GREMLIN Database
Q97TZ2 - Carbon monoxide dehydrogenase, large chain (CutA-8)
UniProt: Q97TZ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 710 (694)
Sequences: 5363 (3554)
Seq/√Len: 134.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_N264_K4.2321.00
37_L99_I4.2211.00
32_L53_N3.9831.00
88_D91_E3.8931.00
364_E391_N3.6301.00
41_K44_A3.5601.00
155_E262_K3.5541.00
398_E401_K3.5131.00
268_K272_T3.3461.00
277_D316_R3.3301.00
267_V351_I3.3231.00
458_V498_M3.1681.00
149_D268_K3.0951.00
149_D269_R3.0791.00
143_Q147_E3.0681.00
437_I464_I3.0581.00
273_I348_I3.0521.00
409_C413_S3.0431.00
357_K365_K3.0381.00
45_K104_E2.9901.00
37_L96_L2.9341.00
140_N143_Q2.9261.00
153_N262_K2.8481.00
279_T318_E2.8181.00
41_K105_E2.8131.00
461_V503_E2.8021.00
44_A103_Y2.7891.00
530_I539_S2.7861.00
53_N87_R2.7651.00
311_R372_P2.7211.00
47_K102_E2.7091.00
361_D365_K2.6951.00
85_V232_L2.6291.00
43_H106_L2.6141.00
264_K277_D2.5881.00
182_V196_L2.5561.00
87_R91_E2.4831.00
499_Y503_E2.4761.00
593_K657_E2.4671.00
688_V704_I2.4051.00
181_N208_I2.3761.00
34_V242_W2.3371.00
272_T365_K2.3171.00
113_Q260_R2.2961.00
174_Y183_W2.2841.00
87_R238_R2.2771.00
581_K592_R2.2281.00
701_N708_E2.2241.00
179_R477_D2.2181.00
357_K362_I2.2121.00
691_V704_I2.2081.00
145_L266_A2.1781.00
397_Y577_L2.1681.00
283_D326_K2.1611.00
66_D70_P2.1441.00
541_T544_E2.1411.00
206_R475_D2.1411.00
279_T320_Y2.1401.00
351_I362_I2.1381.00
67_F70_P2.0951.00
137_E316_R2.0811.00
114_D117_K2.0681.00
265_V347_I2.0431.00
148_A266_A2.0141.00
49_K100_E2.0001.00
617_A656_I1.9851.00
392_K395_E1.9791.00
34_V83_I1.9761.00
393_A577_L1.9751.00
436_K468_N1.9711.00
392_K659_H1.9651.00
36_F228_A1.9631.00
364_E394_R1.9601.00
361_D364_E1.9531.00
40_V81_L1.9291.00
272_T311_R1.9281.00
431_A505_L1.9211.00
506_R510_I1.9141.00
150_V269_R1.9131.00
429_V439_I1.9041.00
157_Y701_N1.8991.00
150_V267_V1.8961.00
618_L653_A1.8891.00
7_I466_I1.8841.00
263_F347_I1.8831.00
391_N395_E1.8681.00
436_K470_E1.8551.00
45_K72_E1.8511.00
578_A686_A1.8491.00
369_R387_I1.8421.00
86_G92_A1.8351.00
24_D241_K1.8341.00
111_D114_D1.8211.00
45_K73_E1.8051.00
409_C415_Y1.8021.00
369_R372_P1.8011.00
455_A471_V1.7901.00
50_K55_V1.7841.00
85_V236_M1.7831.00
520_D523_E1.7771.00
491_V604_I1.7711.00
465_P468_N1.7591.00
396_Y657_E1.7551.00
179_R204_N1.7451.00
413_S417_E1.7411.00
67_F71_I1.7231.00
41_K103_Y1.7201.00
170_G243_I1.7191.00
34_V240_L1.7121.00
360_F394_R1.7111.00
432_K438_M1.7051.00
53_N238_R1.6931.00
83_I232_L1.6911.00
589_I709_V1.6791.00
268_K274_L1.6731.00
432_K436_K1.6731.00
457_I495_G1.6451.00
68_P71_I1.6431.00
54_N235_K1.6411.00
609_A675_I1.6211.00
576_H594_Y1.6181.00
413_S419_T1.6141.00
392_K396_Y1.6071.00
8_K607_L1.6061.00
148_A274_L1.6011.00
705_R708_E1.5981.00
164_N642_L1.5961.00
145_L264_K1.5951.00
265_V273_I1.5931.00
165_P218_S1.5861.00
353_L692_E1.5851.00
602_R662_E1.5671.00
265_V351_I1.5641.00
155_E260_R1.5461.00
262_K279_T1.5381.00
408_E581_K1.5371.00
150_V354_E1.5361.00
437_I462_L1.5331.00
603_V660_Y1.5261.00
427_A498_M1.5241.00
594_Y617_A1.5221.00
439_I458_V1.5201.00
28_L31_T1.5171.00
83_I228_A1.5171.00
578_A594_Y1.5051.00
409_C419_T1.4991.00
609_A660_Y1.4921.00
43_H73_E1.4911.00
142_E146_K1.4901.00
96_L99_I1.4901.00
133_Y318_E1.4851.00
73_E124_S1.4841.00
59_Y72_E1.4781.00
385_D388_G1.4731.00
387_I391_N1.4691.00
142_E316_R1.4601.00
429_V502_A1.4601.00
461_V670_T1.4581.00
181_N206_R1.4541.00
28_L174_Y1.4511.00
151_V264_K1.4481.00
137_E140_N1.4471.00
66_D69_I1.4401.00
396_Y659_H1.4361.00
150_V268_K1.4331.00
23_V170_G1.4251.00
349_N689_N1.4141.00
593_K655_R1.4141.00
364_E387_I1.4131.00
600_V603_V1.4091.00
150_V355_L1.4081.00
620_G683_S1.3991.00
389_L575_V1.3981.00
56_F236_M1.3921.00
353_L693_K1.3851.00
157_Y260_R1.3831.00
393_A575_V1.3821.00
527_K532_S1.3781.00
94_D98_S1.3751.00
65_K70_P1.3731.00
510_I524_V1.3671.00
36_F242_W1.3661.00
591_V621_I1.3641.00
461_V499_Y1.3621.00
410_I581_K1.3611.00
454_F498_M1.3611.00
145_L275_G1.3601.00
91_E95_L1.3601.00
406_T409_C1.3601.00
589_I691_V1.3581.00
150_V351_I1.3531.00
500_K504_E1.3481.00
415_Y419_T1.3461.00
197_M205_I1.3431.00
24_D243_I1.3351.00
459_A469_I1.3341.00
504_E507_R1.3341.00
202_I205_I1.3271.00
180_L230_A1.3271.00
32_L238_R1.3261.00
525_E532_S1.3221.00
273_I312_I1.3111.00
270_D365_K1.3091.00
524_V531_F1.2961.00
31_T241_K1.2931.00
20_S211_D1.2901.00
595_I657_E1.2881.00
457_I491_V1.2851.00
551_S554_Y1.2841.00
154_G350_I1.2821.00
332_Y619_Q1.2821.00
196_L205_I1.2811.00
141_I145_L1.2811.00
144_S275_G1.2771.00
345_E363_R1.2771.00
622_G648_P1.2761.00
178_N204_N1.2731.00
73_E106_L1.2721.00
144_S314_N1.2691.00
417_E574_G1.2681.00
558_V562_Y1.2661.00
56_F232_L1.2641.00
394_R400_L1.2571.00
453_A491_V1.2561.00
173_A182_V1.2531.00
511_E521_V1.2531.00
46_I101_V1.2461.00
258_D283_D1.2451.00
145_L151_V1.2421.00
349_N359_E1.2401.00
232_L240_L1.2381.00
81_L101_V1.2351.00
409_C417_E1.2351.00
396_Y597_L1.2321.00
519_A533_H1.2251.00
397_Y595_I1.2251.00
35_A96_L1.2211.00
261_L343_F1.2191.00
133_Y320_Y1.2161.00
367_L390_L1.2111.00
562_Y565_T1.2071.00
75_T79_Q1.2051.00
267_V355_L1.2021.00
10_I452_T1.2001.00
28_L172_L1.1991.00
142_E277_D1.1991.00
141_I144_S1.1951.00
180_L202_I1.1921.00
355_L362_I1.1910.99
173_A233_A1.1910.99
582_V589_I1.1910.99
513_S545_V1.1890.99
597_L659_H1.1840.99
630_I639_N1.1840.99
559_T562_Y1.1830.99
38_R248_E1.1830.99
532_S539_S1.1820.99
284_L292_N1.1820.99
603_V609_A1.1820.99
516_M548_N1.1790.99
580_V691_V1.1780.99
350_I700_V1.1740.99
254_G330_Q1.1680.99
47_K100_E1.1640.99
164_N647_F1.1630.99
35_A93_Y1.1630.99
14_K19_G1.1600.99
35_A89_R1.1560.99
200_L230_A1.1550.99
393_A597_L1.1530.99
45_K106_L1.1510.99
281_I320_Y1.1510.99
395_E400_L1.1500.99
13_P17_T1.1480.99
303_V317_I1.1460.99
509_L545_V1.1450.99
589_I625_I1.1440.99
504_E508_R1.1420.99
519_A523_E1.1380.99
40_V103_Y1.1380.99
143_Q146_K1.1370.99
468_N543_K1.1370.99
95_L98_S1.1350.99
43_H325_N1.1300.99
27_E31_T1.1280.99
10_I455_A1.1280.99
112_P281_I1.1280.99
496_S499_Y1.1260.99
135_K318_E1.1240.99
578_A687_V1.1240.99
183_W208_I1.1150.99
613_I617_A1.1100.99
299_V319_E1.1090.99
31_T172_L1.1090.99
455_A466_I1.1050.99
154_G354_E1.1030.99
342_Y688_V1.1030.99
147_E274_L1.1010.99
43_H107_P1.1000.99
361_D400_L1.0950.99
407_D583_D1.0940.99
265_V276_I1.0870.99
267_V362_I1.0870.99
510_I526_Y1.0850.99
35_A92_A1.0830.99
123_Y323_N1.0790.99
156_L347_I1.0770.99
173_A229_I1.0760.99
409_C414_M1.0750.99
53_N91_E1.0740.99
81_L103_Y1.0720.99
176_D181_N1.0710.99
456_Q605_N1.0700.99
699_I704_I1.0680.99
267_V273_I1.0660.99
428_R440_I1.0630.99
165_P249_E1.0620.99
52_G95_L1.0610.99
409_C420_A1.0580.99
392_K597_L1.0530.99
215_A446_H1.0500.99
116_L322_V1.0490.99
503_E507_R1.0480.99
117_K120_V1.0480.99
56_F235_K1.0430.99
389_L597_L1.0380.99
388_G392_K1.0360.99
175_F234_L1.0350.99
407_D584_K1.0350.99
578_A591_V1.0340.99
32_L236_M1.0330.99
48_I101_V1.0330.99
413_S420_A1.0300.99
53_N85_V1.0290.99
36_F83_I1.0280.99
74_T103_Y1.0260.98
58_G71_I1.0250.98
507_R511_E1.0240.98
152_I354_E1.0240.98
587_G709_V1.0240.98
61_I231_K1.0240.98
704_I708_E1.0220.98
348_I362_I1.0220.98
625_I687_V1.0210.98
533_H536_S1.0170.98
113_Q157_Y1.0130.98
440_I472_R1.0090.98
526_Y531_F1.0090.98
631_Y637_L1.0070.98
69_I228_A1.0050.98
54_N236_M1.0040.98
599_D663_K1.0020.98
82_A99_I1.0020.98
50_K99_I1.0010.98
55_V82_A1.0000.98
438_M472_R0.9980.98
266_A275_G0.9980.98
51_N87_R0.9940.98
523_E533_H0.9940.98
89_R93_Y0.9880.98
145_L277_D0.9870.98
512_V549_A0.9840.98
152_I267_V0.9810.98
468_N529_G0.9810.98
512_V545_V0.9780.98
48_I99_I0.9780.98
174_Y181_N0.9770.98
452_T456_Q0.9770.98
632_S636_Y0.9760.98
439_I469_I0.9750.98
626_Y652_E0.9740.98
176_D179_R0.9720.98
171_I229_I0.9720.98
113_Q155_E0.9710.98
149_D274_L0.9700.98
281_I322_V0.9690.98
621_I653_A0.9690.98
147_E268_K0.9690.98
402_K579_L0.9670.98
30_G238_R0.9670.98
44_A106_L0.9670.98
141_I277_D0.9630.98
84_V96_L0.9620.98
413_S421_F0.9620.98
141_I314_N0.9610.98
175_F233_A0.9610.98
46_I81_L0.9600.98
66_D71_I0.9590.98
458_V502_A0.9580.98
266_A274_L0.9580.98
152_I265_V0.9560.98
34_V232_L0.9560.98
367_L387_I0.9560.98
163_A218_S0.9550.98
388_G661_I0.9550.98
44_A101_V0.9530.98
185_S219_K0.9520.98
409_C418_I0.9490.97
135_K316_R0.9460.97
557_D562_Y0.9460.97
65_K68_P0.9440.97
259_K302_T0.9430.97
431_A542_I0.9420.97
580_V591_V0.9410.97
144_S266_A0.9400.97
162_I629_T0.9350.97
461_V506_R0.9340.97
56_F85_V0.9340.97
560_Y565_T0.9280.97
141_I275_G0.9270.97
509_L542_I0.9260.97
405_S409_C0.9250.97
461_V502_A0.9250.97
530_I541_T0.9250.97
349_N363_R0.9240.97
406_T413_S0.9240.97
212_V446_H0.9230.97
257_R339_E0.9200.97
399_T402_K0.9150.97
206_R477_D0.9150.97
704_I709_V0.9110.97
174_Y233_A0.9100.97
58_G72_E0.9090.97
82_A101_V0.9070.97
6_P610_E0.9030.97
641_N644_D0.9010.97
175_F178_N0.9000.97
360_F390_L0.9000.97
417_E421_F0.8990.97
187_Q215_A0.8960.96
407_D413_S0.8960.96
109_V115_A0.8950.96
403_E693_K0.8910.96
43_H108_Y0.8910.96
116_L281_I0.8900.96
551_S556_L0.8890.96
229_I242_W0.8880.96
628_G708_E0.8870.96
531_F545_V0.8830.96
118_N121_K0.8810.96
14_K451_G0.8800.96
553_G556_L0.8800.96
92_A96_L0.8780.96
620_G680_A0.8780.96
404_A407_D0.8770.96
59_Y71_I0.8760.96
518_N533_H0.8730.96
37_L82_A0.8720.96
637_L640_S0.8710.96
56_F231_K0.8700.96
310_Y345_E0.8700.96
388_G391_N0.8680.96
220_I486_W0.8670.96
202_I234_L0.8670.96
555_S558_V0.8650.96
247_S640_S0.8650.96
277_D318_E0.8620.96
596_A617_A0.8620.96
443_S490_T0.8610.96
310_Y363_R0.8570.95
610_E614_I0.8560.95
417_E423_P0.8550.95
430_L440_I0.8530.95
507_R521_V0.8500.95
205_I230_A0.8500.95
456_Q606_P0.8500.95
610_E660_Y0.8500.95
46_I103_Y0.8490.95
449_G608_L0.8490.95
151_V266_A0.8490.95
37_L101_V0.8480.95
556_L562_Y0.8480.95
438_M470_E0.8470.95
65_K69_I0.8450.95
458_V469_I0.8450.95
148_A275_G0.8450.95
579_L593_K0.8450.95
33_F241_K0.8390.95
411_G421_F0.8390.95
44_A74_T0.8370.95
558_V565_T0.8360.95
57_T69_I0.8360.95
144_S274_L0.8340.95
48_I81_L0.8320.95
457_I604_I0.8310.95
180_L234_L0.8300.95
264_K316_R0.8270.94
629_T637_L0.8270.94
185_S212_V0.8260.94
554_Y565_T0.8240.94
259_K282_A0.8220.94
112_P260_R0.8220.94
350_I698_K0.8220.94
36_F80_P0.8210.94
93_Y245_T0.8200.94
60_D235_K0.8190.94
448_Q485_T0.8170.94
156_L350_I0.8120.94
14_K211_D0.8110.94
41_K74_T0.8090.94
15_F22_Y0.8080.94
271_G357_K0.8070.94
425_E494_G0.8070.94
156_L700_V0.8050.94
443_S450_D0.8040.94
141_I316_R0.8030.94
600_V609_A0.8020.94
38_R252_S0.8010.93
23_V26_I0.7990.93
52_G87_R0.7990.93
346_R688_V0.7990.93
86_G95_L0.7970.93
342_Y346_R0.7960.93
91_E94_D0.7960.93
558_V564_V0.7950.93
232_L236_M0.7950.93
558_V561_V0.7930.93
263_F343_F0.7920.93
419_T423_P0.7910.93
169_R249_E0.7910.93
267_V347_I0.7900.93
394_R399_T0.7890.93
33_F89_R0.7860.93
110_I635_G0.7850.93
145_L274_L0.7850.93
50_K57_T0.7840.93
692_E698_K0.7830.93
374_K380_T0.7810.93
500_K503_E0.7790.93
140_N314_N0.7770.92
464_I468_N0.7770.92
276_I312_I0.7770.92
7_I455_A0.7760.92
115_A120_V0.7760.92
506_R526_Y0.7760.92
580_V589_I0.7760.92
410_I413_S0.7750.92
561_V565_T0.7750.92
429_V505_L0.7740.92
244_P249_E0.7740.92
307_L315_V0.7740.92
261_L278_G0.7730.92
6_P607_L0.7730.92
557_D560_Y0.7730.92
156_L346_R0.7720.92
89_R245_T0.7710.92
153_N277_D0.7700.92
559_T565_T0.7690.92
600_V675_I0.7690.92
555_S559_T0.7690.92
193_R476_T0.7690.92
347_I351_I0.7690.92
668_H672_S0.7640.92
186_T192_L0.7630.92
453_A608_L0.7620.92
286_A325_N0.7620.92
344_I347_I0.7620.92
79_Q288_Y0.7610.92
576_H682_A0.7600.92
545_V549_A0.7590.92
184_S192_L0.7570.91
168_T243_I0.7560.91
416_V419_T0.7560.91
111_D260_R0.7550.91
138_G315_V0.7540.91
274_L314_N0.7530.91
621_I687_V0.7520.91
518_N523_E0.7520.91
437_I505_L0.7500.91
200_L231_K0.7500.91
178_N234_L0.7480.91
689_N698_K0.7480.91
680_A684_T0.7470.91
28_L183_W0.7470.91
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312_I315_V0.5700.75
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482_G494_G0.5540.73
346_R689_N0.5530.73
368_I384_G0.5530.73
513_S524_V0.5520.73
519_A524_V0.5520.73
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335_A487_G0.5490.72
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183_W210_P0.5330.70
561_V564_V0.5330.70
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68_P199_F0.5310.70
351_I357_K0.5310.70
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589_I706_P0.5300.70
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354_E698_K0.5240.69
603_V606_P0.5240.69
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158_N261_L0.5230.69
582_V694_C0.5230.69
208_I475_D0.5220.69
626_Y647_F0.5220.69
446_H450_D0.5210.68
574_G598_D0.5210.68
33_F88_D0.5210.68
556_L565_T0.5200.68
674_G679_G0.5200.68
492_T667_G0.5200.68
112_P322_V0.5190.68
359_E363_R0.5190.68
524_V533_H0.5190.68
613_I679_G0.5190.68
621_I626_Y0.5180.68
385_D663_K0.5180.68
502_A506_R0.5180.68
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551_S562_Y0.5160.68
456_Q460_D0.5160.68
34_V85_V0.5160.68
451_G473_W0.5160.68
408_E417_E0.5160.68
409_C422_G0.5150.68
39_S91_E0.5150.68
164_N250_M0.5150.68
407_D415_Y0.5140.67
259_K339_E0.5140.67
267_V354_E0.5130.67
46_I58_G0.5120.67
284_L329_T0.5110.67
406_T584_K0.5110.67
169_R253_A0.5100.67
291_A335_A0.5090.67
602_R664_G0.5090.67
208_I477_D0.5080.67
576_H596_A0.5080.67
358_D362_I0.5070.66
40_V74_T0.5070.66
579_L592_R0.5070.66
355_L365_K0.5060.66
175_F205_I0.5060.66
147_E314_N0.5060.66
196_L201_G0.5050.66
412_S581_K0.5050.66
427_A501_A0.5050.66
361_D394_R0.5050.66
420_A493_I0.5040.66
396_Y595_I0.5040.66
412_S693_K0.5040.66
685_P688_V0.5040.66
544_E548_N0.5030.66
359_E403_E0.5030.66
557_D563_N0.5030.66
405_S410_I0.5020.66
554_Y561_V0.5020.66
221_I290_D0.5020.66
463_E528_N0.5020.66
408_E422_G0.5020.66
307_L312_I0.5010.66
272_T361_D0.5010.66
427_A441_T0.5010.66
70_P74_T0.5000.65
505_L509_L0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rm6A 2 0.9915 100 0.12 Contact Map
1t3qB 2 0.993 100 0.126 Contact Map
1ffvB 2 0.9887 100 0.134 Contact Map
1n62B 2 0.9915 100 0.137 Contact Map
2w3sB 2 0.9789 100 0.149 Contact Map
3uncA 2 0.9676 100 0.159 Contact Map
3zyvA 3 0.9648 100 0.171 Contact Map
3nvzC 2 0.9676 100 0.172 Contact Map
4usaA 2 0.9521 100 0.175 Contact Map
1dgjA 1 0.9507 100 0.176 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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