COBS - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

COBS - Adenosylcobinamide-GDP ribazoletransferase

UniProt:	Q97TZ6	Sequences: MHLKEILAQFSFFTAIPVKSSASLEEIAESSYISPIIVGISLGLIESVAYLILYRILGELTGIVLLGIIELLRGFNHLDGLLDLGDALMIRGNREKKIKALKDVEVGSGGIGLLLVYLSIQIVALLKLDFSLYTIFYLISSNVLSMSLSLYILSTISPIPESNLGRIFHDKLKGKSTILLLELIPFISLYNVIVFIIFYMIMYKICGSLGGSSGDIAGASITLSFPLFLITDEITNLNYSLLSILCYLFSHLH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	253 (229)
Sequences:	2764 (2262)
Seq/√Len:	149.5

ECOLI - COBS
HALSA - COBS
SULSO - COBS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
96_K	99_K	5.253	1.00
97_K	208_S	4.020	1.00
85_G	113_L	3.615	1.00
75_F	112_G	3.418	1.00
149_S	221_I	3.131	1.00
90_I	100_A	3.092	1.00
46_E	69_I	3.037	1.00
81_L	117_Y	3.015	1.00
66_L	122_I	2.965	1.00
141_S	228_F	2.941	1.00
10_F	41_S	2.940	1.00
49_A	68_I	2.872	1.00
205_I	216_I	2.756	1.00
7_L	19_K	2.720	1.00
82_L	114_L	2.599	1.00
13_F	34_S	2.562	1.00
145_S	221_I	2.415	1.00
70_E	116_V	2.335	1.00
106_V	111_I	2.315	1.00
117_Y	226_P	2.284	1.00
63_I	119_S	2.272	1.00
6_I	10_F	2.210	1.00
67_G	116_V	2.083	1.00
82_L	110_G	2.082	1.00
84_L	216_I	2.072	1.00
88_L	209_L	2.015	1.00
98_I	213_S	2.008	1.00
63_I	120_I	1.934	1.00
92_G	96_K	1.933	1.00
137_Y	232_D	1.886	1.00
160_P	213_S	1.837	1.00
121_Q	222_T	1.828	1.00
197_I	227_L	1.818	1.00
42_L	72_L	1.814	1.00
201_I	205_I	1.809	1.00
152_I	220_S	1.774	1.00
11_S	18_V	1.752	1.00
87_A	101_L	1.743	1.00
119_S	122_I	1.738	1.00
50_Y	65_L	1.645	1.00
14_T	42_L	1.564	1.00
7_L	18_V	1.542	1.00
61_T	65_L	1.542	1.00
81_L	113_L	1.532	1.00
153_L	217_A	1.516	1.00
115_L	118_L	1.506	1.00
49_A	53_L	1.492	1.00
98_I	160_P	1.487	1.00
50_Y	134_T	1.461	1.00
82_L	106_V	1.459	1.00
108_S	112_G	1.436	1.00
159_I	213_S	1.433	1.00
121_Q	225_F	1.427	1.00
46_E	65_L	1.404	1.00
16_I	45_I	1.404	1.00
212_S	217_A	1.370	1.00
78_L	222_T	1.363	1.00
106_V	114_L	1.329	1.00
63_I	123_V	1.306	1.00
87_A	91_R	1.301	1.00
88_L	97_K	1.293	1.00
102_K	160_P	1.292	1.00
124_A	230_I	1.282	1.00
63_I	122_I	1.277	1.00
81_L	85_G	1.276	1.00
115_L	119_S	1.276	1.00
141_S	229_L	1.267	1.00
45_I	68_I	1.257	1.00
97_K	209_L	1.252	1.00
166_R	170_D	1.252	1.00
12_F	76_N	1.249	1.00
62_G	126_L	1.247	1.00
94_R	98_I	1.238	1.00
50_Y	129_D	1.236	1.00
47_S	135_I	1.232	1.00
84_L	88_L	1.201	1.00
106_V	110_G	1.188	1.00
117_Y	222_T	1.177	1.00
8_A	11_S	1.167	1.00
120_I	226_P	1.163	1.00
10_F	38_V	1.159	1.00
89_M	109_G	1.148	1.00
200_M	204_K	1.146	1.00
13_F	38_V	1.138	1.00
81_L	223_L	1.135	1.00
156_I	206_C	1.133	1.00
202_M	206_C	1.131	1.00
142_N	222_T	1.128	0.99
6_I	33_I	1.121	0.99
78_L	114_L	1.121	0.99
42_L	46_E	1.105	0.99
5_E	29_E	1.105	0.99
94_R	97_K	1.097	0.99
98_I	101_L	1.093	0.99
203_Y	206_C	1.088	0.99
153_L	169_H	1.086	0.99
142_N	225_F	1.084	0.99
82_L	108_S	1.083	0.99
112_G	118_L	1.069	0.99
64_V	120_I	1.062	0.99
148_L	224_S	1.058	0.99
70_E	78_L	1.056	0.99
173_K	176_S	1.052	0.99
182_E	186_F	1.038	0.99
185_P	188_S	1.028	0.99
13_F	149_S	1.027	0.99
160_P	163_N	1.024	0.99
156_I	202_M	1.021	0.99
69_I	142_N	1.019	0.99
70_E	112_G	1.019	0.99
16_I	41_S	1.011	0.99
23_S	26_E	1.002	0.99
53_L	65_L	0.997	0.99
193_I	231_T	0.995	0.99
117_Y	121_Q	0.982	0.99
179_L	182_E	0.981	0.99
4_K	26_E	0.981	0.99
93_N	96_K	0.975	0.99
157_S	206_C	0.960	0.98
121_Q	226_P	0.950	0.98
156_I	217_A	0.943	0.98
51_L	55_R	0.939	0.98
105_E	108_S	0.935	0.98
90_I	97_K	0.926	0.98
101_L	213_S	0.925	0.98
90_I	93_N	0.925	0.98
60_L	124_A	0.922	0.98
47_S	139_I	0.921	0.98
42_L	73_R	0.918	0.98
45_I	72_L	0.904	0.98
90_I	109_G	0.903	0.98
161_E	166_R	0.885	0.97
217_A	220_S	0.883	0.97
62_G	66_L	0.875	0.97
92_G	100_A	0.874	0.97
66_L	125_L	0.871	0.97
220_S	224_S	0.871	0.97
42_L	142_N	0.866	0.97
139_I	143_V	0.858	0.97
146_M	221_I	0.856	0.97
53_L	57_L	0.848	0.96
31_S	153_L	0.847	0.96
47_S	51_L	0.845	0.96
92_G	97_K	0.844	0.96
4_K	7_L	0.835	0.96
187_I	190_Y	0.835	0.96
88_L	216_I	0.834	0.96
34_S	168_F	0.833	0.96
201_I	220_S	0.827	0.96
30_S	34_S	0.821	0.96
124_A	233_E	0.817	0.96
59_E	122_I	0.816	0.96
224_S	228_F	0.812	0.95
203_Y	207_G	0.812	0.95
48_V	51_L	0.811	0.95
144_L	228_F	0.810	0.95
44_L	48_V	0.810	0.95
172_L	176_S	0.800	0.95
98_I	159_I	0.799	0.95
15_A	71_L	0.793	0.95
88_L	205_I	0.790	0.95
62_G	122_I	0.785	0.94
145_S	225_F	0.783	0.94
75_F	109_G	0.783	0.94
95_E	99_K	0.778	0.94
7_L	10_F	0.773	0.94
46_E	142_N	0.772	0.94
14_T	142_N	0.771	0.94
8_A	22_A	0.767	0.94
108_S	111_I	0.767	0.94
70_E	118_L	0.764	0.94
13_F	30_S	0.763	0.94
9_Q	34_S	0.763	0.94
69_I	225_F	0.761	0.94
58_G	127_K	0.757	0.93
60_L	123_V	0.757	0.93
111_I	114_L	0.755	0.93
93_N	99_K	0.755	0.93
49_A	64_V	0.753	0.93
40_I	143_V	0.751	0.93
147_S	151_Y	0.750	0.93
9_Q	13_F	0.749	0.93
180_L	187_I	0.748	0.93
53_L	56_I	0.743	0.93
182_E	185_P	0.742	0.93
158_P	162_S	0.736	0.92
46_E	50_Y	0.736	0.92
186_F	189_L	0.735	0.92
91_R	104_V	0.730	0.92
110_G	113_L	0.726	0.92
82_L	111_I	0.724	0.92
221_I	224_S	0.723	0.92
87_A	219_A	0.723	0.92
70_E	75_F	0.723	0.92
145_S	148_L	0.715	0.91
42_L	146_M	0.714	0.91
68_I	72_L	0.711	0.91
152_I	212_S	0.707	0.91
94_R	210_G	0.707	0.91
111_I	115_L	0.706	0.91
8_A	26_E	0.704	0.91
156_I	212_S	0.704	0.91
102_K	162_S	0.704	0.91
192_V	195_F	0.703	0.91
147_S	155_T	0.701	0.90
97_K	109_G	0.701	0.90
84_L	205_I	0.697	0.90
33_I	36_I	0.696	0.90
212_S	216_I	0.694	0.90
133_Y	136_F	0.690	0.90
194_V	228_F	0.687	0.90
12_F	74_G	0.686	0.89
179_L	183_L	0.684	0.89
204_K	207_G	0.682	0.89
49_A	128_L	0.675	0.89
76_N	92_G	0.673	0.89
122_I	126_L	0.671	0.88
48_V	52_I	0.670	0.88
40_I	139_I	0.668	0.88
12_F	27_I	0.667	0.88
54_Y	61_T	0.667	0.88
43_G	47_S	0.666	0.88
9_Q	38_V	0.666	0.88
87_A	104_V	0.665	0.88
217_A	221_I	0.664	0.88
38_V	41_S	0.662	0.88
47_S	138_L	0.660	0.88
53_L	61_T	0.659	0.88
78_L	90_I	0.654	0.87
12_F	164_L	0.653	0.87
148_L	220_S	0.652	0.87
15_A	91_R	0.652	0.87
110_G	224_S	0.645	0.86
57_L	60_L	0.637	0.86
6_I	36_I	0.636	0.86
157_S	169_H	0.635	0.86
204_K	208_S	0.635	0.86
148_L	198_F	0.635	0.86
91_R	96_K	0.632	0.85
39_G	43_G	0.631	0.85
42_L	69_I	0.631	0.85
41_S	143_V	0.630	0.85
141_S	145_S	0.630	0.85
82_L	217_A	0.628	0.85
159_I	211_G	0.627	0.85
15_A	74_G	0.625	0.85
136_F	139_I	0.621	0.84
7_L	11_S	0.617	0.84
120_I	123_V	0.616	0.84
69_I	121_Q	0.615	0.84
174_G	178_I	0.614	0.84
198_F	220_S	0.614	0.84
138_L	142_N	0.613	0.84
152_I	202_M	0.613	0.84
184_I	189_L	0.613	0.84
168_F	212_S	0.608	0.83
43_G	143_V	0.608	0.83
109_G	113_L	0.607	0.83
124_A	229_L	0.605	0.83
100_A	109_G	0.602	0.82
124_A	226_P	0.602	0.82
153_L	165_G	0.601	0.82
52_I	56_I	0.600	0.82
85_G	219_A	0.598	0.82
27_I	34_S	0.598	0.82
117_Y	223_L	0.595	0.82
227_L	233_E	0.594	0.82
83_D	214_G	0.593	0.81
198_F	202_M	0.593	0.81
14_T	18_V	0.592	0.81
147_S	179_L	0.591	0.81
145_S	224_S	0.589	0.81
120_I	230_I	0.588	0.81
7_L	14_T	0.586	0.81
93_N	97_K	0.584	0.80
104_V	108_S	0.581	0.80
8_A	30_S	0.580	0.80
9_Q	146_M	0.579	0.80
153_L	164_L	0.578	0.80
99_K	105_E	0.576	0.80
78_L	121_Q	0.575	0.79
8_A	27_I	0.575	0.79
158_P	165_G	0.575	0.79
99_K	103_D	0.574	0.79
74_G	103_D	0.571	0.79
9_Q	30_S	0.571	0.79
34_S	149_S	0.570	0.79
67_G	120_I	0.566	0.78
82_L	97_K	0.563	0.78
69_I	217_A	0.562	0.78
149_S	217_A	0.562	0.78
151_Y	177_T	0.557	0.77
181_L	186_F	0.554	0.77
133_Y	193_I	0.551	0.77
50_Y	138_L	0.551	0.77
197_I	223_L	0.551	0.77
120_I	124_A	0.550	0.76
152_I	217_A	0.545	0.76
137_Y	141_S	0.543	0.75
139_I	142_N	0.543	0.75
31_S	168_F	0.542	0.75
103_D	108_S	0.538	0.75
5_E	26_E	0.538	0.75
63_I	116_V	0.537	0.75
121_Q	146_M	0.537	0.75
223_L	227_L	0.537	0.75
127_K	233_E	0.535	0.74
184_I	188_S	0.534	0.74
16_I	29_E	0.534	0.74
43_G	142_N	0.533	0.74
90_I	104_V	0.533	0.74
84_L	213_S	0.531	0.74
42_L	68_I	0.530	0.74
214_G	218_G	0.529	0.74
158_P	164_L	0.528	0.73
67_G	71_L	0.527	0.73
31_S	212_S	0.527	0.73
66_L	69_I	0.526	0.73
130_F	190_Y	0.524	0.73
65_L	125_L	0.522	0.73
102_K	213_S	0.522	0.73
76_N	169_H	0.521	0.72
46_E	68_I	0.520	0.72
191_N	195_F	0.519	0.72
199_Y	203_Y	0.518	0.72
139_I	188_S	0.517	0.72
183_L	187_I	0.513	0.71
153_L	156_I	0.513	0.71
21_S	25_E	0.512	0.71
57_L	127_K	0.512	0.71
65_L	138_L	0.511	0.71
65_L	69_I	0.511	0.71
149_S	220_S	0.510	0.71
64_V	124_A	0.509	0.71
96_K	100_A	0.509	0.71
15_A	109_G	0.508	0.71
5_E	33_I	0.507	0.70
180_L	184_I	0.506	0.70
53_L	58_G	0.505	0.70
140_S	232_D	0.504	0.70
129_D	133_Y	0.504	0.70
121_Q	125_L	0.503	0.70
165_G	212_S	0.502	0.70
175_K	178_I	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wjnL	1	0.5296	24.2	0.955	Contact Map
1rzhL	1	0.5296	18.8	0.957	Contact Map
1eysL	1	0.5494	10.7	0.962	Contact Map
4o6mA	2	0.7312	5.8	0.966	Contact Map
2kixA	3	0.0751	4.4	0.968	Contact Map
4humA	1	0.6245	2.1	0.973	Contact Map
4pl0A	2	0.3636	1.9	0.973	Contact Map
2kncA	1	0.2134	1.8	0.974	Contact Map
4mveA	1	0.2016	1.7	0.974	Contact Map
2jttC	1	0.1107	1.6	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.