GREMLIN Database
GUAAB - GMP synthase [glutamine-hydrolyzing] subunit B
UniProt: Q97TZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (358)
Sequences: 131 (109)
Seq/√Len: 5.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
294_D301_T3.8770.92
16_R111_T3.8250.91
28_V78_L3.7180.90
327_Y358_S3.6170.88
294_D297_H3.4900.86
297_H301_T3.4410.85
283_V290_L3.1930.81
294_D299_L3.1490.80
296_T301_T2.7600.70
91_I103_R2.7600.70
39_V183_L2.7450.69
110_S150_I2.6640.67
151_G156_K2.5670.64
146_V156_K2.5080.62
131_A134_V2.5080.62
208_R217_A2.5050.62
296_T299_L2.4790.61
104_F199_L2.4600.60
11_I169_L2.4340.59
146_V151_G2.4200.59
315_R324_T2.3610.57
317_V364_I2.3490.56
317_V325_A2.3460.56
294_D304_E2.3140.55
53_L64_A2.2550.53
262_V265_D2.2490.53
61_K183_L2.2490.53
168_D177_L2.1160.48
115_L118_K2.0270.45
201_R365_E1.9950.44
16_R84_K1.9910.44
109_Y150_I1.9480.43
315_R323_M1.9120.41
325_A364_I1.9090.41
283_V289_T1.8710.40
92_E221_V1.8490.39
16_R177_L1.8310.39
28_V163_I1.8220.38
154_T157_E1.7510.36
130_A133_W1.7440.36
52_V138_G1.7280.35
283_V293_Y1.7280.35
61_K216_E1.7140.35
214_V217_A1.7130.35
299_L302_L1.7010.34
46_G96_D1.6940.34
191_Q313_A1.6920.34
118_K220_I1.6710.34
9_E16_R1.6670.33
327_Y332_K1.6550.33
315_R321_D1.6500.33
322_F365_E1.6330.32
355_D361_P1.6310.32
355_D360_P1.6310.32
355_D363_T1.6310.32
359_K363_T1.6310.32
360_P363_T1.6310.32
355_D359_K1.6310.32
301_T304_E1.6210.32
97_A105_R1.6150.32
319_T322_F1.6020.31
42_Y72_S1.5990.31
59_L64_A1.5980.31
15_L40_L1.5820.31
221_V273_A1.5810.31
297_H302_L1.5650.30
68_K78_L1.5510.30
255_Y263_K1.5440.30
322_F325_A1.5440.30
299_L304_E1.5160.29
284_K291_V1.4840.28
98_E201_R1.4660.28
2_F259_A1.4660.28
296_T304_E1.4620.27
125_M200_V1.4520.27
106_E138_G1.4460.27
26_A125_M1.4400.27
322_F364_I1.4400.27
18_K163_I1.4390.27
235_A238_F1.4230.26
255_Y261_G1.4210.26
25_L129_I1.3990.26
121_A161_T1.3960.26
133_W170_Y1.3960.26
14_Q26_A1.3930.26
363_T367_E1.3900.25
355_D367_E1.3900.25
360_P367_E1.3900.25
361_P367_E1.3900.25
359_K367_E1.3900.25
261_G265_D1.3870.25
17_Q84_K1.3870.25
71_L201_R1.3860.25
105_R136_T1.3710.25
169_L191_Q1.3680.25
111_T188_S1.3660.25
297_H303_D1.3560.25
32_V40_L1.3540.25
125_M177_L1.3540.25
157_E345_K1.3430.24
22_E167_A1.3290.24
130_A170_Y1.3200.24
310_Y322_F1.3160.24
298_V339_S1.3130.23
27_A187_I1.3110.23
136_T143_Q1.2980.23
68_K80_I1.2840.23
311_S315_R1.2820.23
2_F123_Y1.2760.23
130_A146_V1.2750.23
332_K336_S1.2710.22
52_V115_L1.2680.22
114_S163_I1.2650.22
133_W364_I1.2640.22
28_V177_L1.2640.22
202_A353_L1.2540.22
261_G264_G1.2510.22
59_L200_V1.2510.22
129_I133_W1.2330.22
294_D300_C1.2270.21
25_L200_V1.2190.21
143_Q155_E1.2160.21
2_F319_T1.2100.21
296_T365_E1.1940.21
213_V216_E1.1850.20
296_T322_F1.1820.20
315_R360_P1.1760.20
315_R359_K1.1760.20
315_R361_P1.1760.20
315_R363_T1.1760.20
315_R355_D1.1760.20
313_A316_A1.1730.20
16_R247_L1.1730.20
81_V109_Y1.1690.20
297_H304_E1.1620.20
252_A258_R1.1580.20
97_A136_T1.1560.20
136_T260_T1.1540.20
357_T361_P1.1480.20
357_T363_T1.1480.20
357_T360_P1.1480.20
261_G269_Y1.1410.19
257_A272_I1.1330.19
105_R260_T1.1280.19
301_T306_N1.1270.19
294_D302_L1.1260.19
283_V291_V1.1260.19
52_V186_E1.1240.19
357_T365_E1.1190.19
52_V65_E1.1190.19
334_I356_V1.1170.19
321_D324_T1.1120.19
2_F161_T1.1100.19
67_I80_I1.1020.19
17_Q47_D1.0990.19
5_A168_D1.0920.18
179_R189_E1.0820.18
17_Q22_E1.0810.18
356_V362_A1.0770.18
161_T225_L1.0720.18
179_R186_E1.0700.18
105_R143_Q1.0660.18
102_K183_L1.0630.18
303_D353_L1.0620.18
278_S330_I1.0610.18
312_V321_D1.0560.18
261_G267_R1.0550.18
212_E226_D1.0540.18
72_S258_R1.0460.17
216_E235_A1.0430.17
230_Y258_R1.0380.17
7_F325_A1.0370.17
2_F189_E1.0350.17
94_I103_R1.0330.17
154_T158_W1.0290.17
283_V287_I1.0270.17
24_V347_P1.0220.17
23_K59_L1.0200.17
260_T263_K1.0150.17
133_W146_V1.0090.17
141_K144_H1.0080.17
140_I144_H1.0080.17
74_I162_L1.0050.17
314_I323_M1.0010.17
82_D312_V0.9970.17
289_T293_Y0.9940.16
133_W322_F0.9930.16
323_M359_K0.9920.16
323_M363_T0.9920.16
323_M361_P0.9920.16
323_M360_P0.9920.16
323_M355_D0.9920.16
123_Y313_A0.9880.16
12_G15_L0.9860.16
71_L87_F0.9840.16
341_E345_K0.9830.16
56_T88_I0.9810.16
255_Y260_T0.9760.16
212_E216_E0.9750.16
92_E285_N0.9690.16
65_E243_N0.9690.16
299_L303_D0.9680.16
322_F357_T0.9650.16
97_A104_F0.9630.16
361_P365_E0.9610.16
355_D365_E0.9610.16
359_K365_E0.9610.16
360_P365_E0.9610.16
35_T122_R0.9540.16
63_E87_F0.9520.16
98_E365_E0.9450.16
148_V177_L0.9440.16
48_K216_E0.9430.16
294_D306_N0.9370.15
27_A201_R0.9370.15
317_V362_A0.9350.15
167_A330_I0.9330.15
176_E216_E0.9330.15
113_S282_N0.9310.15
28_V200_V0.9290.15
13_P148_V0.9270.15
16_R282_N0.9230.15
79_I275_I0.9210.15
71_L365_E0.9190.15
65_E268_A0.9190.15
315_R322_F0.9170.15
296_T302_L0.9160.15
321_D328_V0.9120.15
169_L302_L0.9120.15
173_E183_L0.9110.15
242_G248_D0.9110.15
158_W284_K0.9100.15
69_D139_G0.9090.15
315_R367_E0.9070.15
18_K275_I0.9050.15
240_S243_N0.9030.15
170_Y325_A0.9030.15
97_A260_T0.9020.15
3_D151_G0.9020.15
11_I191_Q0.8980.15
5_A189_E0.8960.15
357_T367_E0.8950.15
154_T252_A0.8930.15
4_P150_I0.8910.15
140_I145_N0.8900.15
141_K145_N0.8900.15
114_S250_I0.8870.15
84_K88_I0.8870.15
96_D109_Y0.8860.14
324_T361_P0.8700.14
324_T360_P0.8700.14
324_T363_T0.8700.14
324_T355_D0.8700.14
324_T359_K0.8700.14
7_F170_Y0.8690.14
282_N354_Y0.8680.14
207_T235_A0.8620.14
303_D321_D0.8560.14
200_V281_N0.8520.14
146_V364_I0.8510.14
143_Q260_T0.8510.14
256_K260_T0.8480.14
297_H349_V0.8460.14
264_G267_R0.8450.14
20_G102_K0.8450.14
49_V54_V0.8410.14
97_A143_Q0.8390.14
89_S316_A0.8360.14
104_F136_T0.8330.14
109_Y147_L0.8300.14
331_P334_I0.8240.13
314_I324_T0.8220.13
19_L28_V0.8210.13
98_E364_I0.8200.13
91_I98_E0.8190.13
134_V172_N0.8190.13
129_I364_I0.8190.13
95_D242_G0.8150.13
147_L151_G0.8060.13
16_R120_N0.8060.13
203_V215_R0.8040.13
42_Y163_I0.8040.13
310_Y314_I0.8030.13
62_N224_Y0.8020.13
208_R214_V0.7990.13
146_V362_A0.7980.13
300_C306_N0.7970.13
121_A259_A0.7970.13
140_I143_Q0.7960.13
62_N251_D0.7950.13
43_N73_N0.7940.13
123_Y342_I0.7920.13
226_D242_G0.7920.13
42_Y47_D0.7900.13
312_V336_S0.7890.13
296_T300_C0.7890.13
303_D351_E0.7890.13
130_A147_L0.7850.13
232_Q258_R0.7840.13
350_K353_L0.7830.13
239_E306_N0.7800.13
61_K235_A0.7760.13
114_S216_E0.7680.13
245_V285_N0.7670.13
93_G169_L0.7650.13
264_G269_Y0.7640.13
16_R122_R0.7640.13
43_N309_K0.7630.13
296_T314_I0.7620.12
203_V254_L0.7610.12
30_G33_D0.7580.12
31_G34_S0.7580.12
29_S33_D0.7580.12
30_G34_S0.7580.12
29_S34_S0.7580.12
75_L268_A0.7500.12
97_A256_K0.7490.12
219_D273_A0.7480.12
39_V51_P0.7480.12
82_D186_E0.7460.12
10_E274_K0.7460.12
256_K262_V0.7420.12
17_Q330_I0.7420.12
37_A170_Y0.7410.12
147_L316_A0.7400.12
2_F130_A0.7380.12
47_D228_F0.7360.12
58_F63_E0.7360.12
203_V228_F0.7340.12
16_R35_T0.7300.12
256_K263_K0.7290.12
21_N273_A0.7290.12
50_I254_L0.7230.12
45_L113_S0.7200.12
250_I277_C0.7200.12
90_E245_V0.7200.12
43_N273_A0.7200.12
42_Y79_I0.7190.12
131_A172_N0.7190.12
114_S235_A0.7190.12
304_E307_S0.7180.12
9_E89_S0.7170.12
314_I322_F0.7070.12
72_S89_S0.7070.12
332_K339_S0.7060.12
163_I224_Y0.7060.12
235_A241_Y0.7060.12
147_L156_K0.7000.12
323_M367_E0.6970.12
65_E239_E0.6960.12
73_N79_I0.6940.11
136_T178_A0.6940.11
43_N50_I0.6930.11
314_I318_T0.6930.11
362_A365_E0.6910.11
252_A288_D0.6910.11
39_V52_V0.6900.11
265_D269_Y0.6890.11
303_D348_N0.6890.11
90_E259_A0.6870.11
9_E22_E0.6850.11
240_S244_L0.6820.11
62_N226_D0.6810.11
2_F6_S0.6810.11
143_Q316_A0.6800.11
77_N118_K0.6800.11
3_D8_V0.6790.11
18_K28_V0.6770.11
124_L183_L0.6760.11
151_G155_E0.6750.11
10_E120_N0.6740.11
115_L200_V0.6710.11
79_I106_E0.6700.11
177_L268_A0.6690.11
115_L353_L0.6670.11
83_K99_M0.6660.11
105_R178_A0.6650.11
66_K358_S0.6610.11
297_H314_I0.6610.11
315_R325_A0.6590.11
169_L301_T0.6570.11
7_F130_A0.6550.11
69_D117_K0.6540.11
241_Y313_A0.6530.11
316_A366_F0.6520.11
59_L65_E0.6500.11
50_I122_R0.6500.11
169_L294_D0.6480.11
80_I122_R0.6460.11
48_K61_K0.6430.11
72_S229_N0.6420.11
68_K74_I0.6400.11
49_V244_L0.6380.11
292_K358_S0.6330.11
242_G246_N0.6300.11
53_L56_T0.6290.11
150_I155_E0.6290.11
178_A188_S0.6280.11
215_R227_P0.6280.11
222_E231_S0.6260.11
315_R357_T0.6250.11
129_I322_F0.6250.11
38_A98_E0.6230.11
96_D106_E0.6210.11
262_V269_Y0.6200.10
118_K352_V0.6200.10
22_E46_G0.6200.10
290_L293_Y0.6180.10
179_R185_K0.6170.10
226_D252_A0.6150.10
163_I211_L0.6150.10
82_D189_E0.6120.10
28_V47_D0.6120.10
49_V258_R0.6100.10
21_N95_D0.6090.10
157_E259_A0.6080.10
200_V205_K0.6060.10
121_A155_E0.6050.10
254_L347_P0.6040.10
200_V259_A0.6000.10
129_I170_Y0.5970.10
47_D278_S0.5960.10
162_L188_S0.5960.10
294_D303_D0.5950.10
213_V217_A0.5940.10
52_V96_D0.5940.10
113_S138_G0.5910.10
26_A88_I0.5900.10
324_T367_E0.5900.10
21_N239_E0.5900.10
306_N349_V0.5890.10
5_A16_R0.5890.10
65_E279_N0.5890.10
59_L63_E0.5880.10
146_V170_Y0.5880.10
128_T196_P0.5870.10
128_T197_G0.5870.10
25_L56_T0.5870.10
239_E258_R0.5830.10
322_F351_E0.5820.10
73_N77_N0.5810.10
139_G154_T0.5800.10
46_G223_K0.5800.10
3_D20_G0.5800.10
8_V151_G0.5790.10
62_N218_N0.5790.10
86_T225_L0.5780.10
170_Y327_Y0.5740.10
104_F260_T0.5730.10
330_I347_P0.5720.10
28_V244_L0.5720.10
70_Y253_F0.5710.10
212_E279_N0.5710.10
107_L258_R0.5700.10
330_I339_S0.5700.10
26_A107_L0.5700.10
180_Y203_V0.5680.10
9_E279_N0.5670.10
136_T256_K0.5670.10
74_I106_E0.5660.10
201_R364_I0.5650.10
71_L98_E0.5650.10
296_T323_M0.5650.10
259_A327_Y0.5640.10
307_S321_D0.5620.10
249_G259_A0.5620.10
78_L225_L0.5620.10
50_I77_N0.5620.10
220_I250_I0.5620.10
125_M266_V0.5610.10
313_A366_F0.5610.10
167_A191_Q0.5610.10
110_S157_E0.5610.10
204_G263_K0.5610.10
317_V322_F0.5580.10
91_I201_R0.5580.10
259_A319_T0.5570.10
301_T335_L0.5550.10
200_V291_V0.5520.10
212_E223_K0.5490.10
297_H323_M0.5490.10
259_A272_I0.5480.10
216_E223_K0.5470.10
130_A151_G0.5470.10
7_F25_L0.5460.10
27_A365_E0.5450.10
99_M117_K0.5440.10
82_D302_L0.5440.10
348_N353_L0.5420.10
163_I243_N0.5410.10
112_I162_L0.5400.09
162_L271_N0.5400.09
11_I56_T0.5390.09
297_H300_C0.5390.09
56_T263_K0.5380.09
14_Q221_V0.5380.09
301_T307_S0.5370.09
104_F151_G0.5360.09
329_R341_E0.5340.09
105_R256_K0.5340.09
84_K290_L0.5300.09
74_I279_N0.5300.09
125_M163_I0.5290.09
356_V366_F0.5280.09
46_G250_I0.5280.09
48_K114_S0.5270.09
311_S321_D0.5270.09
241_Y245_V0.5250.09
25_L125_M0.5250.09
17_Q43_N0.5240.09
52_V78_L0.5230.09
296_T303_D0.5230.09
61_K266_V0.5220.09
7_F133_W0.5220.09
227_P233_Y0.5200.09
74_I233_Y0.5190.09
47_D72_S0.5180.09
72_S275_I0.5180.09
150_I158_W0.5180.09
52_V69_D0.5170.09
98_E108_F0.5150.09
163_I186_E0.5150.09
130_A319_T0.5140.09
169_L325_A0.5140.09
109_Y316_A0.5140.09
75_L80_I0.5080.09
245_V253_F0.5070.09
7_F37_A0.5070.09
227_P235_A0.5070.09
35_T121_A0.5050.09
303_D307_S0.5050.09
321_D355_D0.5010.09
321_D359_K0.5010.09
321_D361_P0.5010.09
321_D363_T0.5010.09
321_D360_P0.5010.09
221_V282_N0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vxoA 2 0.9891 100 0.431 Contact Map
3uowA 2 0.7793 100 0.506 Contact Map
1gpmA 3 0.8038 100 0.512 Contact Map
3tqiA 3 0.7493 100 0.519 Contact Map
2ywbA 4 0.782 100 0.521 Contact Map
2dplA 2 0.7793 100 0.54 Contact Map
1xngA 2 0.6594 99.9 0.847 Contact Map
3sdbA 6 0.7357 99.9 0.851 Contact Map
4f4hA 2 0.6621 99.9 0.851 Contact Map
3n05A 2 0.6403 99.9 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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