GREMLIN Database
Q97TZ5 - Probable cobalamin biosynthesis protein CobD
UniProt: Q97TZ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (279)
Sequences: 2655 (2071)
Seq/√Len: 124.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_A190_L4.7191.00
151_F155_G4.6041.00
42_Y181_W3.8871.00
49_W186_I3.2291.00
95_V133_L3.0881.00
172_K177_R2.9001.00
199_G220_L2.8931.00
121_E124_H2.8381.00
169_V183_S2.7031.00
177_R181_W2.6751.00
28_T52_S2.6381.00
48_L169_V2.5691.00
46_V181_W2.5261.00
49_W53_V2.5161.00
253_V256_G2.5021.00
85_T156_A2.4411.00
34_I38_P2.3381.00
82_L148_F2.2671.00
254_G259_P2.2641.00
263_D266_K2.1781.00
237_A270_L2.0621.00
57_L158_L1.9961.00
89_K93_D1.9771.00
42_Y178_K1.9431.00
108_Y111_Q1.9161.00
260_C263_D1.9151.00
46_V182_F1.9111.00
7_L79_T1.8871.00
206_G240_L1.8711.00
95_V129_L1.8671.00
253_V259_P1.8481.00
120_S124_H1.8441.00
216_G239_G1.8231.00
92_Y268_L1.8011.00
142_T198_T1.7801.00
137_T198_T1.7521.00
130_I267_A1.7351.00
49_W183_S1.7121.00
144_P159_Q1.7031.00
189_I192_Y1.6861.00
142_T278_Y1.6711.00
31_I52_S1.6701.00
36_I175_E1.6591.00
109_A128_A1.6541.00
257_N263_D1.6351.00
143_S159_Q1.6171.00
212_D215_Q1.6111.00
53_V158_L1.5511.00
220_L232_Y1.5441.00
146_F197_L1.5431.00
173_T176_L1.5261.00
39_Y179_E1.5191.00
159_Q191_N1.5151.00
158_L190_L1.5091.00
140_G167_S1.5051.00
92_Y272_K1.4981.00
205_A277_L1.4891.00
223_A232_Y1.4841.00
254_G258_L1.4821.00
148_F156_A1.4751.00
36_I176_L1.4751.00
256_G259_P1.4691.00
253_V258_L1.4661.00
85_T157_M1.4621.00
181_W185_K1.4571.00
160_R167_S1.4521.00
6_A283_S1.4411.00
60_F157_M1.4361.00
49_W165_M1.4261.00
162_A186_I1.4141.00
99_S265_E1.4091.00
82_L156_A1.4071.00
40_K44_Y1.3981.00
255_F258_L1.3961.00
186_I190_L1.3941.00
138_V143_S1.3891.00
109_A125_I1.3761.00
114_R171_Y1.3721.00
202_M237_A1.3711.00
12_D17_E1.3671.00
165_M183_S1.3661.00
215_Q218_K1.3471.00
101_L104_Q1.3351.00
201_I278_Y1.3251.00
30_K34_I1.3181.00
219_A222_E1.3031.00
53_V186_I1.2801.00
8_A79_T1.2771.00
202_M274_S1.2741.00
142_T201_I1.2691.00
49_W182_F1.2651.00
223_A231_K1.2641.00
17_E26_V1.2621.00
13_L88_I1.2561.00
137_T202_M1.2420.99
9_L279_F1.2350.99
104_Q108_Y1.2220.99
104_Q107_Y1.2180.99
203_L217_W1.2100.99
52_S55_P1.2010.99
4_I8_A1.1960.99
178_K181_W1.1940.99
134_F237_A1.1930.99
22_I27_W1.1890.99
140_G160_R1.1780.99
225_M234_I1.1780.99
127_S249_G1.1770.99
66_V77_I1.1760.99
98_G125_I1.1710.99
220_L223_A1.1670.99
92_Y96_T1.1660.99
9_L275_L1.1660.99
8_A82_L1.1620.99
28_T161_L1.1420.99
130_I245_L1.1400.99
129_L264_I1.1390.99
159_Q163_N1.1300.99
40_K179_E1.1260.99
32_S169_V1.1260.99
94_I97_K1.1210.99
137_T142_T1.1210.99
26_V30_K1.1150.99
96_T265_E1.1090.99
39_Y48_L1.1080.99
35_L51_L1.1060.99
74_K78_L1.0980.99
244_S252_K1.0960.99
5_L148_F1.0810.99
253_V257_N1.0740.99
9_L88_I1.0640.98
42_Y182_F1.0640.98
31_I55_P1.0620.98
94_I108_Y1.0520.98
97_K108_Y1.0460.98
4_I79_T1.0350.98
57_L154_I1.0320.98
35_L48_L1.0310.98
216_G240_L1.0300.98
182_F186_I1.0270.98
114_R234_I1.0210.98
32_S165_M1.0210.98
94_I132_S1.0210.98
11_W83_K1.0010.98
206_G270_L1.0010.98
269_K273_L0.9970.98
252_K256_G0.9940.98
49_W162_A0.9930.98
237_A267_A0.9890.97
252_K258_L0.9890.97
15_I83_K0.9840.97
29_G168_M0.9810.97
133_L271_F0.9780.97
102_D126_A0.9720.97
138_V233_P0.9660.97
81_S153_L0.9660.97
78_L153_L0.9650.97
113_V117_L0.9630.97
214_K218_K0.9620.97
203_L213_V0.9620.97
203_L216_G0.9620.97
126_A261_E0.9580.97
255_F259_P0.9530.97
149_L282_I0.9500.97
75_I79_T0.9450.97
7_L75_I0.9390.97
147_W155_G0.9380.97
110_Q117_L0.9370.96
98_G101_L0.9270.96
201_I274_S0.9260.96
102_D122_K0.9210.96
207_L213_V0.9210.96
240_L270_L0.9150.96
248_V257_N0.9090.96
43_F47_I0.9080.96
114_R167_S0.9050.96
107_Y111_Q0.9040.96
206_G216_G0.9010.96
36_I40_K0.9000.96
199_G232_Y0.8990.96
114_R128_A0.8990.96
94_I111_Q0.8970.95
252_K259_P0.8960.95
203_L240_L0.8920.95
219_A239_G0.8860.95
226_E249_G0.8790.95
215_Q219_A0.8770.95
254_G257_N0.8770.95
158_L162_A0.8650.95
223_A235_A0.8640.94
39_Y47_I0.8600.94
202_M236_I0.8560.94
10_I14_T0.8550.94
126_A264_I0.8550.94
96_T99_S0.8490.94
88_I275_L0.8480.94
56_P161_L0.8440.94
138_V191_N0.8420.94
117_L120_S0.8390.94
39_Y44_Y0.8390.94
150_I155_G0.8380.94
138_V159_Q0.8380.94
226_E230_A0.8350.93
199_G203_L0.8300.93
205_A274_S0.8270.93
166_D184_A0.8240.93
268_L271_F0.8210.93
127_S247_K0.8190.93
163_N167_S0.8180.93
278_Y282_I0.8170.93
137_T274_S0.8160.93
6_A279_F0.8130.92
283_S286_Y0.8100.92
201_I277_L0.8080.92
135_E163_N0.8030.92
222_E239_G0.8000.92
174_P177_R0.7960.92
105_A125_I0.7960.92
122_K126_A0.7870.91
22_I26_V0.7870.91
80_F84_T0.7850.91
124_H249_G0.7850.91
51_L55_P0.7820.91
42_Y46_V0.7800.91
96_T268_L0.7650.90
243_V263_D0.7610.90
52_S161_L0.7600.90
205_A273_L0.7590.90
103_D118_S0.7580.90
153_L156_A0.7520.89
126_A130_I0.7520.89
101_L108_Y0.7490.89
99_S264_I0.7460.89
198_T233_P0.7450.89
70_P74_K0.7430.89
5_L145_I0.7410.89
13_L272_K0.7330.88
29_G136_S0.7300.88
147_W151_F0.7280.88
102_D105_A0.7270.88
109_A124_H0.7250.87
95_V268_L0.7250.87
119_K250_H0.7240.87
55_P58_L0.7230.87
220_L235_A0.7150.87
17_E22_I0.7130.87
55_P59_I0.7080.86
120_S128_A0.7080.86
136_S168_M0.7050.86
124_H127_S0.7050.86
246_E249_G0.7010.86
40_K176_L0.6990.85
114_R188_T0.6990.85
94_I101_L0.6980.85
60_F64_P0.6980.85
101_L105_A0.6980.85
216_G220_L0.6980.85
130_I237_A0.6950.85
91_L136_S0.6940.85
215_Q242_N0.6900.85
8_A156_A0.6890.85
135_E139_D0.6880.85
23_H29_G0.6870.85
82_L153_L0.6820.84
252_K255_F0.6820.84
207_L212_D0.6820.84
5_L149_L0.6810.84
26_V83_K0.6810.84
158_L161_L0.6810.84
201_I281_V0.6800.84
166_D227_S0.6770.84
9_L13_L0.6750.83
103_D107_Y0.6750.83
139_D187_D0.6730.83
257_N260_C0.6720.83
203_L220_L0.6670.83
130_I263_D0.6610.82
130_I243_V0.6580.82
119_K124_H0.6580.82
50_I54_L0.6570.82
96_T100_R0.6570.82
124_H248_V0.6560.82
61_V64_P0.6560.82
72_Y76_I0.6550.82
148_F153_L0.6540.82
163_N191_N0.6540.82
17_E234_I0.6540.82
135_E166_D0.6530.81
35_L52_S0.6490.81
241_L267_A0.6480.81
186_I189_I0.6460.81
49_W190_L0.6450.81
84_T157_M0.6450.81
225_M247_K0.6420.80
281_V285_I0.6410.80
115_R251_Y0.6410.80
97_K101_L0.6400.80
89_K92_Y0.6390.80
26_V29_G0.6390.80
136_S171_Y0.6360.80
65_I69_I0.6360.80
166_D188_T0.6350.80
139_D166_D0.6340.79
241_L263_D0.6340.79
29_G164_T0.6310.79
135_E187_D0.6300.79
22_I84_T0.6290.79
32_S48_L0.6290.79
146_F150_I0.6280.79
88_I272_K0.6280.79
19_P26_V0.6270.79
268_L272_K0.6250.79
134_F234_I0.6250.79
172_K226_E0.6250.79
85_T153_L0.6240.78
46_V50_I0.6240.78
260_C266_K0.6220.78
23_H113_V0.6180.78
166_D170_G0.6160.78
90_M94_I0.6150.77
260_C284_T0.6150.77
29_G135_E0.6130.77
4_I78_L0.6100.77
134_F225_M0.6080.77
135_E164_T0.6070.76
34_I37_K0.6060.76
23_H164_T0.6060.76
236_I240_L0.6030.76
270_L274_S0.6020.76
179_E183_S0.6010.76
127_S234_I0.5990.76
29_G171_Y0.5990.76
136_S139_D0.5980.75
136_S188_T0.5970.75
199_G236_I0.5960.75
107_Y110_Q0.5960.75
48_L179_E0.5960.75
141_I271_F0.5950.75
31_I34_I0.5920.75
197_L201_I0.5910.75
164_T171_Y0.5900.74
213_V216_G0.5860.74
188_T227_S0.5860.74
9_L276_I0.5840.74
184_A188_T0.5820.73
234_I247_K0.5790.73
127_S246_E0.5760.73
95_V101_L0.5720.72
170_G188_T0.5720.72
28_T157_M0.5710.72
98_G109_A0.5700.72
70_P73_L0.5690.72
13_L276_I0.5690.72
16_S89_K0.5670.72
166_D187_D0.5660.71
172_K181_W0.5630.71
106_R120_S0.5630.71
68_E71_I0.5570.70
116_D250_H0.5560.70
282_I286_Y0.5540.70
276_I280_L0.5530.70
219_A223_A0.5520.70
19_P22_I0.5510.69
130_I264_I0.5510.69
182_F189_I0.5490.69
262_D269_K0.5490.69
217_W220_L0.5490.69
64_P78_L0.5480.69
135_E184_A0.5480.69
85_T160_R0.5470.69
94_I109_A0.5470.69
187_D227_S0.5460.69
27_W31_I0.5460.69
53_V161_L0.5450.69
154_I158_L0.5450.69
69_I73_L0.5440.68
170_G180_G0.5440.68
160_R163_N0.5420.68
43_F46_V0.5410.68
202_M240_L0.5390.68
230_A235_A0.5380.68
138_V198_T0.5380.68
164_T168_M0.5360.67
98_G113_V0.5330.67
152_G155_G0.5320.67
115_R131_E0.5290.66
94_I112_I0.5280.66
29_G167_S0.5280.66
91_L135_E0.5270.66
11_W15_I0.5240.66
198_T275_L0.5240.66
184_A227_S0.5230.65
52_S56_P0.5230.65
4_I7_L0.5230.65
188_T228_V0.5230.65
141_I275_L0.5230.65
77_I81_S0.5210.65
261_E265_E0.5180.65
124_H246_E0.5170.65
206_G213_V0.5160.64
53_V165_M0.5160.64
135_E188_T0.5160.64
126_A179_E0.5150.64
53_V162_A0.5150.64
275_L278_Y0.5150.64
139_D164_T0.5110.64
164_T167_S0.5110.64
100_R265_E0.5100.63
138_V199_G0.5080.63
116_D119_K0.5070.63
23_H135_E0.5070.63
29_G139_D0.5070.63
184_A187_D0.5050.63
163_N187_D0.5030.62
252_K257_N0.5020.62
43_F75_I0.5010.62
131_E246_E0.5010.62
85_T148_F0.5000.62
204_I207_L0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ksdA 1 0.2426 5.2 0.971 Contact Map
2lzrA 1 0.1607 3.8 0.973 Contact Map
3j01B 1 0.3705 3.7 0.973 Contact Map
2l16A 1 0.1705 3.2 0.974 Contact Map
4av3A 2 0.2393 2.6 0.975 Contact Map
4tq3A 1 0.6295 2.6 0.975 Contact Map
2f95B 2 0.1738 1.9 0.977 Contact Map
2mkbA 1 0.082 1.7 0.977 Contact Map
3r1fA 2 0.3148 1.5 0.978 Contact Map
2mn6B 2 0.1541 1.4 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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