88
223_P235_I0.9840.88
87_I160_Y0.9840.88
272_T277_F0.9840.88
141_L354_D0.9730.88
306_P310_I0.9710.88
271_S274_W0.9660.87
300_L304_T0.9450.86
192_E227_Y0.9450.86
161_V190_S0.9450.86
11_Y15_I0.9440.86
189_L194_A0.9440.86
54_F86_Y0.9410.86
300_L357_V0.9400.86
228_I231_S0.9390.86
296_Y303_I0.9380.86
10_F14_L0.9330.85
84_A190_S0.9320.85
234_L238_Y0.9310.85
161_V194_A0.9250.85
126_S133_L0.9170.84
18_I23_Y0.9130.84
42_Y79_E0.9110.84
172_L177_P0.9010.83
49_M86_Y0.8940.83
220_I223_P0.8940.83
128_G133_L0.8930.83
95_V98_Y0.8910.83
311_F314_S0.8910.83
206_G210_N0.8890.82
215_R219_G0.8880.82
169_L321_M0.8860.82
231_S238_Y0.8830.82
114_L139_A0.8780.82
15_I19_S0.8750.81
14_L136_I0.8750.81
362_F366_Q0.8740.81
255_W258_T0.8730.81
341_L348_D0.8690.81
310_I313_D0.8690.81
235_I238_Y0.8670.81
250_I253_A0.8670.81
38_D80_H0.8650.81
77_N85_K0.8630.81
233_P237_Y0.8630.81
15_I115_I0.8630.81
118_Y122_K0.8620.80
101_V105_P0.8550.80
79_E85_K0.8530.80
80_H193_S0.8530.80
80_H192_E0.8520.80
36_I154_I0.8520.80
331_V334_Y0.8510.80
164_F183_A0.8460.79
17_L143_A0.8440.79
21_Y25_T0.8420.79
96_G101_V0.8410.79
98_Y101_V0.8410.79
165_S187_A0.8380.79
216_A219_G0.8350.78
172_L184_L0.8330.78
315_K319_T0.8330.78
209_S212_V0.8320.78
230_F233_P0.8320.78
134_A362_F0.8290.78
91_F105_P0.8280.78
231_S240_G0.8260.78
79_E157_L0.8260.78
216_A220_I0.8260.78
125_V355_A0.8240.77
245_L250_I0.8240.77
164_F213_K0.8210.77
275_D280_I0.8190.77
298_L301_W0.8190.77
187_A194_A0.8170.77
300_L303_I0.8160.77
20_V140_L0.8140.77
17_L23_Y0.8130.76
37_G40_V0.8120.76
19_S22_T0.8090.76
252_R256_D0.8080.76
168_S218_Y0.8030.76
114_L171_F0.8010.75
40_V44_T0.8000.75
42_Y156_L0.7950.75
229_L233_P0.7920.75
301_W310_I0.7900.74
127_N135_G0.7880.74
233_P236_A0.7870.74
252_R255_W0.7870.74
89_A93_Y0.7860.74
37_G41_W0.7860.74
194_A200_P0.7850.74
78_P86_Y0.7840.74
97_Y100_I0.7750.73
250_I254_L0.7740.73
44_T77_N0.7730.73
41_W45_A0.7730.73
10_F118_Y0.7710.73
115_I135_G0.7700.72
323_A355_A0.7670.72
209_S213_K0.7660.72
85_K193_S0.7660.72
92_I97_Y0.7620.72
83_L160_Y0.7590.71
69_E73_Q0.7570.71
206_G321_M0.7570.71
333_V345_Y0.7560.71
87_I109_L0.7550.71
322_W326_M0.7530.71
290_Y294_N0.7510.71
344_F350_M0.7500.70
42_Y255_W0.7500.70
11_Y14_L0.7490.70
88_M157_L0.7490.70
146_P192_E0.7480.70
115_I224_A0.7470.70
46_A88_M0.7450.70
80_H145_D0.7440.70
273_P276_W0.7320.69
327_W331_V0.7320.69
313_D316_L0.7310.68
41_W77_N0.7300.68
327_W346_V0.7290.68
121_G125_V0.7260.68
72_I77_N0.7260.68
38_D42_Y0.7240.68
291_A297_V0.7230.68
271_S275_D0.7200.67
187_A195_Y0.7200.67
40_V342_F0.7190.67
167_L182_I0.7170.67
86_Y345_Y0.7160.67
41_W48_N0.7150.67
283_F343_S0.7130.67
41_W344_F0.7130.67
290_Y301_W0.7090.66
199_F203_Y0.7080.66
48_N72_I0.7040.66
311_F319_T0.7040.66
230_F235_I0.7030.65
214_K218_Y0.7020.65
78_P85_K0.7010.65
119_F170_Y0.7000.65
206_G211_N0.6940.64
105_P109_L0.6940.64
141_L144_L0.6920.64
216_A221_G0.6880.64
163_F167_L0.6870.64
171_F180_A0.6870.64
189_L192_E0.6800.63
208_I211_N0.6770.63
165_S194_A0.6750.62
266_A270_I0.6730.62
216_A223_P0.6690.62
308_A356_Y0.6630.61
37_G269_Q0.6610.61
80_H157_L0.6590.60
186_L189_L0.6590.60
85_K157_L0.6550.60
215_R220_I0.6540.60
245_L258_T0.6540.60
330_F333_V0.6540.60
42_Y45_A0.6540.60
160_Y164_F0.6530.60
18_I111_D0.6530.60
219_G233_P0.6530.60
220_I231_S0.6520.60
23_Y303_I0.6520.60
30_S100_I0.6510.60
259_N264_L0.6500.59
298_L302_I0.6500.59
327_W333_V0.6480.59
37_G342_F0.6470.59
158_D345_Y0.6460.59
106_S155_A0.6420.58
300_L306_P0.6400.58
297_V300_L0.6360.58
17_L226_I0.6360.58
172_L201_F0.6350.58
279_N282_P0.6350.58
112_L212_V0.6330.57
161_V193_S0.6330.57
84_A88_M0.6330.57
251_H254_L0.6320.57
20_V28_T0.6310.57
304_T357_V0.6300.57
256_D271_S0.6300.57
276_W294_N0.6290.57
303_I306_P0.6280.57
80_H342_F0.6280.57
36_I340_T0.6270.57
160_Y190_S0.6250.56
334_Y337_G0.6250.56
207_E210_N0.6190.56
295_P298_L0.6180.56
151_L154_I0.6170.56
289_L293_T0.6170.56
14_L18_I0.6170.56
277_F280_I0.6160.55
328_I332_I0.6150.55
18_I22_T0.6150.55
226_I230_F0.6150.55
227_Y233_P0.6140.55
279_N283_F0.6130.55
326_M349_F0.6120.55
15_I221_G0.6120.55
147_N291_A0.6070.54
304_T307_L0.6060.54
310_I314_S0.6060.54
218_Y223_P0.6050.54
80_H345_Y0.6030.54
29_F173_L0.6030.54
185_A189_L0.6020.54
42_Y78_P0.6020.54
41_W157_L0.6010.54
87_I105_P0.6010.54
269_Q273_P0.6000.53
272_T278_L0.5990.53
217_I222_I0.5990.53
106_S109_L0.5990.53
117_G140_L0.5980.53
156_L344_F0.5960.53
299_I304_T0.5950.53
346_V350_M0.5940.53
20_V144_L0.5920.52
148_V347_T0.5920.52
147_N346_V0.5910.52
288_N291_A0.5900.52
326_M334_Y0.5900.52
234_L239_G0.5890.52
80_H86_Y0.5880.52
193_S344_F0.5880.52
107_W111_D0.5860.52
168_S180_A0.5860.52
37_G344_F0.5850.52
188_M194_A0.5840.52
116_V163_F0.5830.51
196_V256_D0.5810.51
15_I208_I0.5810.51
188_M198_I0.5790.51
148_V152_H0.5790.51
216_A227_Y0.5790.51
37_G80_H0.5780.51
36_I156_L0.5750.50
20_V226_I0.5740.50
234_L240_G0.5730.50
19_S264_L0.5730.50
252_R257_V0.5720.50
284_Y288_N0.5710.50
135_G275_D0.5700.50
42_Y85_K0.5680.50
83_L289_L0.5670.49
267_T342_F0.5670.49
235_I241_I0.5660.49
232_T235_I0.5660.49
77_N252_R0.5660.49
70_Q74_T0.5630.49
157_L345_Y0.5630.49
317_I320_T0.5630.49
117_G138_T0.5620.49
10_F119_F0.5610.49
272_T275_D0.5600.49
20_V225_L0.5590.48
88_M91_F0.5580.48
311_F315_K0.5560.48
25_T152_H0.5550.48
298_L304_T0.5550.48
41_W75_Y0.5540.48
164_F230_F0.5530.48
324_W335_I0.5530.48
32_I181_S0.5520.48
315_K318_T0.5510.47
245_L365_V0.5500.47
217_I224_A0.5490.47
288_N293_T0.5490.47
138_T351_P0.5490.47
271_S276_W0.5480.47
161_V165_S0.5470.47
297_V304_T0.5450.47
357_V360_S0.5450.47
12_L224_A0.5430.47
105_P252_R0.5420.46
362_F365_V0.5410.46
102_W344_F0.5410.46
140_L319_T0.5400.46
148_V159_I0.5400.46
124_L325_T0.5400.46
30_S107_W0.5380.46
77_N157_L0.5380.46
248_T255_W0.5360.46
345_Y351_P0.5350.46
327_W337_G0.5350.46
43_P193_S0.5340.45
286_G297_V0.5340.45
23_Y363_K0.5300.45
170_Y203_Y0.5280.45
322_W325_T0.5280.45
275_D278_L0.5280.45
113_M289_L0.5280.45
316_L319_T0.5270.45
40_V84_A0.5260.44
277_F349_F0.5250.44
41_W80_H0.5250.44
147_N297_V0.5240.44
32_I106_S0.5230.44
223_P234_L0.5230.44
324_W328_I0.5220.44
23_Y360_S0.5210.44
162_S347_T0.5200.44
330_F349_F0.5200.44
177_P181_S0.5200.44
53_V86_Y0.5180.43
231_S237_Y0.5170.43
122_K150_S0.5160.43
299_I303_I0.5160.43
182_I264_L0.5160.43
101_V104_I0.5150.43
22_T108_I0.5140.43
50_L85_K0.5140.43
19_S313_D0.5120.43
164_F167_L0.5120.43
39_E80_H0.5120.43
45_A48_N0.5110.43
183_A186_L0.5100.43
110_G140_L0.5090.42
298_L305_T0.5080.42
37_G75_Y0.5080.42
139_A328_I0.5080.42
305_T308_A0.5080.42
37_G181_S0.5060.42
173_L321_M0.5050.42
237_Y241_I0.5040.42
38_D157_L0.5020.42
83_L180_A0.5020.42
338_N341_L0.5010.41
264_L267_T0.5010.41
42_Y155_A0.5000.41
267_T270_I0.5000.41
104_I112_L0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.8306 100 0.65 Contact Map
3rceA 1 0.828 99.8 0.75 Contact Map
2l34A 2 0.0887 5.3 0.97 Contact Map
2looA 1 0.2634 2.8 0.973 Contact Map
2gfpA 2 0.5699 2.3 0.975 Contact Map
2m8fA 1 0.0645 2 0.976 Contact Map
2l35A 2 0.1586 1.6 0.977 Contact Map
1xrdA 1 0.1263 1.6 0.977 Contact Map
2j5lA 1 0 1.6 0.977 Contact Map
2h3oA 1 0.0887 1.3 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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