GREMLIN Database
Q97TX5 - Gamma-glutamyltranspeptidase, hypothetical
UniProt: Q97TX5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 478 (471)
Sequences: 5278 (3627)
Seq/√Len: 167.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_T172_K6.8211.00
247_V302_I4.0951.00
179_R183_E3.8901.00
27_E116_E3.7081.00
188_E203_Y3.6921.00
123_S127_N3.5591.00
9_V465_G3.4461.00
243_K298_I3.4351.00
12_T18_S3.1111.00
71_A101_L2.9751.00
12_T38_I2.8961.00
265_V430_V2.7471.00
191_T203_Y2.7101.00
221_Y409_D2.6781.00
136_H158_F2.5321.00
63_P327_N2.4451.00
413_E416_E2.4231.00
243_K295_E2.4161.00
41_T124_L2.3461.00
222_K409_D2.3401.00
246_E295_E2.2841.00
103_E107_E2.2821.00
40_A118_L2.2741.00
406_Y412_M2.2511.00
21_G38_I2.2311.00
227_Y380_E2.2051.00
414_I455_A2.1931.00
104_F211_G2.1901.00
247_V299_A2.1851.00
69_Y213_I2.1831.00
122_I175_S2.1821.00
58_L105_I2.1421.00
103_E178_P2.1421.00
119_I123_S2.1061.00
220_K225_M2.0981.00
10_V21_G2.0971.00
328_E387_F2.0921.00
155_S160_D2.0921.00
241_L401_A2.0901.00
38_I320_F2.0791.00
194_L199_V2.0761.00
67_I109_Y2.0681.00
7_K325_G2.0351.00
218_K225_M1.9591.00
180_S186_I1.9541.00
108_N213_I1.9311.00
177_D180_S1.9011.00
404_F408_A1.8981.00
173_E177_D1.8751.00
157_R160_D1.8721.00
183_E207_S1.8491.00
173_E185_K1.8431.00
23_K26_E1.8391.00
172_K176_K1.8251.00
32_F105_I1.8201.00
244_M267_L1.8141.00
415_D419_Q1.8131.00
379_A404_F1.8131.00
236_L279_I1.8131.00
219_M239_L1.8051.00
323_A463_Y1.7941.00
100_D211_G1.7941.00
104_F107_E1.7891.00
68_A229_L1.7861.00
204_E208_E1.7811.00
115_H176_K1.7781.00
173_E180_S1.7761.00
212_E283_R1.7721.00
218_K227_Y1.7581.00
418_V455_A1.7361.00
323_A328_E1.7341.00
36_I106_Y1.7311.00
23_K27_E1.7271.00
18_S476_L1.7151.00
126_T169_K1.7031.00
77_K208_E1.7021.00
381_K384_E1.6951.00
188_E192_K1.6941.00
415_D466_V1.6581.00
19_Y23_K1.6581.00
189_E346_N1.6401.00
386_I407_Y1.6371.00
321_A387_F1.6361.00
419_Q469_I1.6301.00
300_N303_A1.6181.00
263_D307_F1.6061.00
99_V174_I1.6031.00
191_T195_R1.6031.00
118_L122_I1.5991.00
45_V129_F1.5961.00
61_K66_L1.5781.00
10_V38_I1.5781.00
111_S326_E1.5771.00
381_K385_R1.5551.00
106_Y117_L1.5491.00
262_N266_R1.5481.00
386_I457_K1.5321.00
90_P194_L1.5261.00
306_G309_V1.5231.00
173_E186_I1.5181.00
23_K123_S1.5161.00
38_I322_V1.5151.00
56_G101_L1.5021.00
106_Y114_L1.5001.00
74_W209_F1.4951.00
260_R410_Y1.4911.00
405_E409_D1.4781.00
104_F213_I1.4731.00
334_S353_R1.4671.00
253_L263_D1.4651.00
78_E202_S1.4631.00
133_R158_F1.4611.00
238_T375_S1.4571.00
403_V453_V1.4561.00
61_K65_G1.4551.00
122_I172_K1.4391.00
452_I471_S1.4361.00
24_V112_K1.4351.00
130_M161_E1.4231.00
191_T202_S1.4211.00
192_K196_E1.4121.00
103_E114_L1.4041.00
266_R269_A1.3971.00
32_F60_A1.3921.00
219_M243_K1.3801.00
301_K304_E1.3681.00
113_S116_E1.3661.00
78_E200_P1.3661.00
22_A26_E1.3621.00
258_V443_T1.3461.00
459_K462_R1.3401.00
100_D178_P1.3391.00
457_K464_I1.3371.00
68_A230_P1.3341.00
249_E252_K1.3331.00
75_A367_R1.3331.00
56_G71_A1.3281.00
220_K223_D1.3211.00
70_N214_I1.3161.00
146_S149_W1.3151.00
66_L227_Y1.3081.00
248_T302_I1.3041.00
106_Y111_S1.2981.00
243_K246_E1.2981.00
203_Y207_S1.2921.00
24_V27_E1.2861.00
208_E367_R1.2831.00
406_Y410_Y1.2831.00
93_V350_F1.2681.00
89_G343_I1.2651.00
148_D151_R1.2611.00
24_V117_L1.2561.00
402_E422_R1.2521.00
226_L379_A1.2511.00
194_L201_V1.2501.00
407_Y457_K1.2451.00
100_D179_R1.2431.00
116_E119_I1.2411.00
299_A302_I1.2341.00
270_L304_E1.2331.00
185_K188_E1.2311.00
458_Y463_Y1.2291.00
22_A476_L1.2281.00
345_V350_F1.2001.00
11_T454_Q1.1981.00
412_M420_A1.1941.00
259_R307_F1.1911.00
95_V201_V1.1901.00
77_K367_R1.1831.00
30_N111_S1.1801.00
67_I108_N1.1761.00
59_L68_A1.1731.00
147_D151_R1.1711.00
238_T401_A1.1711.00
20_V41_T1.1641.00
156_K160_D1.1631.00
241_L267_L1.1541.00
241_L268_S1.1541.00
27_E112_K1.1541.00
32_F329_I1.1491.00
69_Y109_Y1.1481.00
69_Y211_G1.1441.00
32_F327_N1.1371.00
67_I213_I1.1361.00
204_E207_S1.1281.00
406_Y420_A1.1241.00
245_I401_A1.1241.00
248_T263_D1.1211.00
99_V178_P1.1211.00
57_F231_P1.1191.00
320_F331_F1.1191.00
70_N232_N1.1181.00
183_E187_A1.1161.00
274_D301_K1.1091.00
35_A329_I1.1071.00
407_Y414_I1.1061.00
365_E368_K1.1061.00
61_K380_E1.1051.00
224_F408_A1.1031.00
69_Y105_I1.1031.00
100_D104_F1.1001.00
284_F368_K1.0981.00
306_G310_K1.0961.00
90_P197_R1.0921.00
295_E299_A1.0891.00
274_D297_Y1.0881.00
261_V265_V1.0851.00
249_E253_L1.0851.00
382_D385_R1.0841.00
17_A42_L1.0811.00
225_M383_D1.0791.00
24_V37_A1.0791.00
74_W367_R1.0771.00
60_A105_I1.0711.00
236_L289_V1.0670.99
438_V442_Q1.0560.99
414_I466_V1.0520.99
119_I122_I1.0490.99
36_I117_L1.0480.99
106_Y113_S1.0480.99
319_F330_G1.0470.99
79_L83_K1.0460.99
104_F108_N1.0450.99
170_V348_I1.0420.99
23_K120_P1.0410.99
240_E274_D1.0400.99
257_D260_R1.0370.99
260_R264_H1.0370.99
193_G345_V1.0350.99
114_L118_L1.0350.99
219_M295_E1.0280.99
432_A441_T1.0280.99
58_L101_L1.0270.99
151_R166_G1.0270.99
187_A206_F1.0230.99
388_I403_V1.0220.99
201_V206_F1.0130.99
114_L117_L1.0120.99
323_A456_L1.0110.99
81_V363_K1.0100.99
77_K204_E1.0100.99
136_H157_R1.0100.99
104_F210_H1.0090.99
8_K25_L1.0080.99
12_T21_G1.0070.99
250_I253_L1.0020.99
225_M380_E1.0010.99
39_S333_Q0.9980.99
140_I157_R0.9980.99
465_G475_V0.9970.99
97_G209_F0.9940.99
24_V116_E0.9920.99
36_I102_W0.9880.99
189_E192_K0.9860.99
226_L242_L0.9850.99
169_K172_K0.9850.99
241_L271_A0.9840.99
328_E378_M0.9800.99
356_G394_D0.9800.99
126_T165_R0.9780.99
359_E363_K0.9740.99
24_V120_P0.9740.99
185_K189_E0.9710.99
335_L349_P0.9700.99
258_V440_A0.9690.99
186_I189_E0.9670.99
14_N45_V0.9660.99
81_V365_E0.9650.99
43_S167_I0.9620.99
244_M247_V0.9600.99
390_C399_I0.9600.99
170_V346_N0.9590.99
437_G441_T0.9590.99
100_D103_E0.9570.99
239_L293_L0.9570.99
20_V121_A0.9530.99
387_F456_L0.9520.99
170_V186_I0.9510.99
19_Y26_E0.9510.99
319_F389_G0.9500.99
11_T467_A0.9490.99
126_T168_A0.9490.99
72_S232_N0.9480.99
35_A322_V0.9450.99
324_D327_N0.9450.99
135_L139_I0.9420.99
187_A203_Y0.9370.99
5_V9_V0.9340.99
362_N368_K0.9330.99
190_L350_F0.9300.99
250_I405_E0.9250.99
164_L348_I0.9220.99
437_G440_A0.9210.99
261_V436_L0.9210.99
9_V463_Y0.9210.99
285_V288_P0.9170.98
93_V343_I0.9150.98
40_A99_V0.9130.98
358_S363_K0.9100.98
395_L399_I0.9090.98
112_K116_E0.9090.98
13_Q46_I0.9050.98
379_A386_I0.9040.98
20_V37_A0.9030.98
388_I455_A0.9020.98
224_F381_K0.9000.98
71_A331_F0.8990.98
169_K176_K0.8950.98
244_M305_Y0.8870.98
260_R405_E0.8750.98
222_K248_T0.8740.98
147_D150_N0.8740.98
131_V136_H0.8740.98
244_M302_I0.8730.98
50_S333_Q0.8710.98
270_L301_K0.8700.98
174_I178_P0.8670.98
136_H140_I0.8660.98
318_T333_Q0.8650.98
418_V453_V0.8640.98
106_Y112_K0.8630.98
11_T456_L0.8630.98
93_V341_S0.8620.98
69_Y104_F0.8590.98
169_K173_E0.8590.98
140_I143_F0.8580.98
398_Q424_M0.8570.98
16_I20_V0.8550.98
9_V456_L0.8550.98
193_G343_I0.8530.98
79_L200_P0.8500.97
75_A79_L0.8490.97
186_I348_I0.8470.97
259_R263_D0.8430.97
242_L404_F0.8420.97
91_L200_P0.8410.97
83_K87_D0.8390.97
220_K246_E0.8390.97
167_I171_L0.8370.97
280_A370_P0.8370.97
5_V8_K0.8360.97
149_W349_P0.8350.97
191_T194_L0.8320.97
41_T45_V0.8300.97
193_G196_E0.8270.97
222_K246_E0.8250.97
69_Y108_N0.8180.97
216_P227_Y0.8180.97
43_S171_L0.8170.97
377_L388_I0.8170.97
164_L167_I0.8140.97
133_R137_H0.8140.97
336_F356_G0.8140.97
262_N305_Y0.8130.97
44_V125_A0.8130.97
113_S117_L0.8120.97
412_M416_E0.8100.97
257_D410_Y0.8090.97
90_P193_G0.8080.97
194_L350_F0.8080.97
297_Y301_K0.8070.97
74_W283_R0.8070.97
284_F365_E0.8060.97
25_L322_V0.8010.96
295_E298_I0.8000.96
6_G462_R0.7990.96
219_M298_I0.7980.96
193_G197_R0.7980.96
44_V167_I0.7980.96
261_V440_A0.7940.96
39_S320_F0.7920.96
131_V135_L0.7890.96
112_K117_L0.7840.96
121_A125_A0.7760.96
261_V423_F0.7760.96
53_G348_I0.7760.96
82_D85_N0.7750.96
73_G353_R0.7740.96
44_V121_A0.7730.96
336_F355_A0.7720.96
79_L84_I0.7720.96
222_K408_A0.7710.96
56_G331_F0.7700.96
425_Y430_V0.7680.95
83_K200_P0.7630.95
432_A436_L0.7620.95
220_K295_E0.7620.95
238_T400_H0.7590.95
268_S401_A0.7590.95
323_A458_Y0.7590.95
14_N132_G0.7570.95
197_R343_I0.7570.95
62_T67_I0.7550.95
152_V164_L0.7550.95
21_G322_V0.7540.95
131_V156_K0.7530.95
89_G92_T0.7520.95
337_Y352_N0.7520.95
217_I228_E0.7500.95
228_E377_L0.7480.95
244_M298_I0.7470.95
81_V85_N0.7370.94
294_S298_I0.7370.94
74_W212_E0.7370.94
131_V162_I0.7360.94
407_Y411_N0.7360.94
262_N269_A0.7340.94
61_K64_E0.7320.94
94_V354_G0.7310.94
37_A117_L0.7310.94
18_S38_I0.7310.94
18_S474_I0.7300.94
380_E385_R0.7300.94
244_M301_K0.7290.94
18_S475_V0.7250.94
414_I464_I0.7250.94
251_N411_N0.7240.94
125_A168_A0.7240.94
386_I414_I0.7240.94
256_N260_R0.7240.94
228_E400_H0.7180.94
237_T275_R0.7180.94
96_P350_F0.7160.93
264_H423_F0.7150.93
228_E238_T0.7150.93
456_L463_Y0.7130.93
59_L378_M0.7120.93
149_W344_V0.7120.93
268_S398_Q0.7100.93
195_R202_S0.7100.93
139_I156_K0.7090.93
39_S331_F0.7090.93
16_I45_V0.7080.93
321_A456_L0.7050.93
194_L197_R0.7050.93
19_Y22_A0.7050.93
16_I124_L0.7030.93
190_L206_F0.7030.93
20_V124_L0.7000.93
165_R169_K0.7000.93
60_A329_I0.6990.93
306_G311_V0.6990.93
10_V25_L0.6980.93
18_S22_A0.6960.92
132_G472_E0.6950.92
224_F379_A0.6950.92
302_I305_Y0.6940.92
19_Y476_L0.6930.92
79_L364_P0.6930.92
214_I230_P0.6920.92
360_G363_K0.6910.92
82_D86_S0.6900.92
105_I329_I0.6900.92
122_I126_T0.6900.92
20_V24_V0.6860.92
16_I130_M0.6840.92
57_F372_H0.6820.92
16_I19_Y0.6820.92
40_A114_L0.6820.92
186_I190_L0.6810.92
266_R305_Y0.6800.92
248_T305_Y0.6790.91
166_G169_K0.6790.91
345_V348_I0.6770.91
180_S185_K0.6760.91
328_E385_R0.6750.91
38_I41_T0.6750.91
351_N354_G0.6750.91
103_E106_Y0.6720.91
414_I418_V0.6720.91
55_D73_G0.6720.91
32_F62_T0.6680.91
52_L99_V0.6670.91
253_L260_R0.6650.91
90_P343_I0.6650.91
41_T121_A0.6640.91
418_V466_V0.6630.91
78_E195_R0.6630.91
237_T271_A0.6610.90
219_M246_E0.6550.90
323_A387_F0.6520.90
60_A327_N0.6510.90
454_Q467_A0.6500.90
66_L380_E0.6500.90
233_T397_P0.6500.90
240_E297_Y0.6490.90
255_F412_M0.6480.89
299_A303_A0.6470.89
8_K22_A0.6460.89
291_M294_S0.6460.89
214_I283_R0.6460.89
31_A329_I0.6450.89
280_A361_N0.6440.89
228_E375_S0.6440.89
245_I250_I0.6420.89
223_D382_D0.6400.89
189_E345_V0.6390.89
177_D185_K0.6360.89
39_S102_W0.6350.89
240_E244_M0.6350.89
170_V173_E0.6320.88
377_L404_F0.6310.88
388_I404_F0.6300.88
399_I453_V0.6290.88
161_E462_R0.6290.88
83_K86_S0.6280.88
241_L398_Q0.6280.88
402_E406_Y0.6280.88
259_R443_T0.6280.88
138_A338_P0.6270.88
98_L333_Q0.6260.88
43_S51_G0.6250.88
264_H405_E0.6250.88
46_I452_I0.6240.88
332_I396_R0.6230.88
388_I400_H0.6230.88
319_F332_I0.6220.88
119_I175_S0.6210.87
58_L71_A0.6210.87
152_V344_V0.6200.87
40_A102_W0.6200.87
217_I279_I0.6200.87
267_L271_A0.6200.87
67_I215_N0.6190.87
379_A408_A0.6180.87
179_R207_S0.6170.87
84_I92_T0.6160.87
84_I89_G0.6150.87
73_G94_V0.6150.87
395_L424_M0.6120.87
146_S344_V0.6100.87
52_L348_I0.6090.86
42_L318_T0.6090.86
63_P326_E0.6060.86
100_D209_F0.6060.86
37_A121_A0.6050.86
146_S341_S0.6050.86
89_G341_S0.6040.86
52_L174_I0.6030.86
293_L298_I0.6010.86
80_K83_K0.6010.86
237_T279_I0.6000.86
407_Y417_A0.5980.85
46_I49_T0.5970.85
353_R373_T0.5970.85
217_I236_L0.5970.85
280_A285_V0.5950.85
30_N326_E0.5950.85
129_F162_I0.5930.85
296_K300_N0.5930.85
384_E458_Y0.5920.85
436_L440_A0.5920.85
149_W152_V0.5920.85
143_F155_S0.5910.85
36_I118_L0.5900.85
191_T201_V0.5900.85
375_S400_H0.5880.84
245_I264_H0.5880.84
240_E298_I0.5880.84
62_T327_N0.5880.84
186_I346_N0.5880.84
195_R201_V0.5880.84
43_S50_S0.5880.84
57_F72_S0.5870.84
467_A475_V0.5870.84
73_G373_T0.5870.84
435_R446_Y0.5860.84
433_E470_R0.5850.84
262_N307_F0.5850.84
395_L450_V0.5840.84
8_K325_G0.5840.84
275_R279_I0.5820.84
98_L334_S0.5790.84
436_L441_T0.5770.83
322_V329_I0.5760.83
49_T335_L0.5760.83
344_V349_P0.5760.83
30_N112_K0.5740.83
264_H267_L0.5730.83
145_L150_N0.5720.83
36_I110_A0.5710.83
245_I263_D0.5700.83
395_L398_Q0.5700.83
255_F410_Y0.5690.82
62_T109_Y0.5680.82
118_L175_S0.5680.82
264_H268_S0.5670.82
75_A357_F0.5660.82
76_P79_L0.5660.82
229_L233_T0.5660.82
13_Q318_T0.5640.82
32_F58_L0.5630.82
17_A41_T0.5630.82
137_H141_S0.5630.82
328_E458_Y0.5630.82
228_E397_P0.5620.82
92_T354_G0.5620.82
226_L377_L0.5590.81
467_A471_S0.5580.81
39_S98_L0.5580.81
253_L257_D0.5580.81
111_S117_L0.5580.81
55_D72_S0.5570.81
5_V22_A0.5560.81
273_A301_K0.5550.81
46_I50_S0.5530.81
379_A388_I0.5530.81
272_Y397_P0.5530.81
247_V295_E0.5520.81
307_F310_K0.5520.81
194_L206_F0.5510.80
405_E410_Y0.5500.80
335_L338_P0.5500.80
74_W369_R0.5490.80
72_S372_H0.5490.80
217_I239_L0.5490.80
56_G98_L0.5490.80
221_Y250_I0.5480.80
90_P93_V0.5480.80
74_W77_K0.5480.80
362_N371_L0.5460.80
60_A67_I0.5460.80
181_F187_A0.5450.80
20_V23_K0.5440.80
88_R91_L0.5440.80
92_T341_S0.5440.80
20_V120_P0.5430.80
76_P199_V0.5430.80
103_E117_L0.5420.79
166_G345_V0.5420.79
59_L229_L0.5390.79
45_V89_G0.5380.79
226_L404_F0.5380.79
440_A443_T0.5370.79
48_H135_L0.5370.79
77_K202_S0.5370.79
24_V38_I0.5360.79
60_A213_I0.5360.79
172_K175_S0.5360.79
270_L311_V0.5360.79
70_N212_E0.5330.78
399_I451_G0.5330.78
214_I229_L0.5320.78
42_L320_F0.5320.78
241_L397_P0.5320.78
267_L305_Y0.5320.78
135_L162_I0.5320.78
467_A474_I0.5310.78
253_L259_R0.5300.78
409_D412_M0.5300.78
437_G442_Q0.5290.78
190_L348_I0.5290.78
168_A172_K0.5280.78
356_G373_T0.5270.77
374_L396_R0.5270.77
46_I51_G0.5260.77
127_N416_E0.5230.77
255_F260_R0.5230.77
74_W208_E0.5220.77
219_M293_L0.5210.77
146_S152_V0.5210.77
60_A69_Y0.5210.77
173_E189_E0.5190.76
300_N304_E0.5190.76
180_S183_E0.5180.76
181_F186_I0.5180.76
100_D183_E0.5170.76
391_A471_S0.5170.76
353_R396_R0.5170.76
160_D163_K0.5160.76
354_G364_P0.5160.76
21_G37_A0.5160.76
30_N106_Y0.5150.76
238_T377_L0.5150.76
148_D152_V0.5150.76
158_F161_E0.5150.76
354_G357_F0.5140.76
60_A109_Y0.5140.76
287_V291_M0.5140.76
101_L211_G0.5140.76
193_G346_N0.5140.76
263_D305_Y0.5120.75
321_A330_G0.5120.75
332_I372_H0.5110.75
262_N306_G0.5110.75
200_P364_P0.5100.75
72_S356_G0.5100.75
222_K249_E0.5100.75
336_F353_R0.5100.75
84_I364_P0.5090.75
62_T65_G0.5090.75
390_C451_G0.5080.75
7_K26_E0.5080.75
55_D94_V0.5080.75
68_A214_I0.5060.75
268_S423_F0.5060.75
72_S353_R0.5050.74
221_Y408_A0.5040.74
54_G351_N0.5040.74
434_K445_Y0.5030.74
438_V441_T0.5020.74
20_V45_V0.5020.74
58_L329_I0.5020.74
192_K203_Y0.5020.74
250_I410_Y0.5010.74
166_G170_V0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e0wA 1 0.9435 100 0.069 Contact Map
2nlzA 4 0.9874 100 0.074 Contact Map
2i3oA 2 0.9686 100 0.1 Contact Map
3whrA 1 0.6799 100 0.366 Contact Map
2dg5A 1 0.6778 100 0.392 Contact Map
2qmcA 1 0.6778 100 0.395 Contact Map
4gdxA 1 0.6695 100 0.402 Contact Map
3g9kL 1 0.5774 100 0.42 Contact Map
4gdxB 1 0.3389 100 0.679 Contact Map
3g9kS 1 0.3201 100 0.683 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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