Q97TZ5 - SULSO - GREMLIN Contacts

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Q97TZ5 - Probable cobalamin biosynthesis protein CobD

UniProt:	Q97TZ5	Sequences: MLFILALALIWDLTISEPPIYIHPVVWTGKISEILIKPYKGYFYGVILWILSVLPPLLIFVYLPIVAEIPIYLKIIILTFSLKTTFSIKMLYDIVTKGSRLDDQARYYAQQIVRRDLSKSEKGHIASALIESLFESTVDGITSPIFWFLIFGLIGAMLQRLANTMDSMVGYKTPELRKEGWFSAKIDTILNYIPARLTGMIMLIAGLILGLDVKQGWKALREAKMESVNAKYPIAIAAGLLNVSLEKVGHYKVGFGNLPCEDDIEKALKLFKLSLILYFLVISTIYYYLYGISLLTYPYGLIELI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	305 (279)
Sequences:	2655 (2071)
Seq/√Len:	124.0

ECOLI - AMPE
HALSA - Q9HPL3
SULSO - Q97TZ5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
162_A	190_L	4.719	1.00
151_F	155_G	4.604	1.00
42_Y	181_W	3.887	1.00
49_W	186_I	3.229	1.00
95_V	133_L	3.088	1.00
172_K	177_R	2.900	1.00
199_G	220_L	2.893	1.00
121_E	124_H	2.838	1.00
169_V	183_S	2.703	1.00
177_R	181_W	2.675	1.00
28_T	52_S	2.638	1.00
48_L	169_V	2.569	1.00
46_V	181_W	2.526	1.00
49_W	53_V	2.516	1.00
253_V	256_G	2.502	1.00
85_T	156_A	2.441	1.00
34_I	38_P	2.338	1.00
82_L	148_F	2.267	1.00
254_G	259_P	2.264	1.00
263_D	266_K	2.178	1.00
237_A	270_L	2.062	1.00
57_L	158_L	1.996	1.00
89_K	93_D	1.977	1.00
42_Y	178_K	1.943	1.00
108_Y	111_Q	1.916	1.00
260_C	263_D	1.915	1.00
46_V	182_F	1.911	1.00
7_L	79_T	1.887	1.00
206_G	240_L	1.871	1.00
95_V	129_L	1.867	1.00
253_V	259_P	1.848	1.00
120_S	124_H	1.844	1.00
216_G	239_G	1.823	1.00
92_Y	268_L	1.801	1.00
142_T	198_T	1.780	1.00
137_T	198_T	1.752	1.00
130_I	267_A	1.735	1.00
49_W	183_S	1.712	1.00
144_P	159_Q	1.703	1.00
189_I	192_Y	1.686	1.00
142_T	278_Y	1.671	1.00
31_I	52_S	1.670	1.00
36_I	175_E	1.659	1.00
109_A	128_A	1.654	1.00
257_N	263_D	1.635	1.00
143_S	159_Q	1.617	1.00
212_D	215_Q	1.611	1.00
53_V	158_L	1.551	1.00
220_L	232_Y	1.544	1.00
146_F	197_L	1.543	1.00
173_T	176_L	1.526	1.00
39_Y	179_E	1.519	1.00
159_Q	191_N	1.515	1.00
158_L	190_L	1.509	1.00
140_G	167_S	1.505	1.00
92_Y	272_K	1.498	1.00
205_A	277_L	1.489	1.00
223_A	232_Y	1.484	1.00
254_G	258_L	1.482	1.00
148_F	156_A	1.475	1.00
36_I	176_L	1.475	1.00
256_G	259_P	1.469	1.00
253_V	258_L	1.466	1.00
85_T	157_M	1.462	1.00
181_W	185_K	1.457	1.00
160_R	167_S	1.452	1.00
6_A	283_S	1.441	1.00
60_F	157_M	1.436	1.00
49_W	165_M	1.426	1.00
162_A	186_I	1.414	1.00
99_S	265_E	1.409	1.00
82_L	156_A	1.407	1.00
40_K	44_Y	1.398	1.00
255_F	258_L	1.396	1.00
186_I	190_L	1.394	1.00
138_V	143_S	1.389	1.00
109_A	125_I	1.376	1.00
114_R	171_Y	1.372	1.00
202_M	237_A	1.371	1.00
12_D	17_E	1.367	1.00
165_M	183_S	1.366	1.00
215_Q	218_K	1.347	1.00
101_L	104_Q	1.335	1.00
201_I	278_Y	1.325	1.00
30_K	34_I	1.318	1.00
219_A	222_E	1.303	1.00
53_V	186_I	1.280	1.00
8_A	79_T	1.277	1.00
202_M	274_S	1.274	1.00
142_T	201_I	1.269	1.00
49_W	182_F	1.265	1.00
223_A	231_K	1.264	1.00
17_E	26_V	1.262	1.00
13_L	88_I	1.256	1.00
137_T	202_M	1.242	0.99
9_L	279_F	1.235	0.99
104_Q	108_Y	1.222	0.99
104_Q	107_Y	1.218	0.99
203_L	217_W	1.210	0.99
52_S	55_P	1.201	0.99
4_I	8_A	1.196	0.99
178_K	181_W	1.194	0.99
134_F	237_A	1.193	0.99
22_I	27_W	1.189	0.99
140_G	160_R	1.178	0.99
225_M	234_I	1.178	0.99
127_S	249_G	1.177	0.99
66_V	77_I	1.176	0.99
98_G	125_I	1.171	0.99
220_L	223_A	1.167	0.99
92_Y	96_T	1.166	0.99
9_L	275_L	1.166	0.99
8_A	82_L	1.162	0.99
28_T	161_L	1.142	0.99
130_I	245_L	1.140	0.99
129_L	264_I	1.139	0.99
159_Q	163_N	1.130	0.99
40_K	179_E	1.126	0.99
32_S	169_V	1.126	0.99
94_I	97_K	1.121	0.99
137_T	142_T	1.121	0.99
26_V	30_K	1.115	0.99
96_T	265_E	1.109	0.99
39_Y	48_L	1.108	0.99
35_L	51_L	1.106	0.99
74_K	78_L	1.098	0.99
244_S	252_K	1.096	0.99
5_L	148_F	1.081	0.99
253_V	257_N	1.074	0.99
9_L	88_I	1.064	0.98
42_Y	182_F	1.064	0.98
31_I	55_P	1.062	0.98
94_I	108_Y	1.052	0.98
97_K	108_Y	1.046	0.98
4_I	79_T	1.035	0.98
57_L	154_I	1.032	0.98
35_L	48_L	1.031	0.98
216_G	240_L	1.030	0.98
182_F	186_I	1.027	0.98
114_R	234_I	1.021	0.98
32_S	165_M	1.021	0.98
94_I	132_S	1.021	0.98
11_W	83_K	1.001	0.98
206_G	270_L	1.001	0.98
269_K	273_L	0.997	0.98
252_K	256_G	0.994	0.98
49_W	162_A	0.993	0.98
237_A	267_A	0.989	0.97
252_K	258_L	0.989	0.97
15_I	83_K	0.984	0.97
29_G	168_M	0.981	0.97
133_L	271_F	0.978	0.97
102_D	126_A	0.972	0.97
138_V	233_P	0.966	0.97
81_S	153_L	0.966	0.97
78_L	153_L	0.965	0.97
113_V	117_L	0.963	0.97
214_K	218_K	0.962	0.97
203_L	213_V	0.962	0.97
203_L	216_G	0.962	0.97
126_A	261_E	0.958	0.97
255_F	259_P	0.953	0.97
149_L	282_I	0.950	0.97
75_I	79_T	0.945	0.97
7_L	75_I	0.939	0.97
147_W	155_G	0.938	0.97
110_Q	117_L	0.937	0.96
98_G	101_L	0.927	0.96
201_I	274_S	0.926	0.96
102_D	122_K	0.921	0.96
207_L	213_V	0.921	0.96
240_L	270_L	0.915	0.96
248_V	257_N	0.909	0.96
43_F	47_I	0.908	0.96
114_R	167_S	0.905	0.96
107_Y	111_Q	0.904	0.96
206_G	216_G	0.901	0.96
36_I	40_K	0.900	0.96
199_G	232_Y	0.899	0.96
114_R	128_A	0.899	0.96
94_I	111_Q	0.897	0.95
252_K	259_P	0.896	0.95
203_L	240_L	0.892	0.95
219_A	239_G	0.886	0.95
226_E	249_G	0.879	0.95
215_Q	219_A	0.877	0.95
254_G	257_N	0.877	0.95
158_L	162_A	0.865	0.95
223_A	235_A	0.864	0.94
39_Y	47_I	0.860	0.94
202_M	236_I	0.856	0.94
10_I	14_T	0.855	0.94
126_A	264_I	0.855	0.94
96_T	99_S	0.849	0.94
88_I	275_L	0.848	0.94
56_P	161_L	0.844	0.94
138_V	191_N	0.842	0.94
117_L	120_S	0.839	0.94
39_Y	44_Y	0.839	0.94
150_I	155_G	0.838	0.94
138_V	159_Q	0.838	0.94
226_E	230_A	0.835	0.93
199_G	203_L	0.830	0.93
205_A	274_S	0.827	0.93
166_D	184_A	0.824	0.93
268_L	271_F	0.821	0.93
127_S	247_K	0.819	0.93
163_N	167_S	0.818	0.93
278_Y	282_I	0.817	0.93
137_T	274_S	0.816	0.93
6_A	279_F	0.813	0.92
283_S	286_Y	0.810	0.92
201_I	277_L	0.808	0.92
135_E	163_N	0.803	0.92
222_E	239_G	0.800	0.92
174_P	177_R	0.796	0.92
105_A	125_I	0.796	0.92
122_K	126_A	0.787	0.91
22_I	26_V	0.787	0.91
80_F	84_T	0.785	0.91
124_H	249_G	0.785	0.91
51_L	55_P	0.782	0.91
42_Y	46_V	0.780	0.91
96_T	268_L	0.765	0.90
243_V	263_D	0.761	0.90
52_S	161_L	0.760	0.90
205_A	273_L	0.759	0.90
103_D	118_S	0.758	0.90
153_L	156_A	0.752	0.89
126_A	130_I	0.752	0.89
101_L	108_Y	0.749	0.89
99_S	264_I	0.746	0.89
198_T	233_P	0.745	0.89
70_P	74_K	0.743	0.89
5_L	145_I	0.741	0.89
13_L	272_K	0.733	0.88
29_G	136_S	0.730	0.88
147_W	151_F	0.728	0.88
102_D	105_A	0.727	0.88
109_A	124_H	0.725	0.87
95_V	268_L	0.725	0.87
119_K	250_H	0.724	0.87
55_P	58_L	0.723	0.87
220_L	235_A	0.715	0.87
17_E	22_I	0.713	0.87
55_P	59_I	0.708	0.86
120_S	128_A	0.708	0.86
136_S	168_M	0.705	0.86
124_H	127_S	0.705	0.86
246_E	249_G	0.701	0.86
40_K	176_L	0.699	0.85
114_R	188_T	0.699	0.85
94_I	101_L	0.698	0.85
60_F	64_P	0.698	0.85
101_L	105_A	0.698	0.85
216_G	220_L	0.698	0.85
130_I	237_A	0.695	0.85
91_L	136_S	0.694	0.85
215_Q	242_N	0.690	0.85
8_A	156_A	0.689	0.85
135_E	139_D	0.688	0.85
23_H	29_G	0.687	0.85
82_L	153_L	0.682	0.84
252_K	255_F	0.682	0.84
207_L	212_D	0.682	0.84
5_L	149_L	0.681	0.84
26_V	83_K	0.681	0.84
158_L	161_L	0.681	0.84
201_I	281_V	0.680	0.84
166_D	227_S	0.677	0.84
9_L	13_L	0.675	0.83
103_D	107_Y	0.675	0.83
139_D	187_D	0.673	0.83
257_N	260_C	0.672	0.83
203_L	220_L	0.667	0.83
130_I	263_D	0.661	0.82
130_I	243_V	0.658	0.82
119_K	124_H	0.658	0.82
50_I	54_L	0.657	0.82
96_T	100_R	0.657	0.82
124_H	248_V	0.656	0.82
61_V	64_P	0.656	0.82
72_Y	76_I	0.655	0.82
148_F	153_L	0.654	0.82
163_N	191_N	0.654	0.82
17_E	234_I	0.654	0.82
135_E	166_D	0.653	0.81
35_L	52_S	0.649	0.81
241_L	267_A	0.648	0.81
186_I	189_I	0.646	0.81
49_W	190_L	0.645	0.81
84_T	157_M	0.645	0.81
225_M	247_K	0.642	0.80
281_V	285_I	0.641	0.80
115_R	251_Y	0.641	0.80
97_K	101_L	0.640	0.80
89_K	92_Y	0.639	0.80
26_V	29_G	0.639	0.80
136_S	171_Y	0.636	0.80
65_I	69_I	0.636	0.80
166_D	188_T	0.635	0.80
139_D	166_D	0.634	0.79
241_L	263_D	0.634	0.79
29_G	164_T	0.631	0.79
135_E	187_D	0.630	0.79
22_I	84_T	0.629	0.79
32_S	48_L	0.629	0.79
146_F	150_I	0.628	0.79
88_I	272_K	0.628	0.79
19_P	26_V	0.627	0.79
268_L	272_K	0.625	0.79
134_F	234_I	0.625	0.79
172_K	226_E	0.625	0.79
85_T	153_L	0.624	0.78
46_V	50_I	0.624	0.78
260_C	266_K	0.622	0.78
23_H	113_V	0.618	0.78
166_D	170_G	0.616	0.78
90_M	94_I	0.615	0.77
260_C	284_T	0.615	0.77
29_G	135_E	0.613	0.77
4_I	78_L	0.610	0.77
134_F	225_M	0.608	0.77
135_E	164_T	0.607	0.76
34_I	37_K	0.606	0.76
23_H	164_T	0.606	0.76
236_I	240_L	0.603	0.76
270_L	274_S	0.602	0.76
179_E	183_S	0.601	0.76
127_S	234_I	0.599	0.76
29_G	171_Y	0.599	0.76
136_S	139_D	0.598	0.75
136_S	188_T	0.597	0.75
199_G	236_I	0.596	0.75
107_Y	110_Q	0.596	0.75
48_L	179_E	0.596	0.75
141_I	271_F	0.595	0.75
31_I	34_I	0.592	0.75
197_L	201_I	0.591	0.75
164_T	171_Y	0.590	0.74
213_V	216_G	0.586	0.74
188_T	227_S	0.586	0.74
9_L	276_I	0.584	0.74
184_A	188_T	0.582	0.73
234_I	247_K	0.579	0.73
127_S	246_E	0.576	0.73
95_V	101_L	0.572	0.72
170_G	188_T	0.572	0.72
28_T	157_M	0.571	0.72
98_G	109_A	0.570	0.72
70_P	73_L	0.569	0.72
13_L	276_I	0.569	0.72
16_S	89_K	0.567	0.72
166_D	187_D	0.566	0.71
172_K	181_W	0.563	0.71
106_R	120_S	0.563	0.71
68_E	71_I	0.557	0.70
116_D	250_H	0.556	0.70
282_I	286_Y	0.554	0.70
276_I	280_L	0.553	0.70
219_A	223_A	0.552	0.70
19_P	22_I	0.551	0.69
130_I	264_I	0.551	0.69
182_F	189_I	0.549	0.69
262_D	269_K	0.549	0.69
217_W	220_L	0.549	0.69
64_P	78_L	0.548	0.69
135_E	184_A	0.548	0.69
85_T	160_R	0.547	0.69
94_I	109_A	0.547	0.69
187_D	227_S	0.546	0.69
27_W	31_I	0.546	0.69
53_V	161_L	0.545	0.69
154_I	158_L	0.545	0.69
69_I	73_L	0.544	0.68
170_G	180_G	0.544	0.68
160_R	163_N	0.542	0.68
43_F	46_V	0.541	0.68
202_M	240_L	0.539	0.68
230_A	235_A	0.538	0.68
138_V	198_T	0.538	0.68
164_T	168_M	0.536	0.67
98_G	113_V	0.533	0.67
152_G	155_G	0.532	0.67
115_R	131_E	0.529	0.66
94_I	112_I	0.528	0.66
29_G	167_S	0.528	0.66
91_L	135_E	0.527	0.66
11_W	15_I	0.524	0.66
198_T	275_L	0.524	0.66
184_A	227_S	0.523	0.65
52_S	56_P	0.523	0.65
4_I	7_L	0.523	0.65
188_T	228_V	0.523	0.65
141_I	275_L	0.523	0.65
77_I	81_S	0.521	0.65
261_E	265_E	0.518	0.65
124_H	246_E	0.517	0.65
206_G	213_V	0.516	0.64
53_V	165_M	0.516	0.64
135_E	188_T	0.516	0.64
126_A	179_E	0.515	0.64
53_V	162_A	0.515	0.64
275_L	278_Y	0.515	0.64
139_D	164_T	0.511	0.64
164_T	167_S	0.511	0.64
100_R	265_E	0.510	0.63
138_V	199_G	0.508	0.63
116_D	119_K	0.507	0.63
23_H	135_E	0.507	0.63
29_G	139_D	0.507	0.63
184_A	187_D	0.505	0.63
163_N	187_D	0.503	0.62
252_K	257_N	0.502	0.62
43_F	75_I	0.501	0.62
131_E	246_E	0.501	0.62
85_T	148_F	0.500	0.62
204_I	207_L	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ksdA	1	0.2426	5.2	0.971	Contact Map
2lzrA	1	0.1607	3.8	0.973	Contact Map
3j01B	1	0.3705	3.7	0.973	Contact Map
2l16A	1	0.1705	3.2	0.974	Contact Map
4av3A	2	0.2393	2.6	0.975	Contact Map
4tq3A	1	0.6295	2.6	0.975	Contact Map
2f95B	2	0.1738	1.9	0.977	Contact Map
2mkbA	1	0.082	1.7	0.977	Contact Map
3r1fA	2	0.3148	1.5	0.978	Contact Map
2mn6B	2	0.1541	1.4	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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