Y3226 - SULSO - GREMLIN Contacts

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Y3226 - Uncharacterized aldolase SSO3226

UniProt:	Q97U03	Sequences: MIGSEIRMAKLFDKGRALVVALDHGLVMGPLKGIENPVEVVAKIAKNGPDALQMTPSMVKLVKENFFSRGSPMLITRLDTANVWRQKYKVYNEGYYASIYTVKDAISAGADAVVTYLVVGYGNDTVEGYNLSVLSSLRKEANDYGIPFIVEPLYVTKDNPDSVKEVDLVKYVTRLASEIGADILKVDYTGNKESFRQVINVAFSPILIRGGPKTNTTEEFLRMLRDALEAGAKGVTVGRNLWQAEEPDKLAKAISKVIHENADIGEALKILK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	272 (243)
Sequences:	1107 (627)
Seq/√Len:	40.2

ECOLI - LSRF ALF1
HALSA - ADHS ALF1
SULSO - Y3226

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
225_R	229_E	4.675	1.00
228_L	257_V	4.623	1.00
18_L	258_I	4.327	1.00
222_R	226_D	4.192	1.00
227_A	232_A	3.463	1.00
141_A	148_F	3.445	1.00
183_I	207_L	3.346	1.00
138_R	148_F	3.048	1.00
16_R	233_K	2.884	1.00
153_L	176_A	2.746	1.00
237_V	254_I	2.739	1.00
218_E	222_R	2.684	1.00
256_K	260_E	2.673	1.00
170_K	197_Q	2.553	1.00
112_A	147_P	2.528	1.00
177_S	203_F	2.456	1.00
189_T	194_S	2.403	1.00
215_N	219_E	2.299	1.00
246_E	249_K	2.212	1.00
50_D	259_H	2.207	0.99
51_A	75_I	2.179	0.99
166_V	170_K	2.069	0.99
56_P	104_D	2.058	0.99
241_L	254_I	2.040	0.99
235_V	254_I	2.014	0.99
191_N	194_S	2.012	0.99
188_Y	195_F	2.004	0.99
103_K	140_E	1.989	0.99
115_T	134_L	1.985	0.99
104_D	139_K	1.935	0.99
106_I	146_I	1.927	0.99
103_K	143_D	1.842	0.98
19_V	207_L	1.833	0.98
224_L	254_I	1.815	0.98
169_V	189_T	1.803	0.98
220_F	250_L	1.777	0.98
16_R	228_L	1.758	0.97
77_R	114_V	1.721	0.97
134_L	150_V	1.720	0.97
75_I	149_I	1.698	0.97
100_Y	104_D	1.692	0.97
221_L	257_V	1.689	0.97
49_P	251_A	1.656	0.96
217_T	250_L	1.624	0.96
174_R	178_E	1.579	0.95
36_N	39_E	1.578	0.95
214_T	220_F	1.573	0.95
113_V	137_L	1.568	0.95
119_V	175_L	1.568	0.95
11_L	17_A	1.566	0.95
197_Q	200_N	1.560	0.95
103_K	144_Y	1.547	0.95
220_F	237_V	1.532	0.94
221_L	253_A	1.515	0.94
78_L	137_L	1.496	0.94
101_T	139_K	1.483	0.93
77_R	118_V	1.455	0.93
189_T	195_F	1.432	0.92
25_G	178_E	1.409	0.91
132_S	136_S	1.387	0.91
155_V	172_V	1.379	0.90
188_Y	226_D	1.355	0.90
77_R	116_Y	1.343	0.89
219_E	222_R	1.343	0.89
121_Y	130_N	1.337	0.89
208_I	227_A	1.331	0.89
12_F	17_A	1.330	0.89
76_T	100_Y	1.328	0.89
225_R	261_N	1.321	0.88
213_K	240_N	1.319	0.88
220_F	224_L	1.318	0.88
96_Y	118_V	1.317	0.88
173_T	186_V	1.316	0.88
96_Y	114_V	1.283	0.87
97_A	141_A	1.267	0.86
96_Y	116_Y	1.242	0.85
77_R	154_Y	1.229	0.84
59_V	74_L	1.207	0.83
46_K	248_D	1.206	0.83
78_L	102_V	1.196	0.83
98_S	137_L	1.175	0.82
9_A	71_S	1.164	0.81
26_L	80_T	1.158	0.81
77_R	171_Y	1.144	0.80
118_V	242_W	1.131	0.79
18_L	235_V	1.126	0.79
113_V	182_D	1.111	0.78
77_R	96_Y	1.111	0.78
80_T	99_I	1.091	0.76
79_D	114_V	1.089	0.76
193_E	196_R	1.086	0.76
42_A	257_V	1.074	0.75
228_L	232_A	1.073	0.75
98_S	133_V	1.070	0.75
16_R	261_N	1.063	0.75
190_G	194_S	1.050	0.74
8_M	143_D	1.045	0.73
114_V	118_V	1.032	0.72
39_E	43_K	1.031	0.72
44_I	47_N	1.018	0.71
55_T	77_R	1.016	0.71
164_K	212_P	1.014	0.71
60_K	142_N	1.012	0.71
240_N	243_Q	1.006	0.70
27_V	77_R	0.997	0.70
13_D	50_D	0.990	0.69
149_I	236_T	0.989	0.69
111_D	147_P	0.986	0.69
144_Y	148_F	0.985	0.69
7_R	10_K	0.983	0.69
224_L	237_V	0.983	0.69
26_L	130_N	0.969	0.67
199_I	230_A	0.969	0.67
116_Y	154_Y	0.965	0.67
173_T	183_I	0.964	0.67
8_M	201_V	0.964	0.67
249_K	253_A	0.962	0.67
34_I	174_R	0.962	0.67
27_V	114_V	0.958	0.67
96_Y	171_Y	0.957	0.66
140_E	143_D	0.957	0.66
79_D	116_Y	0.952	0.66
17_A	207_L	0.951	0.66
245_E	249_K	0.949	0.66
169_V	186_V	0.948	0.66
68_S	71_S	0.947	0.66
53_Q	114_V	0.944	0.65
79_D	117_L	0.940	0.65
120_G	157_K	0.935	0.65
97_A	128_G	0.929	0.64
98_S	134_L	0.924	0.64
188_Y	227_A	0.917	0.63
188_Y	232_A	0.917	0.63
162_S	165_E	0.910	0.63
54_M	108_A	0.908	0.62
127_E	131_L	0.907	0.62
150_V	176_A	0.907	0.62
25_G	174_R	0.904	0.62
107_S	143_D	0.901	0.62
129_Y	132_S	0.901	0.62
155_V	236_T	0.898	0.61
155_V	186_V	0.896	0.61
11_L	51_A	0.895	0.61
214_T	217_T	0.895	0.61
17_A	50_D	0.881	0.60
79_D	154_Y	0.880	0.60
43_K	248_D	0.878	0.60
38_V	42_A	0.878	0.60
18_L	251_A	0.874	0.59
122_G	158_D	0.873	0.59
22_L	37_P	0.867	0.59
253_A	256_K	0.866	0.59
214_T	223_M	0.864	0.58
217_T	244_A	0.862	0.58
136_S	252_K	0.859	0.58
19_V	75_I	0.858	0.58
78_L	113_V	0.854	0.58
118_V	171_Y	0.853	0.58
150_V	153_L	0.849	0.57
123_N	130_N	0.848	0.57
189_T	198_V	0.844	0.57
100_Y	139_K	0.834	0.56
47_N	251_A	0.831	0.56
86_Q	93_E	0.830	0.55
175_L	246_E	0.829	0.55
117_L	224_L	0.824	0.55
8_M	17_A	0.819	0.54
19_V	51_A	0.816	0.54
95_Y	123_N	0.805	0.53
208_I	223_M	0.804	0.53
12_F	183_I	0.800	0.53
76_T	110_A	0.793	0.52
132_S	245_E	0.788	0.52
9_A	64_E	0.783	0.51
79_D	209_R	0.780	0.51
173_T	198_V	0.779	0.51
16_R	135_S	0.773	0.50
77_R	209_R	0.772	0.50
248_D	257_V	0.770	0.50
25_G	30_P	0.768	0.50
96_Y	242_W	0.766	0.50
163_V	187_D	0.762	0.49
102_V	137_L	0.758	0.49
30_P	242_W	0.755	0.49
102_V	146_I	0.755	0.49
169_V	198_V	0.752	0.48
20_V	44_I	0.752	0.48
221_L	261_N	0.751	0.48
11_L	149_I	0.748	0.48
150_V	181_A	0.748	0.48
112_A	229_E	0.748	0.48
8_M	12_F	0.746	0.48
118_V	130_N	0.745	0.48
53_Q	153_L	0.741	0.47
27_V	96_Y	0.739	0.47
59_V	76_T	0.735	0.47
45_A	59_V	0.735	0.47
214_T	219_E	0.734	0.47
111_D	182_D	0.732	0.46
207_L	254_I	0.731	0.46
26_L	79_D	0.728	0.46
119_V	203_F	0.722	0.46
166_V	197_Q	0.721	0.45
18_L	255_S	0.720	0.45
8_M	11_L	0.720	0.45
115_T	138_R	0.716	0.45
186_V	198_V	0.709	0.44
104_D	107_S	0.709	0.44
157_K	160_P	0.708	0.44
28_M	121_Y	0.705	0.44
113_V	141_A	0.702	0.44
46_K	245_E	0.701	0.44
221_L	250_L	0.699	0.43
82_N	127_E	0.698	0.43
20_V	95_Y	0.695	0.43
215_N	218_E	0.695	0.43
229_E	257_V	0.694	0.43
218_E	221_L	0.691	0.43
55_T	114_V	0.684	0.42
121_Y	186_V	0.684	0.42
35_E	197_Q	0.683	0.42
217_T	253_A	0.681	0.42
153_L	209_R	0.680	0.42
112_A	175_L	0.678	0.42
21_A	77_R	0.675	0.41
228_L	245_E	0.675	0.41
153_L	172_V	0.674	0.41
117_L	140_E	0.674	0.41
116_Y	130_N	0.673	0.41
102_V	113_V	0.671	0.41
73_M	111_D	0.668	0.41
12_F	246_E	0.665	0.40
219_E	245_E	0.664	0.40
176_A	184_L	0.664	0.40
121_Y	236_T	0.664	0.40
44_I	251_A	0.663	0.40
116_Y	171_Y	0.662	0.40
41_V	140_E	0.662	0.40
37_P	41_V	0.660	0.40
33_G	174_R	0.660	0.40
116_Y	181_A	0.656	0.40
24_H	31_L	0.655	0.40
221_L	240_N	0.655	0.40
170_K	201_V	0.653	0.39
247_P	259_H	0.653	0.39
79_D	96_Y	0.651	0.39
177_S	204_S	0.649	0.39
27_V	118_V	0.648	0.39
117_L	150_V	0.645	0.39
195_F	208_I	0.643	0.38
185_K	239_R	0.643	0.38
221_L	241_L	0.642	0.38
207_L	233_K	0.642	0.38
153_L	237_V	0.640	0.38
102_V	144_Y	0.639	0.38
87_K	251_A	0.639	0.38
156_T	242_W	0.638	0.38
55_T	96_Y	0.637	0.38
205_P	259_H	0.636	0.38
219_E	226_D	0.633	0.38
93_E	96_Y	0.632	0.38
195_F	232_A	0.632	0.38
139_K	142_N	0.629	0.37
61_L	202_A	0.628	0.37
60_K	204_S	0.625	0.37
33_G	178_E	0.620	0.36
81_A	96_Y	0.620	0.36
63_K	67_F	0.617	0.36
19_V	224_L	0.614	0.36
134_L	149_I	0.614	0.36
196_R	200_N	0.611	0.36
190_G	193_E	0.611	0.36
39_E	42_A	0.610	0.36
54_M	59_V	0.609	0.36
6_I	59_V	0.608	0.35
163_V	242_W	0.607	0.35
181_A	205_P	0.607	0.35
81_A	86_Q	0.606	0.35
188_Y	208_I	0.604	0.35
176_A	180_G	0.602	0.35
74_L	110_A	0.600	0.35
183_I	254_I	0.600	0.35
162_S	172_V	0.599	0.35
219_E	223_M	0.596	0.34
114_V	154_Y	0.596	0.34
199_I	202_A	0.593	0.34
102_V	106_I	0.591	0.34
136_S	245_E	0.590	0.34
119_V	172_V	0.589	0.34
155_V	201_V	0.588	0.34
132_S	249_K	0.585	0.34
116_Y	242_W	0.585	0.34
54_M	163_V	0.585	0.34
200_N	254_I	0.585	0.34
95_Y	129_Y	0.583	0.33
42_A	46_K	0.582	0.33
51_A	111_D	0.581	0.33
169_V	195_F	0.578	0.33
153_L	204_S	0.575	0.33
252_K	257_V	0.575	0.33
205_P	233_K	0.575	0.33
147_P	242_W	0.575	0.33
187_D	209_R	0.574	0.33
119_V	209_R	0.573	0.33
133_V	136_S	0.572	0.33
9_A	63_K	0.570	0.32
27_V	116_Y	0.569	0.32
118_V	154_Y	0.568	0.32
76_T	108_A	0.566	0.32
146_I	197_Q	0.565	0.32
228_L	258_I	0.565	0.32
81_A	242_W	0.564	0.32
160_P	165_E	0.562	0.32
41_V	62_V	0.562	0.32
68_S	107_S	0.561	0.32
211_G	239_R	0.561	0.32
8_M	136_S	0.561	0.32
41_V	108_A	0.560	0.32
21_A	81_A	0.559	0.31
137_L	143_D	0.559	0.31
199_I	237_V	0.557	0.31
6_I	62_V	0.556	0.31
195_F	199_I	0.555	0.31
44_I	49_P	0.552	0.31
24_H	205_P	0.552	0.31
255_S	260_E	0.552	0.31
244_A	247_P	0.551	0.31
21_A	100_Y	0.548	0.31
10_K	111_D	0.547	0.31
81_A	118_V	0.546	0.30
41_V	54_M	0.545	0.30
56_P	108_A	0.544	0.30
6_I	20_V	0.544	0.30
226_D	252_K	0.543	0.30
210_G	239_R	0.539	0.30
115_T	179_I	0.538	0.30
40_V	142_N	0.538	0.30
56_P	114_V	0.535	0.30
195_F	198_V	0.535	0.30
60_K	235_V	0.534	0.30
80_T	84_W	0.528	0.29
106_I	140_E	0.528	0.29
212_P	223_M	0.525	0.29
18_L	218_E	0.523	0.29
21_A	96_Y	0.521	0.29
132_S	196_R	0.521	0.29
134_L	148_F	0.520	0.28
247_P	258_I	0.518	0.28
186_V	195_F	0.518	0.28
16_R	260_E	0.516	0.28
114_V	171_Y	0.516	0.28
164_K	186_V	0.516	0.28
66_F	187_D	0.514	0.28
9_A	12_F	0.511	0.28
141_A	144_Y	0.510	0.28
73_M	114_V	0.510	0.28
28_M	168_L	0.509	0.28
104_D	122_G	0.508	0.28
120_G	155_V	0.506	0.27
87_K	121_Y	0.506	0.27
22_L	52_L	0.505	0.27
172_V	187_D	0.502	0.27
138_R	141_A	0.502	0.27
25_G	242_W	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fokA	3	0.8971	100	0.341	Contact Map
3iv3A	2	0.9596	100	0.406	Contact Map
4mozA	5	0.9632	100	0.413	Contact Map
1to3A	2	0.9191	100	0.442	Contact Map
3glcA	6	0.9154	100	0.5	Contact Map
1w8sA	4	0.9007	100	0.517	Contact Map
2qjgA	6	0.9596	100	0.549	Contact Map
3r12A	2	0.8199	100	0.662	Contact Map
3oa3A	2	0.8051	100	0.663	Contact Map
3ndoA	2	0.7868	100	0.678	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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