GREMLIN Database
Q97TY3 - Uncharacterized protein
UniProt: Q97TY3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (223)
Sequences: 2132 (1419)
Seq/√Len: 95.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_Y93_K4.6861.00
84_I135_L3.9821.00
36_I57_A3.7561.00
112_T122_Y3.5541.00
94_F97_M3.4351.00
99_K121_D3.2941.00
198_G216_A3.0541.00
107_M113_K3.0371.00
174_S188_T3.0351.00
117_E121_D2.9541.00
99_K124_L2.6071.00
127_E132_E2.5891.00
194_I224_L2.4401.00
115_V118_K2.4041.00
119_I123_L2.3961.00
99_K103_V2.2321.00
103_V117_E2.2191.00
67_I222_T2.2071.00
202_I212_K2.1841.00
105_F137_H2.1601.00
85_R88_K2.1131.00
90_Q139_L2.1011.00
106_Y119_I2.0691.00
63_F67_I2.0491.00
194_I220_I2.0071.00
198_G220_I2.0061.00
101_E138_E1.9991.00
100_Q117_E1.9881.00
90_Q138_E1.9421.00
103_V113_K1.9391.00
154_F158_F1.9261.00
113_K117_E1.8581.00
66_G153_G1.8341.00
118_K121_D1.8161.00
115_V122_Y1.7851.00
106_Y137_H1.7771.00
100_Q104_N1.7261.00
104_N107_M1.7011.00
30_L196_T1.6961.00
87_E101_E1.6511.00
103_V107_M1.6401.00
229_G232_L1.6321.00
206_K212_K1.5991.00
98_E138_E1.5871.00
187_I191_L1.5811.00
84_I88_K1.5771.00
111_F119_I1.5731.00
69_E156_M1.5341.00
83_E86_K1.5201.00
87_E98_E1.5151.00
58_T161_I1.5021.00
67_I226_A1.4861.00
98_E134_M1.4771.00
111_F123_L1.4701.00
98_E101_E1.4541.00
228_M232_L1.4491.00
21_T69_E1.4471.00
43_F52_V1.4401.00
204_G216_A1.4220.99
24_F156_M1.4180.99
134_M138_E1.4100.99
87_E138_E1.4040.99
35_A227_L1.4000.99
58_T164_G1.4000.99
100_Q113_K1.3920.99
170_P192_L1.3920.99
32_G57_A1.3820.99
87_E134_M1.3770.99
90_Q101_E1.3680.99
37_A189_S1.3490.99
91_L131_L1.3450.99
204_G219_Q1.3430.99
86_K139_L1.3350.99
204_G215_G1.2820.99
184_F187_I1.2290.99
46_D49_A1.2280.98
41_A186_L1.2200.98
232_L235_V1.2130.98
210_L214_R1.1960.98
61_Q160_L1.1920.98
121_D125_K1.1890.98
212_K216_A1.1490.98
184_F188_T1.1370.98
171_F185_A1.1230.97
231_Y235_V1.1160.97
211_S214_R1.1130.97
106_Y109_K1.1130.97
13_I204_G1.1070.97
150_V154_F1.1050.97
101_E139_L1.1010.97
58_T168_V1.1000.97
190_I224_L1.0950.97
34_G227_L1.0830.97
83_E139_L1.0810.97
42_G231_Y1.0700.96
115_V119_I1.0660.96
161_I164_G1.0660.96
133_E137_H1.0540.96
48_I52_V1.0530.96
61_Q197_L1.0450.96
61_Q156_M1.0370.96
45_H53_A1.0370.96
92_K127_E1.0290.95
99_K117_E1.0260.95
54_G168_V1.0170.95
25_G65_M1.0090.95
55_L172_A0.9920.95
49_A53_A0.9870.94
32_G61_Q0.9810.94
32_G160_L0.9810.94
87_E139_L0.9790.94
95_P99_K0.9680.94
169_F173_I0.9650.94
114_E118_K0.9460.93
191_L195_L0.9420.93
87_E90_Q0.9380.93
86_K90_Q0.9360.93
188_T191_L0.9350.93
69_E152_L0.9310.92
55_L168_V0.9260.92
184_F195_L0.9230.92
33_V164_G0.9200.92
222_T226_A0.9170.92
101_E105_F0.9140.92
105_F138_E0.9070.91
104_N108_K0.9020.91
37_A54_G0.9000.91
105_F109_K0.8960.91
111_F122_Y0.8960.91
99_K120_A0.8820.90
170_P189_S0.8720.90
95_P124_L0.8690.90
199_I202_I0.8680.90
30_L200_F0.8560.89
90_Q98_E0.8530.89
32_G197_L0.8510.89
30_L170_P0.8440.88
116_S120_A0.8360.88
213_P216_A0.8280.87
57_A160_L0.8260.87
155_L159_Y0.8250.87
73_T218_E0.8230.87
197_L223_G0.8190.87
12_Y233_A0.8040.86
205_T208_T0.8000.85
22_K159_Y0.7980.85
38_L190_I0.7970.85
118_K122_Y0.7960.85
132_E136_M0.7910.85
37_A171_F0.7900.85
96_E100_Q0.7790.84
21_T152_L0.7780.84
136_M140_K0.7750.83
195_L213_P0.7640.83
24_F73_T0.7640.83
77_M146_F0.7630.83
69_E72_S0.7600.82
60_G227_L0.7590.82
21_T156_M0.7560.82
187_I196_T0.7510.82
114_E236_I0.7490.81
109_K137_H0.7470.81
157_S219_Q0.7450.81
20_R163_G0.7450.81
142_F145_E0.7420.81
216_A219_Q0.7410.81
205_T215_G0.7390.80
21_T72_S0.7380.80
195_L199_I0.7360.80
170_P174_S0.7350.80
65_M68_G0.7350.80
77_M144_E0.7340.80
101_E134_M0.7330.80
158_F217_L0.7330.80
32_G41_A0.7310.80
86_K89_Y0.7280.79
61_Q163_G0.7280.79
17_D22_K0.7270.79
102_L133_E0.7270.79
160_L197_L0.7200.79
170_P188_T0.7190.79
224_L228_M0.7130.78
114_E121_D0.7070.77
84_I131_L0.7070.77
91_L130_A0.7030.77
26_I163_G0.7030.77
69_E73_T0.7030.77
33_V57_A0.7020.77
152_L156_M0.7010.77
74_R77_M0.6950.76
50_V53_A0.6940.76
59_I157_S0.6930.76
47_A50_V0.6920.76
102_L134_M0.6820.75
87_E131_L0.6820.75
38_L186_L0.6790.75
68_G72_S0.6770.74
40_A43_F0.6760.74
59_I229_G0.6750.74
186_L193_V0.6730.74
162_F165_L0.6710.74
122_Y135_L0.6710.74
21_T24_F0.6680.73
31_I57_A0.6680.73
32_G156_M0.6670.73
71_I76_R0.6670.73
229_G233_A0.6660.73
25_G29_G0.6630.73
217_L221_G0.6620.73
164_G230_S0.6610.73
175_T182_F0.6600.72
84_I132_E0.6590.72
190_I228_M0.6580.72
123_L126_N0.6570.72
109_K119_I0.6560.72
211_S236_I0.6550.72
61_Q230_S0.6540.72
189_S196_T0.6510.71
74_R78_Q0.6490.71
156_M218_E0.6490.71
30_L166_I0.6480.71
38_L171_F0.6370.70
162_F225_I0.6370.70
132_E144_E0.6360.70
73_T76_R0.6350.70
57_A61_Q0.6350.70
193_V227_L0.6340.69
60_G147_E0.6280.69
109_K123_L0.6270.69
203_L206_K0.6250.68
21_T27_Q0.6240.68
116_S124_L0.6240.68
42_G186_L0.6230.68
89_Y165_L0.6230.68
10_V14_H0.6230.68
117_E154_F0.6210.68
222_T237_L0.6160.67
77_M142_F0.6160.67
183_N191_L0.6150.67
170_P185_A0.6130.67
105_F139_L0.6120.67
126_N130_A0.6100.67
25_G28_D0.6100.67
156_M230_S0.6090.66
30_L163_G0.6090.66
109_K136_M0.6030.66
130_A139_L0.6020.65
94_F217_L0.6010.65
202_I206_K0.6000.65
171_F189_S0.5990.65
120_A238_A0.5990.65
93_K100_Q0.5980.65
33_V36_I0.5980.65
103_V135_L0.5980.65
74_R218_E0.5980.65
54_G230_S0.5970.65
21_T218_E0.5960.65
127_E134_M0.5940.64
27_Q32_G0.5910.64
67_I227_L0.5910.64
77_M81_Q0.5900.64
112_T118_K0.5890.64
75_V136_M0.5850.63
169_F188_T0.5840.63
103_V124_L0.5830.63
23_V238_A0.5810.63
106_Y133_E0.5810.63
66_G229_G0.5810.63
62_A73_T0.5760.62
21_T204_G0.5750.62
232_L236_I0.5720.62
88_K92_K0.5720.62
104_N114_E0.5680.61
122_Y125_K0.5650.61
134_M139_L0.5650.61
75_V79_V0.5640.60
74_R204_G0.5640.60
42_G148_R0.5620.60
120_A130_A0.5610.60
34_G225_I0.5610.60
35_A230_S0.5600.60
26_I160_L0.5600.60
66_G152_L0.5580.60
31_I189_S0.5560.59
20_R27_Q0.5550.59
41_A171_F0.5540.59
107_M116_S0.5530.59
24_F69_E0.5510.59
24_F80_I0.5500.59
111_F115_V0.5490.58
69_E218_E0.5440.58
62_A69_E0.5400.57
166_I191_L0.5390.57
108_K221_G0.5350.57
42_G171_F0.5350.57
31_I226_A0.5300.56
74_R215_G0.5290.56
71_I222_T0.5290.56
126_N203_L0.5280.56
32_G69_E0.5280.56
148_R151_K0.5280.56
73_T156_M0.5260.55
33_V58_T0.5260.55
69_E160_L0.5260.55
65_M72_S0.5250.55
213_P217_L0.5250.55
113_K121_D0.5250.55
92_K121_D0.5250.55
64_S210_L0.5250.55
27_Q30_L0.5240.55
14_H86_K0.5240.55
226_A237_L0.5230.55
50_V166_I0.5210.55
81_Q212_K0.5210.55
67_I223_G0.5180.54
44_S49_A0.5180.54
235_V238_A0.5150.54
158_F162_F0.5120.53
151_K154_F0.5120.53
98_E130_A0.5110.53
184_F217_L0.5100.53
92_K96_E0.5100.53
11_H14_H0.5100.53
114_E184_F0.5090.53
156_M160_L0.5090.53
92_K145_E0.5070.53
206_K237_L0.5070.53
57_A79_V0.5060.52
119_I122_Y0.5050.52
183_N187_I0.5050.52
171_F186_L0.5050.52
87_E126_N0.5030.52
233_A239_H0.5020.52
65_M201_G0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.5466 31.2 0.955 Contact Map
3hy0A 1 0.5547 26.6 0.957 Contact Map
1z96A 1 0.1538 26.6 0.957 Contact Map
4mh4A 2 0.5182 26.5 0.957 Contact Map
2dakA 1 0.2551 24.7 0.958 Contact Map
4aurA 1 0.5668 22.5 0.958 Contact Map
1vegA 1 0.336 21.2 0.959 Contact Map
4oh3A 2 0.502 20.7 0.959 Contact Map
4un2B 1 0.17 20.4 0.959 Contact Map
2mr9A 1 0.1781 18.6 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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