GREMLIN Database
Q97TV3 - Transposase ISC1225
UniProt: Q97TV3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 376 (321)
Sequences: 188 (120)
Seq/√Len: 6.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_T296_Y6.3191.00
122_I177_V4.6130.98
196_L295_S4.2190.97
191_V215_V3.7200.93
348_F352_L3.5510.91
86_R313_F3.3550.89
125_T300_K3.1910.86
272_T308_S3.1280.85
139_S145_S3.0420.83
198_A217_G2.9020.80
197_D289_R2.8230.78
272_T290_S2.7120.75
161_L296_Y2.7000.74
184_I194_V2.6750.74
191_V296_Y2.5480.70
316_L320_L2.5400.69
39_V215_V2.5270.69
272_T325_Y2.3860.64
129_W309_T2.2700.60
151_A163_A2.2330.59
150_T319_V2.1890.57
184_I214_F2.1290.55
33_Q191_V2.0090.51
123_D293_E1.9830.50
318_F325_Y1.9800.49
157_N207_K1.9230.47
120_I184_I1.9130.47
294_T297_R1.8920.46
65_C85_V1.8610.45
324_F335_M1.8220.44
302_F325_Y1.8180.43
122_I273_N1.8180.43
146_W296_Y1.7920.42
48_S191_V1.7880.42
124_W191_V1.7870.42
222_D297_R1.7570.41
123_D289_R1.7110.40
289_R293_E1.7110.40
126_T147_N1.7070.39
31_P34_N1.6780.38
191_V232_E1.6740.38
191_V299_I1.6730.38
178_K308_S1.6600.38
177_V180_L1.6550.38
120_I154_K1.6530.37
272_T320_L1.6450.37
171_M215_V1.6400.37
272_T300_K1.6400.37
200_F306_T1.6330.37
79_N224_K1.6220.36
180_L273_N1.6170.36
303_L315_E1.6130.36
140_S305_F1.5930.35
80_V150_T1.5880.35
220_V223_V1.5610.34
273_N318_F1.5450.34
138_G318_F1.5350.33
121_S137_L1.5350.33
332_K336_T1.5330.33
123_D197_D1.5330.33
197_D293_E1.5330.33
39_V198_A1.5210.33
159_V297_R1.5180.33
80_V131_G1.5160.33
88_Y310_K1.5060.32
193_L301_A1.4930.32
159_V192_G1.4800.32
129_W326_S1.4690.31
89_V163_A1.4640.31
103_S205_V1.4580.31
125_T138_G1.4510.31
180_L214_F1.4490.31
125_T159_V1.4450.31
78_Y181_M1.4430.30
201_Y218_V1.4300.30
61_L201_Y1.4250.30
150_T292_I1.4110.29
285_Y292_I1.3990.29
138_G155_Y1.3910.29
313_F317_I1.3880.29
296_Y306_T1.3560.28
300_K325_Y1.3550.28
144_N209_I1.3490.28
146_W302_F1.3390.27
181_M206_L1.3320.27
270_R316_L1.3290.27
348_F351_D1.3190.27
158_M192_G1.3130.26
347_C351_D1.2950.26
286_N326_S1.2940.26
59_R73_S1.2920.26
226_Y229_F1.2920.26
281_V327_L1.2890.26
206_L214_F1.2790.25
61_L85_V1.2760.25
145_S290_S1.2650.25
123_D285_Y1.2600.25
285_Y293_E1.2600.25
343_L347_C1.2560.25
272_T302_F1.2520.25
87_N310_K1.2390.24
151_A181_M1.2360.24
105_R302_F1.2150.24
36_L157_N1.2120.24
167_Q195_T1.2080.24
149_A180_L1.2040.23
308_S325_Y1.2040.23
347_C350_D1.2030.23
189_F234_T1.1980.23
57_V65_C1.1890.23
161_L322_M1.1880.23
180_L299_I1.1740.23
314_R328_Y1.1670.22
141_A297_R1.1590.22
215_V253_Y1.1540.22
85_V201_Y1.1460.22
305_F326_S1.1450.22
64_A199_G1.1440.22
340_F352_L1.1230.21
39_V146_W1.1120.21
114_G146_W1.1110.21
149_A214_F1.1100.21
300_K308_S1.1060.21
254_G313_F1.1030.21
290_S302_F1.1000.21
160_L220_V1.0990.21
143_G251_L1.0990.21
161_L295_S1.0980.21
64_A341_R1.0980.21
73_S127_K1.0970.21
64_A248_F1.0970.21
329_T332_K1.0950.21
273_N302_F1.0880.20
82_P285_Y1.0840.20
63_S72_E1.0760.20
151_A184_I1.0750.20
84_T138_G1.0750.20
124_W167_Q1.0700.20
166_P339_E1.0680.20
348_F353_S1.0660.20
65_C321_A1.0650.20
346_L352_L1.0550.20
316_L324_F1.0500.20
121_S205_V1.0460.19
102_E137_L1.0460.19
55_E304_P1.0400.19
83_Q253_Y1.0400.19
185_V215_V1.0300.19
177_V273_N1.0250.19
196_L209_I1.0220.19
201_Y219_P1.0210.19
177_V184_I1.0190.19
65_C324_F1.0190.19
137_L248_F1.0190.19
199_G327_L1.0170.19
196_L201_Y1.0130.19
34_N281_V1.0110.19
353_S356_K1.0100.19
232_E276_L0.9990.18
351_D355_L0.9990.18
33_Q133_P0.9980.18
150_T318_F0.9870.18
308_S318_F0.9810.18
95_E167_Q0.9810.18
153_T220_V0.9790.18
98_E102_E0.9780.18
137_L163_A0.9760.18
340_F343_L0.9750.18
104_M316_L0.9740.18
118_V265_V0.9730.18
95_E275_D0.9700.18
48_S143_G0.9680.18
32_H35_N0.9610.18
37_Q40_G0.9570.17
172_S202_T0.9530.17
89_V144_N0.9510.17
308_S314_R0.9500.17
151_A335_M0.9420.17
345_I355_L0.9410.17
275_D287_K0.9400.17
45_S141_A0.9380.17
123_D200_F0.9310.17
200_F293_E0.9310.17
346_L354_D0.9300.17
209_I212_F0.9270.17
139_S320_L0.9270.17
57_V215_V0.9260.17
58_S136_G0.9220.17
285_Y289_R0.9190.17
145_S302_F0.9190.17
150_T180_L0.9170.17
117_E244_E0.9170.17
352_L355_L0.9170.17
167_Q244_E0.9140.17
175_E198_A0.9130.17
64_A206_L0.9120.16
83_Q216_I0.9110.16
293_E314_R0.9110.16
123_D314_R0.9110.16
133_P220_V0.9060.16
50_K338_E0.9060.16
48_S253_Y0.9040.16
131_G309_T0.9020.16
131_G201_Y0.9010.16
81_S218_V0.9010.16
299_I318_F0.8940.16
116_K190_K0.8930.16
210_S338_E0.8910.16
209_I233_Y0.8850.16
60_V89_V0.8810.16
343_L349_L0.8770.16
201_Y294_T0.8760.16
217_G278_K0.8750.16
296_Y307_S0.8730.16
349_L356_K0.8730.16
149_A176_I0.8720.16
348_F355_L0.8720.16
63_S201_Y0.8710.16
324_F328_Y0.8690.16
65_C72_E0.8680.16
137_L308_S0.8610.15
205_V260_K0.8590.15
341_R346_L0.8560.15
244_E313_F0.8560.15
196_L271_A0.8550.15
352_L356_K0.8540.15
300_K318_F0.8520.15
216_I227_E0.8520.15
71_V181_M0.8490.15
97_I131_G0.8480.15
31_P185_V0.8480.15
106_R187_M0.8460.15
273_N308_S0.8420.15
290_S325_Y0.8400.15
192_G290_S0.8370.15
145_S329_T0.8350.15
34_N243_E0.8330.15
126_T145_S0.8320.15
294_T330_V0.8270.15
75_S171_M0.8270.15
65_C116_K0.8250.15
243_E267_Y0.8240.15
339_E342_L0.8180.15
195_T217_G0.8170.15
131_G160_L0.8160.15
121_S140_S0.8160.15
57_V85_V0.8110.14
138_G273_N0.8080.14
157_N164_F0.8060.14
90_E121_S0.8010.14
146_W256_E0.8000.14
44_L304_P0.7990.14
123_D292_I0.7980.14
87_N136_G0.7980.14
68_N181_M0.7980.14
106_R137_L0.7940.14
47_L232_E0.7920.14
243_E310_K0.7920.14
143_G292_I0.7920.14
125_T317_I0.7910.14
122_I149_A0.7910.14
128_T324_F0.7830.14
262_K275_D0.7810.14
290_S308_S0.7810.14
125_T299_I0.7800.14
77_G96_V0.7790.14
286_N291_P0.7790.14
63_S173_K0.7780.14
181_M316_L0.7770.14
235_T287_K0.7700.14
90_E251_L0.7690.14
100_L316_L0.7630.14
47_L96_V0.7630.14
294_T327_L0.7590.14
47_L52_R0.7580.14
51_G177_V0.7580.14
161_L201_Y0.7520.13
82_P310_K0.7510.13
147_N199_G0.7460.13
181_M230_D0.7460.13
255_K341_R0.7440.13
270_R290_S0.7430.13
350_D355_L0.7400.13
84_T300_K0.7400.13
159_V218_V0.7380.13
158_M337_R0.7380.13
63_S76_K0.7370.13
146_W269_A0.7310.13
43_L153_T0.7290.13
163_A181_M0.7280.13
136_G311_F0.7270.13
215_V285_Y0.7270.13
205_V296_Y0.7260.13
89_V198_A0.7250.13
106_R145_S0.7240.13
347_C355_L0.7240.13
125_T308_S0.7230.13
144_N159_V0.7230.13
184_I273_N0.7220.13
239_R266_V0.7210.13
214_F273_N0.7190.13
74_K291_P0.7170.13
294_T298_N0.7160.13
89_V256_E0.7160.13
197_D285_Y0.7130.13
49_F307_S0.7110.13
350_D356_K0.7100.13
38_Q42_K0.7090.13
206_L216_I0.7090.13
214_F267_Y0.7040.13
290_S300_K0.7040.13
339_E352_L0.7010.13
165_V232_E0.6980.13
148_Y201_Y0.6910.12
36_L44_L0.6900.12
206_L294_T0.6890.12
41_Y44_L0.6890.12
174_D208_F0.6890.12
119_D195_T0.6880.12
87_N235_T0.6810.12
60_V215_V0.6800.12
126_T199_G0.6790.12
99_K224_K0.6780.12
304_P317_I0.6780.12
167_Q177_V0.6770.12
147_N299_I0.6770.12
101_L301_A0.6760.12
113_K276_L0.6760.12
107_I313_F0.6730.12
200_F285_Y0.6710.12
209_I267_Y0.6710.12
108_S154_K0.6680.12
164_F220_V0.6640.12
318_F334_V0.6620.12
94_T313_F0.6610.12
227_E235_T0.6600.12
162_L180_L0.6600.12
80_V113_K0.6600.12
131_G148_Y0.6580.12
176_I335_M0.6550.12
103_S162_L0.6550.12
129_W341_R0.6530.12
95_E131_G0.6520.12
328_Y345_I0.6510.12
184_I334_V0.6510.12
45_S129_W0.6510.12
159_V290_S0.6510.12
138_G300_K0.6490.12
155_Y166_P0.6490.12
66_L198_A0.6470.12
89_V340_F0.6470.12
32_H205_V0.6450.12
112_L330_V0.6440.12
122_I205_V0.6420.12
93_G97_I0.6400.12
318_F340_F0.6400.12
142_K172_S0.6390.12
51_G161_L0.6370.12
121_S154_K0.6350.12
54_A198_A0.6340.12
69_D97_I0.6340.12
286_N328_Y0.6330.11
35_N41_Y0.6310.11
242_K262_K0.6260.11
146_W271_A0.6250.11
92_Q316_L0.6250.11
86_R254_G0.6220.11
84_T304_P0.6210.11
345_I352_L0.6210.11
309_T316_L0.6200.11
163_A196_L0.6170.11
33_Q112_L0.6170.11
44_L276_L0.6150.11
154_K265_V0.6140.11
121_S194_V0.6130.11
54_A58_S0.6130.11
104_M109_M0.6130.11
232_E272_T0.6130.11
87_N312_I0.6100.11
129_W146_W0.6090.11
91_E326_S0.6090.11
273_N299_I0.6050.11
122_I193_L0.6030.11
189_F212_F0.6030.11
84_T345_I0.6010.11
232_E302_F0.6010.11
105_R297_R0.6000.11
64_A336_T0.5990.11
47_L297_R0.5990.11
90_E164_F0.5980.11
252_V312_I0.5980.11
54_A310_K0.5960.11
44_L116_K0.5950.11
225_I279_R0.5940.11
321_A338_E0.5930.11
195_T279_R0.5920.11
145_S304_P0.5910.11
160_L297_R0.5890.11
194_V261_R0.5870.11
232_E312_I0.5870.11
117_E223_V0.5860.11
200_F289_R0.5860.11
200_F292_I0.5850.11
156_Q210_S0.5840.11
144_N329_T0.5840.11
256_E294_T0.5840.11
104_M321_A0.5830.11
291_P297_R0.5820.11
289_R314_R0.5820.11
129_W137_L0.5810.11
84_T247_K0.5810.11
152_T181_M0.5780.11
51_G87_N0.5750.11
240_H243_E0.5740.11
214_F268_F0.5740.11
138_G270_R0.5730.11
214_F332_K0.5730.11
167_Q205_V0.5720.11
127_K216_I0.5690.11
322_M325_Y0.5670.11
216_I274_L0.5670.11
200_F296_Y0.5670.11
154_K195_T0.5660.11
346_L349_L0.5650.10
138_G272_T0.5640.10
151_A175_E0.5620.10
92_Q237_S0.5620.10
83_Q173_K0.5620.10
168_V327_L0.5620.10
148_Y285_Y0.5620.10
297_R350_D0.5610.10
107_I163_A0.5610.10
51_G56_E0.5610.10
77_G192_G0.5600.10
217_G310_K0.5580.10
331_F334_V0.5570.10
168_V181_M0.5560.10
125_T214_F0.5530.10
64_A143_G0.5500.10
65_C301_A0.5500.10
71_V158_M0.5490.10
94_T180_L0.5480.10
253_Y278_K0.5470.10
94_T167_Q0.5460.10
307_S319_V0.5460.10
51_G82_P0.5460.10
48_S133_P0.5440.10
47_L107_I0.5420.10
188_G316_L0.5410.10
89_V237_S0.5410.10
31_P355_L0.5400.10
273_N300_K0.5370.10
32_H64_A0.5360.10
157_N216_I0.5350.10
74_K161_L0.5340.10
146_W263_K0.5330.10
66_L69_D0.5320.10
310_K323_I0.5300.10
82_P302_F0.5290.10
230_D284_L0.5270.10
51_G270_R0.5270.10
49_F249_R0.5270.10
155_Y319_V0.5260.10
151_A326_S0.5220.10
79_N198_A0.5210.10
84_T236_N0.5200.10
75_S213_K0.5190.10
135_E215_V0.5180.10
295_S312_I0.5180.10
350_D353_S0.5180.10
86_R295_S0.5180.10
201_Y275_D0.5180.10
63_S317_I0.5160.10
209_I306_T0.5140.10
100_L223_V0.5130.10
343_L346_L0.5110.10
144_N156_Q0.5100.10
176_I253_Y0.5060.10
169_N234_T0.5040.10
176_I223_V0.5010.10
95_E277_P0.5000.10
84_T121_S0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8537 99.3 0.87 Contact Map
1f6yA 2 0.6011 20.5 0.972 Contact Map
2yciX 2 0.609 15.1 0.974 Contact Map
2vxzA 1 0.3777 10.7 0.975 Contact Map
1jkoC 1 0.117 7.8 0.977 Contact Map
4xb4A 1 0.3723 7.3 0.977 Contact Map
4mq3A 1 0.3271 7.1 0.977 Contact Map
4x86A 1 0.1356 6.9 0.977 Contact Map
2m8eA 1 0.1516 6.7 0.978 Contact Map
1qgpA 1 0.1995 6.3 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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