GREMLIN Database
Q97TZ4 - Sorbitol dehydrogenase
UniProt: Q97TZ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (300)
Sequences: 52824 (36604)
Seq/√Len: 2113.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_K143_F3.0191.00
36_K70_Q3.0121.00
38_K68_I2.8751.00
325_E328_E2.8011.00
34_L70_Q2.6021.00
14_E21_K2.5301.00
78_K81_D2.5071.00
82_R137_L2.5061.00
81_D136_K2.3711.00
33_V134_V2.3671.00
142_S145_E2.3051.00
187_K213_N2.2941.00
25_L121_Y2.2921.00
169_T192_G2.2671.00
321_F332_I2.2461.00
14_E19_V2.2321.00
36_K68_I2.2151.00
36_K121_Y2.2051.00
165_D168_D2.1931.00
65_P117_G2.1861.00
170_V186_A2.1751.00
319_H332_I2.1511.00
144_E320_R2.1461.00
226_E229_R2.1351.00
65_P85_A2.0701.00
12_I21_K2.0651.00
204_T208_Y2.0541.00
29_Q32_D2.0521.00
34_L123_R1.9601.00
76_W126_A1.9571.00
30_Q72_S1.9491.00
183_A212_I1.9381.00
140_N307_A1.9271.00
51_C334_K1.9131.00
304_A308_N1.8921.00
70_Q121_Y1.8891.00
331_R335_E1.8491.00
204_T215_S1.8401.00
188_V310_K1.8371.00
30_Q73_T1.8291.00
152_L181_L1.8261.00
322_S325_E1.8251.00
82_R143_F1.8181.00
66_T143_F1.8141.00
205_E208_Y1.7881.00
205_E209_K1.7821.00
261_R287_S1.7451.00
31_G73_T1.7291.00
332_I337_N1.7241.00
237_D257_R1.7231.00
171_F197_S1.7221.00
171_F236_A1.6851.00
137_L143_F1.6751.00
261_R289_I1.6621.00
328_E331_R1.6541.00
195_I236_A1.6481.00
206_F209_K1.6351.00
328_E332_I1.6221.00
214_Y230_L1.6181.00
11_V326_F1.5651.00
27_K71_E1.5611.00
34_L121_Y1.5481.00
321_F329_A1.5421.00
173_V252_G1.5391.00
175_I196_A1.5341.00
71_E79_P1.5321.00
68_I82_R1.5301.00
198_D204_T1.5291.00
77_L81_D1.5201.00
201_D205_E1.5031.00
256_T262_V1.4991.00
221_V226_E1.4951.00
9_K22_E1.4941.00
201_D217_N1.4811.00
137_L146_G1.4761.00
118_F330_V1.4691.00
239_T256_T1.4621.00
162_V238_V1.4591.00
327_N331_R1.4541.00
256_T286_I1.4441.00
31_G125_P1.4401.00
34_L71_E1.4361.00
32_D125_P1.4321.00
37_M65_P1.4181.00
77_L136_K1.4131.00
256_T260_G1.4081.00
32_D123_R1.4021.00
201_D220_K1.3991.00
10_S23_L1.3901.00
168_D261_R1.3741.00
192_G214_Y1.3631.00
222_N225_D1.3611.00
82_R139_D1.3561.00
28_L123_R1.3461.00
239_T252_G1.3461.00
318_T332_I1.3431.00
188_V305_I1.3311.00
28_L34_L1.3281.00
39_A144_E1.3271.00
9_K324_D1.3251.00
33_V77_L1.3161.00
50_I330_V1.3151.00
199_V218_A1.3061.00
304_A307_A1.2921.00
68_I143_F1.2881.00
173_V197_S1.2851.00
192_G213_N1.2831.00
11_V20_I1.2781.00
169_T195_I1.2731.00
217_N220_K1.2701.00
160_K298_D1.2651.00
209_K315_K1.2591.00
201_D204_T1.2581.00
182_H240_I1.2551.00
38_K82_R1.2541.00
9_K120_E1.2511.00
69_I77_L1.2491.00
183_A196_A1.2421.00
37_M122_F1.2221.00
225_D229_R1.2041.00
226_E230_L1.1961.00
149_I306_I1.1931.00
204_T217_N1.1931.00
25_L34_L1.1921.00
184_M312_D1.1651.00
77_L134_V1.1521.00
31_G126_A1.1401.00
169_T237_D1.1331.00
305_I310_K1.1191.00
208_Y215_S1.1171.00
296_E300_K1.1151.00
160_K301_E1.1111.00
224_V254_N1.1051.00
254_N280_D1.1041.00
164_I191_A1.0901.00
157_R298_D1.0841.00
168_D237_D1.0781.00
124_V134_V1.0761.00
312_D315_K1.0701.00
8_M25_L1.0651.00
162_V263_L1.0621.00
301_E304_A1.0611.00
206_F338_A1.0581.00
164_I168_D1.0561.00
224_V251_S1.0531.00
222_N226_E1.0471.00
12_I23_L1.0451.00
50_I334_K1.0411.00
42_L329_A1.0331.00
155_V182_H1.0181.00
39_A143_F1.0181.00
127_W133_G1.0091.00
11_V323_L1.0091.00
35_V83_V1.0071.00
161_R287_S1.0061.00
70_Q79_P1.0051.00
186_A191_A0.9971.00
175_I198_D0.9941.00
220_K226_E0.9881.00
35_V67_G0.9861.00
243_S248_A0.9851.00
251_S254_N0.9841.00
331_R334_K0.9821.00
326_F343_I0.9821.00
40_C118_F0.9781.00
20_I324_D0.9761.00
196_A207_G0.9731.00
321_F325_E0.9721.00
200_S203_R0.9611.00
156_I301_E0.9581.00
158_A265_F0.9541.00
224_V228_K0.9541.00
300_K304_A0.9511.00
155_V185_M0.9471.00
28_L32_D0.9471.00
195_I214_Y0.9441.00
74_V126_A0.9441.00
208_Y214_Y0.9441.00
14_E17_K0.9381.00
332_I341_V0.9351.00
152_L302_A0.9331.00
145_E312_D0.9291.00
141_V146_G0.9281.00
47_I333_G0.9211.00
301_E305_I0.9191.00
43_C64_E0.9181.00
158_A240_I0.9161.00
199_V219_K0.9131.00
196_A212_I0.9111.00
280_D284_N0.9081.00
241_I244_G0.9061.00
40_C117_G0.9041.00
250_V254_N0.8951.00
38_K66_T0.8941.00
118_F326_F0.8931.00
183_A194_I0.8921.00
84_F303_L0.8911.00
9_K20_I0.8841.00
197_S218_A0.8821.00
161_R289_I0.8801.00
227_V236_A0.8741.00
203_R338_A0.8731.00
180_L206_F0.8701.00
171_F255_A0.8691.00
259_G285_E0.8691.00
39_A342_I0.8681.00
72_S75_D0.8671.00
168_D238_V0.8651.00
231_T235_G0.8591.00
75_D126_A0.8561.00
202_F205_E0.8481.00
172_I182_H0.8381.00
43_C63_H0.8371.00
173_V239_T0.8361.00
297_E301_E0.8361.00
36_K120_E0.8341.00
174_G196_A0.8321.00
195_I216_L0.8291.00
12_I60_I0.8261.00
11_V18_A0.8251.00
25_L71_E0.8251.00
10_S60_I0.8251.00
23_L115_P0.8231.00
118_F343_I0.8211.00
153_A298_D0.8201.00
172_I186_A0.8181.00
25_L70_Q0.8181.00
199_V204_T0.8111.00
65_P122_F0.8061.00
198_D215_S0.8031.00
43_C46_D0.8021.00
169_T236_A0.8011.00
78_K136_K0.8011.00
173_V248_A0.7971.00
135_L300_K0.7961.00
185_M302_A0.7961.00
239_T262_V0.7901.00
41_G64_E0.7891.00
207_G212_I0.7881.00
252_G262_V0.7871.00
139_D307_A0.7801.00
163_A261_R0.7781.00
242_A265_F0.7771.00
297_E300_K0.7771.00
281_L288_I0.7771.00
170_V191_A0.7761.00
33_V126_A0.7751.00
185_M305_I0.7751.00
85_A124_V0.7691.00
223_V251_S0.7681.00
159_Q186_A0.7681.00
189_N301_E0.7631.00
321_F341_V0.7631.00
305_I308_N0.7621.00
27_K34_L0.7611.00
42_L333_G0.7601.00
277_D280_D0.7591.00
209_K312_D0.7561.00
319_H328_E0.7561.00
155_V181_L0.7551.00
225_D228_K0.7491.00
117_G122_F0.7491.00
175_I207_G0.7471.00
224_V255_A0.7451.00
23_L60_I0.7441.00
195_I227_V0.7381.00
186_A194_I0.7331.00
20_I323_L0.7311.00
29_Q123_R0.7311.00
332_I335_E0.7271.00
175_I183_A0.7251.00
158_A182_H0.7251.00
83_V134_V0.7231.00
45_T63_H0.7221.00
317_I320_R0.7221.00
84_F137_L0.7201.00
333_G341_V0.7181.00
192_G195_I0.7171.00
250_V273_I0.7151.00
66_T147_A0.7111.00
195_I230_L0.7081.00
194_I213_N0.7011.00
250_V280_D0.6981.00
321_F343_I0.6981.00
28_L71_E0.6971.00
191_A238_V0.6941.00
163_A287_S0.6881.00
156_I305_I0.6881.00
164_I238_V0.6871.00
135_L299_T0.6861.00
76_W296_E0.6831.00
37_M40_C0.6831.00
39_A320_R0.6831.00
138_P307_A0.6821.00
222_N251_S0.6821.00
303_L307_A0.6791.00
157_R285_E0.6791.00
8_M120_E0.6781.00
172_I196_A0.6781.00
281_L290_P0.6741.00
31_G127_W0.6741.00
200_S217_N0.6721.00
84_F150_E0.6711.00
11_V327_N0.6711.00
47_I334_K0.6691.00
305_I309_K0.6681.00
155_V178_M0.6671.00
141_V306_I0.6661.00
156_I298_D0.6641.00
8_M26_P0.6611.00
246_P250_V0.6611.00
264_L288_I0.6581.00
81_D139_D0.6581.00
206_F210_V0.6561.00
245_S248_A0.6531.00
241_I262_V0.6531.00
249_I262_V0.6501.00
156_I302_A0.6501.00
66_T137_L0.6481.00
16_G331_R0.6471.00
236_A239_T0.6461.00
281_L286_I0.6461.00
39_A66_T0.6431.00
13_M17_K0.6431.00
160_K189_N0.6421.00
163_A289_I0.6421.00
238_V263_L0.6411.00
166_N190_K0.6401.00
26_P123_R0.6371.00
214_Y226_E0.6361.00
258_K284_N0.6361.00
155_V159_Q0.6321.00
191_A194_I0.6301.00
160_K163_A0.6291.00
8_M119_S0.6291.00
232_D235_G0.6261.00
183_A210_V0.6251.00
198_D218_A0.6251.00
154_T178_M0.6241.00
167_G192_G0.6241.00
33_V69_I0.6221.00
319_H341_V0.6211.00
85_A134_V0.6201.00
43_C151_P0.6191.00
31_G72_S0.6191.00
184_M210_V0.6181.00
185_M189_N0.6151.00
63_H151_P0.6151.00
66_T82_R0.6081.00
182_H265_F0.6071.00
82_R140_N0.6061.00
45_T49_K0.6051.00
35_V134_V0.6051.00
280_D283_N0.6031.00
135_L303_L0.6001.00
238_V261_R0.5991.00
228_K235_G0.5971.00
183_A207_G0.5951.00
298_D301_E0.5951.00
35_V85_A0.5911.00
86_H135_L0.5891.00
47_I51_C0.5881.00
44_G48_E0.5871.00
250_V275_N0.5861.00
187_K194_I0.5861.00
227_V255_A0.5851.00
330_V334_K0.5841.00
17_K327_N0.5841.00
223_V227_V0.5831.00
135_L296_E0.5831.00
42_L118_F0.5821.00
204_T207_G0.5811.00
236_A255_A0.5811.00
319_H338_A0.5761.00
15_N19_V0.5751.00
216_L230_L0.5741.00
48_E53_Q0.5731.00
149_I302_A0.5701.00
171_F239_T0.5691.00
207_G215_S0.5691.00
216_L226_E0.5691.00
158_A263_L0.5691.00
148_F342_I0.5681.00
40_C343_I0.5671.00
18_A330_V0.5651.00
162_V261_R0.5641.00
180_L210_V0.5631.00
274_L277_D0.5631.00
75_D78_K0.5631.00
76_W79_P0.5621.00
198_D217_N0.5611.00
142_S146_G0.5611.00
62_G118_F0.5601.00
150_E154_T0.5591.00
26_P32_D0.5581.00
125_P133_G0.5571.00
273_I277_D0.5551.00
45_T48_E0.5551.00
170_V238_V0.5531.00
286_I290_P0.5501.00
199_V207_G0.5481.00
272_T275_N0.5461.00
285_E295_V0.5461.00
228_K231_T0.5431.00
180_L316_L0.5401.00
169_T231_T0.5381.00
154_T265_F0.5371.00
248_A252_G0.5371.00
85_A117_G0.5361.00
26_P121_Y0.5361.00
160_K297_E0.5351.00
159_Q185_M0.5341.00
239_T255_A0.5341.00
43_C340_K0.5331.00
318_T339_I0.5321.00
59_P62_G0.5311.00
203_R337_N0.5291.00
319_H325_E0.5271.00
64_E151_P0.5271.00
77_L126_A0.5251.00
151_P154_T0.5251.00
197_S216_L0.5231.00
31_G74_V0.5231.00
181_L311_I0.5221.00
300_K303_L0.5211.00
76_W136_K0.5201.00
24_P27_K0.5181.00
172_I183_A0.5171.00
292_N295_V0.5171.00
17_K50_I0.5161.00
181_L185_M0.5161.00
175_I179_G0.5161.00
263_L291_S0.5151.00
166_N189_N0.5151.00
241_I266_G0.5141.00
163_A189_N0.5121.00
89_V133_G0.5111.00
66_T146_G0.5101.00
187_K212_I0.5091.00
309_K312_D0.5081.00
158_A291_S0.5071.00
248_A251_S0.5071.00
37_M85_A0.5061.00
321_F328_E0.5051.00
44_G176_G0.5031.00
159_Q182_H0.5031.00
157_R161_R0.5031.00
263_L289_I0.5011.00
184_M315_K0.5001.00
136_K139_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ej6A 1 0.9681 100 0.188 Contact Map
1vj0A 4 0.9739 100 0.196 Contact Map
4gi2A 2 0.971 100 0.198 Contact Map
1f8fA 4 0.9652 100 0.199 Contact Map
3m6iA 4 0.9623 100 0.201 Contact Map
4cpdA 2 0.9623 100 0.202 Contact Map
3ukoA 4 0.9797 100 0.202 Contact Map
1e3iA 2 0.9739 100 0.204 Contact Map
4ilkA 2 0.9565 100 0.206 Contact Map
1p0fA 2 0.9739 100 0.207 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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