GREMLIN Database
HTPX2 - Protease HtpX homolog 2
UniProt: Q97TZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (278)
Sequences: 4715 (3480)
Seq/√Len: 208.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_A320_D5.0511.00
91_E142_M4.3911.00
108_D130_L4.3801.00
150_G229_N4.2681.00
140_E247_K4.1211.00
77_P90_A3.7491.00
139_D237_G3.4281.00
146_G230_S3.1671.00
84_W138_R3.1571.00
224_A314_K2.9521.00
120_P123_G2.8701.00
128_F145_A2.8391.00
228_V232_L2.5571.00
86_Y101_V2.5111.00
49_I53_F2.4491.00
249_T313_A2.4461.00
314_K317_Q2.4011.00
72_T105_Y2.3851.00
76_T79_D2.3711.00
88_T142_M2.2851.00
246_A316_I2.1511.00
139_D240_N2.1481.00
74_E103_K2.1221.00
140_E243_L2.0981.00
73_V79_D1.9981.00
90_A94_K1.9771.00
192_N195_G1.9551.00
156_D225_Y1.9111.00
231_A319_L1.8961.00
137_N243_L1.8861.00
137_N247_K1.8841.00
184_S187_G1.8671.00
13_A17_L1.8621.00
237_G240_N1.8601.00
73_V108_D1.8331.00
53_F57_I1.8121.00
17_L20_T1.7991.00
311_H314_K1.7851.00
90_A101_V1.7551.00
135_L251_S1.7401.00
64_Y68_W1.6621.00
239_E320_D1.6391.00
16_T20_T1.6311.00
89_V104_V1.6271.00
24_F28_L1.6201.00
19_I24_F1.6171.00
249_T312_P1.5931.00
174_G177_L1.5721.00
83_G86_Y1.5571.00
136_L248_L1.5371.00
304_D314_K1.5241.00
212_Q216_L1.5071.00
21_L25_A1.5061.00
13_A16_T1.4751.00
201_G207_V1.4661.00
130_L134_K1.4561.00
82_Y106_I1.4521.00
86_Y90_A1.4471.00
88_T138_R1.4441.00
115_F127_A1.4251.00
87_S91_E1.4161.00
156_D222_R1.3941.00
74_E105_Y1.3911.00
132_I141_I1.3891.00
57_I61_F1.3811.00
124_K152_L1.3461.00
317_Q320_D1.3451.00
84_W87_S1.3331.00
105_Y125_R1.3251.00
164_G168_A1.3161.00
155_R158_E1.3161.00
87_S90_A1.3151.00
151_H223_E1.3091.00
110_P134_K1.3051.00
55_N58_Q1.2961.00
116_A126_I1.2871.00
143_A241_L1.2701.00
191_G194_G1.2671.00
26_L30_V1.2651.00
32_D35_F1.2561.00
147_H223_E1.2481.00
92_V149_L1.2441.00
203_I207_V1.2411.00
314_K318_L1.2381.00
16_T19_I1.2381.00
183_F186_G1.2251.00
154_H229_N1.2171.00
142_M237_G1.2131.00
148_E223_E1.2021.00
17_L21_L1.2021.00
20_T24_F1.1991.00
182_L186_G1.1741.00
189_G192_N1.1661.00
133_L141_I1.1551.00
201_G205_M1.1511.00
83_G87_S1.1431.00
110_P130_L1.1411.00
20_T28_L1.1391.00
98_F149_L1.1311.00
16_T24_F1.1241.00
154_H225_Y1.1141.00
239_E242_Q1.1111.00
221_M225_Y1.1061.00
182_L185_G1.1001.00
185_G188_N1.0971.00
61_F65_M1.0941.00
190_R193_N1.0931.00
164_G170_I1.0901.00
29_A33_Y1.0851.00
67_N115_F1.0841.00
147_H151_H1.0811.00
20_T23_G1.0781.00
182_L187_G1.0731.00
144_V244_A1.0651.00
143_A240_N1.0651.00
160_L222_R1.0651.00
77_P86_Y1.0591.00
197_V200_L1.0541.00
25_A29_A1.0501.00
180_G184_S1.0451.00
85_L128_F1.0421.00
200_L204_M1.0401.00
13_A20_T1.0281.00
19_I23_G1.0221.00
225_Y229_N1.0201.00
241_L319_L1.0131.00
48_L52_F1.0131.00
164_G167_P1.0121.00
44_I48_L1.0101.00
181_G184_S1.0101.00
196_L199_L1.0071.00
180_G183_F1.0051.00
61_F64_Y1.0031.00
128_F133_L1.0021.00
16_T26_L0.9931.00
55_N59_W0.9921.00
191_G195_G0.9911.00
222_R225_Y0.9901.00
175_W178_F0.9851.00
223_E226_A0.9831.00
238_K241_L0.9751.00
132_I136_L0.9751.00
17_L24_F0.9741.00
139_D243_L0.9721.00
179_W182_L0.9701.00
87_S138_R0.9691.00
214_L218_L0.9681.00
126_I145_A0.9641.00
24_F31_A0.9571.00
216_L308_D0.9480.99
20_T32_D0.9430.99
240_N243_L0.9400.99
119_S123_G0.9390.99
128_F132_I0.9390.99
188_N192_N0.9380.99
148_E151_H0.9370.99
91_E94_K0.9340.99
28_L32_D0.9340.99
47_I172_Y0.9340.99
120_P124_K0.9270.99
33_Y37_A0.9240.99
189_G194_G0.9230.99
270_A274_F0.9210.99
29_A32_D0.9170.99
203_I206_A0.9070.99
188_N191_G0.9050.99
43_L47_I0.8950.99
313_A317_Q0.8950.99
54_L58_Q0.8940.99
75_V106_I0.8920.99
30_V33_Y0.8860.99
13_A24_F0.8850.99
181_G185_G0.8830.99
62_G67_N0.8820.99
179_W183_F0.8810.99
16_T21_L0.8780.99
56_I60_L0.8760.99
225_Y228_V0.8750.99
60_L119_S0.8750.99
312_P316_I0.8730.99
79_D83_G0.8710.99
165_L169_L0.8690.99
183_F187_G0.8680.99
16_T27_A0.8680.99
82_Y86_Y0.8670.99
93_A101_V0.8640.99
15_A19_I0.8600.99
147_H226_A0.8600.99
248_L252_M0.8570.99
52_F165_L0.8560.99
23_G27_A0.8460.99
77_P83_G0.8450.99
63_P103_K0.8320.99
107_A127_A0.8310.99
112_P251_S0.8290.99
159_L222_R0.8280.99
15_A23_G0.8220.99
92_V145_A0.8190.98
31_A35_F0.8190.98
15_A24_F0.8170.98
93_A149_L0.8140.98
241_L245_L0.8130.98
216_L307_M0.8120.98
159_L225_Y0.8110.98
15_A20_T0.8080.98
88_T92_V0.8060.98
184_S188_N0.8040.98
160_L219_N0.7990.98
204_M207_V0.7990.98
106_I133_L0.7990.98
91_E95_Y0.7970.98
112_P135_L0.7960.98
183_F188_N0.7940.98
165_L168_A0.7910.98
82_Y85_L0.7910.98
40_G43_L0.7880.98
248_L312_P0.7880.98
42_G45_L0.7830.98
249_T253_D0.7830.98
310_P315_R0.7790.98
117_Y157_V0.7750.98
62_G115_F0.7740.98
256_A259_R0.7730.98
102_P222_R0.7730.98
17_L29_A0.7720.98
157_V161_M0.7720.98
242_Q279_I0.7690.98
70_Y107_A0.7680.98
174_G178_F0.7650.98
316_I320_D0.7640.98
20_T35_F0.7640.98
13_A19_I0.7600.98
98_F153_K0.7530.97
255_E258_E0.7530.97
20_T26_L0.7520.97
175_W179_W0.7520.97
199_L206_A0.7520.97
70_Y274_F0.7490.97
42_G46_S0.7480.97
48_L55_N0.7420.97
239_E243_L0.7410.97
164_G169_L0.7330.97
224_A318_L0.7310.97
304_D307_M0.7310.97
85_L133_L0.7280.97
25_A30_V0.7260.97
246_A249_T0.7240.97
77_P87_S0.7220.97
304_D311_H0.7190.97
149_L152_L0.7190.97
236_G240_N0.7180.97
51_I55_N0.7180.97
75_V85_L0.7160.96
138_R142_M0.7160.96
274_F277_N0.7160.96
49_I57_I0.7130.96
231_A238_K0.7090.96
25_A34_A0.7090.96
94_K97_G0.7070.96
89_V145_A0.7050.96
242_Q316_I0.7040.96
153_K232_L0.7030.96
20_T31_A0.7030.96
243_L247_K0.6940.96
95_Y236_G0.6930.96
209_F212_Q0.6930.96
14_L17_L0.6910.96
248_L276_T0.6890.96
251_S254_P0.6890.96
163_V218_L0.6850.95
20_T25_A0.6850.95
18_G25_A0.6840.95
242_Q320_D0.6840.95
25_A28_L0.6830.95
15_A31_A0.6820.95
190_R194_G0.6800.95
242_Q246_A0.6800.95
136_L247_K0.6780.95
102_P156_D0.6760.95
16_T29_A0.6740.95
47_I171_Y0.6740.95
170_I214_L0.6740.95
197_V201_G0.6710.95
21_L24_F0.6690.95
18_G21_L0.6690.95
151_H226_A0.6650.95
16_T22_L0.6620.95
163_V215_V0.6610.94
307_M312_P0.6570.94
309_H315_R0.6560.94
143_A242_Q0.6530.94
25_A33_Y0.6530.94
217_S220_R0.6510.94
246_A250_L0.6510.94
307_M311_H0.6490.94
187_G190_R0.6440.94
21_L31_A0.6430.94
230_S242_Q0.6430.94
168_A172_Y0.6420.94
167_P208_S0.6390.93
107_A129_T0.6360.93
213_L306_F0.6340.93
30_V35_F0.6340.93
13_A25_A0.6320.93
27_A31_A0.6310.93
180_G185_G0.6270.93
158_E162_A0.6270.93
167_P171_Y0.6260.93
180_G186_G0.6240.93
93_A98_F0.6230.93
16_T31_A0.6190.92
26_L31_A0.6170.92
303_A314_K0.6160.92
116_A124_K0.6110.92
113_N147_H0.6100.92
22_L29_A0.6100.92
243_L246_A0.6100.92
178_F181_G0.6070.92
167_P170_I0.6070.92
22_L26_L0.6060.92
247_K250_L0.6050.91
189_G193_N0.6050.91
276_T312_P0.6040.91
63_P66_I0.6040.91
93_A100_E0.6020.91
24_F27_A0.6000.91
261_K264_S0.5990.91
36_G39_F0.5990.91
59_W120_P0.5950.91
200_L205_M0.5940.91
303_A307_M0.5920.91
142_M146_G0.5890.90
71_R108_D0.5890.90
142_M240_N0.5880.90
16_T25_A0.5870.90
75_V82_Y0.5860.90
96_N149_L0.5860.90
13_A21_L0.5860.90
116_A127_A0.5820.90
249_T316_I0.5810.90
201_G204_M0.5810.90
178_F182_L0.5800.90
23_G28_L0.5800.90
257_L260_F0.5780.90
138_R177_L0.5770.89
172_Y175_W0.5730.89
111_F248_L0.5730.89
136_L144_V0.5720.89
16_T23_G0.5720.89
101_V104_V0.5710.89
117_Y125_R0.5680.89
217_S221_M0.5680.89
90_A93_A0.5670.89
137_N140_E0.5660.89
153_K229_N0.5650.88
66_I69_A0.5640.88
186_G192_N0.5640.88
29_A36_G0.5640.88
168_A171_Y0.5600.88
182_L188_N0.5600.88
16_T35_F0.5570.88
126_I149_L0.5570.88
67_N72_T0.5550.88
208_S211_F0.5540.87
111_F252_M0.5530.87
154_H222_R0.5520.87
29_A35_F0.5500.87
177_L181_G0.5460.87
180_G187_G0.5440.87
173_L177_L0.5430.86
167_P215_V0.5430.86
198_F202_I0.5430.86
162_A166_I0.5420.86
252_M255_E0.5420.86
89_V96_N0.5370.86
67_N117_Y0.5360.86
16_T32_D0.5360.86
198_F201_G0.5350.86
93_A97_G0.5350.86
67_N125_R0.5340.86
75_V86_Y0.5340.86
269_M272_M0.5330.85
97_G100_E0.5320.85
193_N196_L0.5320.85
230_S241_L0.5310.85
51_I59_W0.5310.85
85_L104_V0.5300.85
230_S236_G0.5300.85
238_K242_Q0.5290.85
256_A260_F0.5280.85
224_A274_F0.5250.85
241_L244_A0.5240.84
204_M208_S0.5240.84
128_F152_L0.5230.84
272_M275_F0.5230.84
19_I31_A0.5230.84
25_A32_D0.5190.84
270_A273_L0.5190.84
118_G152_L0.5190.84
136_L141_I0.5180.84
202_I207_V0.5170.84
160_L163_V0.5160.84
211_F214_L0.5160.84
188_N193_N0.5160.84
160_L171_Y0.5140.83
40_G46_S0.5110.83
17_L22_L0.5090.83
259_R263_K0.5090.83
89_V142_M0.5090.83
76_T86_Y0.5060.82
143_A245_L0.5050.82
165_L170_I0.5040.82
137_N143_A0.5040.82
13_A27_A0.5040.82
67_N73_V0.5020.82
179_W184_S0.5010.82
302_Y314_K0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il3A 1 0.84 100 0.269 Contact Map
4aw6A 2 0.84 100 0.279 Contact Map
3c37A 1 0.5877 100 0.533 Contact Map
3cqbA 4 0.3231 99.9 0.662 Contact Map
4qhjA 2 0.3138 97.5 0.873 Contact Map
4jiuA 1 0.3108 95.8 0.896 Contact Map
4jixA 2 0.3323 95.7 0.898 Contact Map
3dteA 2 0.5723 91.4 0.914 Contact Map
4i0uA 4 0.1785 16 0.954 Contact Map
4ev6A 3 0.1969 12.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0131 seconds.