GREMLIN Database
Q97TY4 - Uncharacterized protein
UniProt: Q97TY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (145)
Sequences: 348 (257)
Seq/√Len: 21.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_D63_D5.1251.00
31_Y63_D3.3781.00
17_L74_L2.9610.99
55_G92_I2.9100.99
69_K88_S2.8540.99
29_D62_G2.7900.99
30_L64_I2.7840.99
82_K142_G2.6980.99
111_Y115_K2.4530.98
76_S84_I2.4320.97
109_L120_V2.3970.97
27_K63_D2.1660.95
57_I64_I2.1490.95
104_F109_L2.1390.94
122_N130_L2.1380.94
76_S83_E2.0580.93
48_V64_I2.0300.93
113_L117_G1.8920.90
43_D46_P1.8770.89
41_L46_P1.8670.89
14_V134_L1.8300.88
13_L74_L1.7970.87
95_F99_L1.7810.87
109_L113_L1.7080.84
109_L114_E1.6990.84
102_K107_E1.6730.83
86_K141_S1.6690.83
99_L131_Q1.6530.82
17_L20_L1.6470.82
62_G127_L1.6330.82
20_L101_L1.5690.79
61_E87_D1.5640.79
113_L120_V1.5350.77
78_L82_K1.4610.74
121_Y133_T1.3940.70
68_D83_E1.3890.70
105_T114_E1.3870.70
24_F28_T1.3850.69
85_I140_Y1.3740.69
16_L86_K1.3430.67
47_I86_K1.3230.66
5_D118_I1.3220.66
134_L144_L1.3220.66
104_F113_L1.3180.65
131_Q135_V1.3060.65
29_D64_I1.2650.62
104_F120_V1.2200.59
115_K126_G1.2060.58
42_D46_P1.1980.58
20_L116_K1.1680.56
51_A57_I1.1530.55
47_I143_L1.1380.54
67_T70_G1.1300.53
73_F141_S1.1280.53
10_V112_V1.1180.53
73_F121_Y1.1100.52
10_V136_E1.1040.52
108_E128_Y1.0900.51
104_F117_G1.0870.51
19_S88_S1.0850.50
11_A14_V1.0530.48
85_I93_E1.0530.48
27_K84_I1.0530.48
78_L112_V1.0430.48
87_D145_K1.0370.47
39_V121_Y1.0360.47
93_E96_K1.0310.47
20_L81_R1.0220.46
56_F72_E1.0140.46
80_R83_E1.0050.45
27_K65_I0.9910.44
18_Y122_N0.9850.44
43_D80_R0.9800.43
88_S92_I0.9790.43
13_L50_T0.9790.43
11_A40_D0.9690.43
34_E54_L0.9670.43
109_L117_G0.9560.42
68_D128_Y0.9500.41
118_I127_L0.9460.41
70_G143_L0.9320.40
112_V116_K0.9290.40
113_L130_L0.9270.40
58_T65_I0.9060.39
89_I100_E0.9030.38
55_G88_S0.9000.38
41_L123_S0.8960.38
67_T73_F0.8840.37
16_L40_D0.8840.37
35_K90_K0.8800.37
56_F88_S0.8790.37
28_T51_A0.8770.37
36_E67_T0.8730.37
71_I75_K0.8590.36
81_R89_I0.8520.35
43_D132_I0.8490.35
7_H83_E0.8440.35
8_A26_G0.8420.35
31_Y95_F0.8410.35
33_L115_K0.8260.34
59_V62_G0.8200.33
17_L56_F0.8150.33
7_H133_T0.8110.33
30_L70_G0.8060.32
5_D127_L0.7940.32
48_V59_V0.7820.31
106_I125_E0.7780.31
95_F134_L0.7750.31
16_L136_E0.7700.30
76_S149_E0.7690.30
10_V16_L0.7680.30
46_P57_I0.7680.30
44_L123_S0.7680.30
31_Y94_P0.7640.30
96_K134_L0.7620.30
68_D71_I0.7620.30
12_D49_Y0.7610.30
96_K99_L0.7580.30
67_T76_S0.7550.30
48_V58_T0.7510.29
133_T138_G0.7430.29
122_N126_G0.7370.29
79_K132_I0.7360.29
14_V79_K0.7340.28
114_E135_V0.7290.28
52_N66_I0.7280.28
75_K135_V0.7130.27
63_D141_S0.7090.27
94_P99_L0.7040.27
19_S109_L0.7000.27
6_P129_D0.7000.27
78_L142_G0.6990.27
95_F101_L0.6970.26
68_D75_K0.6920.26
114_E139_V0.6910.26
115_K135_V0.6910.26
101_L128_Y0.6900.26
59_V126_G0.6860.26
116_K147_E0.6840.26
23_T144_L0.6820.26
7_H18_Y0.6790.26
50_T133_T0.6760.25
40_D82_K0.6690.25
14_V142_G0.6650.25
104_F130_L0.6630.25
22_N125_E0.6610.25
24_F36_E0.6560.24
60_G71_I0.6500.24
5_D139_V0.6440.24
59_V129_D0.6400.24
31_Y34_E0.6400.24
7_H25_N0.6360.23
49_Y59_V0.6330.23
16_L133_T0.6320.23
49_Y142_G0.6300.23
27_K131_Q0.6250.23
16_L42_D0.6240.23
25_N76_S0.6210.23
6_P53_S0.6180.23
26_G87_D0.6090.22
30_L48_V0.6070.22
56_F64_I0.6020.22
66_I131_Q0.6010.22
111_Y148_G0.5980.22
11_A145_K0.5950.21
40_D67_T0.5940.21
20_L43_D0.5910.21
20_L98_T0.5880.21
58_T83_E0.5830.21
88_S115_K0.5770.21
38_E53_S0.5760.21
40_D129_D0.5730.21
25_N132_I0.5700.20
71_I83_E0.5700.20
111_Y132_I0.5690.20
52_N119_Q0.5660.20
84_I106_I0.5650.20
23_T28_T0.5620.20
48_V130_L0.5610.20
78_L116_K0.5570.20
119_Q127_L0.5530.20
90_K110_K0.5480.19
17_L39_V0.5470.19
107_E141_S0.5470.19
7_H149_E0.5450.19
46_P135_V0.5440.19
14_V78_L0.5440.19
22_N107_E0.5430.19
19_S102_K0.5370.19
116_K130_L0.5320.19
27_K43_D0.5320.19
69_K87_D0.5300.19
9_R104_F0.5270.19
112_V128_Y0.5260.19
108_E143_L0.5250.18
122_N136_E0.5250.18
93_E127_L0.5220.18
77_N83_E0.5210.18
92_I95_F0.5200.18
18_Y53_S0.5200.18
23_T27_K0.5190.18
74_L114_E0.5170.18
135_V146_K0.5170.18
66_I146_K0.5160.18
17_L84_I0.5140.18
63_D73_F0.5100.18
51_A103_Y0.5100.18
136_E144_L0.5080.18
9_R40_D0.5070.18
83_E97_T0.5050.18
33_L150_R0.5050.18
127_L146_K0.5050.18
76_S86_K0.5040.18
110_K120_V0.5030.18
17_L135_V0.5020.18
104_F114_E0.5020.18
42_D78_L0.5010.18
12_D82_K0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bjaA 1 0.5641 86.3 0.911 Contact Map
2o0mA 1 0.4487 80.2 0.918 Contact Map
1p4xA 1 0.609 78.7 0.919 Contact Map
1r7jA 2 0.5449 76.6 0.92 Contact Map
2wteA 2 0.5064 75.1 0.921 Contact Map
1hsjA 2 0.5513 74.6 0.922 Contact Map
2qvoA 2 0.5064 73.8 0.922 Contact Map
2pg4A 3 0.5385 73 0.923 Contact Map
3nqoA 2 0.8782 71.4 0.923 Contact Map
2fxaA 4 0.8654 70.3 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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