GREMLIN Database
Q97TZ7 - Probable cobyric acid synthase
UniProt: Q97TZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 465 (453)
Sequences: 2216 (1459)
Seq/√Len: 68.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_G450_L4.5941.00
66_Y110_Q4.5351.00
193_N197_K4.0401.00
144_R176_N3.7581.00
43_W62_R3.3381.00
319_K342_D3.0161.00
320_K344_N2.9651.00
320_K334_E2.9541.00
285_L335_Y2.9061.00
317_L405_I2.8011.00
211_L450_L2.7721.00
9_M12_S2.7421.00
181_I454_L2.7091.00
242_Y278_L2.6721.00
48_I53_A2.6301.00
141_K172_S2.6181.00
214_F449_F2.6121.00
141_K176_N2.5671.00
322_V334_E2.5481.00
190_K193_N2.5271.00
236_E262_S2.5061.00
151_L158_A2.4451.00
292_V297_V2.4181.00
275_L422_L2.3721.00
127_P198_W2.3261.00
84_M107_K2.3021.00
236_E260_R2.3021.00
163_Y202_K2.2751.00
167_M202_K2.2271.00
17_I211_L2.2261.00
256_K420_K2.2201.00
322_V344_N2.2121.00
130_I173_V2.2051.00
141_K173_V2.2031.00
342_D378_M2.1581.00
343_I375_I2.1291.00
276_V300_L2.1241.00
130_I170_P2.1001.00
94_N190_K2.0961.00
451_R460_V2.0551.00
54_Y219_I2.0511.00
253_A415_F2.0491.00
5_V150_V2.0341.00
62_R355_M2.0131.00
26_N114_N2.0061.00
6_A147_A2.0021.00
54_Y443_A1.9971.00
238_A264_V1.9751.00
40_I53_A1.9621.00
243_P290_W1.9571.00
6_A137_I1.9521.00
103_K106_K1.9501.00
21_L25_L1.9411.00
171_Q175_E1.9321.00
197_K201_E1.9251.00
108_V112_L1.9121.00
322_V346_H1.9111.00
198_W202_K1.8861.00
238_A273_A1.8831.00
236_E273_A1.8781.00
308_L414_L1.8751.00
291_L300_L1.8701.00
356_T410_V1.8461.00
162_A180_F1.8221.00
151_L162_A1.8061.00
163_Y167_M1.7901.00
148_I208_L1.7751.00
297_V338_L1.7541.00
365_M410_V1.7481.00
24_I450_L1.7401.00
19_T443_A1.7261.00
118_I139_V1.7101.00
139_V143_K1.7071.00
308_L406_I1.6881.00
3_I117_V1.6670.99
41_S353_V1.6620.99
57_W443_A1.6560.99
22_V117_V1.6390.99
325_Y349_K1.6280.99
458_E461_E1.6120.99
241_A265_R1.6110.99
20_G24_I1.6080.99
192_L196_I1.6050.99
72_L81_V1.5990.99
24_I451_R1.5990.99
294_N297_V1.5940.99
276_V303_R1.5900.99
239_I261_V1.5710.99
251_F263_F1.5650.99
417_D420_K1.5650.99
211_L453_Y1.5540.99
44_D64_E1.5490.99
5_V21_L1.5450.99
109_S112_L1.5400.99
64_E110_Q1.5290.99
46_G65_R1.5290.99
406_I422_L1.5260.99
455_H458_E1.5170.99
158_A182_I1.5170.99
42_T45_G1.5150.99
28_K114_N1.5140.99
375_I409_S1.5130.99
54_Y220_M1.5050.99
84_M106_K1.4980.99
166_Y205_M1.4830.99
348_S374_V1.4820.99
105_W142_E1.4820.99
148_I181_I1.4810.99
289_K335_Y1.4800.99
314_F407_G1.4760.99
24_I456_I1.4720.99
198_W201_E1.4710.99
61_L114_N1.4700.99
319_K378_M1.4590.99
5_V18_T1.4510.98
5_V181_I1.4500.98
197_K200_E1.4480.98
91_M99_L1.4350.98
171_Q174_R1.4300.98
308_L413_T1.4270.98
239_I263_F1.4240.98
417_D434_S1.4240.98
291_L294_N1.4200.98
19_T54_Y1.4200.98
191_F194_D1.4180.98
357_T366_N1.4170.98
262_S273_A1.4140.98
318_G345_V1.4140.98
2_S108_V1.4110.98
326_G333_T1.4040.98
400_A404_N1.4030.98
226_N229_N1.3980.98
166_Y177_L1.3910.98
424_K427_N1.3880.98
289_K293_E1.3830.98
84_M103_K1.3830.98
434_S437_E1.3780.98
86_S350_D1.3760.98
341_F405_I1.3740.98
39_S246_S1.3680.98
270_T299_Q1.3660.98
218_P438_E1.3550.98
352_V374_V1.3550.98
104_L134_I1.3540.98
357_T364_E1.3520.98
57_W439_I1.3470.98
66_Y84_M1.3430.97
83_F103_K1.3370.97
314_F343_I1.3340.97
319_K344_N1.3210.97
137_I147_A1.3160.97
75_M283_N1.3140.97
141_K170_P1.3110.97
396_V399_G1.2960.97
112_L116_V1.2860.97
275_L426_F1.2790.97
438_E442_Q1.2780.97
127_P192_L1.2700.96
300_L307_I1.2660.96
21_L454_L1.2630.96
196_I207_Y1.2580.96
208_L458_E1.2580.96
442_Q445_R1.2440.96
92_S95_E1.2440.96
220_M439_I1.2370.96
175_E205_M1.2300.96
408_I413_T1.2280.96
321_I347_Y1.2230.96
170_P173_V1.2210.96
189_E193_N1.2140.95
26_N115_D1.2120.95
275_L306_N1.2100.95
365_M419_M1.2080.95
200_E207_Y1.2040.95
290_W294_N1.2030.95
9_M161_S1.2030.95
259_A423_L1.1990.95
285_L333_T1.1980.95
196_I210_Y1.1980.95
321_I335_Y1.1970.95
81_V88_L1.1960.95
287_S316_I1.1930.95
2_S143_K1.1820.95
307_I340_I1.1820.95
75_M90_I1.1770.95
345_V409_S1.1650.94
344_N376_K1.1540.94
178_K462_I1.1520.94
166_Y174_R1.1490.94
308_L422_L1.1330.93
384_L408_I1.1320.93
456_I460_V1.1310.93
75_M78_G1.1270.93
419_M422_L1.1230.93
358_G365_M1.1230.93
292_V335_Y1.1200.93
288_L292_V1.1170.93
76_G244_Y1.1140.93
57_W436_E1.1120.93
239_I251_F1.1100.93
285_L321_I1.1090.93
84_M110_Q1.1080.93
66_Y107_K1.1070.93
6_A124_I1.1000.92
65_R84_M1.0960.92
397_E400_A1.0960.92
450_L454_L1.0950.92
278_L316_I1.0950.92
28_K61_L1.0910.92
5_V12_S1.0880.92
167_M174_R1.0880.92
236_E272_K1.0800.92
276_V305_M1.0790.92
242_Y291_L1.0740.91
166_Y180_F1.0660.91
353_V370_I1.0610.91
127_P202_K1.0590.91
240_I296_F1.0580.91
288_L335_Y1.0530.91
283_N286_E1.0510.91
17_I450_L1.0470.90
174_R205_M1.0470.90
32_I70_I1.0470.90
251_F310_I1.0470.90
77_K92_S1.0450.90
240_I278_L1.0420.90
342_D377_Y1.0340.90
266_K269_E1.0310.90
60_G440_K1.0250.89
162_A199_L1.0240.89
149_L177_L1.0190.89
180_F207_Y1.0190.89
240_I264_V1.0160.89
105_W109_S1.0140.89
127_P168_M1.0120.89
267_P299_Q1.0090.89
288_L321_I1.0070.89
95_E98_N1.0010.88
288_L316_I0.9980.88
330_G333_T0.9980.88
284_T321_I0.9970.88
109_S142_E0.9910.88
366_N436_E0.9910.88
427_N430_I0.9900.88
152_D155_R0.9860.87
234_N258_N0.9810.87
211_L454_L0.9810.87
159_F195_A0.9800.87
269_E299_Q0.9780.87
16_F19_T0.9780.87
99_L102_E0.9740.87
80_E282_R0.9640.86
148_I459_I0.9610.86
355_M366_N0.9590.86
274_D430_I0.9590.86
382_P385_K0.9580.86
108_V139_V0.9570.86
208_L462_I0.9550.86
383_L406_I0.9530.86
206_R458_E0.9510.86
87_S372_R0.9510.86
417_D435_M0.9470.85
234_N260_R0.9460.85
329_A332_P0.9450.85
159_F168_M0.9410.85
11_D226_N0.9360.85
108_V118_I0.9320.84
324_P346_H0.9320.84
264_V273_A0.9310.84
458_E462_I0.9300.84
358_G410_V0.9250.84
437_E441_Q0.9230.84
91_M96_Y0.9220.84
103_K107_K0.9180.83
4_I137_I0.9170.83
326_G332_P0.9160.83
266_K290_W0.9130.83
301_R340_I0.9120.83
320_K336_E0.9110.83
371_R409_S0.9110.83
292_V336_E0.9110.83
342_D398_D0.9100.83
130_I138_K0.9070.83
237_V277_I0.9070.83
251_F261_V0.9060.83
317_L341_F0.9060.83
97_Y100_A0.9040.83
39_S249_N0.9030.82
70_I134_I0.9010.82
28_K111_F0.8960.82
281_S347_Y0.8960.82
60_G448_Q0.8940.82
236_E271_A0.8900.82
163_Y166_Y0.8900.82
275_L308_L0.8890.81
18_T21_L0.8820.81
326_G329_A0.8820.81
179_G208_L0.8800.81
124_I137_I0.8760.80
32_I104_L0.8760.80
158_A162_A0.8690.80
244_Y283_N0.8670.80
17_I150_V0.8660.80
258_N427_N0.8660.80
193_N210_Y0.8650.80
25_L460_V0.8600.79
5_V148_I0.8590.79
346_H376_K0.8570.79
78_G100_A0.8560.79
18_T117_V0.8490.78
151_L180_F0.8450.78
107_K110_Q0.8440.78
88_L99_L0.8410.78
220_M443_A0.8400.78
325_Y346_H0.8390.78
242_Y281_S0.8370.77
111_F116_V0.8340.77
143_K176_N0.8330.77
238_A262_S0.8300.77
65_R110_Q0.8300.77
300_L338_L0.8280.77
345_V375_I0.8240.76
449_F453_Y0.8240.76
348_S352_V0.8170.76
296_F300_L0.8160.76
439_I443_A0.8150.75
449_F452_K0.8040.74
325_Y348_S0.8020.74
11_D221_P0.8020.74
306_N404_N0.8020.74
105_W143_K0.8020.74
39_S220_M0.8000.74
32_I139_V0.7960.74
109_S113_S0.7960.74
48_I64_E0.7960.74
181_I211_L0.7940.74
125_G192_L0.7930.73
440_K444_I0.7920.73
255_V263_F0.7900.73
273_A300_L0.7870.73
456_I459_I0.7830.73
146_P178_K0.7780.72
127_P159_F0.7780.72
318_G343_I0.7750.72
189_E196_I0.7730.72
180_F205_M0.7720.71
5_V161_S0.7690.71
286_E329_A0.7690.71
194_D197_K0.7660.71
64_E114_N0.7640.71
24_I211_L0.7620.70
233_G260_R0.7620.70
9_M199_L0.7610.70
16_F217_P0.7590.70
262_S271_A0.7580.70
36_S194_D0.7580.70
218_P442_Q0.7570.70
163_Y203_T0.7530.70
168_M177_L0.7520.69
182_I199_L0.7510.69
414_L422_L0.7510.69
163_Y199_L0.7510.69
6_A32_I0.7500.69
57_W440_K0.7490.69
285_L289_K0.7490.69
15_S49_A0.7470.69
124_I165_T0.7440.69
149_L162_A0.7420.68
24_I460_V0.7400.68
37_L82_I0.7380.68
311_C351_K0.7370.68
32_I135_T0.7350.68
397_E401_K0.7290.67
108_V116_V0.7260.67
169_L177_L0.7240.67
141_K144_R0.7230.66
388_L395_S0.7230.66
436_E440_K0.7190.66
301_R336_E0.7190.66
51_I118_I0.7160.66
327_I347_Y0.7140.65
251_F277_I0.7120.65
318_G409_S0.7100.65
297_V301_R0.7090.65
105_W134_I0.7090.65
448_Q452_K0.7080.65
421_K427_N0.7070.65
451_R459_I0.7070.65
137_I173_V0.7060.65
227_V248_F0.7050.64
46_G86_S0.7050.64
53_A63_P0.7020.64
40_I48_I0.7010.64
339_G342_D0.7010.64
343_I405_I0.6980.64
306_N425_E0.6960.63
220_M435_M0.6950.63
27_A115_D0.6930.63
180_F203_T0.6910.63
162_A182_I0.6910.63
21_L459_I0.6880.63
53_A57_W0.6860.62
100_A138_K0.6860.62
17_I181_I0.6860.62
298_E301_R0.6850.62
267_P296_F0.6850.62
110_Q113_S0.6840.62
381_K401_K0.6840.62
168_M194_D0.6820.62
256_K417_D0.6800.62
303_R307_I0.6790.62
357_T387_T0.6770.61
182_I196_I0.6750.61
424_K430_I0.6740.61
48_I63_P0.6740.61
158_A195_A0.6740.61
96_Y224_S0.6730.61
3_I224_S0.6730.61
125_G169_L0.6730.61
366_N416_S0.6730.61
284_T347_Y0.6730.61
106_K110_Q0.6720.61
182_I192_L0.6700.61
57_W220_M0.6690.60
75_M87_S0.6680.60
138_K146_P0.6680.60
166_Y207_Y0.6650.60
25_L114_N0.6640.60
88_L103_K0.6640.60
277_I310_I0.6640.60
192_L198_W0.6630.60
39_S75_M0.6620.60
178_K205_M0.6620.60
172_S175_E0.6600.59
211_L449_F0.6590.59
75_M249_N0.6570.59
22_V59_A0.6570.59
385_K395_S0.6550.59
450_L453_Y0.6540.59
25_L117_V0.6530.59
220_M249_N0.6510.58
342_D400_A0.6510.58
189_E210_Y0.6510.58
396_V400_A0.6510.58
267_P290_W0.6450.58
43_W355_M0.6440.58
262_S268_K0.6430.57
212_P453_Y0.6430.57
243_P281_S0.6430.57
220_M252_Y0.6430.57
397_E402_K0.6420.57
118_I145_I0.6420.57
240_I270_T0.6410.57
5_V147_A0.6410.57
97_Y101_T0.6400.57
81_V91_M0.6400.57
299_Q302_Q0.6390.57
199_L207_Y0.6370.57
298_E302_Q0.6370.57
193_N196_I0.6360.57
315_Q345_V0.6350.56
75_M276_V0.6310.56
292_V301_R0.6300.56
24_I447_E0.6300.56
159_F196_I0.6290.56
100_A132_K0.6290.56
154_D186_R0.6280.56
50_F220_M0.6280.56
162_A208_L0.6280.56
8_T161_S0.6280.56
127_P195_A0.6270.56
256_K421_K0.6260.55
214_F442_Q0.6260.55
78_G92_S0.6260.55
235_V423_L0.6250.55
82_I173_V0.6250.55
101_T132_K0.6240.55
117_V460_V0.6230.55
343_I407_G0.6230.55
35_M121_A0.6230.55
282_R409_S0.6220.55
127_P158_A0.6220.55
11_D229_N0.6190.55
292_V321_I0.6190.55
36_S192_L0.6180.54
137_I169_L0.6170.54
84_M108_V0.6160.54
16_F135_T0.6160.54
77_K189_E0.6150.54
292_V338_L0.6140.54
163_Y168_M0.6140.54
200_E206_R0.6140.54
142_E176_N0.6120.54
238_A267_P0.6100.53
457_D460_V0.6060.53
159_F198_W0.6060.53
42_T53_A0.6060.53
178_K181_I0.6040.53
410_V416_S0.6020.53
118_I143_K0.6010.52
80_E372_R0.6000.52
334_E344_N0.5990.52
25_L462_I0.5980.52
383_L408_I0.5960.52
358_G386_I0.5960.52
363_G418_G0.5960.52
178_K208_L0.5950.52
300_L303_R0.5950.52
153_I182_I0.5950.52
290_W299_Q0.5940.52
307_I405_I0.5940.52
125_G160_A0.5930.51
220_M442_Q0.5930.51
243_P347_Y0.5920.51
285_L332_P0.5910.51
245_M263_F0.5900.51
308_L383_L0.5900.51
238_A299_Q0.5890.51
221_P248_F0.5880.51
37_L249_N0.5880.51
16_F225_M0.5870.51
270_T296_F0.5850.50
127_P194_D0.5840.50
385_K388_L0.5830.50
253_A420_K0.5820.50
309_G405_I0.5820.50
309_G318_G0.5820.50
155_R224_S0.5810.50
201_E456_I0.5810.50
54_Y439_I0.5800.50
365_M384_L0.5790.50
130_I137_I0.5790.50
113_S364_E0.5790.50
6_A118_I0.5790.50
377_Y380_E0.5770.50
384_L410_V0.5760.49
230_F233_G0.5750.49
196_I203_T0.5750.49
39_S408_I0.5730.49
408_I416_S0.5730.49
214_F217_P0.5720.49
327_I372_R0.5720.49
3_I353_V0.5710.49
238_A271_A0.5700.49
147_A177_L0.5680.48
127_P163_Y0.5680.48
239_I277_I0.5670.48
36_S99_L0.5670.48
244_Y286_E0.5660.48
426_F430_I0.5660.48
264_V303_R0.5650.48
452_K456_I0.5650.48
426_F429_N0.5650.48
265_R268_K0.5650.48
415_F435_M0.5630.48
166_Y203_T0.5630.48
9_M155_R0.5620.48
62_R366_N0.5620.48
93_G96_Y0.5610.48
182_I210_Y0.5610.48
80_E87_S0.5600.47
214_F445_R0.5600.47
301_R338_L0.5580.47
66_Y111_F0.5560.47
245_M248_F0.5560.47
199_L202_K0.5540.47
5_V16_F0.5540.47
172_S176_N0.5540.47
86_S293_E0.5530.47
252_Y255_V0.5530.47
184_K360_S0.5530.47
265_R269_E0.5520.47
46_G135_T0.5510.46
283_N329_A0.5510.46
384_L388_L0.5510.46
237_V349_K0.5500.46
28_K107_K0.5490.46
125_G244_Y0.5490.46
332_P335_Y0.5480.46
217_P445_R0.5480.46
61_L67_M0.5480.46
420_K423_L0.5460.46
24_I453_Y0.5460.46
88_L91_M0.5450.46
270_T276_V0.5450.46
209_G454_L0.5440.46
315_Q409_S0.5440.46
192_L274_D0.5430.45
78_G90_I0.5430.45
240_I300_L0.5430.45
39_S50_F0.5430.45
163_Y177_L0.5420.45
235_V259_A0.5420.45
135_T139_V0.5420.45
105_W139_V0.5410.45
243_P321_I0.5400.45
439_I442_Q0.5390.45
104_L107_K0.5390.45
163_Y198_W0.5390.45
86_S106_K0.5380.45
76_G79_L0.5360.45
8_T239_I0.5360.45
5_V225_M0.5360.45
50_F147_A0.5360.45
412_G415_F0.5350.45
4_I124_I0.5340.44
256_K419_M0.5320.44
359_I362_Y0.5310.44
383_L395_S0.5310.44
76_G158_A0.5310.44
98_N101_T0.5290.44
326_G330_G0.5290.44
207_Y210_Y0.5290.44
36_S57_W0.5270.44
12_S244_Y0.5260.43
343_I346_H0.5250.43
79_L93_G0.5230.43
377_Y398_D0.5230.43
240_I273_A0.5220.43
60_G116_V0.5210.43
130_I141_K0.5210.43
149_L180_F0.5210.43
149_L278_L0.5210.43
83_F353_V0.5200.43
4_I173_V0.5200.43
237_V423_L0.5200.43
104_L142_E0.5200.43
21_L181_I0.5190.43
208_L459_I0.5190.43
235_V274_D0.5180.43
128_N153_I0.5180.43
350_D374_V0.5170.42
135_T142_E0.5170.42
63_P97_Y0.5170.42
319_K339_G0.5160.42
54_Y450_L0.5150.42
290_W293_E0.5150.42
192_L197_K0.5150.42
282_R345_V0.5140.42
238_A261_V0.5140.42
18_T54_Y0.5130.42
197_K457_D0.5130.42
327_I349_K0.5130.42
116_V423_L0.5130.42
240_I267_P0.5130.42
224_S241_A0.5120.42
354_S372_R0.5120.42
342_D380_E0.5120.42
384_L413_T0.5110.42
48_I107_K0.5100.42
146_P462_I0.5100.42
243_P426_F0.5090.41
25_L459_I0.5080.41
9_M151_L0.5070.41
9_M347_Y0.5060.41
314_F398_D0.5060.41
131_D170_P0.5060.41
98_N102_E0.5060.41
154_D182_I0.5050.41
5_V125_G0.5050.41
448_Q451_R0.5050.41
311_C373_G0.5040.41
175_E293_E0.5040.41
93_G138_K0.5040.41
158_A192_L0.5030.41
353_V443_A0.5030.41
289_K292_V0.5030.41
254_L308_L0.5030.41
433_Q459_I0.5030.41
179_G281_S0.5020.41
433_Q438_E0.5020.41
139_V145_I0.5010.41
441_Q445_R0.5010.41
236_E264_V0.5010.41
20_G454_L0.5010.41
124_I151_L0.5000.40
62_R452_K0.5000.40
236_E261_V0.5000.40
70_I401_K0.5000.40
321_I337_G0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s1mA 4 0.8667 100 0.787 Contact Map
4zdjA 4 0.8516 100 0.791 Contact Map
3nvaA 2 0.8581 100 0.801 Contact Map
1vcoA 4 0.8538 100 0.812 Contact Map
4a0gA 2 0.7699 99.9 0.873 Contact Map
2issD 1 0.372 99.9 0.892 Contact Map
2ywjA 1 0.3763 99.9 0.892 Contact Map
1q7rA 1 0.4086 99.9 0.893 Contact Map
3l7nA 1 0.4538 99.8 0.896 Contact Map
2nv0A 1 0.3892 99.8 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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