GREMLIN Database
Q97U00 - Uncharacterized protein
UniProt: Q97U00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (122)
Sequences: 10328 (7755)
Seq/√Len: 702.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_T52_E2.9631.00
64_S127_H2.6531.00
107_I130_V2.5491.00
109_E132_D2.2861.00
107_I111_S2.1751.00
53_V96_A2.1611.00
46_R97_E2.1581.00
105_I123_Y2.1351.00
108_K111_S2.0901.00
111_S115_G2.0591.00
44_V48_T1.9291.00
109_E138_R1.8841.00
45_G48_T1.8811.00
33_V116_A1.8751.00
44_V65_V1.8691.00
46_R74_I1.8521.00
66_I73_P1.8221.00
44_V67_V1.8071.00
44_V53_V1.7661.00
108_K133_Y1.7581.00
94_T98_E1.7021.00
129_P137_L1.6581.00
107_I116_A1.6401.00
105_I125_I1.6231.00
53_V77_I1.5961.00
95_I98_E1.5731.00
34_K109_E1.5521.00
126_R143_I1.5261.00
44_V96_A1.5011.00
42_I60_N1.4601.00
46_R69_D1.4521.00
69_D72_K1.4521.00
56_I60_N1.4491.00
55_R59_D1.4381.00
79_E83_V1.3821.00
69_D74_I1.3741.00
116_A128_L1.3581.00
47_N97_E1.3511.00
48_T56_I1.3001.00
43_T68_V1.2981.00
107_I128_L1.2771.00
34_K110_D1.2691.00
132_D136_N1.2661.00
119_L123_Y1.2541.00
106_T131_I1.2261.00
112_P115_G1.1691.00
73_P137_L1.1651.00
49_M52_E1.1631.00
79_E126_R1.1541.00
50_L99_I1.1541.00
111_S119_L1.1481.00
53_V65_V1.1281.00
32_F35_E1.1281.00
63_G79_E1.1211.00
77_I96_A1.1181.00
77_I99_I1.1131.00
67_V100_M1.1111.00
77_I82_V1.1061.00
36_Y113_I1.0981.00
81_D101_T1.0931.00
36_Y141_I1.0701.00
94_T99_I1.0571.00
52_E55_R1.0561.00
51_K55_R1.0541.00
73_P104_L1.0361.00
105_I119_L1.0271.00
42_I56_I1.0251.00
62_V65_V1.0221.00
31_E35_E1.0131.00
64_S126_R0.9891.00
66_I137_L0.9821.00
76_I129_P0.9801.00
113_I146_I0.9631.00
75_G100_M0.9541.00
118_S122_T0.9531.00
73_P129_P0.9521.00
116_A141_I0.9471.00
38_K145_D0.9301.00
54_T82_V0.9271.00
66_I129_P0.9051.00
119_L128_L0.9021.00
45_G69_D0.9011.00
57_M65_V0.8881.00
71_G136_N0.8871.00
83_V126_R0.8821.00
110_D133_Y0.8781.00
107_I119_L0.8601.00
72_K136_N0.8481.00
51_K93_D0.8461.00
56_I59_D0.8261.00
42_I62_V0.8211.00
33_V107_I0.8151.00
74_I100_M0.8081.00
115_G119_L0.8001.00
121_R148_R0.7911.00
82_V85_A0.7861.00
63_G126_R0.7841.00
44_V56_I0.7841.00
37_M130_V0.7831.00
45_G68_V0.7831.00
96_A100_M0.7731.00
84_R87_G0.7731.00
127_H142_S0.7701.00
64_S140_I0.7691.00
127_H140_I0.7661.00
68_V74_I0.7601.00
63_G127_H0.7551.00
43_T71_G0.7541.00
63_G66_I0.7521.00
91_S94_T0.7451.00
72_K135_G0.7351.00
32_F110_D0.7341.00
64_S76_I0.7321.00
126_R144_R0.7291.00
68_V73_P0.7281.00
129_P140_I0.7201.00
106_T135_G0.7141.00
52_E56_I0.7141.00
120_M128_L0.7071.00
56_I65_V0.7041.00
62_V66_I0.7001.00
144_R148_R0.6981.00
47_N95_I0.6981.00
32_F112_P0.6961.00
131_I135_G0.6931.00
38_K41_V0.6811.00
36_Y149_A0.6801.00
76_I101_T0.6711.00
132_D138_R0.6701.00
63_G80_R0.6631.00
76_I127_H0.6601.00
53_V57_M0.6451.00
115_G118_S0.6441.00
79_E144_R0.6441.00
97_E102_A0.6401.00
108_K132_D0.6381.00
33_V37_M0.6371.00
41_V66_I0.6351.00
135_G138_R0.6251.00
37_M139_G0.6181.00
109_E133_Y0.6131.00
58_T88_K0.6111.00
64_S78_T0.6081.00
143_I147_A0.6061.00
54_T79_E0.6051.00
31_E149_A0.6051.00
76_I104_L0.6031.00
131_I137_L0.6001.00
127_H143_I0.6001.00
63_G143_I0.5991.00
50_L85_A0.5981.00
42_I65_V0.5821.00
40_R60_N0.5821.00
50_L94_T0.5711.00
83_V87_G0.5601.00
117_L146_I0.5591.00
48_T65_V0.5551.00
114_T118_S0.5551.00
33_V36_Y0.5521.00
41_V62_V0.5471.00
85_A88_K0.5441.00
145_D148_R0.5441.00
43_T65_V0.5431.00
108_K135_G0.5421.00
101_T104_L0.5411.00
97_E100_M0.5401.00
85_A89_G0.5371.00
49_M95_I0.5341.00
66_I74_I0.5341.00
80_R126_R0.5331.00
104_L129_P0.5321.00
68_V71_G0.5301.00
37_M138_R0.5251.00
129_P138_R0.5241.00
50_L53_V0.5231.00
51_K92_L0.5201.00
62_V142_S0.5130.99
119_L122_T0.5100.99
90_K93_D0.5100.99
73_P131_I0.5090.99
72_K134_D0.5020.99
58_T148_R0.5000.99
66_I127_H0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l2bA 2 0.75 99.9 0.323 Contact Map
4cooA 2 0.9679 99.9 0.343 Contact Map
2ef7A 3 0.8141 99.9 0.348 Contact Map
4esyA 2 0.891 99.8 0.355 Contact Map
3pc3A 2 0.9872 99.8 0.356 Contact Map
2ouxA 2 0.9679 99.8 0.36 Contact Map
1o50A 2 0.8397 99.8 0.361 Contact Map
2qrdG 1 0.9744 99.8 0.365 Contact Map
2nycA 2 0.7949 99.8 0.365 Contact Map
3fhmA 2 0.8333 99.8 0.367 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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