Q97TZ4 - SULSO - GREMLIN Contacts

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Q97TZ4 - Sorbitol dehydrogenase

UniProt:	Q97TZ4	Sequences: MVEGFSPMKSVIMENGKAVIKELPLPKLQQGDVLVKMKACGLCGTDIEKICGQYTASQPILGHEPTGIIQESTVDWLKPGDRVFAHHHVPCYECYYCKKGSPTMCPYYRKTNLDPGGFSEYFRVPAWNVARGGVLKLPDNVSFEEGAFIEPLATVIRAQKRVAIDNGDTVFIVGIGPMGLLHAMMAKVNKAGVIIASDVSDFRTEFGYKVGINYSLNAKKVNVVDEVKRLTDGRGADVTIIASGSPSAIVSGLNATRKGGRVLLFGVPYKGTILNYDISDLLNNEISIIPSNAAVEEDTKEALAIIANKKIDVTKLITHRFSLDEFNEAVRIGKEGNAIKVIIYS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	345 (300)
Sequences:	52824 (36604)
Seq/√Len:	2113.3

ECOLI - YBDR YDJL GATD FRMA YPHC RSPB YGGP YDJJ YJJN IDND ADHP TDH YAHK AHR YCJQ QOR1 ACUI CURA
BACSU - DHSO TDH ADHB YJMD YYCR ADHA BDHA YOGA YHFP YFMJ
HALSA - Q9HMB6 Q9HP38 GLCDH Q9HQS8 Q9HR85
SULSO - Q97TZ4 Q97ZV3 Q97YT7 Q97XR4 Q97VV5 ADH Q97WA1 Q7LXK1 Q97YM2 Q97V32 GLCD1 Q97VW0 GLCD2 GLCD3 Q97W06 Q97VB8 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
38_K	143_F	3.019	1.00
36_K	70_Q	3.012	1.00
38_K	68_I	2.875	1.00
325_E	328_E	2.801	1.00
34_L	70_Q	2.602	1.00
14_E	21_K	2.530	1.00
78_K	81_D	2.507	1.00
82_R	137_L	2.506	1.00
81_D	136_K	2.371	1.00
33_V	134_V	2.367	1.00
142_S	145_E	2.305	1.00
187_K	213_N	2.294	1.00
25_L	121_Y	2.292	1.00
169_T	192_G	2.267	1.00
321_F	332_I	2.246	1.00
14_E	19_V	2.232	1.00
36_K	68_I	2.215	1.00
36_K	121_Y	2.205	1.00
165_D	168_D	2.193	1.00
65_P	117_G	2.186	1.00
170_V	186_A	2.175	1.00
319_H	332_I	2.151	1.00
144_E	320_R	2.146	1.00
226_E	229_R	2.135	1.00
65_P	85_A	2.070	1.00
12_I	21_K	2.065	1.00
204_T	208_Y	2.054	1.00
29_Q	32_D	2.052	1.00
34_L	123_R	1.960	1.00
76_W	126_A	1.957	1.00
30_Q	72_S	1.949	1.00
183_A	212_I	1.938	1.00
140_N	307_A	1.927	1.00
51_C	334_K	1.913	1.00
304_A	308_N	1.892	1.00
70_Q	121_Y	1.889	1.00
331_R	335_E	1.849	1.00
204_T	215_S	1.840	1.00
188_V	310_K	1.837	1.00
30_Q	73_T	1.829	1.00
152_L	181_L	1.826	1.00
322_S	325_E	1.825	1.00
82_R	143_F	1.818	1.00
66_T	143_F	1.814	1.00
205_E	208_Y	1.788	1.00
205_E	209_K	1.782	1.00
261_R	287_S	1.745	1.00
31_G	73_T	1.729	1.00
332_I	337_N	1.724	1.00
237_D	257_R	1.723	1.00
171_F	197_S	1.722	1.00
171_F	236_A	1.685	1.00
137_L	143_F	1.675	1.00
261_R	289_I	1.662	1.00
328_E	331_R	1.654	1.00
195_I	236_A	1.648	1.00
206_F	209_K	1.635	1.00
328_E	332_I	1.622	1.00
214_Y	230_L	1.618	1.00
11_V	326_F	1.565	1.00
27_K	71_E	1.561	1.00
34_L	121_Y	1.548	1.00
321_F	329_A	1.542	1.00
173_V	252_G	1.539	1.00
175_I	196_A	1.534	1.00
71_E	79_P	1.532	1.00
68_I	82_R	1.530	1.00
198_D	204_T	1.529	1.00
77_L	81_D	1.520	1.00
201_D	205_E	1.503	1.00
256_T	262_V	1.499	1.00
221_V	226_E	1.495	1.00
9_K	22_E	1.494	1.00
201_D	217_N	1.481	1.00
137_L	146_G	1.476	1.00
118_F	330_V	1.469	1.00
239_T	256_T	1.462	1.00
162_V	238_V	1.459	1.00
327_N	331_R	1.454	1.00
256_T	286_I	1.444	1.00
31_G	125_P	1.440	1.00
34_L	71_E	1.436	1.00
32_D	125_P	1.432	1.00
37_M	65_P	1.418	1.00
77_L	136_K	1.413	1.00
256_T	260_G	1.408	1.00
32_D	123_R	1.402	1.00
201_D	220_K	1.399	1.00
10_S	23_L	1.390	1.00
168_D	261_R	1.374	1.00
192_G	214_Y	1.363	1.00
222_N	225_D	1.361	1.00
82_R	139_D	1.356	1.00
28_L	123_R	1.346	1.00
239_T	252_G	1.346	1.00
318_T	332_I	1.343	1.00
188_V	305_I	1.331	1.00
28_L	34_L	1.328	1.00
39_A	144_E	1.327	1.00
9_K	324_D	1.325	1.00
33_V	77_L	1.316	1.00
50_I	330_V	1.315	1.00
199_V	218_A	1.306	1.00
304_A	307_A	1.292	1.00
68_I	143_F	1.288	1.00
173_V	197_S	1.285	1.00
192_G	213_N	1.283	1.00
11_V	20_I	1.278	1.00
169_T	195_I	1.273	1.00
217_N	220_K	1.270	1.00
160_K	298_D	1.265	1.00
209_K	315_K	1.259	1.00
201_D	204_T	1.258	1.00
182_H	240_I	1.255	1.00
38_K	82_R	1.254	1.00
9_K	120_E	1.251	1.00
69_I	77_L	1.249	1.00
183_A	196_A	1.242	1.00
37_M	122_F	1.222	1.00
225_D	229_R	1.204	1.00
226_E	230_L	1.196	1.00
149_I	306_I	1.193	1.00
204_T	217_N	1.193	1.00
25_L	34_L	1.192	1.00
184_M	312_D	1.165	1.00
77_L	134_V	1.152	1.00
31_G	126_A	1.140	1.00
169_T	237_D	1.133	1.00
305_I	310_K	1.119	1.00
208_Y	215_S	1.117	1.00
296_E	300_K	1.115	1.00
160_K	301_E	1.111	1.00
224_V	254_N	1.105	1.00
254_N	280_D	1.104	1.00
164_I	191_A	1.090	1.00
157_R	298_D	1.084	1.00
168_D	237_D	1.078	1.00
124_V	134_V	1.076	1.00
312_D	315_K	1.070	1.00
8_M	25_L	1.065	1.00
162_V	263_L	1.062	1.00
301_E	304_A	1.061	1.00
206_F	338_A	1.058	1.00
164_I	168_D	1.056	1.00
224_V	251_S	1.053	1.00
222_N	226_E	1.047	1.00
12_I	23_L	1.045	1.00
50_I	334_K	1.041	1.00
42_L	329_A	1.033	1.00
155_V	182_H	1.018	1.00
39_A	143_F	1.018	1.00
127_W	133_G	1.009	1.00
11_V	323_L	1.009	1.00
35_V	83_V	1.007	1.00
161_R	287_S	1.006	1.00
70_Q	79_P	1.005	1.00
186_A	191_A	0.997	1.00
175_I	198_D	0.994	1.00
220_K	226_E	0.988	1.00
35_V	67_G	0.986	1.00
243_S	248_A	0.985	1.00
251_S	254_N	0.984	1.00
331_R	334_K	0.982	1.00
326_F	343_I	0.982	1.00
40_C	118_F	0.978	1.00
20_I	324_D	0.976	1.00
196_A	207_G	0.973	1.00
321_F	325_E	0.972	1.00
200_S	203_R	0.961	1.00
156_I	301_E	0.958	1.00
158_A	265_F	0.954	1.00
224_V	228_K	0.954	1.00
300_K	304_A	0.951	1.00
155_V	185_M	0.947	1.00
28_L	32_D	0.947	1.00
195_I	214_Y	0.944	1.00
74_V	126_A	0.944	1.00
208_Y	214_Y	0.944	1.00
14_E	17_K	0.938	1.00
332_I	341_V	0.935	1.00
152_L	302_A	0.933	1.00
145_E	312_D	0.929	1.00
141_V	146_G	0.928	1.00
47_I	333_G	0.921	1.00
301_E	305_I	0.919	1.00
43_C	64_E	0.918	1.00
158_A	240_I	0.916	1.00
199_V	219_K	0.913	1.00
196_A	212_I	0.911	1.00
280_D	284_N	0.908	1.00
241_I	244_G	0.906	1.00
40_C	117_G	0.904	1.00
250_V	254_N	0.895	1.00
38_K	66_T	0.894	1.00
118_F	326_F	0.893	1.00
183_A	194_I	0.892	1.00
84_F	303_L	0.891	1.00
9_K	20_I	0.884	1.00
197_S	218_A	0.882	1.00
161_R	289_I	0.880	1.00
227_V	236_A	0.874	1.00
203_R	338_A	0.873	1.00
180_L	206_F	0.870	1.00
171_F	255_A	0.869	1.00
259_G	285_E	0.869	1.00
39_A	342_I	0.868	1.00
72_S	75_D	0.867	1.00
168_D	238_V	0.865	1.00
231_T	235_G	0.859	1.00
75_D	126_A	0.856	1.00
202_F	205_E	0.848	1.00
172_I	182_H	0.838	1.00
43_C	63_H	0.837	1.00
173_V	239_T	0.836	1.00
297_E	301_E	0.836	1.00
36_K	120_E	0.834	1.00
174_G	196_A	0.832	1.00
195_I	216_L	0.829	1.00
12_I	60_I	0.826	1.00
11_V	18_A	0.825	1.00
25_L	71_E	0.825	1.00
10_S	60_I	0.825	1.00
23_L	115_P	0.823	1.00
118_F	343_I	0.821	1.00
153_A	298_D	0.820	1.00
172_I	186_A	0.818	1.00
25_L	70_Q	0.818	1.00
199_V	204_T	0.811	1.00
65_P	122_F	0.806	1.00
198_D	215_S	0.803	1.00
43_C	46_D	0.802	1.00
169_T	236_A	0.801	1.00
78_K	136_K	0.801	1.00
173_V	248_A	0.797	1.00
135_L	300_K	0.796	1.00
185_M	302_A	0.796	1.00
239_T	262_V	0.790	1.00
41_G	64_E	0.789	1.00
207_G	212_I	0.788	1.00
252_G	262_V	0.787	1.00
139_D	307_A	0.780	1.00
163_A	261_R	0.778	1.00
242_A	265_F	0.777	1.00
297_E	300_K	0.777	1.00
281_L	288_I	0.777	1.00
170_V	191_A	0.776	1.00
33_V	126_A	0.775	1.00
185_M	305_I	0.775	1.00
85_A	124_V	0.769	1.00
223_V	251_S	0.768	1.00
159_Q	186_A	0.768	1.00
189_N	301_E	0.763	1.00
321_F	341_V	0.763	1.00
305_I	308_N	0.762	1.00
27_K	34_L	0.761	1.00
42_L	333_G	0.760	1.00
277_D	280_D	0.759	1.00
209_K	312_D	0.756	1.00
319_H	328_E	0.756	1.00
155_V	181_L	0.755	1.00
225_D	228_K	0.749	1.00
117_G	122_F	0.749	1.00
175_I	207_G	0.747	1.00
224_V	255_A	0.745	1.00
23_L	60_I	0.744	1.00
195_I	227_V	0.738	1.00
186_A	194_I	0.733	1.00
20_I	323_L	0.731	1.00
29_Q	123_R	0.731	1.00
332_I	335_E	0.727	1.00
175_I	183_A	0.725	1.00
158_A	182_H	0.725	1.00
83_V	134_V	0.723	1.00
45_T	63_H	0.722	1.00
317_I	320_R	0.722	1.00
84_F	137_L	0.720	1.00
333_G	341_V	0.718	1.00
192_G	195_I	0.717	1.00
250_V	273_I	0.715	1.00
66_T	147_A	0.711	1.00
195_I	230_L	0.708	1.00
194_I	213_N	0.701	1.00
250_V	280_D	0.698	1.00
321_F	343_I	0.698	1.00
28_L	71_E	0.697	1.00
191_A	238_V	0.694	1.00
163_A	287_S	0.688	1.00
156_I	305_I	0.688	1.00
164_I	238_V	0.687	1.00
135_L	299_T	0.686	1.00
76_W	296_E	0.683	1.00
37_M	40_C	0.683	1.00
39_A	320_R	0.683	1.00
138_P	307_A	0.682	1.00
222_N	251_S	0.682	1.00
303_L	307_A	0.679	1.00
157_R	285_E	0.679	1.00
8_M	120_E	0.678	1.00
172_I	196_A	0.678	1.00
281_L	290_P	0.674	1.00
31_G	127_W	0.674	1.00
200_S	217_N	0.672	1.00
84_F	150_E	0.671	1.00
11_V	327_N	0.671	1.00
47_I	334_K	0.669	1.00
305_I	309_K	0.668	1.00
155_V	178_M	0.667	1.00
141_V	306_I	0.666	1.00
156_I	298_D	0.664	1.00
8_M	26_P	0.661	1.00
246_P	250_V	0.661	1.00
264_L	288_I	0.658	1.00
81_D	139_D	0.658	1.00
206_F	210_V	0.656	1.00
245_S	248_A	0.653	1.00
241_I	262_V	0.653	1.00
249_I	262_V	0.650	1.00
156_I	302_A	0.650	1.00
66_T	137_L	0.648	1.00
16_G	331_R	0.647	1.00
236_A	239_T	0.646	1.00
281_L	286_I	0.646	1.00
39_A	66_T	0.643	1.00
13_M	17_K	0.643	1.00
160_K	189_N	0.642	1.00
163_A	289_I	0.642	1.00
238_V	263_L	0.641	1.00
166_N	190_K	0.640	1.00
26_P	123_R	0.637	1.00
214_Y	226_E	0.636	1.00
258_K	284_N	0.636	1.00
155_V	159_Q	0.632	1.00
191_A	194_I	0.630	1.00
160_K	163_A	0.629	1.00
8_M	119_S	0.629	1.00
232_D	235_G	0.626	1.00
183_A	210_V	0.625	1.00
198_D	218_A	0.625	1.00
154_T	178_M	0.624	1.00
167_G	192_G	0.624	1.00
33_V	69_I	0.622	1.00
319_H	341_V	0.621	1.00
85_A	134_V	0.620	1.00
43_C	151_P	0.619	1.00
31_G	72_S	0.619	1.00
184_M	210_V	0.618	1.00
185_M	189_N	0.615	1.00
63_H	151_P	0.615	1.00
66_T	82_R	0.608	1.00
182_H	265_F	0.607	1.00
82_R	140_N	0.606	1.00
45_T	49_K	0.605	1.00
35_V	134_V	0.605	1.00
280_D	283_N	0.603	1.00
135_L	303_L	0.600	1.00
238_V	261_R	0.599	1.00
228_K	235_G	0.597	1.00
183_A	207_G	0.595	1.00
298_D	301_E	0.595	1.00
35_V	85_A	0.591	1.00
86_H	135_L	0.589	1.00
47_I	51_C	0.588	1.00
44_G	48_E	0.587	1.00
250_V	275_N	0.586	1.00
187_K	194_I	0.586	1.00
227_V	255_A	0.585	1.00
330_V	334_K	0.584	1.00
17_K	327_N	0.584	1.00
223_V	227_V	0.583	1.00
135_L	296_E	0.583	1.00
42_L	118_F	0.582	1.00
204_T	207_G	0.581	1.00
236_A	255_A	0.581	1.00
319_H	338_A	0.576	1.00
15_N	19_V	0.575	1.00
216_L	230_L	0.574	1.00
48_E	53_Q	0.573	1.00
149_I	302_A	0.570	1.00
171_F	239_T	0.569	1.00
207_G	215_S	0.569	1.00
216_L	226_E	0.569	1.00
158_A	263_L	0.569	1.00
148_F	342_I	0.568	1.00
40_C	343_I	0.567	1.00
18_A	330_V	0.565	1.00
162_V	261_R	0.564	1.00
180_L	210_V	0.563	1.00
274_L	277_D	0.563	1.00
75_D	78_K	0.563	1.00
76_W	79_P	0.562	1.00
198_D	217_N	0.561	1.00
142_S	146_G	0.561	1.00
62_G	118_F	0.560	1.00
150_E	154_T	0.559	1.00
26_P	32_D	0.558	1.00
125_P	133_G	0.557	1.00
273_I	277_D	0.555	1.00
45_T	48_E	0.555	1.00
170_V	238_V	0.553	1.00
286_I	290_P	0.550	1.00
199_V	207_G	0.548	1.00
272_T	275_N	0.546	1.00
285_E	295_V	0.546	1.00
228_K	231_T	0.543	1.00
180_L	316_L	0.540	1.00
169_T	231_T	0.538	1.00
154_T	265_F	0.537	1.00
248_A	252_G	0.537	1.00
85_A	117_G	0.536	1.00
26_P	121_Y	0.536	1.00
160_K	297_E	0.535	1.00
159_Q	185_M	0.534	1.00
239_T	255_A	0.534	1.00
43_C	340_K	0.533	1.00
318_T	339_I	0.532	1.00
59_P	62_G	0.531	1.00
203_R	337_N	0.529	1.00
319_H	325_E	0.527	1.00
64_E	151_P	0.527	1.00
77_L	126_A	0.525	1.00
151_P	154_T	0.525	1.00
197_S	216_L	0.523	1.00
31_G	74_V	0.523	1.00
181_L	311_I	0.522	1.00
300_K	303_L	0.521	1.00
76_W	136_K	0.520	1.00
24_P	27_K	0.518	1.00
172_I	183_A	0.517	1.00
292_N	295_V	0.517	1.00
17_K	50_I	0.516	1.00
181_L	185_M	0.516	1.00
175_I	179_G	0.516	1.00
263_L	291_S	0.515	1.00
166_N	189_N	0.515	1.00
241_I	266_G	0.514	1.00
163_A	189_N	0.512	1.00
89_V	133_G	0.511	1.00
66_T	146_G	0.510	1.00
187_K	212_I	0.509	1.00
309_K	312_D	0.508	1.00
158_A	291_S	0.507	1.00
248_A	251_S	0.507	1.00
37_M	85_A	0.506	1.00
321_F	328_E	0.505	1.00
44_G	176_G	0.503	1.00
159_Q	182_H	0.503	1.00
157_R	161_R	0.503	1.00
263_L	289_I	0.501	1.00
184_M	315_K	0.500	1.00
136_K	139_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ej6A	1	0.9681	100	0.188	Contact Map
1vj0A	4	0.9739	100	0.196	Contact Map
4gi2A	2	0.971	100	0.198	Contact Map
1f8fA	4	0.9652	100	0.199	Contact Map
3m6iA	4	0.9623	100	0.201	Contact Map
4cpdA	2	0.9623	100	0.202	Contact Map
3ukoA	4	0.9797	100	0.202	Contact Map
1e3iA	2	0.9739	100	0.204	Contact Map
4ilkA	2	0.9565	100	0.206	Contact Map
1p0fA	2	0.9739	100	0.207	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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