GREMLIN Database
Q97TZ1 - Uncharacterized protein
UniProt: Q97TZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 152 (146)
Sequences: 740 (509)
Seq/√Len: 42.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_D134_K3.5651.00
42_Y54_L3.4541.00
47_I63_R3.3811.00
61_I106_L2.9321.00
89_A135_F2.9061.00
8_S12_K2.7721.00
123_P126_K2.6131.00
99_C120_V2.6071.00
118_L136_A2.6021.00
121_L137_L2.3821.00
101_E126_K2.3021.00
125_E129_V2.2621.00
74_D77_A2.2441.00
81_V87_L2.2371.00
29_A45_N2.2091.00
62_I114_P2.2031.00
71_V136_A2.0670.99
120_V127_A2.0150.99
71_V99_C2.0020.99
17_K20_E1.9590.99
100_K123_P1.9470.99
101_E121_L1.8700.99
61_I68_L1.7340.98
55_I104_I1.7310.98
89_A131_K1.6430.97
100_K103_E1.5860.96
119_R137_L1.5410.95
16_N20_E1.4840.94
90_P132_K1.4720.94
75_E108_K1.4540.93
99_C124_K1.4370.93
6_M12_K1.4160.92
34_G43_Y1.3840.92
28_N35_K1.3790.91
102_N120_V1.3600.91
71_V105_V1.3350.90
95_Y124_K1.3120.89
68_L106_L1.2940.89
86_D137_L1.2890.88
77_A80_A1.2850.88
10_D13_I1.2380.86
98_E103_E1.2140.85
14_F54_L1.2090.85
120_V124_K1.2020.84
81_V116_A1.2000.84
15_I19_K1.1930.84
14_F42_Y1.1920.84
104_I119_R1.1900.84
73_I80_A1.1770.83
84_G91_G1.1760.83
100_K125_E1.1740.83
107_A116_A1.1630.82
73_I115_V1.1400.81
114_P147_W1.1380.81
23_N43_Y1.1340.81
22_Y55_I1.1290.81
97_C124_K1.1230.80
101_E128_L1.1080.79
81_V138_N1.1000.79
41_W48_L1.1000.79
55_I139_L1.0930.78
72_I98_E1.0730.77
111_T142_I1.0660.77
78_V108_K1.0620.76
133_G140_H1.0620.76
16_N19_K1.0510.76
108_K111_T1.0330.74
80_A85_A1.0320.74
73_I87_L1.0300.74
80_A88_F1.0280.74
120_V136_A1.0250.74
33_V40_I1.0240.74
85_A133_G1.0210.73
103_E120_V1.0210.73
88_F91_G1.0150.73
7_S115_V1.0140.73
55_I119_R1.0040.72
6_M102_N1.0040.72
105_V136_A0.9900.71
42_Y143_G0.9790.70
76_G141_H0.9730.70
42_Y87_L0.9620.69
97_C135_F0.9590.69
49_A60_A0.9580.68
71_V120_V0.9500.68
27_S30_K0.9380.67
78_V82_S0.9310.66
9_K12_K0.9220.66
122_M135_F0.9170.65
8_S21_K0.9140.65
80_A83_K0.9060.64
61_I67_N0.8950.63
78_V105_V0.8830.62
42_Y75_E0.8820.62
15_I110_K0.8810.62
89_A122_M0.8660.61
4_H135_F0.8650.61
26_I64_L0.8570.60
58_L75_E0.8270.57
73_I77_A0.8140.56
10_D122_M0.8040.55
92_I97_C0.7960.54
87_L116_A0.7920.54
58_L142_I0.7910.54
116_A140_H0.7900.54
49_A149_M0.7900.54
17_K21_K0.7890.54
114_P117_V0.7860.53
74_D80_A0.7840.53
140_H144_D0.7820.53
27_S132_K0.7790.53
45_N99_C0.7680.52
5_V57_T0.7650.51
6_M40_I0.7640.51
59_C62_I0.7630.51
76_G80_A0.7610.51
32_E43_Y0.7600.51
28_N33_V0.7560.50
47_I139_L0.7540.50
48_L138_N0.7510.50
10_D102_N0.7510.50
133_G144_D0.7390.49
104_I139_L0.7390.49
123_P139_L0.7320.48
68_L104_I0.7260.48
79_K147_W0.7250.47
12_K81_V0.7230.47
115_V135_F0.7220.47
86_D116_A0.7200.47
47_I59_C0.7170.47
101_E130_E0.7090.46
103_E127_A0.7060.46
53_D114_P0.7030.45
50_F56_P0.7020.45
11_S132_K0.6940.45
17_K117_V0.6860.44
77_A87_L0.6860.44
46_D148_E0.6860.44
12_K52_D0.6830.44
30_K33_V0.6810.43
43_Y101_E0.6720.43
54_L68_L0.6720.43
54_L106_L0.6720.43
51_F57_T0.6700.42
74_D109_T0.6690.42
138_N141_H0.6660.42
20_E23_N0.6650.42
126_K129_V0.6650.42
89_A92_I0.6630.42
106_L146_I0.6630.42
89_A130_E0.6620.42
30_K36_E0.6570.41
5_V32_E0.6500.41
6_M90_P0.6480.40
10_D107_A0.6430.40
73_I76_G0.6390.40
46_D71_V0.6370.39
25_D67_N0.6330.39
69_P96_N0.6330.39
91_G118_L0.6320.39
12_K97_C0.6310.39
73_I138_N0.6310.39
74_D89_A0.6300.39
16_N54_L0.6270.38
75_E78_V0.6260.38
72_I96_N0.6240.38
95_Y127_A0.6220.38
74_D94_E0.6200.38
75_E109_T0.6170.38
36_E45_N0.6160.37
32_E44_V0.6130.37
74_D93_V0.6130.37
18_I85_A0.6130.37
131_K142_I0.6120.37
87_L136_A0.6060.37
30_K44_V0.6030.36
83_K115_V0.6020.36
10_D16_N0.5990.36
69_P79_K0.5980.36
13_I107_A0.5960.36
31_L147_W0.5930.35
89_A93_V0.5880.35
59_C147_W0.5810.34
102_N119_R0.5770.34
87_L140_H0.5770.34
51_F93_V0.5770.34
132_K147_W0.5760.34
45_N148_E0.5750.34
74_D78_V0.5730.34
85_A104_I0.5730.34
14_F71_V0.5710.34
59_C139_L0.5680.33
95_Y143_G0.5670.33
51_F56_P0.5560.32
102_N129_V0.5540.32
45_N126_K0.5540.32
75_E143_G0.5530.32
49_A121_L0.5430.31
34_G55_I0.5420.31
95_Y99_C0.5420.31
34_G46_D0.5360.31
34_G41_W0.5340.31
82_S110_K0.5310.30
71_V143_G0.5290.30
92_I96_N0.5270.30
132_K141_H0.5240.30
117_V139_L0.5200.29
12_K40_I0.5180.29
92_I120_V0.5180.29
23_N26_I0.5150.29
24_V128_L0.5110.29
99_C128_L0.5090.29
31_L50_F0.5080.29
60_A99_C0.5070.28
43_Y107_A0.5050.28
63_R83_K0.5040.28
88_F118_L0.5040.28
67_N106_L0.5020.28
55_I117_V0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q7hA 2 0.9803 100 0.294 Contact Map
3d79A 1 0.9868 100 0.303 Contact Map
3r90A 5 1 100 0.311 Contact Map
2cx0A 1 1 100 0.355 Contact Map
1iq8A 2 0.9079 99.9 0.521 Contact Map
2q07A 1 0.8553 99.9 0.528 Contact Map
2p38A 4 0.8487 99.9 0.586 Contact Map
3zv0C 2 0.8289 99.8 0.605 Contact Map
2apoA 1 0.9013 99 0.769 Contact Map
2ausC 1 0.9276 98.9 0.773 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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