Q97TZ0 - SULSO - GREMLIN Contacts

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Q97TZ0 - Dolichol-phosphate mannosyltransferase

UniProt:	Q97TZ0	Sequences: MKRRESSPLISTILGIRYGRCVMGNFSIVIPTYNERDNIVKLVEEINRIVPYNSRILIVDDNSPDGTALILQELNIHNLTVLIRHNERGLGSALRYGISKAIELESDFIVTMDADFSHNPKYLPEMMKIALNENCDLVIGSRYVIGGGIENWSLSRRIISKGANYLFKLVSHSPIMDNTSNYRIYSRRAALLALECDTTNGYEFQICSIFKIIRNNLKIKEYPIIFVDRKTGKSKLNLKEILNWFLYIIRLSLSF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	255 (210)
Sequences:	51097 (42088)
Seq/√Len:	2904.4

ECOLI - YIBD ARNC GTRB WCAA PGAC WCAE YAIP WBBL BCSA
BACSU - GGAA CGED EPSH YKCC CSBB EPSJ EPSE YKOT GGAB TUAG SPSA YDAM YFNE YWDF TAGF
HALSA - Q9HQP4 Q9HQP8 Q9HNK3 Q9HQP3 Q9HSB1 Q9HQQ6 Q9HR08 Q9HSC8
SULSO - Q97TZ0 Q7LXF7 Q97TY0 Q7LXY2 Q97YG5 Q97X05 Q97W52 Q97YM4 Q97UK7 Q97WK7 Q7LXG6 Q97YN4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
187_R	191_L	3.159	1.00
35_E	114_A	3.082	1.00
36_R	66_G	2.844	1.00
60_D	83_I	2.672	1.00
27_S	106_S	2.560	1.00
68_A	83_I	2.401	1.00
84_R	96_Y	2.331	1.00
108_F	130_A	2.270	1.00
207_C	211_K	2.267	1.00
125_E	224_I	2.264	1.00
32_T	67_T	2.238	1.00
96_Y	100_K	2.208	1.00
135_C	220_K	2.093	1.00
55_R	80_T	2.086	1.00
68_A	72_Q	2.053	1.00
59_V	97_G	2.050	1.00
40_V	44_E	2.017	1.00
29_V	97_G	2.013	1.00
50_V	124_P	2.005	1.00
25_N	107_D	1.998	1.00
34_N	64_P	1.968	1.00
66_G	69_L	1.939	1.00
27_S	55_R	1.936	1.00
189_A	217_L	1.895	1.00
129_I	220_K	1.857	1.00
94_L	113_D	1.817	1.00
30_I	56_I	1.768	1.00
60_D	63_S	1.737	1.00
82_L	100_K	1.733	1.00
40_V	70_I	1.731	1.00
40_V	74_L	1.726	1.00
118_H	122_Y	1.724	1.00
136_D	186_S	1.722	1.00
88_R	92_S	1.718	1.00
110_V	184_I	1.716	1.00
129_I	222_Y	1.713	1.00
72_Q	83_I	1.692	1.00
41_K	117_S	1.679	1.00
126_M	184_I	1.662	1.00
36_R	70_I	1.645	1.00
90_L	94_L	1.615	1.00
44_E	74_L	1.602	1.00
58_I	71_L	1.594	1.00
30_I	42_L	1.594	1.00
68_A	81_V	1.585	1.00
26_F	127_M	1.543	1.00
80_T	100_K	1.543	1.00
108_F	184_I	1.540	1.00
33_Y	87_E	1.533	1.00
25_N	53_N	1.530	1.00
122_Y	126_M	1.526	1.00
130_A	184_I	1.525	1.00
40_V	73_E	1.509	1.00
96_Y	99_S	1.481	1.00
32_T	58_I	1.429	1.00
55_R	106_S	1.420	1.00
99_S	195_E	1.410	1.00
27_S	101_A	1.409	1.00
44_E	48_R	1.401	1.00
136_D	217_L	1.397	1.00
51_P	127_M	1.388	1.00
112_M	118_H	1.381	1.00
121_K	125_E	1.358	1.00
125_E	128_K	1.358	1.00
82_L	96_Y	1.354	1.00
110_V	123_L	1.350	1.00
91_G	204_F	1.337	1.00
94_L	111_T	1.336	1.00
192_L	215_N	1.335	1.00
192_L	217_L	1.331	1.00
124_P	128_K	1.323	1.00
110_V	122_Y	1.312	1.00
137_L	219_I	1.307	1.00
188_R	192_L	1.297	1.00
32_T	35_E	1.278	1.00
98_I	190_A	1.273	1.00
34_N	63_S	1.255	1.00
61_D	87_E	1.243	1.00
71_L	81_V	1.241	1.00
70_I	73_E	1.238	1.00
84_R	88_R	1.236	1.00
32_T	114_A	1.210	1.00
26_F	123_L	1.206	1.00
45_E	118_H	1.192	1.00
85_H	88_R	1.184	1.00
27_S	57_L	1.184	1.00
128_K	132_N	1.181	1.00
109_I	187_R	1.176	1.00
60_D	68_A	1.163	1.00
35_E	38_N	1.151	1.00
72_Q	75_N	1.136	1.00
84_R	93_A	1.129	1.00
51_P	54_S	1.123	1.00
130_A	138_V	1.117	1.00
126_M	140_G	1.114	1.00
59_V	93_A	1.114	1.00
73_E	77_H	1.103	1.00
25_N	106_S	1.103	1.00
101_A	187_R	1.096	1.00
98_I	111_T	1.091	1.00
70_I	74_L	1.090	1.00
183_R	209_I	1.089	1.00
107_D	186_S	1.088	1.00
43_V	74_L	1.083	1.00
90_L	204_F	1.077	1.00
66_G	70_I	1.068	1.00
189_A	212_I	1.059	1.00
69_L	72_Q	1.051	1.00
127_M	131_L	1.049	1.00
41_K	230_K	1.048	1.00
188_R	191_L	1.041	1.00
101_A	106_S	1.036	1.00
186_S	189_A	1.033	1.00
85_H	96_Y	1.032	1.00
92_S	198_T	1.029	1.00
141_S	221_E	1.010	1.00
55_R	105_E	1.003	1.00
197_D	207_C	1.003	1.00
143_Y	225_I	1.002	1.00
129_I	138_V	0.991	1.00
129_I	133_E	0.990	1.00
98_I	109_I	0.986	1.00
43_V	56_I	0.973	1.00
119_N	227_V	0.960	1.00
25_N	105_E	0.955	1.00
26_F	184_I	0.953	1.00
119_N	228_D	0.952	1.00
69_L	73_E	0.951	1.00
31_P	93_A	0.943	1.00
137_L	212_I	0.943	1.00
110_V	118_H	0.933	1.00
121_K	124_P	0.926	1.00
136_D	218_K	0.922	1.00
152_W	155_S	0.915	1.00
42_L	112_M	0.909	1.00
125_E	222_Y	0.901	1.00
45_E	117_S	0.900	1.00
56_I	79_L	0.900	1.00
48_R	120_P	0.899	1.00
126_M	138_V	0.899	1.00
142_R	181_N	0.895	1.00
46_I	112_M	0.891	1.00
134_N	218_K	0.889	1.00
28_I	46_I	0.888	1.00
117_S	145_I	0.879	1.00
80_T	105_E	0.879	1.00
108_F	127_M	0.875	1.00
232_G	235_K	0.873	1.00
125_E	129_I	0.872	1.00
126_M	130_A	0.872	1.00
129_I	132_N	0.867	1.00
50_V	121_K	0.866	1.00
92_S	96_Y	0.854	1.00
41_K	229_R	0.845	1.00
130_A	186_S	0.844	1.00
90_L	180_S	0.839	1.00
44_E	47_N	0.835	1.00
122_Y	140_G	0.828	1.00
41_K	44_E	0.824	1.00
43_V	58_I	0.823	1.00
75_N	79_L	0.822	1.00
47_N	74_L	0.818	1.00
94_L	204_F	0.818	1.00
25_N	131_L	0.817	1.00
90_L	113_D	0.806	1.00
47_N	78_N	0.799	1.00
73_E	76_I	0.799	1.00
119_N	122_Y	0.782	1.00
46_I	56_I	0.775	1.00
28_I	110_V	0.774	1.00
190_A	208_S	0.772	1.00
95_R	99_S	0.758	1.00
61_D	93_A	0.758	1.00
85_H	92_S	0.753	1.00
61_D	88_R	0.744	1.00
32_T	39_I	0.740	1.00
136_D	189_A	0.735	1.00
141_S	223_P	0.735	1.00
212_I	217_L	0.733	1.00
61_D	89_G	0.730	1.00
91_G	95_R	0.729	1.00
32_T	71_L	0.728	1.00
117_S	228_D	0.721	1.00
75_N	81_V	0.710	1.00
40_V	77_H	0.709	1.00
54_S	123_L	0.709	1.00
74_L	77_H	0.703	1.00
129_I	135_C	0.701	1.00
59_V	96_Y	0.698	1.00
51_P	124_P	0.698	1.00
194_L	197_D	0.693	1.00
193_A	212_I	0.691	1.00
44_E	77_H	0.688	1.00
57_L	97_G	0.686	1.00
127_M	184_I	0.685	1.00
108_F	186_S	0.683	1.00
47_N	79_L	0.681	1.00
57_L	100_K	0.676	1.00
31_P	114_A	0.671	1.00
143_Y	228_D	0.669	1.00
43_V	47_N	0.668	1.00
46_I	118_H	0.668	1.00
122_Y	125_E	0.664	1.00
28_I	123_L	0.662	1.00
154_L	158_I	0.662	1.00
57_L	80_T	0.662	1.00
71_L	75_N	0.660	1.00
128_K	131_L	0.660	1.00
185_Y	190_A	0.660	1.00
39_I	114_A	0.655	1.00
24_G	107_D	0.655	1.00
180_S	183_R	0.651	1.00
200_N	203_E	0.650	1.00
107_D	188_R	0.649	1.00
119_N	143_Y	0.645	1.00
156_R	159_I	0.645	1.00
42_L	45_E	0.645	1.00
155_S	158_I	0.645	1.00
50_V	54_S	0.643	1.00
26_F	110_V	0.641	1.00
98_I	101_A	0.641	1.00
130_A	135_C	0.640	1.00
153_S	156_R	0.639	1.00
155_S	159_I	0.637	1.00
45_E	121_K	0.637	1.00
222_Y	225_I	0.636	1.00
95_R	195_E	0.634	1.00
88_R	93_A	0.633	1.00
151_N	154_L	0.632	1.00
72_Q	76_I	0.631	1.00
162_G	165_Y	0.629	1.00
62_N	87_E	0.625	1.00
122_Y	182_Y	0.625	1.00
84_R	87_E	0.624	1.00
93_A	113_D	0.624	1.00
136_D	188_R	0.620	1.00
101_A	109_I	0.616	1.00
93_A	96_Y	0.615	1.00
36_R	40_V	0.615	1.00
139_I	221_E	0.614	1.00
61_D	84_R	0.611	1.00
36_R	69_L	0.610	1.00
39_I	70_I	0.610	1.00
31_P	94_L	0.609	1.00
84_R	92_S	0.607	1.00
27_S	105_E	0.607	1.00
193_A	215_N	0.606	1.00
80_T	83_I	0.605	1.00
229_R	232_G	0.604	1.00
190_A	195_E	0.603	1.00
68_A	71_L	0.601	1.00
33_Y	61_D	0.600	1.00
116_F	229_R	0.599	1.00
54_S	78_N	0.599	1.00
111_T	196_C	0.598	1.00
42_L	46_I	0.595	1.00
47_N	77_H	0.593	1.00
30_I	58_I	0.593	1.00
140_G	182_Y	0.590	1.00
72_Q	81_V	0.590	1.00
50_V	120_P	0.589	1.00
195_E	208_S	0.583	1.00
90_L	93_A	0.582	1.00
31_P	61_D	0.579	1.00
126_M	129_I	0.577	1.00
24_G	131_L	0.572	1.00
30_I	114_A	0.572	1.00
185_Y	209_I	0.571	1.00
107_D	131_L	0.569	1.00
189_A	192_L	0.566	1.00
133_E	220_K	0.565	1.00
201_G	204_F	0.563	1.00
88_R	96_Y	0.561	1.00
235_K	238_L	0.560	1.00
208_S	212_I	0.559	1.00
41_K	45_E	0.558	1.00
135_C	218_K	0.550	1.00
189_A	193_A	0.548	1.00
185_Y	208_S	0.547	1.00
143_Y	227_V	0.546	1.00
58_I	79_L	0.546	1.00
135_C	186_S	0.543	1.00
111_T	185_Y	0.541	1.00
206_I	210_F	0.539	1.00
109_I	190_A	0.539	1.00
203_E	206_I	0.537	1.00
165_Y	169_L	0.535	1.00
99_S	196_C	0.534	1.00
98_I	195_E	0.534	1.00
29_V	59_V	0.533	1.00
25_N	55_R	0.532	1.00
30_I	46_I	0.531	1.00
110_V	182_Y	0.530	1.00
38_N	230_K	0.526	1.00
49_I	124_P	0.524	1.00
165_Y	168_K	0.523	1.00
164_N	168_K	0.522	1.00
126_M	182_Y	0.519	1.00
39_I	71_L	0.519	1.00
139_I	178_N	0.519	1.00
33_Y	62_N	0.518	1.00
61_D	113_D	0.518	1.00
119_N	226_F	0.517	1.00
27_S	187_R	0.516	1.00
90_L	111_T	0.516	1.00
157_R	160_S	0.515	1.00
161_K	165_Y	0.512	1.00
164_N	167_F	0.511	1.00
101_A	105_E	0.511	1.00
118_H	123_L	0.510	1.00
166_L	169_L	0.507	1.00
29_V	101_A	0.505	1.00
57_L	101_A	0.503	1.00
36_R	65_D	0.503	1.00
151_N	155_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1xhbA	1	0.9569	100	0.282	Contact Map
2d7iA	1	0.9882	100	0.292	Contact Map
5ajoA	1	0.9843	100	0.294	Contact Map
3l7iA	4	0	100	0.294	Contact Map
2z86A	2	0.9529	100	0.303	Contact Map
3bcvA	2	0.698	100	0.305	Contact Map
1qg8A	1	0.8039	100	0.31	Contact Map
4p02A	1	0.9686	100	0.346	Contact Map
4fixA	3	0.9922	100	0.351	Contact Map
3ckjA	2	0.9176	100	0.373	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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