GREMLIN Database
Y3226 - Uncharacterized aldolase SSO3226
UniProt: Q97U03 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (243)
Sequences: 1107 (627)
Seq/√Len: 40.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_R229_E4.6751.00
228_L257_V4.6231.00
18_L258_I4.3271.00
222_R226_D4.1921.00
227_A232_A3.4631.00
141_A148_F3.4451.00
183_I207_L3.3461.00
138_R148_F3.0481.00
16_R233_K2.8841.00
153_L176_A2.7461.00
237_V254_I2.7391.00
218_E222_R2.6841.00
256_K260_E2.6731.00
170_K197_Q2.5531.00
112_A147_P2.5281.00
177_S203_F2.4561.00
189_T194_S2.4031.00
215_N219_E2.2991.00
246_E249_K2.2121.00
50_D259_H2.2070.99
51_A75_I2.1790.99
166_V170_K2.0690.99
56_P104_D2.0580.99
241_L254_I2.0400.99
235_V254_I2.0140.99
191_N194_S2.0120.99
188_Y195_F2.0040.99
103_K140_E1.9890.99
115_T134_L1.9850.99
104_D139_K1.9350.99
106_I146_I1.9270.99
103_K143_D1.8420.98
19_V207_L1.8330.98
224_L254_I1.8150.98
169_V189_T1.8030.98
220_F250_L1.7770.98
16_R228_L1.7580.97
77_R114_V1.7210.97
134_L150_V1.7200.97
75_I149_I1.6980.97
100_Y104_D1.6920.97
221_L257_V1.6890.97
49_P251_A1.6560.96
217_T250_L1.6240.96
174_R178_E1.5790.95
36_N39_E1.5780.95
214_T220_F1.5730.95
113_V137_L1.5680.95
119_V175_L1.5680.95
11_L17_A1.5660.95
197_Q200_N1.5600.95
103_K144_Y1.5470.95
220_F237_V1.5320.94
221_L253_A1.5150.94
78_L137_L1.4960.94
101_T139_K1.4830.93
77_R118_V1.4550.93
189_T195_F1.4320.92
25_G178_E1.4090.91
132_S136_S1.3870.91
155_V172_V1.3790.90
188_Y226_D1.3550.90
77_R116_Y1.3430.89
219_E222_R1.3430.89
121_Y130_N1.3370.89
208_I227_A1.3310.89
12_F17_A1.3300.89
76_T100_Y1.3280.89
225_R261_N1.3210.88
213_K240_N1.3190.88
220_F224_L1.3180.88
96_Y118_V1.3170.88
173_T186_V1.3160.88
96_Y114_V1.2830.87
97_A141_A1.2670.86
96_Y116_Y1.2420.85
77_R154_Y1.2290.84
59_V74_L1.2070.83
46_K248_D1.2060.83
78_L102_V1.1960.83
98_S137_L1.1750.82
9_A71_S1.1640.81
26_L80_T1.1580.81
77_R171_Y1.1440.80
118_V242_W1.1310.79
18_L235_V1.1260.79
113_V182_D1.1110.78
77_R96_Y1.1110.78
80_T99_I1.0910.76
79_D114_V1.0890.76
193_E196_R1.0860.76
42_A257_V1.0740.75
228_L232_A1.0730.75
98_S133_V1.0700.75
16_R261_N1.0630.75
190_G194_S1.0500.74
8_M143_D1.0450.73
114_V118_V1.0320.72
39_E43_K1.0310.72
44_I47_N1.0180.71
55_T77_R1.0160.71
164_K212_P1.0140.71
60_K142_N1.0120.71
240_N243_Q1.0060.70
27_V77_R0.9970.70
13_D50_D0.9900.69
149_I236_T0.9890.69
111_D147_P0.9860.69
144_Y148_F0.9850.69
7_R10_K0.9830.69
224_L237_V0.9830.69
26_L130_N0.9690.67
199_I230_A0.9690.67
116_Y154_Y0.9650.67
173_T183_I0.9640.67
8_M201_V0.9640.67
249_K253_A0.9620.67
34_I174_R0.9620.67
27_V114_V0.9580.67
96_Y171_Y0.9570.66
140_E143_D0.9570.66
79_D116_Y0.9520.66
17_A207_L0.9510.66
245_E249_K0.9490.66
169_V186_V0.9480.66
68_S71_S0.9470.66
53_Q114_V0.9440.65
79_D117_L0.9400.65
120_G157_K0.9350.65
97_A128_G0.9290.64
98_S134_L0.9240.64
188_Y227_A0.9170.63
188_Y232_A0.9170.63
162_S165_E0.9100.63
54_M108_A0.9080.62
127_E131_L0.9070.62
150_V176_A0.9070.62
25_G174_R0.9040.62
107_S143_D0.9010.62
129_Y132_S0.9010.62
155_V236_T0.8980.61
155_V186_V0.8960.61
11_L51_A0.8950.61
214_T217_T0.8950.61
17_A50_D0.8810.60
79_D154_Y0.8800.60
43_K248_D0.8780.60
38_V42_A0.8780.60
18_L251_A0.8740.59
122_G158_D0.8730.59
22_L37_P0.8670.59
253_A256_K0.8660.59
214_T223_M0.8640.58
217_T244_A0.8620.58
136_S252_K0.8590.58
19_V75_I0.8580.58
78_L113_V0.8540.58
118_V171_Y0.8530.58
150_V153_L0.8490.57
123_N130_N0.8480.57
189_T198_V0.8440.57
100_Y139_K0.8340.56
47_N251_A0.8310.56
86_Q93_E0.8300.55
175_L246_E0.8290.55
117_L224_L0.8240.55
8_M17_A0.8190.54
19_V51_A0.8160.54
95_Y123_N0.8050.53
208_I223_M0.8040.53
12_F183_I0.8000.53
76_T110_A0.7930.52
132_S245_E0.7880.52
9_A64_E0.7830.51
79_D209_R0.7800.51
173_T198_V0.7790.51
16_R135_S0.7730.50
77_R209_R0.7720.50
248_D257_V0.7700.50
25_G30_P0.7680.50
96_Y242_W0.7660.50
163_V187_D0.7620.49
102_V137_L0.7580.49
30_P242_W0.7550.49
102_V146_I0.7550.49
169_V198_V0.7520.48
20_V44_I0.7520.48
221_L261_N0.7510.48
11_L149_I0.7480.48
150_V181_A0.7480.48
112_A229_E0.7480.48
8_M12_F0.7460.48
118_V130_N0.7450.48
53_Q153_L0.7410.47
27_V96_Y0.7390.47
59_V76_T0.7350.47
45_A59_V0.7350.47
214_T219_E0.7340.47
111_D182_D0.7320.46
207_L254_I0.7310.46
26_L79_D0.7280.46
119_V203_F0.7220.46
166_V197_Q0.7210.45
18_L255_S0.7200.45
8_M11_L0.7200.45
115_T138_R0.7160.45
186_V198_V0.7090.44
104_D107_S0.7090.44
157_K160_P0.7080.44
28_M121_Y0.7050.44
113_V141_A0.7020.44
46_K245_E0.7010.44
221_L250_L0.6990.43
82_N127_E0.6980.43
20_V95_Y0.6950.43
215_N218_E0.6950.43
229_E257_V0.6940.43
218_E221_L0.6910.43
55_T114_V0.6840.42
121_Y186_V0.6840.42
35_E197_Q0.6830.42
217_T253_A0.6810.42
153_L209_R0.6800.42
112_A175_L0.6780.42
21_A77_R0.6750.41
228_L245_E0.6750.41
153_L172_V0.6740.41
117_L140_E0.6740.41
116_Y130_N0.6730.41
102_V113_V0.6710.41
73_M111_D0.6680.41
12_F246_E0.6650.40
219_E245_E0.6640.40
176_A184_L0.6640.40
121_Y236_T0.6640.40
44_I251_A0.6630.40
116_Y171_Y0.6620.40
41_V140_E0.6620.40
37_P41_V0.6600.40
33_G174_R0.6600.40
116_Y181_A0.6560.40
24_H31_L0.6550.40
221_L240_N0.6550.40
170_K201_V0.6530.39
247_P259_H0.6530.39
79_D96_Y0.6510.39
177_S204_S0.6490.39
27_V118_V0.6480.39
117_L150_V0.6450.39
195_F208_I0.6430.38
185_K239_R0.6430.38
221_L241_L0.6420.38
207_L233_K0.6420.38
153_L237_V0.6400.38
102_V144_Y0.6390.38
87_K251_A0.6390.38
156_T242_W0.6380.38
55_T96_Y0.6370.38
205_P259_H0.6360.38
219_E226_D0.6330.38
93_E96_Y0.6320.38
195_F232_A0.6320.38
139_K142_N0.6290.37
61_L202_A0.6280.37
60_K204_S0.6250.37
33_G178_E0.6200.36
81_A96_Y0.6200.36
63_K67_F0.6170.36
19_V224_L0.6140.36
134_L149_I0.6140.36
196_R200_N0.6110.36
190_G193_E0.6110.36
39_E42_A0.6100.36
54_M59_V0.6090.36
6_I59_V0.6080.35
163_V242_W0.6070.35
181_A205_P0.6070.35
81_A86_Q0.6060.35
188_Y208_I0.6040.35
176_A180_G0.6020.35
74_L110_A0.6000.35
183_I254_I0.6000.35
162_S172_V0.5990.35
219_E223_M0.5960.34
114_V154_Y0.5960.34
199_I202_A0.5930.34
102_V106_I0.5910.34
136_S245_E0.5900.34
119_V172_V0.5890.34
155_V201_V0.5880.34
132_S249_K0.5850.34
116_Y242_W0.5850.34
54_M163_V0.5850.34
200_N254_I0.5850.34
95_Y129_Y0.5830.33
42_A46_K0.5820.33
51_A111_D0.5810.33
169_V195_F0.5780.33
153_L204_S0.5750.33
252_K257_V0.5750.33
205_P233_K0.5750.33
147_P242_W0.5750.33
187_D209_R0.5740.33
119_V209_R0.5730.33
133_V136_S0.5720.33
9_A63_K0.5700.32
27_V116_Y0.5690.32
118_V154_Y0.5680.32
76_T108_A0.5660.32
146_I197_Q0.5650.32
228_L258_I0.5650.32
81_A242_W0.5640.32
160_P165_E0.5620.32
41_V62_V0.5620.32
68_S107_S0.5610.32
211_G239_R0.5610.32
8_M136_S0.5610.32
41_V108_A0.5600.32
21_A81_A0.5590.31
137_L143_D0.5590.31
199_I237_V0.5570.31
6_I62_V0.5560.31
195_F199_I0.5550.31
44_I49_P0.5520.31
24_H205_P0.5520.31
255_S260_E0.5520.31
244_A247_P0.5510.31
21_A100_Y0.5480.31
10_K111_D0.5470.31
81_A118_V0.5460.30
41_V54_M0.5450.30
56_P108_A0.5440.30
6_I20_V0.5440.30
226_D252_K0.5430.30
210_G239_R0.5390.30
115_T179_I0.5380.30
40_V142_N0.5380.30
56_P114_V0.5350.30
195_F198_V0.5350.30
60_K235_V0.5340.30
80_T84_W0.5280.29
106_I140_E0.5280.29
212_P223_M0.5250.29
18_L218_E0.5230.29
21_A96_Y0.5210.29
132_S196_R0.5210.29
134_L148_F0.5200.28
247_P258_I0.5180.28
186_V195_F0.5180.28
16_R260_E0.5160.28
114_V171_Y0.5160.28
164_K186_V0.5160.28
66_F187_D0.5140.28
9_A12_F0.5110.28
141_A144_Y0.5100.28
73_M114_V0.5100.28
28_M168_L0.5090.28
104_D122_G0.5080.28
120_G155_V0.5060.27
87_K121_Y0.5060.27
22_L52_L0.5050.27
172_V187_D0.5020.27
138_R141_A0.5020.27
25_G242_W0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fokA 3 0.8971 100 0.341 Contact Map
3iv3A 2 0.9596 100 0.406 Contact Map
4mozA 5 0.9632 100 0.413 Contact Map
1to3A 2 0.9191 100 0.442 Contact Map
3glcA 6 0.9154 100 0.5 Contact Map
1w8sA 4 0.9007 100 0.517 Contact Map
2qjgA 6 0.9596 100 0.549 Contact Map
3r12A 2 0.8199 100 0.662 Contact Map
3oa3A 2 0.8051 100 0.663 Contact Map
3ndoA 2 0.7868 100 0.678 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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