GREMLIN Database
Q97TZ0 - Dolichol-phosphate mannosyltransferase
UniProt: Q97TZ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (210)
Sequences: 51097 (42088)
Seq/√Len: 2904.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_R191_L3.1591.00
35_E114_A3.0821.00
36_R66_G2.8441.00
60_D83_I2.6721.00
27_S106_S2.5601.00
68_A83_I2.4011.00
84_R96_Y2.3311.00
108_F130_A2.2701.00
207_C211_K2.2671.00
125_E224_I2.2641.00
32_T67_T2.2381.00
96_Y100_K2.2081.00
135_C220_K2.0931.00
55_R80_T2.0861.00
68_A72_Q2.0531.00
59_V97_G2.0501.00
40_V44_E2.0171.00
29_V97_G2.0131.00
50_V124_P2.0051.00
25_N107_D1.9981.00
34_N64_P1.9681.00
66_G69_L1.9391.00
27_S55_R1.9361.00
189_A217_L1.8951.00
129_I220_K1.8571.00
94_L113_D1.8171.00
30_I56_I1.7681.00
60_D63_S1.7371.00
82_L100_K1.7331.00
40_V70_I1.7311.00
40_V74_L1.7261.00
118_H122_Y1.7241.00
136_D186_S1.7221.00
88_R92_S1.7181.00
110_V184_I1.7161.00
129_I222_Y1.7131.00
72_Q83_I1.6921.00
41_K117_S1.6791.00
126_M184_I1.6621.00
36_R70_I1.6451.00
90_L94_L1.6151.00
44_E74_L1.6021.00
58_I71_L1.5941.00
30_I42_L1.5941.00
68_A81_V1.5851.00
26_F127_M1.5431.00
80_T100_K1.5431.00
108_F184_I1.5401.00
33_Y87_E1.5331.00
25_N53_N1.5301.00
122_Y126_M1.5261.00
130_A184_I1.5251.00
40_V73_E1.5091.00
96_Y99_S1.4811.00
32_T58_I1.4291.00
55_R106_S1.4201.00
99_S195_E1.4101.00
27_S101_A1.4091.00
44_E48_R1.4011.00
136_D217_L1.3971.00
51_P127_M1.3881.00
112_M118_H1.3811.00
121_K125_E1.3581.00
125_E128_K1.3581.00
82_L96_Y1.3541.00
110_V123_L1.3501.00
91_G204_F1.3371.00
94_L111_T1.3361.00
192_L215_N1.3351.00
192_L217_L1.3311.00
124_P128_K1.3231.00
110_V122_Y1.3121.00
137_L219_I1.3071.00
188_R192_L1.2971.00
32_T35_E1.2781.00
98_I190_A1.2731.00
34_N63_S1.2551.00
61_D87_E1.2431.00
71_L81_V1.2411.00
70_I73_E1.2381.00
84_R88_R1.2361.00
32_T114_A1.2101.00
26_F123_L1.2061.00
45_E118_H1.1921.00
85_H88_R1.1841.00
27_S57_L1.1841.00
128_K132_N1.1811.00
109_I187_R1.1761.00
60_D68_A1.1631.00
35_E38_N1.1511.00
72_Q75_N1.1361.00
84_R93_A1.1291.00
51_P54_S1.1231.00
130_A138_V1.1171.00
126_M140_G1.1141.00
59_V93_A1.1141.00
73_E77_H1.1031.00
25_N106_S1.1031.00
101_A187_R1.0961.00
98_I111_T1.0911.00
70_I74_L1.0901.00
183_R209_I1.0891.00
107_D186_S1.0881.00
43_V74_L1.0831.00
90_L204_F1.0771.00
66_G70_I1.0681.00
189_A212_I1.0591.00
69_L72_Q1.0511.00
127_M131_L1.0491.00
41_K230_K1.0481.00
188_R191_L1.0411.00
101_A106_S1.0361.00
186_S189_A1.0331.00
85_H96_Y1.0321.00
92_S198_T1.0291.00
141_S221_E1.0101.00
55_R105_E1.0031.00
197_D207_C1.0031.00
143_Y225_I1.0021.00
129_I138_V0.9911.00
129_I133_E0.9901.00
98_I109_I0.9861.00
43_V56_I0.9731.00
119_N227_V0.9601.00
25_N105_E0.9551.00
26_F184_I0.9531.00
119_N228_D0.9521.00
69_L73_E0.9511.00
31_P93_A0.9431.00
137_L212_I0.9431.00
110_V118_H0.9331.00
121_K124_P0.9261.00
136_D218_K0.9221.00
152_W155_S0.9151.00
42_L112_M0.9091.00
125_E222_Y0.9011.00
45_E117_S0.9001.00
56_I79_L0.9001.00
48_R120_P0.8991.00
126_M138_V0.8991.00
142_R181_N0.8951.00
46_I112_M0.8911.00
134_N218_K0.8891.00
28_I46_I0.8881.00
117_S145_I0.8791.00
80_T105_E0.8791.00
108_F127_M0.8751.00
232_G235_K0.8731.00
125_E129_I0.8721.00
126_M130_A0.8721.00
129_I132_N0.8671.00
50_V121_K0.8661.00
92_S96_Y0.8541.00
41_K229_R0.8451.00
130_A186_S0.8441.00
90_L180_S0.8391.00
44_E47_N0.8351.00
122_Y140_G0.8281.00
41_K44_E0.8241.00
43_V58_I0.8231.00
75_N79_L0.8221.00
47_N74_L0.8181.00
94_L204_F0.8181.00
25_N131_L0.8171.00
90_L113_D0.8061.00
47_N78_N0.7991.00
73_E76_I0.7991.00
119_N122_Y0.7821.00
46_I56_I0.7751.00
28_I110_V0.7741.00
190_A208_S0.7721.00
95_R99_S0.7581.00
61_D93_A0.7581.00
85_H92_S0.7531.00
61_D88_R0.7441.00
32_T39_I0.7401.00
136_D189_A0.7351.00
141_S223_P0.7351.00
212_I217_L0.7331.00
61_D89_G0.7301.00
91_G95_R0.7291.00
32_T71_L0.7281.00
117_S228_D0.7211.00
75_N81_V0.7101.00
40_V77_H0.7091.00
54_S123_L0.7091.00
74_L77_H0.7031.00
129_I135_C0.7011.00
59_V96_Y0.6981.00
51_P124_P0.6981.00
194_L197_D0.6931.00
193_A212_I0.6911.00
44_E77_H0.6881.00
57_L97_G0.6861.00
127_M184_I0.6851.00
108_F186_S0.6831.00
47_N79_L0.6811.00
57_L100_K0.6761.00
31_P114_A0.6711.00
143_Y228_D0.6691.00
43_V47_N0.6681.00
46_I118_H0.6681.00
122_Y125_E0.6641.00
28_I123_L0.6621.00
154_L158_I0.6621.00
57_L80_T0.6621.00
71_L75_N0.6601.00
128_K131_L0.6601.00
185_Y190_A0.6601.00
39_I114_A0.6551.00
24_G107_D0.6551.00
180_S183_R0.6511.00
200_N203_E0.6501.00
107_D188_R0.6491.00
119_N143_Y0.6451.00
156_R159_I0.6451.00
42_L45_E0.6451.00
155_S158_I0.6451.00
50_V54_S0.6431.00
26_F110_V0.6411.00
98_I101_A0.6411.00
130_A135_C0.6401.00
153_S156_R0.6391.00
155_S159_I0.6371.00
45_E121_K0.6371.00
222_Y225_I0.6361.00
95_R195_E0.6341.00
88_R93_A0.6331.00
151_N154_L0.6321.00
72_Q76_I0.6311.00
162_G165_Y0.6291.00
62_N87_E0.6251.00
122_Y182_Y0.6251.00
84_R87_E0.6241.00
93_A113_D0.6241.00
136_D188_R0.6201.00
101_A109_I0.6161.00
93_A96_Y0.6151.00
36_R40_V0.6151.00
139_I221_E0.6141.00
61_D84_R0.6111.00
36_R69_L0.6101.00
39_I70_I0.6101.00
31_P94_L0.6091.00
84_R92_S0.6071.00
27_S105_E0.6071.00
193_A215_N0.6061.00
80_T83_I0.6051.00
229_R232_G0.6041.00
190_A195_E0.6031.00
68_A71_L0.6011.00
33_Y61_D0.6001.00
116_F229_R0.5991.00
54_S78_N0.5991.00
111_T196_C0.5981.00
42_L46_I0.5951.00
47_N77_H0.5931.00
30_I58_I0.5931.00
140_G182_Y0.5901.00
72_Q81_V0.5901.00
50_V120_P0.5891.00
195_E208_S0.5831.00
90_L93_A0.5821.00
31_P61_D0.5791.00
126_M129_I0.5771.00
24_G131_L0.5721.00
30_I114_A0.5721.00
185_Y209_I0.5711.00
107_D131_L0.5691.00
189_A192_L0.5661.00
133_E220_K0.5651.00
201_G204_F0.5631.00
88_R96_Y0.5611.00
235_K238_L0.5601.00
208_S212_I0.5591.00
41_K45_E0.5581.00
135_C218_K0.5501.00
189_A193_A0.5481.00
185_Y208_S0.5471.00
143_Y227_V0.5461.00
58_I79_L0.5461.00
135_C186_S0.5431.00
111_T185_Y0.5411.00
206_I210_F0.5391.00
109_I190_A0.5391.00
203_E206_I0.5371.00
165_Y169_L0.5351.00
99_S196_C0.5341.00
98_I195_E0.5341.00
29_V59_V0.5331.00
25_N55_R0.5321.00
30_I46_I0.5311.00
110_V182_Y0.5301.00
38_N230_K0.5261.00
49_I124_P0.5241.00
165_Y168_K0.5231.00
164_N168_K0.5221.00
126_M182_Y0.5191.00
39_I71_L0.5191.00
139_I178_N0.5191.00
33_Y62_N0.5181.00
61_D113_D0.5181.00
119_N226_F0.5171.00
27_S187_R0.5161.00
90_L111_T0.5161.00
157_R160_S0.5151.00
161_K165_Y0.5121.00
164_N167_F0.5111.00
101_A105_E0.5111.00
118_H123_L0.5101.00
166_L169_L0.5071.00
29_V101_A0.5051.00
57_L101_A0.5031.00
36_R65_D0.5031.00
151_N155_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xhbA 1 0.9569 100 0.282 Contact Map
2d7iA 1 0.9882 100 0.292 Contact Map
5ajoA 1 0.9843 100 0.294 Contact Map
3l7iA 4 0 100 0.294 Contact Map
2z86A 2 0.9529 100 0.303 Contact Map
3bcvA 2 0.698 100 0.305 Contact Map
1qg8A 1 0.8039 100 0.31 Contact Map
4p02A 1 0.9686 100 0.346 Contact Map
4fixA 3 0.9922 100 0.351 Contact Map
3ckjA 2 0.9176 100 0.373 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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