GREMLIN Database
TRPB2 - Tryptophan synthase beta chain 2
UniProt: Q97TX6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (376)
Sequences: 4900 (2337)
Seq/√Len: 120.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_A408_L4.8941.00
285_R356_Q4.7021.00
147_S154_A4.2651.00
364_E393_E3.7901.00
160_R184_P3.4061.00
58_K234_M3.3771.00
257_I270_L3.3151.00
83_R96_K3.2871.00
237_T241_M3.2861.00
219_N268_A2.9511.00
160_R193_Q2.9101.00
155_H179_E2.8561.00
256_Y287_K2.8261.00
304_Y350_I2.6161.00
270_L410_S2.5991.00
81_I408_L2.5621.00
90_Y371_L2.5541.00
243_A270_L2.5141.00
252_E406_T2.4511.00
157_F205_L2.4321.00
155_H181_H2.4321.00
38_K351_S2.4191.00
244_K277_D2.3971.00
83_R88_E2.3391.00
79_T105_T2.2171.00
289_I390_I2.1701.00
96_K250_I2.1581.00
85_K89_E2.1231.00
205_L209_I2.1101.00
129_F205_L2.1001.00
398_A405_K2.0921.00
153_K179_E2.0621.00
96_K406_T2.0441.00
255_D405_K2.0341.00
107_T145_L2.0311.00
214_E225_V2.0211.00
256_Y285_R2.0051.00
164_Y171_Y1.9871.00
245_K248_E1.9731.00
384_T412_S1.9551.00
161_T164_Y1.9481.00
257_I286_R1.9371.00
67_E70_E1.9311.00
247_M408_L1.9001.00
50_K53_E1.8471.00
240_G273_P1.8381.00
83_R98_Y1.8381.00
86_R89_E1.8161.00
99_L372_F1.7991.00
61_Y124_L1.7981.00
346_L357_A1.7741.00
34_D42_L1.7691.00
318_L351_S1.7561.00
358_R390_I1.7551.00
247_M406_T1.7511.00
174_Q179_E1.7481.00
309_P316_P1.7421.00
122_A126_N1.7381.00
123_K126_N1.7361.00
287_K356_Q1.7311.00
391_L409_V1.7211.00
205_L208_A1.6881.00
78_P245_K1.6741.00
399_K405_K1.6661.00
369_A385_S1.6631.00
368_W389_P1.6371.00
57_A60_R1.6361.00
168_Y419_L1.6331.00
240_G270_L1.6191.00
75_V105_T1.6171.00
119_V216_A1.6101.00
366_F382_P1.6091.00
270_L286_R1.5761.00
129_F153_K1.5731.00
371_L392_A1.5691.00
98_Y250_I1.5631.00
384_T411_F1.5531.00
91_L392_A1.5491.00
164_Y167_P1.5411.00
192_R329_P1.5371.00
37_G351_S1.5341.00
43_L51_V1.5271.00
363_E367_K1.4901.00
208_A212_A1.4881.00
303_V320_M1.4831.00
318_L350_I1.4751.00
201_H204_S1.4641.00
119_V130_V1.4591.00
303_V306_Y1.4551.00
48_P52_L1.4511.00
91_L396_E1.4471.00
145_L176_Y1.4401.00
90_Y375_L1.4311.00
247_M250_I1.4301.00
289_I360_Y1.4251.00
278_E283_K1.4181.00
199_S220_G1.4081.00
98_Y247_M1.4071.00
360_Y389_P1.4001.00
75_V79_T1.3941.00
258_I287_K1.3911.00
87_L388_L1.3841.00
256_Y398_A1.3821.00
50_K210_S1.3791.00
163_Y182_P1.3791.00
389_P393_E1.3771.00
275_L355_V1.3571.00
289_I358_R1.3511.00
288_Y357_A1.3441.00
292_G361_S1.3321.00
184_P193_Q1.3281.00
348_L352_K1.3201.00
37_G309_P1.3161.00
87_L97_I1.3141.00
55_E59_E1.3031.00
388_L409_V1.2991.00
250_I406_T1.2951.00
256_Y407_V1.2941.00
34_D37_G1.2931.00
199_S203_G1.2901.00
394_I397_E1.2731.00
396_E399_K1.2671.00
98_Y406_T1.2450.99
223_Y227_S1.2410.99
192_R197_K1.2380.99
258_I391_L1.2370.99
370_K374_E1.2320.99
41_E52_L1.2300.99
122_A125_D1.2240.99
390_I394_I1.2220.99
399_K403_E1.2140.99
209_I212_A1.2120.99
41_E48_P1.2100.99
256_Y394_I1.2030.99
361_S364_E1.2020.99
130_V135_G1.1960.99
167_P171_Y1.1890.99
160_R163_Y1.1850.99
295_E302_G1.1720.99
130_V134_T1.1620.99
160_R164_Y1.1600.99
143_V156_I1.1570.99
317_M347_S1.1530.99
312_A317_M1.1460.99
87_L371_L1.1390.99
257_I274_F1.1380.99
366_F425_V1.1350.99
130_V147_S1.1180.99
107_T112_I1.1130.99
287_K390_I1.1130.99
171_Y423_A1.1040.99
35_P227_S1.1020.99
292_G359_D1.0990.99
82_I101_M1.0980.99
119_V150_F1.0970.99
59_E227_S1.0940.99
91_L371_L1.0860.98
302_G307_D1.0850.98
127_A222_K1.0840.98
300_T306_Y1.0800.98
287_K394_I1.0800.98
79_T109_S1.0780.98
204_S208_A1.0770.98
309_P318_L1.0710.98
367_K371_L1.0670.98
364_E389_P1.0630.98
199_S217_H1.0630.98
241_M273_P1.0620.98
62_V234_M1.0610.98
115_A146_A1.0570.98
71_R116_L1.0550.98
243_A274_F1.0510.98
391_L407_V1.0460.98
271_A286_R1.0310.98
163_Y174_Q1.0260.98
302_G305_K1.0220.98
171_Y174_Q1.0200.98
88_E93_N1.0180.98
200_N203_G1.0150.98
368_W388_L1.0100.98
369_A422_Y1.0070.98
420_G424_S1.0060.97
34_D316_P1.0060.97
72_Y75_V0.9990.97
157_F209_I0.9990.97
358_R393_E0.9980.97
86_R375_L0.9970.97
372_F388_L0.9940.97
96_K404_R0.9910.97
289_I359_D0.9890.97
243_A410_S0.9850.97
175_M370_K0.9800.97
52_L56_F0.9730.97
208_A211_D0.9730.97
130_V133_E0.9690.97
421_N425_V0.9670.97
59_E63_K0.9650.97
317_M341_G0.9640.97
141_S172_M0.9630.97
167_P420_G0.9600.97
168_Y420_G0.9580.97
220_G315_L0.9570.97
102_E412_S0.9540.97
380_P384_T0.9540.97
380_P385_S0.9480.96
91_L391_L0.9480.96
49_S52_L0.9470.96
172_M379_I0.9470.96
258_I394_I0.9430.96
65_P69_L0.9420.96
421_N424_S0.9420.96
146_A216_A0.9390.96
129_F155_H0.9370.96
185_S201_H0.9340.96
302_G306_Y0.9320.96
85_K149_L0.9310.96
253_D277_D0.9300.96
58_K235_F0.9260.96
252_E255_D0.9240.96
200_N204_S0.9220.96
93_N97_I0.9220.96
130_V152_M0.9190.96
315_L319_K0.9180.96
97_I395_A0.9180.96
268_A346_L0.9170.96
248_E251_G0.9130.96
239_A410_S0.9110.96
37_G316_P0.9070.95
257_I273_P0.9020.95
193_Q197_K0.9000.95
275_L349_L0.8940.95
373_S379_I0.8930.95
61_Y64_I0.8930.95
58_K62_V0.8890.95
57_A61_Y0.8870.95
52_L55_E0.8850.95
378_Y411_F0.8840.95
258_I289_I0.8840.95
93_N398_A0.8810.95
300_T304_Y0.8800.95
171_Y175_M0.8800.95
161_T193_Q0.8740.94
240_G274_F0.8720.94
420_G423_A0.8700.94
243_A257_I0.8690.94
333_Y366_F0.8680.94
56_F60_R0.8660.94
82_I103_S0.8580.94
131_T134_T0.8570.94
256_Y405_K0.8570.94
373_S380_P0.8560.94
170_K180_V0.8540.94
233_I345_T0.8520.94
237_T273_P0.8520.94
253_D284_V0.8500.94
247_M252_E0.8490.93
34_D46_V0.8470.93
217_H220_G0.8460.93
123_K150_F0.8440.93
155_H205_L0.8420.93
167_P174_Q0.8390.93
261_V288_Y0.8380.93
49_S53_E0.8360.93
199_S330_P0.8280.93
257_I408_L0.8270.93
371_L375_L0.8210.92
44_K49_S0.8210.92
144_A178_A0.8200.92
385_S388_L0.8190.92
197_K200_N0.8190.92
119_V146_A0.8190.92
360_Y393_E0.8150.92
173_M178_A0.8140.92
123_K127_A0.8130.92
199_S218_K0.8120.92
207_I210_S0.8060.92
63_K66_D0.8050.92
164_Y424_S0.8040.91
95_I391_L0.8030.91
394_I398_A0.8030.91
254_P408_L0.8000.91
160_R182_P0.7980.91
297_P306_Y0.7950.91
101_M104_Y0.7930.91
46_V207_I0.7920.91
132_T135_G0.7910.91
306_Y310_D0.7910.91
171_Y419_L0.7910.91
395_A407_V0.7870.91
42_L45_E0.7870.91
301_K305_K0.7850.91
203_G206_G0.7850.91
75_V116_L0.7810.90
360_Y390_I0.7770.90
258_I390_I0.7730.90
390_I393_E0.7720.90
355_V358_R0.7710.90
123_K128_K0.7710.90
268_A272_Y0.7690.90
388_L411_F0.7680.90
84_A87_L0.7640.89
239_A266_N0.7620.89
419_L423_A0.7580.89
204_S326_D0.7550.89
110_H266_N0.7540.89
210_S213_V0.7530.89
93_N395_A0.7520.89
387_A409_V0.7500.88
285_R405_K0.7480.88
112_I145_L0.7420.88
161_T192_R0.7410.88
312_A327_F0.7390.88
270_L273_P0.7390.88
172_M176_Y0.7390.88
143_V147_S0.7360.87
121_Y125_D0.7350.87
309_P312_A0.7340.87
415_G418_D0.7310.87
71_R75_V0.7300.87
293_S362_Q0.7300.87
147_S216_A0.7290.87
256_Y356_Q0.7290.87
119_V152_M0.7280.87
399_K404_R0.7260.87
261_V342_V0.7250.87
87_L90_Y0.7240.87
302_G309_P0.7220.86
303_V307_D0.7220.86
218_K315_L0.7210.86
43_L48_P0.7190.86
200_N326_D0.7180.86
125_D128_K0.7160.86
131_T135_G0.7110.86
288_Y346_L0.7110.86
198_D201_H0.7060.85
39_S42_L0.7020.85
191_G194_L0.7000.85
170_K182_P0.7000.85
61_Y66_D0.6980.85
53_E56_F0.6960.84
64_I124_L0.6950.84
80_P104_Y0.6940.84
95_I407_V0.6930.84
384_T387_A0.6910.84
367_K392_A0.6910.84
66_D69_L0.6860.84
170_K174_Q0.6840.83
233_I272_Y0.6800.83
33_Q41_E0.6790.83
287_K358_R0.6790.83
124_L128_K0.6760.83
300_T303_V0.6750.83
307_D312_A0.6730.82
57_A62_V0.6730.82
273_P276_G0.6720.82
165_A335_G0.6720.82
105_T112_I0.6680.82
201_H205_L0.6680.82
61_Y68_V0.6670.82
128_K153_K0.6670.82
103_S412_S0.6650.82
191_G196_A0.6640.82
277_D284_V0.6630.81
391_L395_A0.6630.81
360_Y365_S0.6630.81
255_D406_T0.6620.81
270_L408_L0.6610.81
112_I149_L0.6600.81
321_Y326_D0.6600.81
294_S331_P0.6590.81
316_P319_K0.6580.81
122_A130_V0.6580.81
41_E55_E0.6550.81
122_A225_V0.6530.80
221_G224_V0.6510.80
133_E156_I0.6500.80
247_M254_P0.6470.80
203_G225_V0.6470.80
226_G344_P0.6450.80
64_I68_V0.6440.80
241_M245_K0.6430.79
406_T410_S0.6400.79
123_K152_M0.6400.79
34_D41_E0.6400.79
194_L198_D0.6390.79
198_D202_P0.6390.79
301_K304_Y0.6380.79
97_I407_V0.6370.79
380_P411_F0.6370.79
36_T39_S0.6350.79
39_S44_K0.6340.78
46_V49_S0.6340.78
32_P37_G0.6320.78
124_L127_A0.6310.78
68_V72_Y0.6300.78
41_E44_K0.6290.78
196_A200_N0.6290.78
48_P51_V0.6280.78
302_G310_D0.6270.78
36_T42_L0.6240.77
192_R201_H0.6220.77
382_P422_Y0.6200.77
169_R335_G0.6200.77
93_N403_E0.6190.77
99_L411_F0.6150.76
87_L392_A0.6150.76
161_T329_P0.6140.76
244_K253_D0.6140.76
36_T41_E0.6140.76
113_N238_I0.6130.76
35_P233_I0.6130.76
253_D274_F0.6130.76
320_M328_V0.6120.76
287_K355_V0.6120.76
147_S153_K0.6110.76
102_E384_T0.6100.76
395_A398_A0.6100.76
171_Y420_G0.6090.76
372_F411_F0.6080.76
194_L204_S0.6080.76
175_M373_S0.6030.75
34_D167_P0.6030.75
312_A319_K0.6030.75
319_K327_F0.6020.75
234_M272_Y0.6010.75
388_L392_A0.6010.75
182_P185_S0.6000.75
145_L149_L0.5980.74
220_G304_Y0.5970.74
93_N396_E0.5960.74
81_I84_A0.5960.74
97_I391_L0.5940.74
45_E48_P0.5940.74
119_V143_V0.5930.74
75_V112_I0.5910.73
251_G255_D0.5900.73
199_S210_S0.5890.73
293_S329_P0.5890.73
244_K274_F0.5880.73
414_H418_D0.5880.73
259_G266_N0.5860.73
172_M419_L0.5860.73
169_R381_A0.5850.73
130_V216_A0.5840.73
403_E406_T0.5830.72
296_V342_V0.5830.72
234_M237_T0.5830.72
59_E62_V0.5820.72
303_V315_L0.5820.72
294_S330_P0.5810.72
245_K249_L0.5800.72
130_V217_H0.5790.72
199_S202_P0.5790.72
284_V354_I0.5790.72
350_I357_A0.5780.72
380_P388_L0.5760.72
272_Y345_T0.5750.71
306_Y309_P0.5750.71
81_I247_M0.5750.71
66_D70_E0.5740.71
107_T176_Y0.5730.71
366_F422_Y0.5720.71
236_K384_T0.5710.71
388_L391_L0.5710.71
414_H417_L0.5710.71
77_R113_N0.5700.71
271_A353_G0.5690.71
78_P246_Q0.5690.71
82_I85_K0.5680.71
227_S234_M0.5680.71
121_Y126_N0.5670.70
220_G317_M0.5670.70
153_K174_Q0.5670.70
361_S393_E0.5660.70
33_Q37_G0.5660.70
197_K201_H0.5650.70
305_K359_D0.5640.70
34_D192_R0.5640.70
56_F59_E0.5640.70
199_S204_S0.5630.70
274_F277_D0.5630.70
369_A382_P0.5620.70
62_V227_S0.5620.70
308_Y321_Y0.5610.70
278_E284_V0.5610.70
297_P300_T0.5600.69
163_Y183_S0.5600.69
241_M272_Y0.5590.69
311_T316_P0.5590.69
364_E367_K0.5570.69
113_N236_K0.5570.69
225_V228_V0.5570.69
129_F157_F0.5560.69
239_A270_L0.5550.69
398_A407_V0.5540.69
195_L199_S0.5530.69
71_R150_F0.5520.68
285_R397_E0.5520.68
88_E95_I0.5520.68
164_Y182_P0.5510.68
171_Y370_K0.5500.68
105_T421_N0.5490.68
194_L199_S0.5480.68
237_T272_Y0.5480.68
244_K273_P0.5470.68
243_A247_M0.5470.68
398_A404_R0.5470.68
300_T305_K0.5460.68
37_G348_L0.5450.67
297_P303_V0.5440.67
313_K340_H0.5420.67
393_E396_E0.5420.67
383_E386_H0.5410.67
98_Y252_E0.5400.67
217_H317_M0.5390.67
81_I250_I0.5390.67
192_R200_N0.5390.67
381_A413_G0.5370.66
133_E206_G0.5360.66
296_V306_Y0.5330.66
307_D310_D0.5310.65
196_A206_G0.5310.65
311_T326_D0.5290.65
88_E97_I0.5280.65
347_S350_I0.5280.65
82_I378_Y0.5250.65
198_D204_S0.5250.65
261_V384_T0.5210.64
302_G308_Y0.5200.64
41_E315_L0.5190.64
40_L44_K0.5180.64
48_P315_L0.5180.64
89_E403_E0.5180.64
136_A339_Y0.5170.63
198_D206_G0.5170.63
132_T156_I0.5160.63
47_L225_V0.5140.63
167_P316_P0.5140.63
253_D283_K0.5140.63
141_S173_M0.5140.63
275_L286_R0.5120.63
356_Q390_I0.5100.62
199_S205_L0.5100.62
304_Y357_A0.5100.62
369_A419_L0.5090.62
367_K374_E0.5090.62
203_G210_S0.5080.62
233_I343_A0.5070.62
333_Y425_V0.5060.62
296_V300_T0.5060.62
62_V68_V0.5040.61
129_F215_Y0.5040.61
308_Y311_T0.5040.61
200_N208_A0.5030.61
35_P38_K0.5030.61
93_N391_L0.5020.61
45_E326_D0.5020.61
243_A273_P0.5020.61
342_V350_I0.5010.61
233_I268_A0.5010.61
95_I396_E0.5010.61
39_S43_L0.5010.61
315_L330_P0.5000.61
32_P318_L0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qysB 2 0.9697 100 0.282 Contact Map
1tdjA 2 0.7622 100 0.36 Contact Map
1x1qA 2 0.8928 100 0.362 Contact Map
2o2eA 2 0.7226 100 0.362 Contact Map
4negA 2 0.7436 100 0.364 Contact Map
2gn0A 2 0.7646 100 0.374 Contact Map
3ss7X 1 0.8904 100 0.378 Contact Map
1v71A 2 0.7389 100 0.38 Contact Map
4ht3B 2 0.8904 100 0.38 Contact Map
3l6bA 2 0.7483 100 0.389 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0121 seconds.