GREMLIN Database
Q97TZ3 - Uncharacterized protein
UniProt: Q97TZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (157)
Sequences: 6521 (4275)
Seq/√Len: 341.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_N64_T3.7661.00
85_G142_F3.5801.00
157_T181_N3.3641.00
165_T175_V3.0251.00
62_V80_I2.9651.00
75_H158_K2.6441.00
22_P26_L2.4321.00
39_P59_K2.4281.00
137_L175_V2.4211.00
71_E158_K2.3591.00
89_L142_F2.3361.00
137_L179_N2.3001.00
81_M143_A2.2121.00
141_R179_N2.0991.00
24_I28_R2.0781.00
143_A147_I1.9941.00
141_R145_R1.8651.00
22_P25_I1.8171.00
175_V178_K1.7581.00
91_H138_G1.6881.00
75_H154_D1.6801.00
22_P28_R1.6451.00
154_D157_T1.6381.00
51_Y61_I1.6381.00
43_I61_I1.6341.00
157_T177_L1.6231.00
52_S87_L1.6001.00
88_K146_F1.5911.00
70_G76_I1.5791.00
46_T68_V1.5601.00
25_I28_R1.5431.00
70_G155_L1.5001.00
25_I40_I1.4981.00
90_N93_V1.4951.00
95_M135_L1.4721.00
74_E149_K1.4231.00
142_F146_F1.4181.00
30_T33_S1.3941.00
54_T92_H1.3841.00
62_V76_I1.3251.00
74_E152_L1.3251.00
64_T68_V1.3241.00
24_I27_K1.3231.00
23_A27_K1.3211.00
174_H178_K1.3031.00
71_E75_H1.3021.00
111_G114_M1.3011.00
178_K181_N1.2991.00
47_E63_L1.2971.00
172_N175_V1.2911.00
35_I38_Y1.2661.00
33_S36_Y1.2611.00
138_G142_F1.2381.00
48_I69_N1.2371.00
77_K152_L1.2201.00
85_G89_L1.2111.00
175_V179_N1.1881.00
154_D158_K1.1791.00
85_G146_F1.1681.00
134_R137_L1.1531.00
101_S105_V1.1391.00
106_F110_L1.1051.00
144_L180_I1.1051.00
88_K142_F1.1001.00
147_I152_L1.0951.00
31_K34_T1.0851.00
30_T34_T1.0811.00
45_S63_L1.0811.00
41_Y59_K1.0781.00
168_S172_N1.0781.00
130_Y133_R1.0761.00
48_I63_L1.0751.00
40_I60_F1.0711.00
156_I159_Y1.0691.00
145_R149_K1.0521.00
52_S61_I1.0491.00
125_L129_R1.0481.00
78_A147_I1.0201.00
164_T167_L1.0191.00
97_L101_S1.0121.00
89_L138_G0.9971.00
29_G32_F0.9881.00
107_T110_L0.9881.00
129_R169_T0.9801.00
23_A26_L0.9801.00
29_G77_K0.9781.00
78_A155_L0.9781.00
125_L130_Y0.9631.00
30_T35_I0.9611.00
98_Y135_L0.9611.00
123_V126_L0.9551.00
132_Q135_L0.9521.00
165_T172_N0.9521.00
102_V106_F0.9501.00
173_I177_L0.9451.00
67_L76_I0.9291.00
22_P27_K0.9271.00
66_G79_A0.9211.00
29_G33_S0.9191.00
46_T64_T0.9021.00
102_V128_Q0.8951.00
127_V131_L0.8901.00
124_A128_Q0.8851.00
130_Y134_R0.8841.00
144_L148_N0.8791.00
114_M118_I0.8751.00
77_K149_K0.8731.00
79_A155_L0.8621.00
137_L141_R0.8511.00
118_I121_A0.8491.00
55_S58_G0.8401.00
105_V109_L0.8391.00
41_Y61_I0.8361.00
62_V66_G0.8221.00
55_S59_K0.8201.00
38_Y88_K0.8201.00
149_K152_L0.8181.00
95_M98_Y0.8091.00
112_V115_L0.8011.00
68_V75_H0.7931.00
94_K135_L0.7881.00
74_E151_M0.7821.00
120_F124_A0.7781.00
29_G34_T0.7771.00
53_L59_K0.7731.00
103_I107_T0.7661.00
42_I67_L0.7651.00
123_V127_V0.7621.00
30_T38_Y0.7611.00
129_R133_R0.7591.00
28_R84_V0.7561.00
98_Y102_V0.7511.00
91_H135_L0.7491.00
125_L128_Q0.7451.00
119_P122_L0.7370.99
121_A124_A0.7370.99
54_T58_G0.7370.99
95_M131_L0.7340.99
58_G87_L0.7320.99
138_G141_R0.7310.99
118_I122_L0.7300.99
34_T38_Y0.7280.99
23_A28_R0.7280.99
161_M164_T0.7200.99
113_N117_L0.7140.99
155_L173_I0.7110.99
66_G75_H0.7100.99
31_K35_I0.7050.99
94_K97_L0.7050.99
116_T119_P0.7040.99
94_K138_G0.6990.99
159_Y173_I0.6990.99
91_H94_K0.6930.99
29_G38_Y0.6920.99
73_E152_L0.6910.99
113_N120_F0.6900.99
43_I64_T0.6890.99
117_L121_A0.6870.99
29_G35_I0.6860.99
163_E168_S0.6860.99
92_H96_S0.6810.99
112_V119_P0.6780.99
62_V67_L0.6780.99
129_R132_Q0.6740.99
147_I150_K0.6740.99
164_T168_S0.6690.99
93_V97_L0.6670.99
150_K153_E0.6640.99
52_S60_F0.6580.99
147_I153_E0.6510.99
143_A150_K0.6460.99
124_A129_R0.6440.99
160_D164_T0.6410.99
49_N52_S0.6390.99
165_T168_S0.6380.98
85_G88_K0.6350.98
78_A156_I0.6310.98
84_V87_L0.6280.98
92_H95_M0.6280.98
88_K145_R0.6230.98
53_L93_V0.6230.98
113_N116_T0.6220.98
53_L61_I0.6190.98
156_I173_I0.6180.98
114_M117_L0.6150.98
99_I103_I0.6150.98
29_G36_Y0.6140.98
129_R168_S0.6130.98
70_G158_K0.6120.98
177_L181_N0.6100.98
164_T175_V0.6060.98
112_V116_T0.6020.98
31_K36_Y0.5920.98
144_L156_I0.5920.98
151_M181_N0.5900.97
162_K173_I0.5890.97
69_N158_K0.5860.97
104_M108_Y0.5760.97
100_I104_M0.5720.97
68_V71_E0.5710.97
162_K165_T0.5700.97
125_L167_L0.5700.97
48_I65_R0.5680.97
116_T120_F0.5680.97
160_D163_E0.5670.97
156_I177_L0.5640.97
129_R172_N0.5610.97
155_L158_K0.5590.97
99_I128_Q0.5580.97
66_G70_G0.5560.96
60_F66_G0.5530.96
120_F126_L0.5480.96
33_S38_Y0.5450.96
78_A180_I0.5420.96
162_K168_S0.5410.96
103_I106_F0.5360.96
25_I29_G0.5350.96
40_I84_V0.5350.96
36_Y87_L0.5320.95
66_G76_I0.5300.95
134_R138_G0.5300.95
30_T150_K0.5280.95
45_S64_T0.5230.95
30_T36_Y0.5220.95
121_A125_L0.5170.95
78_A153_E0.5150.95
45_S65_R0.5140.95
122_L125_L0.5110.94
119_P123_V0.5100.94
101_S104_M0.5100.94
102_V105_V0.5090.94
34_T37_N0.5080.94
98_Y134_R0.5070.94
98_Y127_V0.5040.94
162_K172_N0.5030.94
53_L92_H0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c37A 1 0.9396 100 0.307 Contact Map
4il3A 1 0.978 99.9 0.455 Contact Map
4aw6A 2 0.9835 99.9 0.457 Contact Map
3cqbA 4 0.5385 99.5 0.672 Contact Map
3dteA 2 0.7692 96.7 0.851 Contact Map
4qhjA 2 0.5604 95.1 0.871 Contact Map
4jixA 2 0.5989 95 0.872 Contact Map
4jiuA 1 0.5604 86 0.898 Contact Map
4iuwA 1 0.9231 69.1 0.913 Contact Map
1r1hA 1 0.9451 66.6 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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