HTPX2 - SULSO - GREMLIN Contacts

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HTPX2 - Protease HtpX homolog 2

UniProt:	Q97TZ9	Sequences: MNWEVVKLRLNMALATLGITLLGFALALAVADYAFGAQFGVGLILSILIFIFFLNIIQWLFGPYMINWAYRTVEVTPTDPVYGWLYSTVAEVAKYNGFREVPKVYIADVPFPNAFAYGSPIAGKRIAFTLPILKLLNRDEIMAVAGHELGHLKHRDVELLMAVGLIPALIYYLGWWLFWGGLFSGGGNGRGNNGGLVFLLGIIMMAVSFVFQLLVLSLNRMREAYADVNSALTVPGGKENLQLALAKLTLSMDPEALERFKKKSTTNQMASMLFFTNAIEEVPTWNAKELVEIWKTTKVPWYADIFMDHPHPAKRIQLLDKVSKY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (278)
Sequences:	4715 (3480)
Seq/√Len:	208.7

ECOLI - HTPX
BACSU - YHFN HTPX
HALSA - Q9HSA2 HTPX Q9HS47
SULSO - HTPX2 HTPX1 Q97VD5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
246_A	320_D	5.051	1.00
91_E	142_M	4.391	1.00
108_D	130_L	4.380	1.00
150_G	229_N	4.268	1.00
140_E	247_K	4.121	1.00
77_P	90_A	3.749	1.00
139_D	237_G	3.428	1.00
146_G	230_S	3.167	1.00
84_W	138_R	3.157	1.00
224_A	314_K	2.952	1.00
120_P	123_G	2.870	1.00
128_F	145_A	2.839	1.00
228_V	232_L	2.557	1.00
86_Y	101_V	2.511	1.00
49_I	53_F	2.449	1.00
249_T	313_A	2.446	1.00
314_K	317_Q	2.401	1.00
72_T	105_Y	2.385	1.00
76_T	79_D	2.371	1.00
88_T	142_M	2.285	1.00
246_A	316_I	2.151	1.00
139_D	240_N	2.148	1.00
74_E	103_K	2.122	1.00
140_E	243_L	2.098	1.00
73_V	79_D	1.998	1.00
90_A	94_K	1.977	1.00
192_N	195_G	1.955	1.00
156_D	225_Y	1.911	1.00
231_A	319_L	1.896	1.00
137_N	243_L	1.886	1.00
137_N	247_K	1.884	1.00
184_S	187_G	1.867	1.00
13_A	17_L	1.862	1.00
237_G	240_N	1.860	1.00
73_V	108_D	1.833	1.00
53_F	57_I	1.812	1.00
17_L	20_T	1.799	1.00
311_H	314_K	1.785	1.00
90_A	101_V	1.755	1.00
135_L	251_S	1.740	1.00
64_Y	68_W	1.662	1.00
239_E	320_D	1.639	1.00
16_T	20_T	1.631	1.00
89_V	104_V	1.627	1.00
24_F	28_L	1.620	1.00
19_I	24_F	1.617	1.00
249_T	312_P	1.593	1.00
174_G	177_L	1.572	1.00
83_G	86_Y	1.557	1.00
136_L	248_L	1.537	1.00
304_D	314_K	1.524	1.00
212_Q	216_L	1.507	1.00
21_L	25_A	1.506	1.00
13_A	16_T	1.475	1.00
201_G	207_V	1.466	1.00
130_L	134_K	1.456	1.00
82_Y	106_I	1.452	1.00
86_Y	90_A	1.447	1.00
88_T	138_R	1.444	1.00
115_F	127_A	1.425	1.00
87_S	91_E	1.416	1.00
156_D	222_R	1.394	1.00
74_E	105_Y	1.391	1.00
132_I	141_I	1.389	1.00
57_I	61_F	1.381	1.00
124_K	152_L	1.346	1.00
317_Q	320_D	1.345	1.00
84_W	87_S	1.333	1.00
105_Y	125_R	1.325	1.00
164_G	168_A	1.316	1.00
155_R	158_E	1.316	1.00
87_S	90_A	1.315	1.00
151_H	223_E	1.309	1.00
110_P	134_K	1.305	1.00
55_N	58_Q	1.296	1.00
116_A	126_I	1.287	1.00
143_A	241_L	1.270	1.00
191_G	194_G	1.267	1.00
26_L	30_V	1.265	1.00
32_D	35_F	1.256	1.00
147_H	223_E	1.248	1.00
92_V	149_L	1.244	1.00
203_I	207_V	1.241	1.00
314_K	318_L	1.238	1.00
16_T	19_I	1.238	1.00
183_F	186_G	1.225	1.00
154_H	229_N	1.217	1.00
142_M	237_G	1.213	1.00
148_E	223_E	1.202	1.00
17_L	21_L	1.202	1.00
20_T	24_F	1.199	1.00
182_L	186_G	1.174	1.00
189_G	192_N	1.166	1.00
133_L	141_I	1.155	1.00
201_G	205_M	1.151	1.00
83_G	87_S	1.143	1.00
110_P	130_L	1.141	1.00
20_T	28_L	1.139	1.00
98_F	149_L	1.131	1.00
16_T	24_F	1.124	1.00
154_H	225_Y	1.114	1.00
239_E	242_Q	1.111	1.00
221_M	225_Y	1.106	1.00
182_L	185_G	1.100	1.00
185_G	188_N	1.097	1.00
61_F	65_M	1.094	1.00
190_R	193_N	1.093	1.00
164_G	170_I	1.090	1.00
29_A	33_Y	1.085	1.00
67_N	115_F	1.084	1.00
147_H	151_H	1.081	1.00
20_T	23_G	1.078	1.00
182_L	187_G	1.073	1.00
144_V	244_A	1.065	1.00
143_A	240_N	1.065	1.00
160_L	222_R	1.065	1.00
77_P	86_Y	1.059	1.00
197_V	200_L	1.054	1.00
25_A	29_A	1.050	1.00
180_G	184_S	1.045	1.00
85_L	128_F	1.042	1.00
200_L	204_M	1.040	1.00
13_A	20_T	1.028	1.00
19_I	23_G	1.022	1.00
225_Y	229_N	1.020	1.00
241_L	319_L	1.013	1.00
48_L	52_F	1.013	1.00
164_G	167_P	1.012	1.00
44_I	48_L	1.010	1.00
181_G	184_S	1.010	1.00
196_L	199_L	1.007	1.00
180_G	183_F	1.005	1.00
61_F	64_Y	1.003	1.00
128_F	133_L	1.002	1.00
16_T	26_L	0.993	1.00
55_N	59_W	0.992	1.00
191_G	195_G	0.991	1.00
222_R	225_Y	0.990	1.00
175_W	178_F	0.985	1.00
223_E	226_A	0.983	1.00
238_K	241_L	0.975	1.00
132_I	136_L	0.975	1.00
17_L	24_F	0.974	1.00
139_D	243_L	0.972	1.00
179_W	182_L	0.970	1.00
87_S	138_R	0.969	1.00
214_L	218_L	0.968	1.00
126_I	145_A	0.964	1.00
24_F	31_A	0.957	1.00
216_L	308_D	0.948	0.99
20_T	32_D	0.943	0.99
240_N	243_L	0.940	0.99
119_S	123_G	0.939	0.99
128_F	132_I	0.939	0.99
188_N	192_N	0.938	0.99
148_E	151_H	0.937	0.99
91_E	94_K	0.934	0.99
28_L	32_D	0.934	0.99
47_I	172_Y	0.934	0.99
120_P	124_K	0.927	0.99
33_Y	37_A	0.924	0.99
189_G	194_G	0.923	0.99
270_A	274_F	0.921	0.99
29_A	32_D	0.917	0.99
203_I	206_A	0.907	0.99
188_N	191_G	0.905	0.99
43_L	47_I	0.895	0.99
313_A	317_Q	0.895	0.99
54_L	58_Q	0.894	0.99
75_V	106_I	0.892	0.99
30_V	33_Y	0.886	0.99
13_A	24_F	0.885	0.99
181_G	185_G	0.883	0.99
62_G	67_N	0.882	0.99
179_W	183_F	0.881	0.99
16_T	21_L	0.878	0.99
56_I	60_L	0.876	0.99
225_Y	228_V	0.875	0.99
60_L	119_S	0.875	0.99
312_P	316_I	0.873	0.99
79_D	83_G	0.871	0.99
165_L	169_L	0.869	0.99
183_F	187_G	0.868	0.99
16_T	27_A	0.868	0.99
82_Y	86_Y	0.867	0.99
93_A	101_V	0.864	0.99
15_A	19_I	0.860	0.99
147_H	226_A	0.860	0.99
248_L	252_M	0.857	0.99
52_F	165_L	0.856	0.99
23_G	27_A	0.846	0.99
77_P	83_G	0.845	0.99
63_P	103_K	0.832	0.99
107_A	127_A	0.831	0.99
112_P	251_S	0.829	0.99
159_L	222_R	0.828	0.99
15_A	23_G	0.822	0.99
92_V	145_A	0.819	0.98
31_A	35_F	0.819	0.98
15_A	24_F	0.817	0.98
93_A	149_L	0.814	0.98
241_L	245_L	0.813	0.98
216_L	307_M	0.812	0.98
159_L	225_Y	0.811	0.98
15_A	20_T	0.808	0.98
88_T	92_V	0.806	0.98
184_S	188_N	0.804	0.98
160_L	219_N	0.799	0.98
204_M	207_V	0.799	0.98
106_I	133_L	0.799	0.98
91_E	95_Y	0.797	0.98
112_P	135_L	0.796	0.98
183_F	188_N	0.794	0.98
165_L	168_A	0.791	0.98
82_Y	85_L	0.791	0.98
40_G	43_L	0.788	0.98
248_L	312_P	0.788	0.98
42_G	45_L	0.783	0.98
249_T	253_D	0.783	0.98
310_P	315_R	0.779	0.98
117_Y	157_V	0.775	0.98
62_G	115_F	0.774	0.98
256_A	259_R	0.773	0.98
102_P	222_R	0.773	0.98
17_L	29_A	0.772	0.98
157_V	161_M	0.772	0.98
242_Q	279_I	0.769	0.98
70_Y	107_A	0.768	0.98
174_G	178_F	0.765	0.98
316_I	320_D	0.764	0.98
20_T	35_F	0.764	0.98
13_A	19_I	0.760	0.98
98_F	153_K	0.753	0.97
255_E	258_E	0.753	0.97
20_T	26_L	0.752	0.97
175_W	179_W	0.752	0.97
199_L	206_A	0.752	0.97
70_Y	274_F	0.749	0.97
42_G	46_S	0.748	0.97
48_L	55_N	0.742	0.97
239_E	243_L	0.741	0.97
164_G	169_L	0.733	0.97
224_A	318_L	0.731	0.97
304_D	307_M	0.731	0.97
85_L	133_L	0.728	0.97
25_A	30_V	0.726	0.97
246_A	249_T	0.724	0.97
77_P	87_S	0.722	0.97
304_D	311_H	0.719	0.97
149_L	152_L	0.719	0.97
236_G	240_N	0.718	0.97
51_I	55_N	0.718	0.97
75_V	85_L	0.716	0.96
138_R	142_M	0.716	0.96
274_F	277_N	0.716	0.96
49_I	57_I	0.713	0.96
231_A	238_K	0.709	0.96
25_A	34_A	0.709	0.96
94_K	97_G	0.707	0.96
89_V	145_A	0.705	0.96
242_Q	316_I	0.704	0.96
153_K	232_L	0.703	0.96
20_T	31_A	0.703	0.96
243_L	247_K	0.694	0.96
95_Y	236_G	0.693	0.96
209_F	212_Q	0.693	0.96
14_L	17_L	0.691	0.96
248_L	276_T	0.689	0.96
251_S	254_P	0.689	0.96
163_V	218_L	0.685	0.95
20_T	25_A	0.685	0.95
18_G	25_A	0.684	0.95
242_Q	320_D	0.684	0.95
25_A	28_L	0.683	0.95
15_A	31_A	0.682	0.95
190_R	194_G	0.680	0.95
242_Q	246_A	0.680	0.95
136_L	247_K	0.678	0.95
102_P	156_D	0.676	0.95
16_T	29_A	0.674	0.95
47_I	171_Y	0.674	0.95
170_I	214_L	0.674	0.95
197_V	201_G	0.671	0.95
21_L	24_F	0.669	0.95
18_G	21_L	0.669	0.95
151_H	226_A	0.665	0.95
16_T	22_L	0.662	0.95
163_V	215_V	0.661	0.94
307_M	312_P	0.657	0.94
309_H	315_R	0.656	0.94
143_A	242_Q	0.653	0.94
25_A	33_Y	0.653	0.94
217_S	220_R	0.651	0.94
246_A	250_L	0.651	0.94
307_M	311_H	0.649	0.94
187_G	190_R	0.644	0.94
21_L	31_A	0.643	0.94
230_S	242_Q	0.643	0.94
168_A	172_Y	0.642	0.94
167_P	208_S	0.639	0.93
107_A	129_T	0.636	0.93
213_L	306_F	0.634	0.93
30_V	35_F	0.634	0.93
13_A	25_A	0.632	0.93
27_A	31_A	0.631	0.93
180_G	185_G	0.627	0.93
158_E	162_A	0.627	0.93
167_P	171_Y	0.626	0.93
180_G	186_G	0.624	0.93
93_A	98_F	0.623	0.93
16_T	31_A	0.619	0.92
26_L	31_A	0.617	0.92
303_A	314_K	0.616	0.92
116_A	124_K	0.611	0.92
113_N	147_H	0.610	0.92
22_L	29_A	0.610	0.92
243_L	246_A	0.610	0.92
178_F	181_G	0.607	0.92
167_P	170_I	0.607	0.92
22_L	26_L	0.606	0.92
247_K	250_L	0.605	0.91
189_G	193_N	0.605	0.91
276_T	312_P	0.604	0.91
63_P	66_I	0.604	0.91
93_A	100_E	0.602	0.91
24_F	27_A	0.600	0.91
261_K	264_S	0.599	0.91
36_G	39_F	0.599	0.91
59_W	120_P	0.595	0.91
200_L	205_M	0.594	0.91
303_A	307_M	0.592	0.91
142_M	146_G	0.589	0.90
71_R	108_D	0.589	0.90
142_M	240_N	0.588	0.90
16_T	25_A	0.587	0.90
75_V	82_Y	0.586	0.90
96_N	149_L	0.586	0.90
13_A	21_L	0.586	0.90
116_A	127_A	0.582	0.90
249_T	316_I	0.581	0.90
201_G	204_M	0.581	0.90
178_F	182_L	0.580	0.90
23_G	28_L	0.580	0.90
257_L	260_F	0.578	0.90
138_R	177_L	0.577	0.89
172_Y	175_W	0.573	0.89
111_F	248_L	0.573	0.89
136_L	144_V	0.572	0.89
16_T	23_G	0.572	0.89
101_V	104_V	0.571	0.89
117_Y	125_R	0.568	0.89
217_S	221_M	0.568	0.89
90_A	93_A	0.567	0.89
137_N	140_E	0.566	0.89
153_K	229_N	0.565	0.88
66_I	69_A	0.564	0.88
186_G	192_N	0.564	0.88
29_A	36_G	0.564	0.88
168_A	171_Y	0.560	0.88
182_L	188_N	0.560	0.88
16_T	35_F	0.557	0.88
126_I	149_L	0.557	0.88
67_N	72_T	0.555	0.88
208_S	211_F	0.554	0.87
111_F	252_M	0.553	0.87
154_H	222_R	0.552	0.87
29_A	35_F	0.550	0.87
177_L	181_G	0.546	0.87
180_G	187_G	0.544	0.87
173_L	177_L	0.543	0.86
167_P	215_V	0.543	0.86
198_F	202_I	0.543	0.86
162_A	166_I	0.542	0.86
252_M	255_E	0.542	0.86
89_V	96_N	0.537	0.86
67_N	117_Y	0.536	0.86
16_T	32_D	0.536	0.86
198_F	201_G	0.535	0.86
93_A	97_G	0.535	0.86
67_N	125_R	0.534	0.86
75_V	86_Y	0.534	0.86
269_M	272_M	0.533	0.85
97_G	100_E	0.532	0.85
193_N	196_L	0.532	0.85
230_S	241_L	0.531	0.85
51_I	59_W	0.531	0.85
85_L	104_V	0.530	0.85
230_S	236_G	0.530	0.85
238_K	242_Q	0.529	0.85
256_A	260_F	0.528	0.85
224_A	274_F	0.525	0.85
241_L	244_A	0.524	0.84
204_M	208_S	0.524	0.84
128_F	152_L	0.523	0.84
272_M	275_F	0.523	0.84
19_I	31_A	0.523	0.84
25_A	32_D	0.519	0.84
270_A	273_L	0.519	0.84
118_G	152_L	0.519	0.84
136_L	141_I	0.518	0.84
202_I	207_V	0.517	0.84
160_L	163_V	0.516	0.84
211_F	214_L	0.516	0.84
188_N	193_N	0.516	0.84
160_L	171_Y	0.514	0.83
40_G	46_S	0.511	0.83
17_L	22_L	0.509	0.83
259_R	263_K	0.509	0.83
89_V	142_M	0.509	0.83
76_T	86_Y	0.506	0.82
143_A	245_L	0.505	0.82
165_L	170_I	0.504	0.82
137_N	143_A	0.504	0.82
13_A	27_A	0.504	0.82
67_N	73_V	0.502	0.82
179_W	184_S	0.501	0.82
302_Y	314_K	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4il3A	1	0.84	100	0.269	Contact Map
4aw6A	2	0.84	100	0.279	Contact Map
3c37A	1	0.5877	100	0.533	Contact Map
3cqbA	4	0.3231	99.9	0.662	Contact Map
4qhjA	2	0.3138	97.5	0.873	Contact Map
4jiuA	1	0.3108	95.8	0.896	Contact Map
4jixA	2	0.3323	95.7	0.898	Contact Map
3dteA	2	0.5723	91.4	0.914	Contact Map
4i0uA	4	0.1785	16	0.954	Contact Map
4ev6A	3	0.1969	12.7	0.956	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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