GREMLIN Database
COBS - Adenosylcobinamide-GDP ribazoletransferase
UniProt: Q97TZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (229)
Sequences: 2764 (2262)
Seq/√Len: 149.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_K99_K5.2531.00
97_K208_S4.0201.00
85_G113_L3.6151.00
75_F112_G3.4181.00
149_S221_I3.1311.00
90_I100_A3.0921.00
46_E69_I3.0371.00
81_L117_Y3.0151.00
66_L122_I2.9651.00
141_S228_F2.9411.00
10_F41_S2.9401.00
49_A68_I2.8721.00
205_I216_I2.7561.00
7_L19_K2.7201.00
82_L114_L2.5991.00
13_F34_S2.5621.00
145_S221_I2.4151.00
70_E116_V2.3351.00
106_V111_I2.3151.00
117_Y226_P2.2841.00
63_I119_S2.2721.00
6_I10_F2.2101.00
67_G116_V2.0831.00
82_L110_G2.0821.00
84_L216_I2.0721.00
88_L209_L2.0151.00
98_I213_S2.0081.00
63_I120_I1.9341.00
92_G96_K1.9331.00
137_Y232_D1.8861.00
160_P213_S1.8371.00
121_Q222_T1.8281.00
197_I227_L1.8181.00
42_L72_L1.8141.00
201_I205_I1.8091.00
152_I220_S1.7741.00
11_S18_V1.7521.00
87_A101_L1.7431.00
119_S122_I1.7381.00
50_Y65_L1.6451.00
14_T42_L1.5641.00
7_L18_V1.5421.00
61_T65_L1.5421.00
81_L113_L1.5321.00
153_L217_A1.5161.00
115_L118_L1.5061.00
49_A53_L1.4921.00
98_I160_P1.4871.00
50_Y134_T1.4611.00
82_L106_V1.4591.00
108_S112_G1.4361.00
159_I213_S1.4331.00
121_Q225_F1.4271.00
46_E65_L1.4041.00
16_I45_I1.4041.00
212_S217_A1.3701.00
78_L222_T1.3631.00
106_V114_L1.3291.00
63_I123_V1.3061.00
87_A91_R1.3011.00
88_L97_K1.2931.00
102_K160_P1.2921.00
124_A230_I1.2821.00
63_I122_I1.2771.00
81_L85_G1.2761.00
115_L119_S1.2761.00
141_S229_L1.2671.00
45_I68_I1.2571.00
97_K209_L1.2521.00
166_R170_D1.2521.00
12_F76_N1.2491.00
62_G126_L1.2471.00
94_R98_I1.2381.00
50_Y129_D1.2361.00
47_S135_I1.2321.00
84_L88_L1.2011.00
106_V110_G1.1881.00
117_Y222_T1.1771.00
8_A11_S1.1671.00
120_I226_P1.1631.00
10_F38_V1.1591.00
89_M109_G1.1481.00
200_M204_K1.1461.00
13_F38_V1.1381.00
81_L223_L1.1351.00
156_I206_C1.1331.00
202_M206_C1.1311.00
142_N222_T1.1280.99
6_I33_I1.1210.99
78_L114_L1.1210.99
42_L46_E1.1050.99
5_E29_E1.1050.99
94_R97_K1.0970.99
98_I101_L1.0930.99
203_Y206_C1.0880.99
153_L169_H1.0860.99
142_N225_F1.0840.99
82_L108_S1.0830.99
112_G118_L1.0690.99
64_V120_I1.0620.99
148_L224_S1.0580.99
70_E78_L1.0560.99
173_K176_S1.0520.99
182_E186_F1.0380.99
185_P188_S1.0280.99
13_F149_S1.0270.99
160_P163_N1.0240.99
156_I202_M1.0210.99
69_I142_N1.0190.99
70_E112_G1.0190.99
16_I41_S1.0110.99
23_S26_E1.0020.99
53_L65_L0.9970.99
193_I231_T0.9950.99
117_Y121_Q0.9820.99
179_L182_E0.9810.99
4_K26_E0.9810.99
93_N96_K0.9750.99
157_S206_C0.9600.98
121_Q226_P0.9500.98
156_I217_A0.9430.98
51_L55_R0.9390.98
105_E108_S0.9350.98
90_I97_K0.9260.98
101_L213_S0.9250.98
90_I93_N0.9250.98
60_L124_A0.9220.98
47_S139_I0.9210.98
42_L73_R0.9180.98
45_I72_L0.9040.98
90_I109_G0.9030.98
161_E166_R0.8850.97
217_A220_S0.8830.97
62_G66_L0.8750.97
92_G100_A0.8740.97
66_L125_L0.8710.97
220_S224_S0.8710.97
42_L142_N0.8660.97
139_I143_V0.8580.97
146_M221_I0.8560.97
53_L57_L0.8480.96
31_S153_L0.8470.96
47_S51_L0.8450.96
92_G97_K0.8440.96
4_K7_L0.8350.96
187_I190_Y0.8350.96
88_L216_I0.8340.96
34_S168_F0.8330.96
201_I220_S0.8270.96
30_S34_S0.8210.96
124_A233_E0.8170.96
59_E122_I0.8160.96
224_S228_F0.8120.95
203_Y207_G0.8120.95
48_V51_L0.8110.95
144_L228_F0.8100.95
44_L48_V0.8100.95
172_L176_S0.8000.95
98_I159_I0.7990.95
15_A71_L0.7930.95
88_L205_I0.7900.95
62_G122_I0.7850.94
145_S225_F0.7830.94
75_F109_G0.7830.94
95_E99_K0.7780.94
7_L10_F0.7730.94
46_E142_N0.7720.94
14_T142_N0.7710.94
8_A22_A0.7670.94
108_S111_I0.7670.94
70_E118_L0.7640.94
13_F30_S0.7630.94
9_Q34_S0.7630.94
69_I225_F0.7610.94
58_G127_K0.7570.93
60_L123_V0.7570.93
111_I114_L0.7550.93
93_N99_K0.7550.93
49_A64_V0.7530.93
40_I143_V0.7510.93
147_S151_Y0.7500.93
9_Q13_F0.7490.93
180_L187_I0.7480.93
53_L56_I0.7430.93
182_E185_P0.7420.93
158_P162_S0.7360.92
46_E50_Y0.7360.92
186_F189_L0.7350.92
91_R104_V0.7300.92
110_G113_L0.7260.92
82_L111_I0.7240.92
221_I224_S0.7230.92
87_A219_A0.7230.92
70_E75_F0.7230.92
145_S148_L0.7150.91
42_L146_M0.7140.91
68_I72_L0.7110.91
152_I212_S0.7070.91
94_R210_G0.7070.91
111_I115_L0.7060.91
8_A26_E0.7040.91
156_I212_S0.7040.91
102_K162_S0.7040.91
192_V195_F0.7030.91
147_S155_T0.7010.90
97_K109_G0.7010.90
84_L205_I0.6970.90
33_I36_I0.6960.90
212_S216_I0.6940.90
133_Y136_F0.6900.90
194_V228_F0.6870.90
12_F74_G0.6860.89
179_L183_L0.6840.89
204_K207_G0.6820.89
49_A128_L0.6750.89
76_N92_G0.6730.89
122_I126_L0.6710.88
48_V52_I0.6700.88
40_I139_I0.6680.88
12_F27_I0.6670.88
54_Y61_T0.6670.88
43_G47_S0.6660.88
9_Q38_V0.6660.88
87_A104_V0.6650.88
217_A221_I0.6640.88
38_V41_S0.6620.88
47_S138_L0.6600.88
53_L61_T0.6590.88
78_L90_I0.6540.87
12_F164_L0.6530.87
148_L220_S0.6520.87
15_A91_R0.6520.87
110_G224_S0.6450.86
57_L60_L0.6370.86
6_I36_I0.6360.86
157_S169_H0.6350.86
204_K208_S0.6350.86
148_L198_F0.6350.86
91_R96_K0.6320.85
39_G43_G0.6310.85
42_L69_I0.6310.85
41_S143_V0.6300.85
141_S145_S0.6300.85
82_L217_A0.6280.85
159_I211_G0.6270.85
15_A74_G0.6250.85
136_F139_I0.6210.84
7_L11_S0.6170.84
120_I123_V0.6160.84
69_I121_Q0.6150.84
174_G178_I0.6140.84
198_F220_S0.6140.84
138_L142_N0.6130.84
152_I202_M0.6130.84
184_I189_L0.6130.84
168_F212_S0.6080.83
43_G143_V0.6080.83
109_G113_L0.6070.83
124_A229_L0.6050.83
100_A109_G0.6020.82
124_A226_P0.6020.82
153_L165_G0.6010.82
52_I56_I0.6000.82
85_G219_A0.5980.82
27_I34_S0.5980.82
117_Y223_L0.5950.82
227_L233_E0.5940.82
83_D214_G0.5930.81
198_F202_M0.5930.81
14_T18_V0.5920.81
147_S179_L0.5910.81
145_S224_S0.5890.81
120_I230_I0.5880.81
7_L14_T0.5860.81
93_N97_K0.5840.80
104_V108_S0.5810.80
8_A30_S0.5800.80
9_Q146_M0.5790.80
153_L164_L0.5780.80
99_K105_E0.5760.80
78_L121_Q0.5750.79
8_A27_I0.5750.79
158_P165_G0.5750.79
99_K103_D0.5740.79
74_G103_D0.5710.79
9_Q30_S0.5710.79
34_S149_S0.5700.79
67_G120_I0.5660.78
82_L97_K0.5630.78
69_I217_A0.5620.78
149_S217_A0.5620.78
151_Y177_T0.5570.77
181_L186_F0.5540.77
133_Y193_I0.5510.77
50_Y138_L0.5510.77
197_I223_L0.5510.77
120_I124_A0.5500.76
152_I217_A0.5450.76
137_Y141_S0.5430.75
139_I142_N0.5430.75
31_S168_F0.5420.75
103_D108_S0.5380.75
5_E26_E0.5380.75
63_I116_V0.5370.75
121_Q146_M0.5370.75
223_L227_L0.5370.75
127_K233_E0.5350.74
184_I188_S0.5340.74
16_I29_E0.5340.74
43_G142_N0.5330.74
90_I104_V0.5330.74
84_L213_S0.5310.74
42_L68_I0.5300.74
214_G218_G0.5290.74
158_P164_L0.5280.73
67_G71_L0.5270.73
31_S212_S0.5270.73
66_L69_I0.5260.73
130_F190_Y0.5240.73
65_L125_L0.5220.73
102_K213_S0.5220.73
76_N169_H0.5210.72
46_E68_I0.5200.72
191_N195_F0.5190.72
199_Y203_Y0.5180.72
139_I188_S0.5170.72
183_L187_I0.5130.71
153_L156_I0.5130.71
21_S25_E0.5120.71
57_L127_K0.5120.71
65_L138_L0.5110.71
65_L69_I0.5110.71
149_S220_S0.5100.71
64_V124_A0.5090.71
96_K100_A0.5090.71
15_A109_G0.5080.71
5_E33_I0.5070.70
180_L184_I0.5060.70
53_L58_G0.5050.70
140_S232_D0.5040.70
129_D133_Y0.5040.70
121_Q125_L0.5030.70
165_G212_S0.5020.70
175_K178_I0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wjnL 1 0.5296 24.2 0.955 Contact Map
1rzhL 1 0.5296 18.8 0.957 Contact Map
1eysL 1 0.5494 10.7 0.962 Contact Map
4o6mA 2 0.7312 5.8 0.966 Contact Map
2kixA 3 0.0751 4.4 0.968 Contact Map
4humA 1 0.6245 2.1 0.973 Contact Map
4pl0A 2 0.3636 1.9 0.973 Contact Map
2kncA 1 0.2134 1.8 0.974 Contact Map
4mveA 1 0.2016 1.7 0.974 Contact Map
2jttC 1 0.1107 1.6 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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