GREMLIN Database
Q97TX4 - Arginine deiminase, hypothetical
UniProt: Q97TX4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 341 (340)
Sequences: 972 (568)
Seq/√Len: 30.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_D211_G6.9731.00
9_R341_D5.5651.00
13_M49_R5.1681.00
50_R54_E4.3611.00
310_L318_E4.3251.00
292_L335_T4.2821.00
71_R91_P4.2631.00
12_G338_I4.2311.00
298_K317_I4.1831.00
15_K46_D3.8471.00
51_V319_V3.7801.00
10_A166_I3.6611.00
90_D93_F3.6301.00
51_V317_I3.5001.00
40_K43_R3.4151.00
264_L268_V3.2071.00
10_A60_Y3.1861.00
52_L294_I2.9201.00
190_V204_L2.8021.00
237_S314_Y2.5881.00
269_V272_K2.5741.00
321_V325_T2.4580.99
50_R53_K2.4410.99
29_S121_D2.4370.99
55_E315_D2.4050.99
272_K279_V2.3960.99
261_E265_Y2.3590.99
298_K315_D2.3160.99
99_I126_L2.2850.99
10_A58_K2.2720.99
141_I204_L2.1870.98
98_L156_V2.1680.98
291_F301_S2.1210.98
60_Y166_I2.0340.98
265_Y268_V1.9560.97
134_I181_F1.9470.97
13_M335_T1.8980.96
141_I181_F1.8710.96
264_L269_V1.8410.96
269_V276_L1.8410.96
64_Q92_E1.8190.95
187_F212_E1.7780.95
272_K276_L1.7730.95
62_L99_I1.7680.94
192_V215_I1.7650.94
136_T181_F1.7360.94
269_V279_V1.7350.94
188_N213_I1.7140.93
174_G200_G1.6980.93
217_H249_R1.6710.93
47_N320_E1.6700.93
261_E264_L1.6650.92
268_V277_I1.6490.92
91_P94_L1.6200.91
303_K318_E1.6040.91
66_I95_V1.6010.91
14_H19_E1.5970.91
264_L267_Y1.5850.90
182_F332_H1.5810.90
276_L279_V1.5750.90
39_S43_R1.5590.90
62_L157_M1.5460.89
259_I263_T1.5390.89
234_S237_S1.5340.89
23_G26_D1.5290.89
261_E269_V1.5140.88
310_L315_D1.4990.88
7_K295_D1.4850.87
212_E252_V1.4840.87
34_R326_G1.4740.87
273_G279_V1.4370.85
266_D271_E1.4350.85
83_K158_K1.4330.85
55_E295_D1.4290.85
14_H44_E1.4280.85
266_D269_V1.4180.85
78_E81_I1.4120.84
265_Y276_L1.4120.84
301_S316_V1.4110.84
133_Q157_M1.4080.84
84_V120_T1.3880.83
259_I264_L1.3790.83
282_D285_K1.3550.82
274_F279_V1.3500.82
201_V215_I1.3290.81
265_Y269_V1.3240.80
147_T194_V1.3180.80
128_F287_Y1.3080.79
136_T141_I1.3080.79
81_I87_N1.3010.79
47_N51_V1.2860.78
172_G203_E1.2850.78
46_D49_R1.2740.78
323_N326_G1.2660.77
12_G62_L1.2600.77
18_L100_L1.2510.76
97_L106_Y1.2470.76
22_L221_E1.2430.76
218_W291_F1.2410.76
12_G157_M1.2410.76
228_T287_Y1.2270.75
260_R264_L1.2020.73
55_E298_K1.2020.73
13_M52_L1.1950.73
269_V273_G1.1930.73
237_S278_E1.1910.73
261_E271_E1.1890.73
38_W42_R1.1880.72
261_E267_Y1.1840.72
134_I143_G1.1820.72
290_N333_C1.1800.72
275_N312_K1.1780.72
60_Y338_I1.1760.72
232_V238_V1.1580.70
49_R61_R1.1540.70
69_K72_R1.1530.70
13_M182_F1.1500.70
267_Y273_G1.1420.69
80_V159_L1.1410.69
40_K303_K1.1400.69
64_Q67_V1.1370.69
224_I228_T1.1340.69
158_K162_E1.1270.68
220_R223_F1.1230.68
261_E279_V1.1190.68
133_Q149_Q1.1180.68
269_V278_E1.1160.68
78_E82_E1.1150.68
200_G213_I1.1150.68
311_E318_E1.1080.67
75_R79_K1.1040.67
86_V102_P1.1030.67
104_L116_E1.0980.66
133_Q140_I1.0930.66
39_S306_A1.0840.65
272_K277_I1.0830.65
58_K166_I1.0830.65
145_M283_E1.0790.65
104_L117_V1.0700.64
126_L156_V1.0660.64
240_S246_E1.0600.64
42_R46_D1.0600.64
240_S245_M1.0570.63
25_L281_V1.0550.63
15_K49_R1.0500.63
9_R339_R1.0470.63
268_V272_K1.0380.62
55_E317_I1.0320.61
216_I250_V1.0320.61
47_N50_R1.0210.61
260_R263_T1.0170.60
192_V201_V1.0160.60
218_W292_L1.0080.60
142_M158_K1.0060.59
67_V92_E0.9870.58
285_K302_P0.9840.58
285_K328_A0.9810.57
133_Q336_A0.9800.57
14_H20_V0.9770.57
224_I287_Y0.9770.57
72_R75_R0.9710.57
266_D273_G0.9710.57
31_L125_N0.9700.57
303_K320_E0.9620.56
48_L335_T0.9610.56
62_L338_I0.9610.56
272_K275_N0.9600.56
184_M189_L0.9590.56
92_E96_E0.9520.55
55_E294_I0.9470.55
132_Q193_G0.9440.55
292_L331_I0.9340.54
40_K320_E0.9320.54
310_L316_V0.9240.53
302_P337_V0.9180.52
79_K83_K0.9170.52
129_M132_Q0.9170.52
176_F200_G0.9150.52
183_P210_G0.9150.52
128_F283_E0.9130.52
265_Y279_V0.9060.51
156_V168_Y0.9040.51
267_Y272_K0.8960.51
287_Y328_A0.8960.51
63_R96_E0.8940.51
39_S311_E0.8900.50
306_A321_V0.8900.50
229_F284_A0.8880.50
8_L11_V0.8860.50
33_E221_E0.8850.50
49_R53_K0.8810.49
179_G225_H0.8800.49
77_R91_P0.8790.49
75_R82_E0.8780.49
261_E272_K0.8760.49
275_N279_V0.8700.49
144_R151_E0.8680.48
212_E254_Y0.8670.48
193_G201_V0.8660.48
261_E277_I0.8640.48
116_E213_I0.8630.48
240_S265_Y0.8610.48
292_L332_H0.8560.47
41_A133_Q0.8560.47
273_G276_L0.8450.47
261_E268_V0.8400.46
282_D302_P0.8380.46
214_G267_Y0.8350.46
51_V54_E0.8350.46
34_R286_K0.8330.46
323_N330_G0.8280.45
33_E328_A0.8240.45
21_M117_V0.8240.45
3_A6_G0.8180.44
332_H335_T0.8150.44
230_F238_V0.8150.44
271_E279_V0.8150.44
137_E143_G0.8140.44
135_T336_A0.8130.44
264_L271_E0.8070.44
129_M160_F0.8070.44
266_D270_K0.8040.43
46_D53_K0.8010.43
176_F204_L0.8000.43
43_R47_N0.7980.43
30_F33_E0.7980.43
62_L152_K0.7900.42
224_I328_A0.7870.42
285_K326_G0.7870.42
7_K110_D0.7850.42
229_F244_F0.7820.42
161_W336_A0.7820.42
264_L272_K0.7760.41
133_Q161_W0.7760.41
65_T68_N0.7750.41
229_F285_K0.7720.41
188_N204_L0.7720.41
261_E276_L0.7710.41
135_T161_W0.7670.40
76_F80_V0.7670.40
198_L215_I0.7650.40
252_V271_E0.7650.40
253_Y256_R0.7620.40
62_L129_M0.7620.40
258_I267_Y0.7610.40
21_M306_A0.7610.40
69_K80_V0.7540.39
146_A175_K0.7520.39
138_K207_I0.7500.39
140_I161_W0.7470.39
128_F145_M0.7460.39
264_L273_G0.7460.39
120_T312_K0.7410.38
26_D116_E0.7360.38
75_R78_E0.7340.38
302_P328_A0.7320.38
137_E185_G0.7320.38
214_G250_V0.7230.37
299_I310_L0.7210.37
29_S155_E0.7210.37
22_L26_D0.7180.37
18_L96_E0.7160.37
200_G203_E0.7140.36
83_K171_I0.7130.36
269_V274_F0.7130.36
10_A339_R0.7120.36
83_K176_F0.7100.36
267_Y276_L0.7090.36
109_R112_G0.7060.36
228_T328_A0.7040.36
39_S42_R0.7020.36
267_Y271_E0.6990.35
2_I7_K0.6980.35
15_K47_N0.6980.35
47_N258_I0.6960.35
284_A287_Y0.6960.35
221_E282_D0.6950.35
283_E287_Y0.6950.35
302_P321_V0.6920.35
198_L202_S0.6920.35
43_R50_R0.6920.35
68_N165_N0.6910.35
54_E262_T0.6900.35
118_K184_M0.6900.35
221_E328_A0.6860.34
76_F79_K0.6830.34
183_P193_G0.6830.34
282_D326_G0.6830.34
21_M38_W0.6780.34
37_N40_K0.6770.34
145_M327_G0.6760.34
124_S328_A0.6750.34
65_T160_F0.6730.33
71_R82_E0.6720.33
183_P232_V0.6710.33
2_I210_G0.6630.33
234_S278_E0.6620.33
200_G310_L0.6610.33
246_E265_Y0.6590.32
19_E44_E0.6590.32
64_Q105_G0.6590.32
218_W332_H0.6590.32
5_W235_S0.6580.32
79_K82_E0.6580.32
150_R179_G0.6560.32
150_R178_G0.6560.32
71_R92_E0.6560.32
240_S276_L0.6550.32
66_I94_L0.6540.32
62_L160_F0.6530.32
118_K145_M0.6530.32
300_V319_V0.6520.32
173_R203_E0.6520.32
149_Q301_S0.6490.32
174_G203_E0.6480.32
134_I137_E0.6460.31
177_E195_R0.6460.31
150_R225_H0.6430.31
224_I284_A0.6420.31
329_G333_C0.6400.31
15_K42_R0.6380.31
101_R309_K0.6370.31
150_R153_E0.6340.31
294_I300_V0.6330.31
124_S194_V0.6300.30
155_E223_F0.6300.30
175_K197_D0.6260.30
68_N71_R0.6240.30
68_N164_L0.6230.30
83_K102_P0.6230.30
229_F282_D0.6230.30
192_V197_D0.6220.30
12_G160_F0.6200.30
38_W182_F0.6190.30
42_R96_E0.6190.30
14_H156_V0.6190.30
231_N302_P0.6180.30
90_D109_R0.6170.30
143_G157_M0.6160.29
183_P238_V0.6140.29
20_V44_E0.6140.29
314_Y319_V0.6140.29
10_A167_K0.6140.29
128_F152_K0.6140.29
78_E341_D0.6130.29
271_E274_F0.6100.29
18_L176_F0.6100.29
26_D98_L0.6100.29
21_M42_R0.6090.29
171_I207_I0.6090.29
153_E178_G0.6090.29
131_D150_R0.6070.29
160_F164_L0.6070.29
52_L292_L0.6060.29
268_V279_V0.6050.29
145_M287_Y0.6030.29
232_V245_M0.6020.29
197_D215_I0.6010.28
305_S337_V0.6010.28
260_R267_Y0.6000.28
237_S297_G0.5990.28
124_S231_N0.5990.28
228_T284_A0.5980.28
215_I341_D0.5980.28
15_K61_R0.5980.28
134_I139_G0.5980.28
79_K158_K0.5970.28
216_I248_S0.5970.28
47_N54_E0.5950.28
223_F241_V0.5930.28
291_F331_I0.5920.28
274_F277_I0.5910.28
250_V264_L0.5910.28
60_Y339_R0.5910.28
135_T316_V0.5880.28
40_K325_T0.5880.28
259_I267_Y0.5870.28
127_Y145_M0.5860.27
192_V246_E0.5860.27
150_R177_E0.5850.27
178_G225_H0.5830.27
131_D178_G0.5820.27
285_K330_G0.5820.27
73_D87_N0.5820.27
30_F149_Q0.5810.27
91_P294_I0.5800.27
22_L319_V0.5800.27
298_K303_K0.5800.27
284_A290_N0.5790.27
282_D328_A0.5780.27
126_L152_K0.5780.27
261_E273_G0.5770.27
256_R341_D0.5760.27
153_E179_G0.5750.27
20_V146_A0.5740.27
173_R176_F0.5740.27
130_R150_R0.5730.27
147_T175_K0.5710.27
288_V331_I0.5710.27
34_R322_S0.5700.26
99_I129_M0.5700.26
266_D272_K0.5690.26
299_I314_Y0.5680.26
155_E326_G0.5680.26
186_D209_N0.5670.26
136_T332_H0.5670.26
31_L224_I0.5670.26
302_P305_S0.5670.26
118_K287_Y0.5670.26
231_N285_K0.5660.26
102_P306_A0.5650.26
77_R81_I0.5640.26
134_I318_E0.5630.26
137_E184_M0.5630.26
131_D153_E0.5630.26
141_I176_F0.5630.26
52_L57_V0.5620.26
300_V311_E0.5620.26
110_D199_E0.5610.26
153_E225_H0.5610.26
34_R282_D0.5610.26
164_L167_K0.5600.26
282_D330_G0.5600.26
238_V277_I0.5590.26
197_D200_G0.5590.26
77_R94_L0.5580.26
142_M308_R0.5570.26
304_I326_G0.5570.26
64_Q97_L0.5570.26
287_Y321_V0.5550.26
93_F176_F0.5540.25
121_D200_G0.5530.25
256_R311_E0.5530.25
234_S314_Y0.5530.25
234_S296_D0.5520.25
186_D214_G0.5510.25
13_M61_R0.5490.25
131_D179_G0.5480.25
269_V277_I0.5480.25
143_G239_V0.5450.25
26_D95_V0.5440.25
140_I157_M0.5440.25
136_T169_K0.5430.25
6_G165_N0.5430.25
256_R300_V0.5420.25
301_S308_R0.5420.25
290_N335_T0.5410.25
109_R138_K0.5400.25
212_E222_E0.5390.25
77_R82_E0.5390.25
302_P308_R0.5380.25
26_D281_V0.5380.25
159_L163_A0.5370.24
107_E119_L0.5360.24
146_A223_F0.5360.24
98_L123_L0.5360.24
26_D325_T0.5360.24
64_Q100_L0.5350.24
213_I262_T0.5340.24
131_D225_H0.5340.24
41_A135_T0.5340.24
136_T295_D0.5330.24
283_E330_G0.5320.24
245_M278_E0.5320.24
221_E285_K0.5310.24
247_E279_V0.5300.24
66_I69_K0.5290.24
72_R91_P0.5280.24
150_R329_G0.5270.24
133_Q308_R0.5260.24
34_R285_K0.5260.24
77_R162_E0.5250.24
183_P332_H0.5240.24
37_N325_T0.5230.24
181_F200_G0.5220.24
263_T266_D0.5220.24
13_M183_P0.5210.24
64_Q266_D0.5210.24
23_G119_L0.5190.23
103_I119_L0.5180.23
245_M248_S0.5180.23
80_V84_V0.5150.23
282_D305_S0.5150.23
303_K310_L0.5140.23
91_P243_S0.5140.23
130_R179_G0.5130.23
156_V334_M0.5130.23
130_R178_G0.5130.23
97_L102_P0.5130.23
14_H99_I0.5120.23
177_E225_H0.5110.23
171_I190_V0.5110.23
200_G336_A0.5100.23
20_V140_I0.5090.23
43_R70_I0.5090.23
73_D78_E0.5090.23
81_I98_L0.5080.23
142_M217_H0.5080.23
327_G334_M0.5070.23
324_L327_G0.5070.23
153_E177_E0.5050.23
182_F238_V0.5050.23
33_E222_E0.5050.23
132_Q139_G0.5040.23
75_R93_F0.5040.23
135_T157_M0.5040.23
214_G218_W0.5030.22
150_R227_D0.5020.22
130_R225_H0.5000.22
189_L332_H0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a9gA 3 0.9971 100 0.341 Contact Map
4bofA 4 0.9971 100 0.343 Contact Map
4e4jA 4 0.9883 100 0.345 Contact Map
1s9rA 2 0.9883 100 0.352 Contact Map
1bwdA 1 0.8152 100 0.523 Contact Map
1jdwA 2 0.8182 100 0.523 Contact Map
1h70A 1 0.7185 100 0.561 Contact Map
3i4aA 1 0.7595 100 0.562 Contact Map
2ci1A 1 0.7537 100 0.578 Contact Map
2ewoA 4 0.8475 100 0.742 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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