GREMLIN Database
Q97TV5 - Transposase ISC1048
UniProt: Q97TV5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (284)
Sequences: 2061 (1711)
Seq/√Len: 101.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_S47_I3.5111.00
217_S248_T3.3101.00
99_M119_Y2.9781.00
31_K35_E2.9551.00
143_K146_D2.8571.00
220_V240_M2.8561.00
27_V36_V2.6701.00
25_L36_V2.5941.00
216_N219_S2.5871.00
143_K147_F2.5481.00
164_C283_K2.5081.00
44_Y48_K2.4921.00
68_S71_P2.4541.00
57_E61_G2.4311.00
221_K251_T2.4191.00
36_V47_I2.4021.00
237_Y263_V2.3541.00
114_K120_E2.3111.00
144_W148_K2.2481.00
221_K225_R2.2471.00
34_K44_Y2.1901.00
146_D149_K2.1861.00
27_V51_I2.1701.00
115_K119_Y2.1441.00
240_M262_P2.1331.00
161_L238_M2.1331.00
31_K39_M2.1181.00
33_E48_K2.0831.00
198_L279_F2.0491.00
201_N204_T2.0471.00
114_K117_R2.0211.00
25_L39_M2.0151.00
116_S120_E1.9991.00
35_E38_K1.9961.00
25_L40_L1.9511.00
117_R121_L1.9451.00
166_T196_V1.9021.00
35_E39_M1.8151.00
227_F230_R1.8081.00
34_K38_K1.7971.00
99_M115_K1.7851.00
43_G46_T1.7671.00
79_I124_E1.7351.00
273_N276_E1.7331.00
239_V265_T1.7311.00
150_I153_L1.7151.00
144_W147_F1.7061.00
116_S119_Y1.6961.00
72_R79_I1.6841.00
302_K306_E1.6561.00
20_I24_K1.6311.00
198_L275_A1.6181.00
45_S48_K1.6111.00
304_F308_N1.6031.00
18_E40_L1.6031.00
74_V78_K1.5841.00
221_K250_G1.5791.00
78_K81_Q1.5701.00
87_P90_Y1.5531.00
292_Y296_D1.5381.00
215_P243_Y1.5321.00
79_I121_L1.4871.00
297_V301_I1.4821.00
117_R120_E1.4811.00
241_D246_H1.4801.00
64_D67_R1.4671.00
113_Y117_R1.4531.00
217_S221_K1.4381.00
285_Y304_F1.4361.00
25_L31_K1.4321.00
33_E44_Y1.4211.00
222_Y226_Y1.4161.00
36_V51_I1.4111.00
249_K253_E1.4091.00
83_L125_L1.4081.00
298_K302_K1.4021.00
18_E21_L1.3941.00
37_S40_L1.3831.00
16_I23_V1.3811.00
163_E246_H1.3760.99
240_M255_C1.3750.99
86_K90_Y1.3720.99
52_G56_K1.3710.99
140_E143_K1.3580.99
45_S49_L1.3570.99
62_L66_P1.3530.99
199_A206_E1.3490.99
18_E42_K1.3380.99
160_F164_C1.3360.99
31_K36_V1.3240.99
119_Y123_H1.3190.99
165_R193_S1.3160.99
75_E78_K1.3080.99
165_R195_Y1.3070.99
275_A279_F1.2990.99
280_K284_N1.2930.99
83_L127_Y1.2860.99
33_E51_I1.2810.99
299_N303_Q1.2700.99
36_V40_L1.2510.99
221_K254_V1.2490.99
294_I298_K1.2480.99
199_A223_F1.2110.99
161_L199_A1.2020.99
255_C262_P1.2000.99
164_C169_S1.1920.99
32_S35_E1.1920.99
17_K20_I1.1910.99
103_K118_L1.1900.99
51_I55_K1.1880.99
129_L174_K1.1860.98
74_V121_L1.1820.98
67_R71_P1.1790.98
238_M260_I1.1710.98
100_K115_K1.1690.98
228_K260_I1.1650.98
220_V224_L1.1650.98
49_L52_G1.1530.98
25_L29_D1.1500.98
281_S285_Y1.1480.98
217_S251_T1.1480.98
304_F307_E1.1470.98
82_I102_L1.1420.98
293_T296_D1.1230.98
70_R73_K1.1070.98
52_G55_K1.1060.98
113_Y118_L1.1010.98
296_D299_N1.0950.97
167_V193_S1.0910.97
54_Y58_G1.0890.97
23_V54_Y1.0890.97
160_F265_T1.0810.97
225_R229_R1.0810.97
188_N191_F1.0800.97
138_Q146_D1.0700.97
248_T251_T1.0650.97
83_L87_P1.0600.97
81_Q85_D1.0540.97
303_Q307_E1.0540.97
187_V190_G1.0510.97
229_R258_K1.0430.97
225_R254_V1.0430.97
75_E79_I1.0370.96
22_A42_K1.0360.96
178_K181_S1.0280.96
253_E257_R1.0280.96
102_L118_L1.0250.96
85_D90_Y1.0250.96
217_S250_G1.0220.96
139_A142_D1.0210.96
98_T101_T1.0160.96
21_L24_K1.0030.96
185_M190_G1.0010.96
186_R190_G0.9900.95
86_K102_L0.9790.95
161_L240_M0.9790.95
141_K145_E0.9790.95
82_I121_L0.9750.95
231_V236_V0.9740.95
240_M264_F0.9720.95
160_F166_T0.9700.95
161_L223_F0.9670.95
242_N247_K0.9660.95
160_F239_V0.9530.94
164_C301_I0.9400.94
161_L220_V0.9330.94
165_R245_P0.9330.94
154_E157_A0.9320.94
86_K122_V0.9310.94
27_V33_E0.9270.93
210_S298_K0.9240.93
167_V171_S0.9230.93
80_K84_E0.9230.93
163_E297_V0.9200.93
21_L28_V0.9190.93
214_R219_S0.9090.93
202_A205_G0.9060.93
215_P244_S0.9030.93
121_L125_L0.8990.92
235_R261_H0.8970.92
57_E65_K0.8950.92
194_I282_L0.8930.92
123_H201_N0.8930.92
17_K21_L0.8920.92
155_R160_F0.8870.92
16_I20_I0.8820.92
277_A280_K0.8790.92
276_E279_F0.8660.91
48_K51_I0.8660.91
307_E310_Y0.8640.91
28_V35_E0.8640.91
210_S226_Y0.8630.91
50_W62_L0.8630.91
138_Q142_D0.8630.91
22_A50_W0.8600.91
29_D39_M0.8600.91
175_V183_P0.8590.91
79_I125_L0.8570.90
283_K287_S0.8530.90
159_F201_N0.8530.90
188_N195_Y0.8500.90
180_G183_P0.8500.90
74_V79_I0.8480.90
168_I297_V0.8480.90
99_M176_L0.8440.90
42_K47_I0.8420.90
224_L254_V0.8390.90
78_K111_I0.8390.90
38_K41_N0.8360.89
72_R124_E0.8360.89
253_E256_R0.8330.89
300_C304_F0.8300.89
185_M188_N0.8280.89
43_G49_L0.8250.89
103_K115_K0.8180.88
177_A183_P0.8070.88
185_M191_F0.8050.88
291_F300_C0.8040.87
80_K87_P0.8040.87
291_F297_V0.8020.87
220_V238_M0.8000.87
46_T50_W0.7930.87
39_M56_K0.7920.87
289_K300_C0.7910.87
34_K48_K0.7910.87
64_D68_S0.7860.86
165_R170_T0.7850.86
83_L86_K0.7840.86
33_E37_S0.7810.86
29_D32_S0.7710.85
265_T268_Y0.7660.85
159_F199_A0.7650.85
100_K288_N0.7650.85
33_E40_L0.7630.85
71_P100_K0.7610.84
181_S185_M0.7540.84
227_F231_V0.7530.84
283_K301_I0.7520.84
24_K29_D0.7510.84
54_Y62_L0.7490.83
34_K306_E0.7480.83
80_K83_L0.7470.83
177_A180_G0.7470.83
196_V301_I0.7450.83
170_T287_S0.7450.83
250_G257_R0.7400.83
164_C215_P0.7380.83
132_P175_V0.7370.82
87_P178_K0.7350.82
290_I310_Y0.7320.82
191_F199_A0.7310.82
51_I54_Y0.7290.82
239_V268_Y0.7270.82
22_A36_V0.7250.81
100_K104_I0.7240.81
244_S247_K0.7230.81
21_L29_D0.7170.81
100_K224_L0.7130.80
116_S123_H0.7060.80
216_N221_K0.7050.80
221_K248_T0.7010.79
207_V230_R0.7000.79
254_V258_K0.6970.79
129_L176_L0.6930.78
162_D246_H0.6930.78
160_F200_I0.6880.78
164_C279_F0.6850.78
22_A39_M0.6820.77
282_L304_F0.6800.77
75_E81_Q0.6790.77
181_S184_V0.6790.77
179_V182_K0.6720.76
79_I82_I0.6690.76
254_V257_R0.6670.76
274_M278_V0.6660.76
53_K65_K0.6640.75
45_S52_G0.6620.75
176_L270_P0.6620.75
207_V227_F0.6590.75
306_E310_Y0.6580.75
265_T270_P0.6570.75
23_V27_V0.6570.75
130_V265_T0.6550.74
138_Q240_M0.6490.74
239_V273_N0.6420.73
160_F274_M0.6420.73
255_C260_I0.6410.73
163_E166_T0.6400.73
161_L197_I0.6390.73
226_Y262_P0.6350.72
294_I297_V0.6330.72
278_V305_F0.6310.72
175_V181_S0.6310.72
242_N276_E0.6240.71
224_L255_C0.6220.71
79_I86_K0.6210.71
135_T271_E0.6170.70
85_D97_W0.6160.70
84_E87_P0.6110.69
161_L265_T0.6110.69
77_E84_E0.6100.69
303_Q306_E0.6090.69
16_I27_V0.6080.69
209_V305_F0.6070.69
82_I125_L0.6050.69
165_R169_S0.6050.69
29_D38_K0.6040.68
228_K258_K0.6040.68
244_S249_K0.6040.68
17_K24_K0.6030.68
159_F300_C0.6020.68
300_C303_Q0.6020.68
216_N245_P0.6020.68
19_R30_G0.6010.68
99_M113_Y0.6000.68
145_E267_P0.6000.68
34_K56_K0.5980.68
249_K255_C0.5970.68
23_V32_S0.5960.67
42_K46_T0.5950.67
178_K183_P0.5940.67
136_N268_Y0.5900.67
38_K48_K0.5890.66
198_L208_V0.5880.66
122_V176_L0.5880.66
87_P127_Y0.5880.66
200_I274_M0.5880.66
81_Q108_E0.5880.66
166_T220_V0.5850.66
128_N179_V0.5840.66
47_I51_I0.5830.66
295_E299_N0.5810.65
249_K252_L0.5790.65
215_P254_V0.5780.65
252_L256_R0.5770.65
279_F286_M0.5770.65
243_Y267_P0.5740.65
166_T304_F0.5740.65
220_V247_K0.5730.64
21_L25_L0.5730.64
293_T309_K0.5690.64
73_K78_K0.5690.64
151_K233_S0.5690.64
295_E298_K0.5680.64
79_I84_E0.5680.64
22_A47_I0.5680.64
22_A255_C0.5670.64
291_F296_D0.5660.63
29_D36_V0.5660.63
16_I31_K0.5650.63
69_G73_K0.5640.63
135_T140_E0.5640.63
283_K302_K0.5630.63
160_F165_R0.5620.63
139_A143_K0.5620.63
226_Y302_K0.5620.63
218_E250_G0.5590.62
195_Y215_P0.5590.62
248_T252_L0.5590.62
161_L279_F0.5580.62
16_I19_R0.5580.62
240_M265_T0.5570.62
286_M301_I0.5550.62
195_Y243_Y0.5540.62
303_Q310_Y0.5540.62
242_N268_Y0.5530.62
35_E56_K0.5530.62
139_A146_D0.5530.62
109_Q112_E0.5530.62
215_P220_V0.5520.62
256_R299_N0.5520.62
89_K101_T0.5510.61
287_S301_I0.5500.61
46_T49_L0.5500.61
34_K145_E0.5470.61
184_V188_N0.5470.61
35_E45_S0.5460.61
98_T259_G0.5440.60
166_T301_I0.5440.60
216_N228_K0.5400.60
197_I220_V0.5380.60
77_E81_Q0.5380.60
156_K202_A0.5370.59
291_F294_I0.5360.59
191_F263_V0.5350.59
80_K88_Q0.5340.59
266_P272_L0.5330.59
68_S81_Q0.5320.59
215_P219_S0.5320.59
155_R158_L0.5310.59
290_I296_D0.5300.58
21_L40_L0.5270.58
133_R182_K0.5270.58
139_A271_E0.5270.58
36_V50_W0.5260.58
296_D307_E0.5260.58
29_D44_Y0.5260.58
83_L251_T0.5250.58
131_K284_N0.5240.58
45_S55_K0.5240.58
271_E279_F0.5230.57
289_K303_Q0.5220.57
38_K70_R0.5220.57
108_E111_I0.5220.57
99_M118_L0.5200.57
157_A261_H0.5180.57
128_N186_R0.5170.57
240_M246_H0.5150.56
53_K61_G0.5140.56
75_E80_K0.5130.56
201_N206_E0.5130.56
242_N246_H0.5110.56
142_D267_P0.5110.56
288_N291_F0.5100.56
129_L132_P0.5100.56
53_K56_K0.5100.56
119_Y122_V0.5090.55
104_I111_I0.5080.55
298_K301_I0.5070.55
101_T288_N0.5050.55
177_A182_K0.5020.54
166_T170_T0.5010.54
23_V33_E0.5010.54
280_K297_V0.5010.54
301_I305_F0.5000.54
196_V205_G0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7bA 2 0.9235 100 0.387 Contact Map
3f2kA 1 0.5291 100 0.509 Contact Map
4mdaA 1 0.5229 100 0.517 Contact Map
4fcyA 4 0.8746 99.9 0.666 Contact Map
1u78A 1 0.315 99.7 0.748 Contact Map
1pdnC 1 0.3486 99.7 0.765 Contact Map
1k78A 1 0.3578 99.7 0.766 Contact Map
2k27A 1 0.4281 99.6 0.767 Contact Map
1hlvA 1 0.3609 98.6 0.857 Contact Map
4mq3A 1 0.3914 98.4 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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