GREMLIN Database
Q97TX3 - Second ORF in transposon ISC1229
UniProt: Q97TX3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 131 (123)
Sequences: 3905 (2612)
Seq/√Len: 235.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_K103_G2.6211.00
11_V127_P2.4011.00
101_L105_K2.3861.00
97_H100_K2.3461.00
14_T127_P2.3041.00
102_K105_K2.2231.00
26_I118_V2.1711.00
42_F115_A2.1701.00
7_P125_N2.1221.00
112_R116_R2.0621.00
46_C72_L2.0031.00
30_V42_F1.9811.00
64_I108_T1.9781.00
37_P41_S1.9231.00
54_R59_E1.8491.00
46_C115_A1.7751.00
91_L95_E1.7701.00
48_L111_A1.7481.00
25_I75_L1.7451.00
38_R41_S1.7381.00
120_S124_N1.7251.00
13_L20_K1.6961.00
11_V121_V1.6961.00
90_L110_L1.6671.00
18_I23_A1.6581.00
43_V49_D1.6301.00
126_K129_E1.6161.00
93_L113_K1.5581.00
8_E125_N1.5521.00
78_F81_E1.5371.00
15_I118_V1.5201.00
119_W123_Y1.5131.00
22_A75_L1.5031.00
8_E122_W1.5021.00
96_A100_K1.4811.00
36_F45_Y1.4751.00
11_V14_T1.4541.00
12_L118_V1.4491.00
22_A79_L1.4431.00
90_L117_I1.4101.00
94_H110_L1.3811.00
117_I121_V1.3251.00
121_V127_P1.3121.00
43_V112_R1.3091.00
15_I121_V1.2891.00
7_P11_V1.2731.00
29_I69_N1.2481.00
77_Y111_A1.2421.00
80_A110_L1.2371.00
15_I114_L1.2351.00
33_I122_W1.1711.00
30_V33_I1.1561.00
93_L97_H1.1531.00
97_H106_L1.1501.00
29_I71_Y1.1241.00
80_A111_A1.1221.00
93_L96_A1.1011.00
93_L110_L1.0921.00
88_P92_K1.0911.00
76_F115_A1.0851.00
77_Y81_E1.0791.00
9_I13_L1.0511.00
81_E103_G1.0371.00
55_S59_E1.0171.00
95_E99_D1.0151.00
94_H106_L1.0121.00
77_Y108_T0.9981.00
79_L114_L0.9721.00
88_P91_L0.9701.00
74_S78_F0.9551.00
102_K106_L0.9541.00
81_E104_R0.9521.00
51_V65_S0.9431.00
77_Y104_R0.9331.00
52_V59_E0.9331.00
96_A99_D0.9311.00
97_H101_L0.9181.00
18_I22_A0.9161.00
18_I118_V0.8950.99
92_K96_A0.8820.99
13_L23_A0.8800.99
118_V121_V0.8720.99
81_E84_Y0.8680.99
84_Y94_H0.8680.99
26_I72_L0.8670.99
78_F104_R0.8490.99
90_L114_L0.8280.99
103_G107_Y0.8180.99
64_I73_R0.8140.99
92_K95_E0.8070.99
12_L122_W0.7910.99
120_S123_Y0.7860.99
89_T128_Y0.7850.99
108_T111_A0.7760.99
11_V125_N0.7750.99
98_K106_L0.7710.98
45_Y69_N0.7680.98
86_R91_L0.7660.98
54_R60_V0.7620.98
80_A107_Y0.7610.98
104_R107_Y0.7580.98
81_E107_Y0.7550.98
9_I27_I0.7490.98
121_V126_K0.7490.98
40_E112_R0.7480.98
36_F42_F0.7460.98
49_D65_S0.7290.98
94_H98_K0.7250.98
49_D66_K0.7200.98
21_L25_I0.7190.98
66_K73_R0.7150.98
64_I109_A0.7150.98
63_G105_K0.7100.97
94_H103_G0.7080.97
9_I24_G0.7030.97
18_I114_L0.7010.97
75_L79_L0.6950.97
12_L23_A0.6930.97
97_H109_A0.6920.97
68_G73_R0.6900.97
7_P10_L0.6860.97
38_R119_W0.6860.97
79_L111_A0.6740.96
83_Q90_L0.6710.96
53_E58_I0.6680.96
74_S77_Y0.6610.96
8_E11_V0.6610.96
76_F118_V0.6580.96
82_T86_R0.6550.96
58_I62_K0.6520.96
15_I18_I0.6520.96
79_L83_Q0.6500.96
8_E27_I0.6460.96
10_L127_P0.6450.95
9_I23_A0.6440.95
44_A49_D0.6380.95
29_I46_C0.6340.95
49_D73_R0.6310.95
81_E85_S0.6270.95
52_V61_R0.6230.95
81_E111_A0.6220.95
87_N91_L0.6170.94
116_R120_S0.5990.93
18_I26_I0.5990.93
47_G73_R0.5890.93
59_E62_K0.5870.93
31_G35_R0.5860.93
49_D52_V0.5850.93
84_Y98_K0.5830.92
87_N92_K0.5830.92
9_I20_K0.5830.92
80_A114_L0.5810.92
53_E62_K0.5770.92
41_S44_A0.5760.92
98_K101_L0.5730.92
24_G71_Y0.5710.92
71_Y75_L0.5650.91
95_E98_K0.5630.91
15_I117_I0.5630.91
57_R60_V0.5590.91
117_I120_S0.5580.91
58_I61_R0.5560.91
20_K24_G0.5520.90
51_V62_K0.5520.90
39_P119_W0.5490.90
64_I68_G0.5450.90
25_I71_Y0.5440.90
39_P116_R0.5430.90
113_K116_R0.5430.90
22_A76_F0.5400.89
73_R108_T0.5390.89
49_D67_R0.5380.89
39_P43_V0.5360.89
25_I29_I0.5310.88
87_N117_I0.5290.88
43_V116_R0.5240.88
33_I119_W0.5240.88
33_I42_F0.5190.87
57_R61_R0.5170.87
48_L112_R0.5160.87
84_Y107_Y0.5130.87
84_Y110_L0.5100.86
43_V115_A0.5090.86
34_R123_Y0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fhfA 1 0.7252 91.7 0.871 Contact Map
3n0uA 1 0.7328 90.8 0.874 Contact Map
3c65A 1 0 89.8 0.877 Contact Map
2bgwA 2 0.4962 89.6 0.877 Contact Map
3fhgA 2 0.7405 89.4 0.878 Contact Map
1kftA 1 0.4122 88.7 0.879 Contact Map
2a1jB 2 0.5115 88.2 0.88 Contact Map
1pu6A 1 0.7099 87.1 0.882 Contact Map
2lyhA 1 0.4733 86.9 0.883 Contact Map
4bxoA 1 0.4962 85.4 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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