DPHB - SULSO - GREMLIN Contacts

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DPHB - Diphthine synthase

UniProt:	Q97TX8	Sequences: MSILSLVGLGISKKFITDSAIETLSNSDIIIFDRYTSRSCDINVDVLRRLVKGEREFIEADRSLLENNSKAIIDYLDKGYNVSIASIGDALIATTHVSLLIEAKHRGHEVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKNEKAMTANEALQILLRLEERHKKSVLSKSDIIIVGARLGCDDERIIALKVEEATSFDFGNTPHIIIIPGNLHYMEADAIKWILRS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	257 (247)
Sequences:	533 (326)
Seq/√Len:	20.8

HALSA - DPHB
SULSO - DPHB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
27_S	83_S	7.420	1.00
14_K	22_E	5.718	1.00
139_V	167_L	4.225	1.00
16_I	24_L	4.128	1.00
28_D	80_Y	3.943	1.00
179_A	206_V	3.418	1.00
152_Y	190_E	3.113	1.00
162_G	241_G	3.082	0.99
98_S	102_E	3.000	0.99
73_I	108_H	2.824	0.99
183_L	230_F	2.804	0.99
26_N	81_N	2.749	0.99
111_K	213_D	2.738	0.99
183_L	222_V	2.598	0.98
18_D	50_L	2.378	0.97
118_V	210_L	2.362	0.97
190_E	196_S	2.297	0.96
159_K	197_V	2.293	0.96
60_A	64_L	2.219	0.95
157_D	161_R	2.185	0.95
200_K	223_E	2.181	0.95
4_L	84_I	2.114	0.94
28_D	81_N	2.048	0.93
119_H	136_S	2.018	0.92
12_S	19_S	1.987	0.91
23_T	113_I	1.972	0.91
65_L	84_I	1.949	0.91
103_A	110_V	1.917	0.90
6_L	100_L	1.905	0.90
29_I	75_Y	1.871	0.89
190_E	197_V	1.855	0.88
135_K	154_V	1.851	0.88
126_S	238_I	1.833	0.88
139_V	182_A	1.790	0.86
3_I	110_V	1.736	0.85
115_G	138_T	1.718	0.84
141_F	181_E	1.712	0.84
114_P	215_E	1.682	0.83
220_L	224_E	1.660	0.82
231_G	235_H	1.646	0.81
13_K	46_V	1.646	0.81
126_S	207_G	1.644	0.81
22_E	25_S	1.632	0.81
205_I	251_I	1.596	0.79
92_I	120_C	1.586	0.79
129_S	244_H	1.575	0.78
250_A	254_I	1.543	0.77
156_K	160_E	1.538	0.76
136_S	168_Y	1.482	0.74
24_L	30_I	1.445	0.72
22_E	26_N	1.444	0.72
207_G	210_L	1.443	0.72
206_V	230_F	1.439	0.71
220_L	225_A	1.439	0.71
29_I	77_D	1.437	0.71
203_I	219_A	1.418	0.70
7_V	83_S	1.404	0.69
225_A	230_F	1.397	0.69
86_S	115_G	1.392	0.69
31_I	75_Y	1.384	0.68
74_D	106_R	1.375	0.68
61_D	174_E	1.361	0.67
147_I	188_R	1.351	0.66
125_K	210_L	1.347	0.66
15_F	19_S	1.337	0.66
153_N	193_H	1.334	0.65
23_T	55_R	1.320	0.65
139_V	151_P	1.313	0.64
147_I	192_R	1.313	0.64
30_I	55_R	1.310	0.64
16_I	33_D	1.307	0.64
61_D	64_L	1.293	0.63
5_S	23_T	1.287	0.62
51_V	55_R	1.279	0.62
5_S	27_S	1.277	0.62
97_V	250_A	1.273	0.62
142_P	151_P	1.265	0.61
149_P	189_L	1.262	0.61
63_S	67_N	1.238	0.59
29_I	80_Y	1.220	0.58
168_Y	236_I	1.218	0.58
123_I	207_G	1.209	0.58
24_L	51_V	1.205	0.57
86_S	90_A	1.203	0.57
4_L	103_A	1.190	0.56
149_P	192_R	1.181	0.56
64_L	72_I	1.165	0.55
4_L	7_V	1.150	0.54
156_K	190_E	1.140	0.53
91_L	100_L	1.131	0.52
84_I	98_S	1.119	0.52
6_L	110_V	1.118	0.52
139_V	186_L	1.114	0.51
152_Y	156_K	1.112	0.51
169_L	182_A	1.098	0.50
26_N	80_Y	1.095	0.50
5_S	83_S	1.081	0.49
29_I	82_V	1.054	0.47
77_D	106_R	1.054	0.47
240_P	251_I	1.044	0.47
125_K	215_E	1.043	0.47
248_A	252_K	1.043	0.47
7_V	27_S	1.031	0.46
68_N	163_L	1.024	0.45
178_T	181_E	1.018	0.45
17_T	222_V	1.017	0.45
156_K	195_K	1.016	0.45
189_L	193_H	1.007	0.44
179_A	183_L	1.001	0.44
56_E	155_I	0.998	0.44
76_L	108_H	0.991	0.43
16_I	20_A	0.988	0.43
46_V	49_R	0.987	0.43
72_I	75_Y	0.976	0.42
64_L	68_N	0.972	0.42
198_L	239_I	0.968	0.42
204_I	225_A	0.968	0.42
77_D	108_H	0.961	0.41
100_L	110_V	0.955	0.41
90_A	140_T	0.954	0.41
16_I	21_I	0.953	0.41
27_S	30_I	0.951	0.41
93_A	168_Y	0.950	0.41
157_D	241_G	0.948	0.40
139_V	155_I	0.943	0.40
141_F	177_M	0.940	0.40
209_R	235_H	0.937	0.40
186_L	243_L	0.935	0.40
77_D	205_I	0.932	0.39
183_L	226_T	0.926	0.39
180_N	226_T	0.918	0.39
46_V	159_K	0.917	0.39
70_K	113_I	0.916	0.38
68_N	71_A	0.915	0.38
186_L	190_E	0.914	0.38
97_V	104_K	0.913	0.38
17_T	116_I	0.911	0.38
172_K	175_K	0.909	0.38
122_L	166_I	0.903	0.38
204_I	222_V	0.894	0.37
84_I	102_E	0.893	0.37
26_N	113_I	0.887	0.37
161_R	240_P	0.887	0.37
32_F	138_T	0.884	0.36
190_E	194_K	0.882	0.36
24_L	83_S	0.879	0.36
6_L	30_I	0.873	0.36
135_K	157_D	0.864	0.35
77_D	109_E	0.861	0.35
183_L	220_L	0.859	0.35
179_A	230_F	0.858	0.35
7_V	113_I	0.857	0.35
152_Y	196_S	0.854	0.35
159_K	198_L	0.854	0.35
140_T	203_I	0.852	0.35
69_S	93_A	0.851	0.34
219_A	240_P	0.851	0.34
195_K	213_D	0.851	0.34
39_S	234_P	0.848	0.34
119_H	126_S	0.844	0.34
49_R	161_R	0.840	0.34
32_F	87_I	0.839	0.34
27_S	55_R	0.832	0.33
218_I	228_F	0.831	0.33
135_K	167_L	0.818	0.33
184_Q	226_T	0.817	0.32
4_L	99_L	0.812	0.32
221_K	224_E	0.810	0.32
17_T	113_I	0.809	0.32
183_L	225_A	0.805	0.32
44_V	249_D	0.803	0.32
214_D	232_N	0.803	0.32
143_Y	147_I	0.803	0.32
3_I	240_P	0.799	0.31
31_I	82_V	0.796	0.31
198_L	222_V	0.793	0.31
178_T	232_N	0.791	0.31
112_V	243_L	0.788	0.31
26_N	46_V	0.784	0.31
149_P	193_H	0.772	0.30
194_K	238_I	0.768	0.30
23_T	83_S	0.767	0.30
140_T	196_S	0.766	0.30
126_S	130_S	0.765	0.30
210_L	225_A	0.764	0.29
157_D	163_L	0.764	0.29
6_L	84_I	0.761	0.29
65_L	98_S	0.761	0.29
214_D	229_D	0.759	0.29
182_A	186_L	0.757	0.29
150_T	236_I	0.753	0.29
128_L	251_I	0.753	0.29
186_L	191_E	0.750	0.29
69_S	132_K	0.748	0.29
161_R	241_G	0.747	0.29
23_T	82_V	0.747	0.29
48_R	56_E	0.745	0.28
129_S	208_A	0.740	0.28
73_I	102_E	0.740	0.28
14_K	26_N	0.737	0.28
20_A	114_P	0.736	0.28
157_D	242_N	0.730	0.28
155_I	167_L	0.729	0.28
137_V	148_D	0.723	0.27
150_T	166_I	0.717	0.27
154_V	242_N	0.716	0.27
84_I	99_L	0.712	0.27
29_I	58_I	0.711	0.27
92_I	130_S	0.705	0.26
122_L	207_G	0.701	0.26
156_K	197_V	0.700	0.26
109_E	227_S	0.699	0.26
142_P	147_I	0.695	0.26
32_F	44_V	0.692	0.26
115_G	154_V	0.691	0.26
29_I	81_N	0.691	0.26
70_K	73_I	0.689	0.26
186_L	239_I	0.686	0.25
33_D	234_P	0.686	0.25
142_P	185_I	0.686	0.25
30_I	253_W	0.684	0.25
115_G	168_Y	0.683	0.25
130_S	168_Y	0.680	0.25
94_T	131_Y	0.678	0.25
47_L	51_V	0.677	0.25
37_S	103_A	0.675	0.25
198_L	243_L	0.675	0.25
91_L	132_K	0.675	0.25
44_V	56_E	0.675	0.25
105_H	238_I	0.673	0.25
107_G	194_K	0.670	0.25
63_S	143_Y	0.667	0.24
201_S	226_T	0.663	0.24
28_D	31_I	0.661	0.24
104_K	253_W	0.658	0.24
125_K	217_I	0.658	0.24
34_R	59_E	0.657	0.24
16_I	30_I	0.657	0.24
73_I	221_K	0.656	0.24
26_N	49_R	0.656	0.24
132_K	242_N	0.655	0.24
137_V	154_V	0.654	0.24
73_I	82_V	0.653	0.24
18_D	101_I	0.649	0.24
75_Y	80_Y	0.646	0.23
208_A	235_H	0.644	0.23
43_N	46_V	0.643	0.23
71_A	75_Y	0.642	0.23
219_A	238_I	0.641	0.23
6_L	91_L	0.641	0.23
118_V	236_I	0.639	0.23
173_N	176_A	0.638	0.23
13_K	190_E	0.637	0.23
15_F	138_T	0.634	0.23
136_S	236_I	0.634	0.23
180_N	230_F	0.633	0.23
203_I	218_I	0.633	0.23
167_L	180_N	0.632	0.23
116_I	138_T	0.630	0.23
7_V	23_T	0.629	0.23
198_L	240_P	0.627	0.23
91_L	112_V	0.624	0.22
4_L	76_L	0.621	0.22
24_L	57_F	0.619	0.22
180_N	184_Q	0.619	0.22
115_G	185_I	0.616	0.22
201_S	223_E	0.615	0.22
145_D	160_E	0.615	0.22
56_E	59_E	0.613	0.22
89_D	129_S	0.609	0.22
9_L	16_I	0.607	0.22
84_I	103_A	0.606	0.22
7_V	24_L	0.603	0.21
224_E	246_M	0.603	0.21
111_K	238_I	0.602	0.21
96_H	131_Y	0.601	0.21
159_K	195_K	0.601	0.21
132_K	241_G	0.600	0.21
205_I	219_A	0.600	0.21
7_V	20_A	0.600	0.21
152_Y	194_K	0.598	0.21
128_L	131_Y	0.598	0.21
37_S	236_I	0.597	0.21
99_L	106_R	0.596	0.21
167_L	186_L	0.596	0.21
116_I	124_S	0.594	0.21
85_A	113_I	0.586	0.21
87_I	102_E	0.585	0.21
65_L	102_E	0.585	0.21
209_R	233_T	0.584	0.21
91_L	130_S	0.582	0.21
138_T	148_D	0.582	0.21
35_Y	47_L	0.580	0.20
210_L	217_I	0.580	0.20
98_S	171_L	0.576	0.20
33_D	65_L	0.576	0.20
4_L	210_L	0.575	0.20
11_I	20_A	0.575	0.20
32_F	60_A	0.575	0.20
71_A	74_D	0.574	0.20
175_K	181_E	0.574	0.20
183_L	239_I	0.571	0.20
63_S	84_I	0.570	0.20
171_L	176_A	0.569	0.20
141_F	176_A	0.569	0.20
13_K	42_I	0.566	0.20
239_I	251_I	0.564	0.20
9_L	32_F	0.564	0.20
144_N	147_I	0.564	0.20
9_L	18_D	0.562	0.20
12_S	39_S	0.560	0.20
44_V	59_E	0.560	0.20
16_I	51_V	0.558	0.20
12_S	33_D	0.557	0.19
19_S	213_D	0.557	0.19
123_I	126_S	0.555	0.19
97_V	133_F	0.554	0.19
138_T	234_P	0.554	0.19
74_D	112_V	0.552	0.19
23_T	26_N	0.551	0.19
63_S	163_L	0.547	0.19
56_E	207_G	0.546	0.19
14_K	213_D	0.546	0.19
154_V	236_I	0.543	0.19
138_T	146_F	0.541	0.19
137_V	155_I	0.537	0.19
243_L	248_A	0.536	0.19
92_I	154_V	0.534	0.19
105_H	159_K	0.533	0.19
60_A	151_P	0.532	0.18
49_R	213_D	0.532	0.18
68_N	105_H	0.531	0.18
100_L	120_C	0.531	0.18
119_H	168_Y	0.531	0.18
61_D	130_S	0.531	0.18
130_S	174_E	0.528	0.18
211_G	250_A	0.527	0.18
125_K	142_P	0.525	0.18
159_K	205_I	0.524	0.18
180_N	183_L	0.524	0.18
4_L	23_T	0.524	0.18
23_T	225_A	0.523	0.18
113_I	195_K	0.521	0.18
100_L	107_G	0.521	0.18
142_P	190_E	0.520	0.18
219_A	244_H	0.520	0.18
55_R	205_I	0.519	0.18
92_I	210_L	0.519	0.18
82_V	160_E	0.518	0.18
15_F	118_V	0.518	0.18
102_E	171_L	0.517	0.18
215_E	239_I	0.517	0.18
18_D	75_Y	0.516	0.18
81_N	156_K	0.515	0.18
98_S	129_S	0.514	0.18
107_G	248_A	0.514	0.18
63_S	162_G	0.512	0.18
49_R	56_E	0.511	0.18
191_E	200_K	0.510	0.18
24_L	85_A	0.509	0.18
139_V	239_I	0.509	0.18
106_R	223_E	0.508	0.18
146_F	185_I	0.508	0.18
19_S	111_K	0.505	0.17
129_S	251_I	0.503	0.17
207_G	217_I	0.502	0.17
86_S	142_P	0.502	0.17
114_P	127_L	0.501	0.17
110_V	210_L	0.500	0.17
111_K	224_E	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3i4tA	2	0.9533	100	0.56	Contact Map
1wdeA	2	0.9844	100	0.58	Contact Map
2z6rA	2	0.9805	100	0.582	Contact Map
1vhvA	2	0.9377	100	0.615	Contact Map
2yboA	2	0.9066	100	0.71	Contact Map
1s4dA	4	0.9183	100	0.715	Contact Map
1cbfA	2	0.8794	100	0.718	Contact Map
1pjqA	2	0.9105	100	0.72	Contact Map
4e16A	2	0.8677	100	0.723	Contact Map
2e0nA	2	0.8755	100	0.728	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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