GREMLIN Database
Q97TY8 - Ornithine cyclodeaminase related protein (Ocd-like2)
UniProt: Q97TY8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (292)
Sequences: 3930 (2871)
Seq/√Len: 168.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_S137_I4.1741.00
24_V105_D4.1451.00
119_L143_T3.6001.00
124_L155_I3.2651.00
113_S140_N3.1071.00
138_K164_S3.0401.00
170_K174_E2.9311.00
6_K9_D2.8961.00
201_H274_T2.8791.00
170_K194_Y2.8151.00
106_Y262_L2.7541.00
195_V219_V2.7371.00
128_E159_E2.6171.00
138_K162_D2.4861.00
168_S171_R2.4781.00
115_G172_V2.4121.00
18_Q295_K2.3301.00
116_V127_V2.3081.00
260_W265_K2.2961.00
115_G176_S2.2811.00
224_N272_G2.2521.00
113_S138_K2.2501.00
127_V156_L2.0671.00
290_K294_E2.0481.00
149_M153_L2.0091.00
215_I275_I1.9981.00
127_V139_I1.9941.00
192_L222_A1.9621.00
199_R272_G1.9611.00
146_Q150_E1.9531.00
83_L293_Y1.9251.00
104_T130_A1.8471.00
62_G286_L1.8381.00
145_S148_R1.8341.00
191_K194_Y1.8211.00
192_L216_F1.8101.00
5_L296_A1.7851.00
15_D18_Q1.7511.00
196_N200_I1.7391.00
75_L293_Y1.7231.00
24_V106_Y1.7091.00
268_V272_G1.6851.00
143_T148_R1.6471.00
220_I275_I1.6431.00
260_W266_I1.6261.00
173_C194_Y1.6231.00
140_N175_E1.6161.00
73_T289_G1.6071.00
104_T203_N1.5711.00
26_A287_A1.5611.00
191_K216_F1.5581.00
21_G105_D1.5541.00
150_E154_S1.5531.00
223_S275_I1.5441.00
114_L136_G1.5311.00
267_N272_G1.5231.00
77_D83_L1.5201.00
24_V28_L1.5201.00
119_L141_V1.5091.00
218_E221_K1.4981.00
73_T91_L1.4831.00
217_P247_M1.4811.00
213_I217_P1.4681.00
10_V86_I1.4661.00
114_L130_A1.4561.00
147_Q150_E1.4461.00
73_T88_S1.4211.00
141_V152_A1.4201.00
11_I90_R1.4201.00
19_I288_V1.4191.00
208_N212_K1.4151.00
17_K132_Q1.4081.00
136_G178_V1.3851.00
28_L262_L1.3821.00
3_L297_L1.3801.00
149_M165_P1.3771.00
84_S293_Y1.3761.00
293_Y297_L1.3751.00
10_V292_I1.3751.00
112_S177_E1.3541.00
198_K271_E1.3421.00
105_D134_K1.3361.00
231_L260_W1.3311.00
269_Q272_G1.3291.00
146_Q167_D1.3241.00
204_A215_I1.3221.00
175_E196_N1.3201.00
226_I250_L1.3091.00
9_D12_N1.2721.00
22_A291_L1.2661.00
75_L289_G1.2471.00
23_L102_L1.2431.00
114_L139_I1.2411.00
7_E87_E1.2361.00
99_L284_E1.2321.00
100_S126_I1.2261.00
104_T201_H1.2231.00
109_G270_K1.2201.00
173_C179_V1.2051.00
143_T149_M1.2031.00
295_K298_S1.2021.00
77_D81_N1.1981.00
222_A273_I1.1901.00
117_I142_F1.1891.00
13_L296_A1.1891.00
140_N166_K1.1851.00
154_S158_G1.1821.00
160_G163_V1.1781.00
172_V176_S1.1761.00
111_F134_K1.1751.00
117_I190_L1.1721.00
153_L157_R1.1701.00
111_F178_V1.1691.00
5_L9_D1.1681.00
117_I169_I1.1621.00
20_Y133_L1.1571.00
227_V261_I1.1541.00
230_E233_H1.1491.00
138_K175_E1.1491.00
108_Y111_F1.1461.00
231_L257_L1.1451.00
60_Y294_E1.1441.00
28_L32_N1.1441.00
177_E196_N1.1411.00
235_F252_M1.1391.00
102_L106_Y1.1371.00
101_I133_L1.1201.00
151_K155_I1.1151.00
153_L163_V1.1121.00
153_L165_P1.1061.00
27_F284_E1.1021.00
167_D171_R1.0961.00
107_V227_V1.0941.00
115_G140_N1.0941.00
66_F69_G1.0841.00
111_F177_E1.0811.00
25_N29_L1.0801.00
104_T178_V1.0751.00
154_S157_R1.0741.00
181_T204_A1.0691.00
29_L34_F1.0570.99
231_L252_M1.0550.99
291_L295_K1.0520.99
101_I130_A1.0410.99
65_T74_F1.0400.99
199_R273_I1.0380.99
251_D254_K1.0370.99
245_K250_L1.0330.99
66_F71_H1.0320.99
216_F219_V1.0300.99
152_A156_L1.0290.99
62_G75_L1.0250.99
17_K21_G1.0210.99
16_Y129_I1.0180.99
180_T203_N1.0120.99
122_Y126_I0.9990.99
113_S175_E0.9870.99
60_Y83_L0.9870.99
224_N256_T0.9840.99
7_E11_I0.9840.99
127_V152_A0.9790.99
97_A126_I0.9770.99
126_I182_I0.9700.99
148_R151_K0.9700.99
179_V195_V0.9650.99
119_L152_A0.9570.99
25_N28_L0.9520.99
5_L86_I0.9490.99
65_T76_Y0.9480.99
115_G166_K0.9470.99
74_F82_L0.9450.99
240_R277_K0.9430.99
71_H88_S0.9350.99
186_K211_E0.9340.99
123_G143_T0.9330.99
119_L148_R0.9320.99
151_K154_S0.9310.99
224_N227_V0.9280.99
21_G25_N0.9280.99
27_F99_L0.9240.99
71_H89_D0.9130.98
170_K191_K0.9110.98
250_L254_K0.9080.98
228_V241_V0.9080.98
140_N164_S0.9080.98
199_R267_N0.9050.98
32_N263_S0.9040.98
103_A278_S0.9030.98
86_I292_I0.8990.98
104_T180_T0.8960.98
108_Y134_K0.8920.98
74_F85_I0.8900.98
114_L180_T0.8890.98
70_N81_N0.8870.98
119_L123_G0.8850.98
195_V200_I0.8840.98
115_G169_I0.8810.98
123_G152_A0.8810.98
171_R175_E0.8800.98
30_F230_E0.8760.98
20_Y101_I0.8730.98
150_E153_L0.8720.98
28_L263_S0.8710.98
203_N274_T0.8700.98
104_T134_K0.8690.98
113_S177_E0.8640.98
125_A128_E0.8600.98
169_I173_C0.8550.98
131_N161_I0.8550.98
130_A180_T0.8540.98
231_L235_F0.8480.97
51_T66_F0.8470.97
60_Y290_K0.8430.97
64_K285_D0.8420.97
115_G179_V0.8420.97
40_R53_Q0.8400.97
212_K277_K0.8340.97
105_D133_L0.8330.97
3_L296_A0.8290.97
51_T208_N0.8290.97
200_I273_I0.8250.97
99_L276_F0.8230.97
131_N136_G0.8230.97
53_Q237_R0.8160.97
91_L292_I0.8130.97
18_Q21_G0.8110.97
53_Q66_F0.8050.97
13_L295_K0.8040.97
40_R237_R0.8020.96
22_A26_A0.8000.96
174_E194_Y0.7950.96
93_Q121_K0.7850.96
267_N270_K0.7850.96
115_G168_S0.7820.96
16_Y101_I0.7780.96
141_V165_P0.7770.96
192_L219_V0.7740.96
193_E218_E0.7700.96
150_E165_P0.7690.96
241_V250_L0.7690.96
126_I205_M0.7670.95
101_I132_Q0.7600.95
55_A282_G0.7600.95
103_A203_N0.7570.95
69_G92_S0.7570.95
109_G134_K0.7570.95
104_T108_Y0.7560.95
19_I94_A0.7530.95
257_L260_W0.7460.95
117_I189_F0.7450.95
181_T190_L0.7450.95
86_I289_G0.7430.95
294_E298_S0.7380.94
24_V102_L0.7350.94
217_P221_K0.7300.94
106_Y261_I0.7290.94
235_F255_I0.7270.94
144_P148_R0.7250.94
152_A163_V0.7240.94
51_T69_G0.7230.94
3_L293_Y0.7220.94
123_G182_I0.7200.94
90_R94_A0.7170.94
233_H279_V0.7160.94
245_K252_M0.7130.93
228_V234_E0.7120.93
8_N11_I0.7120.93
230_E257_L0.7120.93
193_E222_A0.7110.93
100_S203_N0.7100.93
140_N172_V0.7100.93
62_G73_T0.7090.93
208_N277_K0.7080.93
221_K249_M0.7070.93
196_N199_R0.7070.93
166_K172_V0.7040.93
51_T212_K0.7020.93
76_Y82_L0.7010.93
170_K193_E0.6990.93
142_F190_L0.6910.92
34_F56_G0.6910.92
5_L292_I0.6880.92
190_L202_I0.6870.92
72_L85_I0.6860.92
8_N12_N0.6850.92
101_I134_K0.6840.92
93_Q125_A0.6840.92
29_L32_N0.6840.92
38_L43_I0.6820.92
202_I219_V0.6780.92
97_A125_A0.6780.92
219_V275_I0.6760.91
75_L286_L0.6740.91
100_S205_M0.6710.91
241_V255_I0.6680.91
137_I162_D0.6680.91
40_R279_V0.6680.91
115_G142_F0.6660.91
141_V153_L0.6650.91
108_Y201_H0.6650.91
16_Y97_A0.6640.91
190_L216_F0.6630.91
29_L57_M0.6630.91
64_K92_S0.6600.90
108_Y178_V0.6590.90
252_M255_I0.6570.90
104_T274_T0.6570.90
31_E257_L0.6540.90
209_I212_K0.6530.90
205_M278_S0.6520.90
156_L163_V0.6480.90
124_L156_L0.6470.90
83_L297_L0.6440.89
198_K273_I0.6400.89
42_R66_F0.6360.89
226_I254_K0.6300.88
191_K218_E0.6290.88
227_V256_T0.6290.88
110_D270_K0.6280.88
29_L56_G0.6250.88
66_F92_S0.6240.88
208_N233_H0.6190.87
101_I114_L0.6180.87
38_L54_A0.6130.87
82_L85_I0.6130.87
195_V273_I0.6120.87
113_S137_I0.6100.87
233_H277_K0.6100.87
31_E260_W0.6080.86
40_R54_A0.6080.86
39_E233_H0.6070.86
54_A66_F0.6070.86
71_H92_S0.6050.86
142_F169_I0.6030.86
59_N290_K0.6010.86
16_Y132_Q0.5980.86
49_T53_Q0.5970.85
113_S176_S0.5960.85
103_A258_L0.5960.85
42_R282_G0.5950.85
192_L218_E0.5930.85
136_G139_I0.5920.85
230_E281_I0.5870.85
238_I277_K0.5870.85
50_L67_I0.5840.84
199_R269_Q0.5830.84
172_V175_E0.5820.84
63_Y74_F0.5800.84
14_L94_A0.5770.84
294_E297_L0.5740.83
174_E196_N0.5720.83
267_N271_E0.5720.83
117_I168_S0.5720.83
49_T208_N0.5720.83
260_W264_R0.5700.83
22_A287_A0.5700.83
146_Q149_M0.5690.83
114_L127_V0.5670.82
42_R51_T0.5660.82
259_S262_L0.5660.82
199_R270_K0.5650.82
228_V231_L0.5620.82
10_V14_L0.5620.82
195_V202_I0.5620.82
206_G214_E0.5610.82
52_F65_T0.5610.82
32_N265_K0.5610.82
245_K248_G0.5600.82
103_A276_F0.5600.82
166_K171_R0.5590.82
234_E237_R0.5560.81
60_Y293_Y0.5560.81
182_I205_M0.5540.81
237_R242_S0.5540.81
23_L284_E0.5520.81
115_G173_C0.5510.81
150_E157_R0.5510.81
100_S130_A0.5490.80
237_R240_R0.5480.80
42_R49_T0.5470.80
22_A288_V0.5470.80
87_E92_S0.5470.80
134_K178_V0.5450.80
61_I78_T0.5450.80
291_L294_E0.5450.80
185_A188_P0.5450.80
9_D296_A0.5420.80
50_L61_I0.5420.80
183_T214_E0.5420.80
49_T209_I0.5390.79
19_I23_L0.5390.79
68_S79_S0.5390.79
36_I44_S0.5390.79
99_L281_I0.5380.79
29_L58_E0.5380.79
202_I215_I0.5360.79
31_E258_L0.5360.79
27_F30_F0.5350.79
179_V200_I0.5340.79
97_A129_I0.5320.78
143_T278_S0.5310.78
141_V163_V0.5310.78
237_R279_V0.5290.78
140_N176_S0.5290.78
4_L85_I0.5270.78
224_N274_T0.5260.78
21_G24_V0.5250.77
7_E88_S0.5240.77
13_L292_I0.5230.77
233_H281_I0.5230.77
31_E263_S0.5220.77
62_G289_G0.5220.77
119_L149_M0.5220.77
20_Y132_Q0.5190.77
35_A283_L0.5190.77
40_R45_F0.5180.76
72_L82_L0.5170.76
264_R267_N0.5130.76
156_L159_E0.5110.76
208_N279_V0.5100.75
61_I65_T0.5100.75
18_Q291_L0.5100.75
204_A240_R0.5090.75
190_L219_V0.5080.75
51_T54_A0.5080.75
268_V273_I0.5070.75
51_T233_H0.5070.75
146_Q165_P0.5060.75
234_E279_V0.5050.75
97_A142_F0.5050.75
128_E156_L0.5050.75
112_S135_K0.5050.75
204_A241_V0.5040.75
257_L261_I0.5040.75
147_Q151_K0.5020.74
170_K173_C0.5010.74
15_D295_K0.5010.74
122_Y180_T0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1omoA 2 0.9528 100 0.325 Contact Map
3hdjA 2 0.9434 100 0.332 Contact Map
4mp8A 2 0.9497 100 0.337 Contact Map
4bvaA 2 0.9057 100 0.376 Contact Map
1x7dA 2 0.9623 100 0.408 Contact Map
3oj0A 1 0.4308 99.4 0.843 Contact Map
4ppmA 2 0.0314 99.2 0.852 Contact Map
3pwzA 1 0.7484 98.8 0.876 Contact Map
4n7rA 2 0.8679 98.7 0.88 Contact Map
1npyA 1 0.7358 98.6 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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