GREMLIN Database
Q97TV4 - Transposase ISC1058
UniProt: Q97TV4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (281)
Sequences: 326 (196)
Seq/√Len: 11.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_D219_R3.3720.98
40_E45_R3.0410.96
284_V288_N2.7790.93
251_S255_R2.7400.92
17_V20_R2.6240.91
10_W13_Y2.5970.90
257_F276_K2.5120.88
42_R45_R2.4320.87
170_T195_V2.4230.87
272_E281_A2.3660.85
17_V21_Y2.2620.82
240_Y247_E2.2310.81
241_G244_W2.1960.80
71_E89_Y2.1830.80
16_N287_A2.1810.80
154_V280_Y2.1650.79
94_K160_T2.1320.78
59_A279_A2.1150.78
14_D89_Y2.0740.76
121_T139_K2.0330.75
145_I250_F1.9760.73
191_D207_K1.9620.72
185_Y203_V1.9340.71
284_V287_A1.9170.70
50_A53_E1.9130.70
142_K166_S1.8840.69
247_E272_E1.8660.68
249_L252_A1.8450.67
216_H220_R1.8440.67
244_W250_F1.8360.67
125_G181_V1.8050.65
266_F270_V1.7910.65
240_Y243_R1.7780.64
166_S281_A1.7770.64
12_K31_E1.7690.64
140_F144_E1.7410.62
130_A135_T1.7410.62
92_I185_Y1.7380.62
124_G241_G1.7340.62
208_K211_S1.7110.61
24_M206_P1.6760.59
65_L193_N1.6700.59
243_R247_E1.6560.58
206_P210_A1.6450.58
44_A144_E1.6360.57
88_D91_T1.6330.57
219_R234_W1.6310.57
27_F145_I1.6180.57
265_S268_G1.6140.56
192_A195_V1.6140.56
57_F74_L1.6110.56
15_E19_T1.6050.56
90_S233_R1.6030.56
119_I159_V1.5990.56
114_A170_T1.5950.55
242_V289_S1.5860.55
114_A174_L1.5770.55
159_V273_A1.5480.53
232_D235_R1.5470.53
63_I83_I1.5400.53
113_I149_N1.5390.53
111_E250_F1.5190.52
51_P54_F1.5100.51
76_A127_Y1.5080.51
151_E241_G1.4940.50
169_K172_K1.4730.49
112_V155_I1.4650.49
69_A160_T1.4590.49
159_V270_V1.4590.49
252_A280_Y1.4550.49
212_T223_V1.4520.48
259_E276_K1.4410.48
152_F249_L1.4210.47
156_N200_V1.4180.47
147_M246_V1.3890.45
229_L233_R1.3810.45
16_N27_F1.3760.45
191_D234_W1.3710.44
54_F95_R1.3690.44
156_N173_D1.3600.44
253_V261_V1.3550.44
74_L155_I1.3540.44
273_A284_V1.3540.44
30_F154_V1.3530.44
195_V213_K1.3520.43
81_K143_I1.3520.43
88_D202_V1.3450.43
202_V222_A1.3390.43
159_V253_V1.3250.42
95_R234_W1.3230.42
65_L149_N1.3170.42
188_K207_K1.3000.41
13_Y20_R1.2960.41
13_Y17_V1.2930.41
128_I235_R1.2830.40
247_E254_K1.2820.40
204_V207_K1.2800.40
243_R254_K1.2800.40
284_V289_S1.2780.40
119_I273_A1.2740.40
82_I92_I1.2690.39
123_T126_Q1.2630.39
152_F252_A1.2620.39
184_F202_V1.2530.39
270_V279_A1.2510.39
139_K162_N1.2490.39
213_K241_G1.2410.38
32_H36_L1.2310.38
51_P95_R1.2300.38
264_T289_S1.2250.37
202_V224_R1.2140.37
95_R191_D1.2020.36
146_V150_N1.1970.36
49_K108_D1.1950.36
51_P145_I1.1880.36
83_I117_T1.1840.36
93_W145_I1.1830.35
130_A136_R1.1780.35
19_T25_F1.1660.35
122_N139_K1.1650.35
185_Y217_L1.1600.34
55_D96_V1.1580.34
174_L263_A1.1570.34
114_A139_K1.1470.34
33_W234_W1.1430.34
161_S246_V1.1350.33
225_E229_L1.1280.33
241_G253_V1.1240.33
128_I135_T1.1180.33
114_A285_H1.1160.33
247_E281_A1.1040.32
30_F47_K1.0980.32
73_V210_A1.0980.32
116_A173_D1.0900.31
205_P269_Q1.0870.31
114_A161_S1.0850.31
76_A95_R1.0820.31
25_F57_F1.0810.31
162_N224_R1.0780.31
140_F205_P1.0730.31
245_R249_L1.0690.30
40_E46_T1.0660.30
9_D21_Y1.0610.30
21_Y26_P1.0520.30
11_S29_V1.0520.30
24_M143_I1.0470.30
159_V261_V1.0410.29
24_M59_A1.0400.29
274_K284_V1.0360.29
90_S209_N1.0300.29
144_E160_T1.0270.29
124_G128_I1.0250.29
16_N288_N1.0250.29
45_R251_S1.0120.28
77_L156_N1.0060.28
19_T90_S1.0050.28
148_D189_T1.0050.28
23_L73_V1.0040.28
13_Y115_D1.0010.28
27_F136_R0.9970.28
207_K219_R0.9960.28
119_I261_V0.9940.27
93_W111_E0.9930.27
16_N284_V0.9910.27
62_H186_G0.9910.27
134_K260_S0.9910.27
129_V135_T0.9900.27
113_I251_S0.9890.27
165_E168_V0.9780.27
83_I154_V0.9760.27
218_A262_R0.9710.27
232_D236_E0.9710.27
24_M49_K0.9670.26
152_F248_S0.9670.26
127_Y144_E0.9640.26
18_I71_E0.9630.26
240_Y254_K0.9600.26
127_Y140_F0.9470.26
66_P69_A0.9410.25
132_W140_F0.9400.25
35_D260_S0.9260.25
172_K208_K0.9170.25
184_F200_V0.9150.24
119_I252_A0.9110.24
280_Y283_M0.9060.24
111_E149_N0.9050.24
16_N32_H0.9040.24
245_R248_S0.9040.24
14_D90_S0.9030.24
48_Y154_V0.8940.24
67_Y80_L0.8930.24
269_Q281_A0.8900.24
159_V225_E0.8880.23
41_N45_R0.8860.23
95_R219_R0.8790.23
8_R18_I0.8770.23
56_E261_V0.8750.23
71_E75_R0.8690.23
122_N136_R0.8650.23
30_F114_A0.8620.23
124_G242_V0.8590.22
27_F259_E0.8580.22
153_N165_E0.8550.22
248_S251_S0.8510.22
252_A261_V0.8500.22
53_E56_E0.8490.22
17_V219_R0.8480.22
188_K191_D0.8460.22
128_I245_R0.8420.22
72_G206_P0.8420.22
107_S261_V0.8380.22
118_G140_F0.8300.21
70_I227_R0.8270.21
80_L112_V0.8230.21
7_K226_F0.8230.21
32_H48_Y0.8220.21
118_G142_K0.8220.21
50_A58_L0.8210.21
274_K277_F0.8180.21
136_R202_V0.8160.21
27_F202_V0.8140.21
273_A287_A0.8140.21
82_I178_G0.8140.21
172_K224_R0.8090.21
120_S132_W0.8070.21
75_R208_K0.8060.21
15_E91_T0.8040.21
111_E289_S0.8010.21
89_Y157_A0.7980.20
102_T236_E0.7980.20
72_G77_L0.7960.20
97_R265_S0.7960.20
206_P219_R0.7910.20
8_R103_F0.7900.20
181_V268_G0.7870.20
7_K114_A0.7850.20
25_F83_I0.7810.20
134_K138_S0.7810.20
144_E166_S0.7790.20
243_R258_G0.7790.20
146_V238_K0.7790.20
213_K217_L0.7790.20
214_R267_A0.7760.20
11_S229_L0.7760.20
72_G125_G0.7730.20
43_N92_I0.7720.20
49_K121_T0.7720.20
228_K265_S0.7710.20
123_T154_V0.7700.20
207_K245_R0.7690.19
17_V191_D0.7640.19
143_I206_P0.7640.19
29_V83_I0.7600.19
136_R241_G0.7600.19
60_F136_R0.7490.19
185_Y285_H0.7390.19
72_G127_Y0.7340.18
19_T22_K0.7330.18
17_V28_Y0.7270.18
262_R277_F0.7260.18
70_I84_P0.7260.18
243_R272_E0.7240.18
11_S232_D0.7240.18
137_D219_R0.7210.18
22_K25_F0.7170.18
164_V277_F0.7110.18
97_R267_A0.7100.18
166_S187_D0.7080.18
278_W282_W0.7070.18
65_L103_F0.7030.18
70_I92_I0.7020.17
72_G95_R0.7000.17
175_Q180_K0.6980.17
14_D20_R0.6960.17
280_Y284_V0.6940.17
18_I31_E0.6920.17
269_Q280_Y0.6910.17
141_L252_A0.6900.17
73_V97_R0.6870.17
36_L97_R0.6860.17
273_A285_H0.6850.17
153_N158_E0.6830.17
259_E279_A0.6820.17
147_M286_L0.6810.17
240_Y272_E0.6810.17
104_P107_S0.6800.17
51_P117_T0.6770.17
269_Q272_E0.6770.17
27_F34_W0.6770.17
25_F90_S0.6760.17
113_I185_Y0.6740.17
236_E255_R0.6730.17
42_R60_F0.6690.17
35_D46_T0.6690.17
271_V274_K0.6680.17
11_S147_M0.6660.16
206_P226_F0.6640.16
106_A263_A0.6640.16
81_K256_T0.6630.16
42_R201_E0.6620.16
152_F257_F0.6600.16
11_S85_T0.6590.16
109_E151_E0.6590.16
184_F195_V0.6530.16
44_A132_W0.6530.16
18_I75_R0.6510.16
90_S207_K0.6510.16
92_I246_V0.6510.16
58_L67_Y0.6500.16
199_G221_K0.6480.16
86_S133_G0.6460.16
253_V257_F0.6460.16
121_T226_F0.6460.16
115_D118_G0.6390.16
186_G238_K0.6390.16
72_G126_Q0.6300.16
169_K223_V0.6250.15
68_R259_E0.6240.15
145_I152_F0.6220.15
21_Y33_W0.6220.15
51_P120_S0.6210.15
49_K56_E0.6200.15
248_S289_S0.6160.15
233_R237_E0.6140.15
16_N286_L0.6140.15
56_E259_E0.6100.15
61_L145_I0.6100.15
32_H90_S0.6070.15
9_D13_Y0.6050.15
15_E18_I0.6040.15
117_T191_D0.6040.15
9_D22_K0.6030.15
282_W286_L0.6020.15
160_T266_F0.6010.15
280_Y289_S0.5990.15
74_L262_R0.5990.15
35_D92_I0.5980.15
21_Y234_W0.5970.15
187_D190_Y0.5960.15
16_N61_L0.5930.15
66_P239_G0.5930.15
80_L124_G0.5910.15
16_N117_T0.5900.15
67_Y251_S0.5840.14
133_G141_L0.5820.14
141_L220_R0.5810.14
199_G225_E0.5810.14
248_S266_F0.5800.14
15_E107_S0.5800.14
77_L155_I0.5790.14
74_L83_I0.5780.14
57_F92_I0.5770.14
246_V272_E0.5770.14
14_D135_T0.5760.14
20_R33_W0.5740.14
83_I236_E0.5740.14
136_R251_S0.5730.14
121_T143_I0.5720.14
275_L282_W0.5720.14
89_Y143_I0.5680.14
72_G76_A0.5670.14
133_G269_Q0.5670.14
154_V277_F0.5650.14
40_E47_K0.5640.14
132_W195_V0.5640.14
125_G207_K0.5640.14
11_S279_A0.5630.14
9_D17_V0.5600.14
187_D243_R0.5580.14
17_V26_P0.5570.14
102_T225_E0.5550.14
195_V253_V0.5550.14
20_R26_P0.5530.14
264_T269_Q0.5520.14
88_D203_V0.5520.14
33_W230_G0.5510.14
242_V248_S0.5490.14
183_K266_F0.5470.13
252_A283_M0.5450.13
42_R49_K0.5420.13
265_S285_H0.5410.13
92_I194_E0.5410.13
92_I175_Q0.5400.13
123_T141_L0.5390.13
18_I35_D0.5380.13
62_H70_I0.5370.13
74_L203_V0.5350.13
10_W133_G0.5340.13
61_L202_V0.5330.13
90_S176_D0.5320.13
206_P252_A0.5310.13
261_V273_A0.5310.13
86_S141_L0.5310.13
100_K163_E0.5290.13
112_V150_N0.5250.13
29_V122_N0.5240.13
15_E200_V0.5240.13
48_Y167_A0.5230.13
105_E155_I0.5220.13
161_S164_V0.5210.13
8_R27_F0.5200.13
86_S165_E0.5190.13
197_K207_K0.5190.13
163_E226_F0.5170.13
86_S91_T0.5170.13
120_S126_Q0.5170.13
90_S219_R0.5170.13
11_S15_E0.5170.13
55_D253_V0.5160.13
66_P212_T0.5150.13
17_V187_D0.5150.13
235_R253_V0.5140.13
229_L237_E0.5130.13
189_T239_G0.5120.13
23_L165_E0.5110.13
165_E244_W0.5110.13
64_F250_F0.5100.13
20_R28_Y0.5090.13
262_R275_L0.5060.13
203_V285_H0.5030.13
215_G227_R0.5020.12
123_T252_A0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8896 97.4 0.925 Contact Map
4fcyA 4 0.8562 87.1 0.953 Contact Map
4u7bA 2 0.903 58.8 0.963 Contact Map
4fw1A 2 0.5117 51.8 0.964 Contact Map
1bcoA 1 0.5652 31.7 0.968 Contact Map
4mq3A 1 0.4114 25.9 0.97 Contact Map
3l3uA 2 0.4749 21.6 0.971 Contact Map
2gloA 1 0.1973 20.5 0.971 Contact Map
1k6yA 4 0.5953 20.3 0.971 Contact Map
2csfA 1 0.2943 17 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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