GREMLIN Database
LYSX - Alpha-aminoadipate--LysW ligase LysX
UniProt: Q7SI95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (258)
Sequences: 29290 (17051)
Seq/√Len: 1061.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_K162_E3.8601.00
213_E217_K3.0561.00
136_N139_V3.0321.00
234_D238_G2.8571.00
112_K137_L2.7821.00
108_I141_Y2.6211.00
116_Y137_L2.4031.00
88_L241_V2.3051.00
88_L218_V2.2341.00
216_L220_D2.2301.00
103_D106_N2.2251.00
59_F76_I2.1911.00
94_P238_G2.1801.00
99_F113_K2.1771.00
82_I100_I2.1491.00
178_D181_P2.1151.00
85_T161_Q2.0501.00
137_L141_Y2.0121.00
133_K163_F1.9391.00
177_G181_P1.8711.00
59_F63_Q1.8431.00
82_I86_Y1.8351.00
60_L64_V1.7691.00
135_D139_V1.7681.00
207_I210_E1.7621.00
86_Y90_R1.7511.00
83_F86_Y1.7441.00
89_A97_K1.7341.00
110_Y114_L1.7321.00
171_I233_E1.7141.00
209_E213_E1.7051.00
110_Y113_K1.6601.00
77_R83_F1.6571.00
91_H221_I1.6461.00
210_E238_G1.6451.00
13_G20_V1.6351.00
219_K227_L1.6341.00
80_N123_V1.6311.00
84_T88_L1.6191.00
177_G180_T1.6181.00
77_R87_I1.6061.00
99_F110_Y1.6061.00
86_Y89_A1.5971.00
111_S116_Y1.5961.00
214_L239_Y1.5911.00
141_Y145_E1.5821.00
108_I137_L1.5811.00
263_K267_E1.5811.00
208_D212_R1.5581.00
260_N263_K1.5521.00
185_Y188_N1.5461.00
44_F66_Y1.5421.00
76_I83_F1.5401.00
90_R221_I1.5401.00
190_N194_T1.5221.00
217_K220_D1.4831.00
94_P214_L1.4681.00
82_I123_V1.4661.00
217_K221_I1.4591.00
71_D74_T1.4371.00
119_V133_K1.4131.00
93_I241_V1.3961.00
142_S146_Y1.3921.00
104_K141_Y1.3911.00
210_E214_L1.3881.00
150_S156_D1.3861.00
87_I221_I1.3831.00
214_L217_K1.3821.00
60_L63_Q1.3801.00
54_A79_E1.3771.00
182_V186_R1.3771.00
132_A146_Y1.3701.00
233_E239_Y1.3651.00
104_K108_I1.3611.00
118_V160_I1.3591.00
73_T77_R1.3571.00
209_E212_R1.3511.00
176_I264_F1.3431.00
123_V157_I1.3401.00
207_I233_E1.3351.00
210_E213_E1.3311.00
89_A95_T1.3261.00
264_F267_E1.3201.00
87_I90_R1.3061.00
18_Y266_L1.3051.00
109_E113_K1.3011.00
62_E72_H1.2931.00
162_E240_L1.2921.00
229_I244_V1.2871.00
104_K145_E1.2861.00
119_V131_V1.2841.00
169_R185_Y1.2801.00
212_R216_L1.2731.00
175_V219_K1.2671.00
15_K263_K1.2661.00
176_I226_F1.2641.00
16_L263_K1.2521.00
232_F242_D1.2511.00
85_T95_T1.2491.00
135_D165_N1.2371.00
12_E263_K1.2121.00
119_V163_F1.2091.00
173_I211_L1.2061.00
182_V185_Y1.1831.00
218_V221_I1.1831.00
97_K113_K1.1801.00
266_L270_A1.1801.00
61_V68_V1.1761.00
87_I91_H1.1731.00
15_K262_S1.1721.00
108_I112_K1.1711.00
132_A143_Y1.1681.00
16_L267_E1.1661.00
9_L45_I1.1661.00
21_A41_T1.1521.00
116_Y136_N1.1461.00
114_L118_V1.1441.00
62_E68_V1.1411.00
62_E71_D1.1251.00
94_P240_L1.1151.00
134_A143_Y1.1141.00
234_D240_L1.1121.00
44_F61_V1.1111.00
201_K204_P1.1081.00
59_F72_H1.1081.00
175_V215_A1.0941.00
97_K114_L1.0941.00
164_V240_L1.0921.00
98_T161_Q1.0901.00
192_W195_N1.0791.00
102_F157_I1.0771.00
173_I215_A1.0751.00
118_V134_A1.0711.00
10_I20_V1.0661.00
259_F264_F1.0641.00
169_R233_E1.0611.00
78_C222_I1.0561.00
102_F106_N1.0561.00
184_I188_N1.0561.00
86_Y98_T1.0481.00
183_G186_R1.0381.00
205_L256_V1.0381.00
164_V242_D1.0361.00
202_A205_L1.0351.00
218_V222_I1.0271.00
105_T108_I1.0171.00
82_I157_I1.0151.00
11_E15_K1.0141.00
104_K144_L1.0021.00
211_L239_Y1.0001.00
80_N124_E0.9991.00
171_I211_L0.9881.00
193_R197_A0.9811.00
162_E234_D0.9791.00
111_S137_L0.9741.00
73_T76_I0.9701.00
13_G18_Y0.9681.00
111_S118_V0.9661.00
175_V227_L0.9651.00
116_Y140_L0.9641.00
215_A231_I0.9611.00
61_V66_Y0.9591.00
109_E112_K0.9551.00
78_C244_V0.9531.00
101_A110_Y0.9501.00
89_A98_T0.9461.00
75_L246_G0.9451.00
96_P164_V0.9451.00
176_I268_K0.9421.00
206_K210_E0.9411.00
213_E216_L0.9301.00
226_F247_V0.9291.00
100_I157_I0.9111.00
214_L218_V0.9091.00
182_V187_V0.9071.00
201_K205_L0.9051.00
18_Y270_A0.9041.00
175_V229_I0.8981.00
106_N109_E0.8981.00
107_A140_L0.8891.00
124_E155_K0.8881.00
59_F73_T0.8841.00
10_I14_K0.8841.00
64_V67_P0.8811.00
107_A144_L0.8811.00
54_A57_T0.8781.00
142_S145_E0.8761.00
139_V142_S0.8731.00
182_V188_N0.8711.00
8_N261_V0.8671.00
67_P270_A0.8651.00
12_E15_K0.8651.00
194_T197_A0.8641.00
211_L231_I0.8601.00
219_K222_I0.8601.00
26_K29_V0.8541.00
120_I160_I0.8471.00
173_I212_R0.8421.00
200_A203_Y0.8411.00
10_I22_T0.8361.00
229_I241_V0.8321.00
165_N234_D0.8291.00
14_K17_G0.8291.00
123_V159_Y0.8221.00
195_N198_L0.8111.00
120_I134_A0.8101.00
190_N196_T0.8061.00
43_L69_I0.7951.00
219_K224_G0.7951.00
164_V234_D0.7931.00
80_N83_F0.7891.00
82_I159_Y0.7891.00
233_E237_R0.7891.00
210_E217_K0.7821.00
165_N236_D0.7801.00
105_T109_E0.7801.00
111_S140_L0.7801.00
14_K20_V0.7771.00
51_H54_A0.7771.00
164_V168_N0.7731.00
120_I143_Y0.7671.00
192_W197_A0.7671.00
80_N157_I0.7641.00
12_E16_L0.7631.00
22_T33_N0.7601.00
115_G162_E0.7591.00
266_L269_A0.7571.00
56_I59_F0.7561.00
231_I239_Y0.7481.00
13_G266_L0.7481.00
53_R58_S0.7481.00
237_R240_L0.7461.00
214_L231_I0.7431.00
10_I36_T0.7421.00
58_S68_V0.7321.00
138_D141_Y0.7321.00
43_L46_Q0.7261.00
74_T223_G0.7261.00
82_I98_T0.7251.00
53_R56_I0.7231.00
104_K107_A0.7231.00
171_I231_I0.7231.00
143_Y146_Y0.7221.00
267_E270_A0.7211.00
83_F87_I0.7201.00
59_F62_E0.7191.00
187_V202_A0.7091.00
96_P240_L0.7091.00
197_A200_A0.7091.00
88_L244_V0.7091.00
190_N195_N0.7051.00
33_N36_T0.7051.00
182_V212_R0.7051.00
57_T61_V0.7041.00
134_A140_L0.7031.00
215_A229_I0.6991.00
45_I265_L0.6991.00
178_D220_D0.6981.00
163_F232_F0.6921.00
165_N168_N0.6911.00
211_L214_L0.6891.00
55_L76_I0.6891.00
191_N194_T0.6891.00
183_G187_V0.6821.00
192_W196_T0.6821.00
93_I214_L0.6781.00
112_K141_Y0.6781.00
14_K36_T0.6771.00
226_F248_P0.6761.00
207_I237_R0.6751.00
24_Y29_V0.6731.00
212_R215_A0.6721.00
54_A58_S0.6671.00
184_I187_V0.6641.00
254_V257_N0.6621.00
32_S36_T0.6611.00
78_C246_G0.6591.00
215_A218_V0.6581.00
53_R57_T0.6571.00
93_I217_K0.6511.00
73_T83_F0.6501.00
175_V216_L0.6501.00
191_N198_L0.6481.00
114_L162_E0.6481.00
35_F38_D0.6451.00
87_I222_I0.6421.00
149_F158_Y0.6401.00
14_K38_D0.6381.00
120_I158_Y0.6381.00
117_P163_F0.6371.00
144_L158_Y0.6361.00
261_V265_L0.6331.00
193_R198_L0.6321.00
234_D237_R0.6321.00
94_P210_E0.6321.00
16_L266_L0.6281.00
106_N110_Y0.6241.00
22_T37_I0.6231.00
74_T224_G0.6211.00
54_A59_F0.6181.00
267_E271_E0.6161.00
8_N252_N0.6151.00
138_D142_S0.6151.00
58_S62_E0.6131.00
52_N59_F0.6131.00
14_K22_T0.6111.00
248_P261_V0.6111.00
162_E238_G0.6101.00
86_Y100_I0.6101.00
72_H76_I0.6081.00
135_D163_F0.6041.00
101_A107_A0.6021.00
191_N195_N0.6021.00
210_E239_Y0.5971.00
132_A142_S0.5971.00
140_L144_L0.5941.00
74_T78_C0.5931.00
200_A256_V0.5921.00
189_E195_N0.5911.00
219_K229_I0.5911.00
173_I231_I0.5861.00
259_F267_E0.5851.00
179_E220_D0.5831.00
99_F114_L0.5821.00
124_E157_I0.5821.00
196_T199_G0.5811.00
111_S114_L0.5801.00
108_I111_S0.5791.00
52_N57_T0.5791.00
189_E196_T0.5781.00
85_T98_T0.5771.00
170_D230_D0.5751.00
165_N169_R0.5741.00
117_P133_K0.5711.00
185_Y208_D0.5691.00
91_H218_V0.5661.00
50_S55_L0.5651.00
198_L201_K0.5651.00
265_L269_A0.5631.00
29_V32_S0.5591.00
134_A139_V0.5581.00
68_V72_H0.5581.00
85_T159_Y0.5551.00
111_S117_P0.5551.00
192_W198_L0.5541.00
96_P242_D0.5541.00
34_D38_D0.5541.00
165_N232_F0.5531.00
88_L95_T0.5511.00
81_K131_V0.5501.00
46_Q69_I0.5491.00
11_E14_K0.5481.00
224_G227_L0.5461.00
52_N55_L0.5441.00
174_F226_F0.5421.00
262_S266_L0.5411.00
146_Y153_K0.5411.00
120_I144_L0.5401.00
183_G188_N0.5381.00
117_P135_D0.5361.00
215_A244_V0.5351.00
228_G249_E0.5341.00
115_G118_V0.5341.00
95_T98_T0.5321.00
110_Y160_I0.5311.00
73_T223_G0.5301.00
61_V64_V0.5281.00
218_V241_V0.5281.00
208_D211_L0.5261.00
262_S265_L0.5241.00
194_T198_L0.5241.00
181_P220_D0.5241.00
71_D223_G0.5231.00
177_G271_E0.5201.00
214_L241_V0.5181.00
191_N197_A0.5171.00
89_A99_F0.5161.00
53_R59_F0.5151.00
174_F228_G0.5131.00
189_E192_W0.5101.00
90_R222_I0.5101.00
197_A201_K0.5101.00
85_T89_A0.5091.00
189_E194_T0.5091.00
58_S61_V0.5051.00
30_L35_F0.5021.00
96_P162_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vpdA 3 0.9927 100 0.276 Contact Map
3vpbA 3 0.9927 100 0.278 Contact Map
3i12A 2 0.9709 100 0.293 Contact Map
3e5nA 2 0.9345 100 0.297 Contact Map
4iwxA 3 0.9818 100 0.3 Contact Map
4fu0A 2 0.9673 100 0.3 Contact Map
2i87A 2 0.9382 100 0.302 Contact Map
3k3pA 2 0.9018 100 0.302 Contact Map
1a9xA 3 0.9855 100 0.304 Contact Map
3tqtA 2 0.9309 100 0.304 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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