GREMLIN Database
DPHB - Diphthine synthase
UniProt: Q97TX8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (247)
Sequences: 533 (326)
Seq/√Len: 20.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_S83_S7.4201.00
14_K22_E5.7181.00
139_V167_L4.2251.00
16_I24_L4.1281.00
28_D80_Y3.9431.00
179_A206_V3.4181.00
152_Y190_E3.1131.00
162_G241_G3.0820.99
98_S102_E3.0000.99
73_I108_H2.8240.99
183_L230_F2.8040.99
26_N81_N2.7490.99
111_K213_D2.7380.99
183_L222_V2.5980.98
18_D50_L2.3780.97
118_V210_L2.3620.97
190_E196_S2.2970.96
159_K197_V2.2930.96
60_A64_L2.2190.95
157_D161_R2.1850.95
200_K223_E2.1810.95
4_L84_I2.1140.94
28_D81_N2.0480.93
119_H136_S2.0180.92
12_S19_S1.9870.91
23_T113_I1.9720.91
65_L84_I1.9490.91
103_A110_V1.9170.90
6_L100_L1.9050.90
29_I75_Y1.8710.89
190_E197_V1.8550.88
135_K154_V1.8510.88
126_S238_I1.8330.88
139_V182_A1.7900.86
3_I110_V1.7360.85
115_G138_T1.7180.84
141_F181_E1.7120.84
114_P215_E1.6820.83
220_L224_E1.6600.82
231_G235_H1.6460.81
13_K46_V1.6460.81
126_S207_G1.6440.81
22_E25_S1.6320.81
205_I251_I1.5960.79
92_I120_C1.5860.79
129_S244_H1.5750.78
250_A254_I1.5430.77
156_K160_E1.5380.76
136_S168_Y1.4820.74
24_L30_I1.4450.72
22_E26_N1.4440.72
207_G210_L1.4430.72
206_V230_F1.4390.71
220_L225_A1.4390.71
29_I77_D1.4370.71
203_I219_A1.4180.70
7_V83_S1.4040.69
225_A230_F1.3970.69
86_S115_G1.3920.69
31_I75_Y1.3840.68
74_D106_R1.3750.68
61_D174_E1.3610.67
147_I188_R1.3510.66
125_K210_L1.3470.66
15_F19_S1.3370.66
153_N193_H1.3340.65
23_T55_R1.3200.65
139_V151_P1.3130.64
147_I192_R1.3130.64
30_I55_R1.3100.64
16_I33_D1.3070.64
61_D64_L1.2930.63
5_S23_T1.2870.62
51_V55_R1.2790.62
5_S27_S1.2770.62
97_V250_A1.2730.62
142_P151_P1.2650.61
149_P189_L1.2620.61
63_S67_N1.2380.59
29_I80_Y1.2200.58
168_Y236_I1.2180.58
123_I207_G1.2090.58
24_L51_V1.2050.57
86_S90_A1.2030.57
4_L103_A1.1900.56
149_P192_R1.1810.56
64_L72_I1.1650.55
4_L7_V1.1500.54
156_K190_E1.1400.53
91_L100_L1.1310.52
84_I98_S1.1190.52
6_L110_V1.1180.52
139_V186_L1.1140.51
152_Y156_K1.1120.51
169_L182_A1.0980.50
26_N80_Y1.0950.50
5_S83_S1.0810.49
29_I82_V1.0540.47
77_D106_R1.0540.47
240_P251_I1.0440.47
125_K215_E1.0430.47
248_A252_K1.0430.47
7_V27_S1.0310.46
68_N163_L1.0240.45
178_T181_E1.0180.45
17_T222_V1.0170.45
156_K195_K1.0160.45
189_L193_H1.0070.44
179_A183_L1.0010.44
56_E155_I0.9980.44
76_L108_H0.9910.43
16_I20_A0.9880.43
46_V49_R0.9870.43
72_I75_Y0.9760.42
64_L68_N0.9720.42
198_L239_I0.9680.42
204_I225_A0.9680.42
77_D108_H0.9610.41
100_L110_V0.9550.41
90_A140_T0.9540.41
16_I21_I0.9530.41
27_S30_I0.9510.41
93_A168_Y0.9500.41
157_D241_G0.9480.40
139_V155_I0.9430.40
141_F177_M0.9400.40
209_R235_H0.9370.40
186_L243_L0.9350.40
77_D205_I0.9320.39
183_L226_T0.9260.39
180_N226_T0.9180.39
46_V159_K0.9170.39
70_K113_I0.9160.38
68_N71_A0.9150.38
186_L190_E0.9140.38
97_V104_K0.9130.38
17_T116_I0.9110.38
172_K175_K0.9090.38
122_L166_I0.9030.38
204_I222_V0.8940.37
84_I102_E0.8930.37
26_N113_I0.8870.37
161_R240_P0.8870.37
32_F138_T0.8840.36
190_E194_K0.8820.36
24_L83_S0.8790.36
6_L30_I0.8730.36
135_K157_D0.8640.35
77_D109_E0.8610.35
183_L220_L0.8590.35
179_A230_F0.8580.35
7_V113_I0.8570.35
152_Y196_S0.8540.35
159_K198_L0.8540.35
140_T203_I0.8520.35
69_S93_A0.8510.34
219_A240_P0.8510.34
195_K213_D0.8510.34
39_S234_P0.8480.34
119_H126_S0.8440.34
49_R161_R0.8400.34
32_F87_I0.8390.34
27_S55_R0.8320.33
218_I228_F0.8310.33
135_K167_L0.8180.33
184_Q226_T0.8170.32
4_L99_L0.8120.32
221_K224_E0.8100.32
17_T113_I0.8090.32
183_L225_A0.8050.32
44_V249_D0.8030.32
214_D232_N0.8030.32
143_Y147_I0.8030.32
3_I240_P0.7990.31
31_I82_V0.7960.31
198_L222_V0.7930.31
178_T232_N0.7910.31
112_V243_L0.7880.31
26_N46_V0.7840.31
149_P193_H0.7720.30
194_K238_I0.7680.30
23_T83_S0.7670.30
140_T196_S0.7660.30
126_S130_S0.7650.30
210_L225_A0.7640.29
157_D163_L0.7640.29
6_L84_I0.7610.29
65_L98_S0.7610.29
214_D229_D0.7590.29
182_A186_L0.7570.29
150_T236_I0.7530.29
128_L251_I0.7530.29
186_L191_E0.7500.29
69_S132_K0.7480.29
161_R241_G0.7470.29
23_T82_V0.7470.29
48_R56_E0.7450.28
129_S208_A0.7400.28
73_I102_E0.7400.28
14_K26_N0.7370.28
20_A114_P0.7360.28
157_D242_N0.7300.28
155_I167_L0.7290.28
137_V148_D0.7230.27
150_T166_I0.7170.27
154_V242_N0.7160.27
84_I99_L0.7120.27
29_I58_I0.7110.27
92_I130_S0.7050.26
122_L207_G0.7010.26
156_K197_V0.7000.26
109_E227_S0.6990.26
142_P147_I0.6950.26
32_F44_V0.6920.26
115_G154_V0.6910.26
29_I81_N0.6910.26
70_K73_I0.6890.26
186_L239_I0.6860.25
33_D234_P0.6860.25
142_P185_I0.6860.25
30_I253_W0.6840.25
115_G168_Y0.6830.25
130_S168_Y0.6800.25
94_T131_Y0.6780.25
47_L51_V0.6770.25
37_S103_A0.6750.25
198_L243_L0.6750.25
91_L132_K0.6750.25
44_V56_E0.6750.25
105_H238_I0.6730.25
107_G194_K0.6700.25
63_S143_Y0.6670.24
201_S226_T0.6630.24
28_D31_I0.6610.24
104_K253_W0.6580.24
125_K217_I0.6580.24
34_R59_E0.6570.24
16_I30_I0.6570.24
73_I221_K0.6560.24
26_N49_R0.6560.24
132_K242_N0.6550.24
137_V154_V0.6540.24
73_I82_V0.6530.24
18_D101_I0.6490.24
75_Y80_Y0.6460.23
208_A235_H0.6440.23
43_N46_V0.6430.23
71_A75_Y0.6420.23
219_A238_I0.6410.23
6_L91_L0.6410.23
118_V236_I0.6390.23
173_N176_A0.6380.23
13_K190_E0.6370.23
15_F138_T0.6340.23
136_S236_I0.6340.23
180_N230_F0.6330.23
203_I218_I0.6330.23
167_L180_N0.6320.23
116_I138_T0.6300.23
7_V23_T0.6290.23
198_L240_P0.6270.23
91_L112_V0.6240.22
4_L76_L0.6210.22
24_L57_F0.6190.22
180_N184_Q0.6190.22
115_G185_I0.6160.22
201_S223_E0.6150.22
145_D160_E0.6150.22
56_E59_E0.6130.22
89_D129_S0.6090.22
9_L16_I0.6070.22
84_I103_A0.6060.22
7_V24_L0.6030.21
224_E246_M0.6030.21
111_K238_I0.6020.21
96_H131_Y0.6010.21
159_K195_K0.6010.21
132_K241_G0.6000.21
205_I219_A0.6000.21
7_V20_A0.6000.21
152_Y194_K0.5980.21
128_L131_Y0.5980.21
37_S236_I0.5970.21
99_L106_R0.5960.21
167_L186_L0.5960.21
116_I124_S0.5940.21
85_A113_I0.5860.21
87_I102_E0.5850.21
65_L102_E0.5850.21
209_R233_T0.5840.21
91_L130_S0.5820.21
138_T148_D0.5820.21
35_Y47_L0.5800.20
210_L217_I0.5800.20
98_S171_L0.5760.20
33_D65_L0.5760.20
4_L210_L0.5750.20
11_I20_A0.5750.20
32_F60_A0.5750.20
71_A74_D0.5740.20
175_K181_E0.5740.20
183_L239_I0.5710.20
63_S84_I0.5700.20
171_L176_A0.5690.20
141_F176_A0.5690.20
13_K42_I0.5660.20
239_I251_I0.5640.20
9_L32_F0.5640.20
144_N147_I0.5640.20
9_L18_D0.5620.20
12_S39_S0.5600.20
44_V59_E0.5600.20
16_I51_V0.5580.20
12_S33_D0.5570.19
19_S213_D0.5570.19
123_I126_S0.5550.19
97_V133_F0.5540.19
138_T234_P0.5540.19
74_D112_V0.5520.19
23_T26_N0.5510.19
63_S163_L0.5470.19
56_E207_G0.5460.19
14_K213_D0.5460.19
154_V236_I0.5430.19
138_T146_F0.5410.19
137_V155_I0.5370.19
243_L248_A0.5360.19
92_I154_V0.5340.19
105_H159_K0.5330.19
60_A151_P0.5320.18
49_R213_D0.5320.18
68_N105_H0.5310.18
100_L120_C0.5310.18
119_H168_Y0.5310.18
61_D130_S0.5310.18
130_S174_E0.5280.18
211_G250_A0.5270.18
125_K142_P0.5250.18
159_K205_I0.5240.18
180_N183_L0.5240.18
4_L23_T0.5240.18
23_T225_A0.5230.18
113_I195_K0.5210.18
100_L107_G0.5210.18
142_P190_E0.5200.18
219_A244_H0.5200.18
55_R205_I0.5190.18
92_I210_L0.5190.18
82_V160_E0.5180.18
15_F118_V0.5180.18
102_E171_L0.5170.18
215_E239_I0.5170.18
18_D75_Y0.5160.18
81_N156_K0.5150.18
98_S129_S0.5140.18
107_G248_A0.5140.18
63_S162_G0.5120.18
49_R56_E0.5110.18
191_E200_K0.5100.18
24_L85_A0.5090.18
139_V239_I0.5090.18
106_R223_E0.5080.18
146_F185_I0.5080.18
19_S111_K0.5050.17
129_S251_I0.5030.17
207_G217_I0.5020.17
86_S142_P0.5020.17
114_P127_L0.5010.17
110_V210_L0.5000.17
111_K224_E0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i4tA 2 0.9533 100 0.56 Contact Map
1wdeA 2 0.9844 100 0.58 Contact Map
2z6rA 2 0.9805 100 0.582 Contact Map
1vhvA 2 0.9377 100 0.615 Contact Map
2yboA 2 0.9066 100 0.71 Contact Map
1s4dA 4 0.9183 100 0.715 Contact Map
1cbfA 2 0.8794 100 0.718 Contact Map
1pjqA 2 0.9105 100 0.72 Contact Map
4e16A 2 0.8677 100 0.723 Contact Map
2e0nA 2 0.8755 100 0.728 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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