GREMLIN Database
ARGD - Acetylornithine/acetyl-lysine aminotransferase
UniProt: Q7SI94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 388 (369)
Sequences: 20721 (12408)
Seq/√Len: 645.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_K59_E4.3121.00
195_R199_E3.8631.00
342_E376_K3.7521.00
22_Y30_K3.4701.00
299_L368_E3.1881.00
17_K24_W3.0331.00
79_E282_K2.9961.00
219_K225_H2.8031.00
299_L364_Q2.7891.00
288_K291_E2.7691.00
292_Q296_K2.6441.00
363_T366_D2.5881.00
49_V286_S2.5281.00
310_D375_R2.4991.00
52_D56_K2.4931.00
159_V193_S2.4291.00
79_E285_K2.3591.00
34_M370_A2.3521.00
279_A282_K2.3061.00
49_V283_V2.2661.00
193_S196_E2.2541.00
22_Y366_D2.2461.00
303_I371_S2.2181.00
338_V380_E2.1921.00
16_I26_E2.1911.00
342_E380_E2.1771.00
47_N283_V2.1491.00
49_V279_A2.1001.00
24_W30_K2.0911.00
295_K364_Q2.0871.00
338_V341_D2.0811.00
196_E200_K2.0791.00
303_I368_E2.0401.00
116_K168_D2.0131.00
79_E278_T2.0031.00
155_E161_S2.0021.00
76_M277_V1.9291.00
116_K152_E1.9051.00
369_W373_A1.8931.00
51_I55_K1.8861.00
311_F375_R1.8601.00
301_M305_K1.8451.00
89_D252_N1.8361.00
338_V342_E1.8051.00
344_V373_A1.7991.00
298_E302_R1.7981.00
25_D29_N1.7921.00
90_N252_N1.7851.00
283_V287_E1.7841.00
252_N256_E1.7811.00
29_N343_K1.7661.00
315_R329_K1.7581.00
173_I206_I1.7551.00
71_P75_E1.7261.00
121_K155_E1.7191.00
16_I60_E1.7111.00
22_Y369_W1.7051.00
303_I306_E1.7051.00
301_M319_G1.6951.00
94_L246_S1.6801.00
83_L285_K1.6741.00
311_F379_S1.6651.00
78_K82_E1.6111.00
157_N187_K1.6071.00
54_L276_A1.6051.00
101_V234_T1.5971.00
163_K200_K1.5801.00
219_K294_Q1.5661.00
54_L58_M1.5461.00
75_E278_T1.5441.00
160_D164_S1.5361.00
19_E48_K1.5351.00
301_M324_I1.5341.00
172_V198_T1.5221.00
79_E82_E1.5211.00
174_V194_L1.5181.00
338_V377_G1.5131.00
296_K299_L1.5041.00
21_Q366_D1.4851.00
235_A247_A1.4841.00
240_G245_V1.4791.00
296_K367_M1.4631.00
56_K60_E1.4561.00
207_I223_Y1.4541.00
189_E192_K1.4361.00
30_K369_W1.4341.00
118_V169_T1.4221.00
111_I254_I1.4091.00
375_R379_S1.4011.00
103_L248_V1.4001.00
235_A249_F1.3951.00
84_K249_F1.3891.00
339_L346_S1.3881.00
21_Q361_L1.3831.00
117_I171_A1.3771.00
195_R198_T1.3751.00
292_Q295_K1.3701.00
195_R205_L1.3661.00
77_I93_L1.3551.00
160_D163_K1.3541.00
48_K52_D1.3511.00
119_A153_F1.3391.00
81_D91_L1.3351.00
278_T282_K1.3331.00
91_L249_F1.3311.00
116_K166_T1.3311.00
279_A283_V1.3261.00
220_I224_Q1.3241.00
296_K364_Q1.3221.00
291_E295_K1.3191.00
111_I257_K1.3181.00
303_I372_D1.3121.00
342_E377_G1.3121.00
120_F190_F1.3101.00
105_L117_I1.3051.00
219_K224_Q1.3011.00
299_L303_I1.3001.00
52_D55_K1.2971.00
162_L194_L1.2961.00
245_V274_A1.2921.00
25_D31_Y1.2861.00
225_H320_L1.2821.00
82_E285_K1.2721.00
104_A234_T1.2611.00
172_V194_L1.2611.00
362_I367_M1.2561.00
174_V191_V1.2531.00
19_E46_R1.2491.00
17_K60_E1.2491.00
223_Y233_L1.2471.00
108_A206_I1.2421.00
101_V173_I1.2381.00
303_I375_R1.2361.00
15_I23_V1.2321.00
229_K251_P1.2311.00
232_I250_L1.2301.00
163_K193_S1.2171.00
75_E282_K1.2141.00
305_K308_L1.2121.00
47_N287_E1.2081.00
46_R51_I1.2061.00
43_L283_V1.2041.00
53_H279_A1.2031.00
226_F320_L1.1971.00
90_N256_E1.1961.00
307_K375_R1.1951.00
294_Q298_E1.1901.00
51_I59_E1.1841.00
366_D369_W1.1821.00
282_K286_S1.1781.00
307_K371_S1.1771.00
239_I245_V1.1771.00
192_K196_E1.1731.00
54_L272_L1.1701.00
154_L165_I1.1611.00
189_E226_F1.1601.00
245_V277_V1.1571.00
94_L248_V1.1451.00
204_L254_I1.1401.00
372_D376_K1.1371.00
51_I58_M1.1311.00
134_V151_V1.1271.00
215_G290_A1.1231.00
55_K58_M1.1211.00
239_I247_A1.1101.00
192_K227_D1.1001.00
305_K309_E1.0971.00
221_W235_A1.0941.00
283_V286_S1.0931.00
339_L373_A1.0811.00
134_V173_I1.0791.00
93_L274_A1.0681.00
339_L377_G1.0641.00
14_K26_E1.0621.00
342_E373_A1.0611.00
21_Q32_L1.0571.00
232_I248_V1.0571.00
22_Y32_L1.0551.00
369_W372_D1.0551.00
344_V370_A1.0551.00
161_S164_S1.0521.00
16_I71_P1.0511.00
207_I228_I1.0421.00
87_D229_K1.0381.00
302_R306_E1.0371.00
114_R202_N1.0331.00
364_Q368_E1.0281.00
19_E30_K1.0241.00
368_E372_D1.0121.00
155_E158_N1.0121.00
16_I24_W1.0071.00
16_I28_N1.0071.00
339_L344_V1.0061.00
198_T203_A0.9901.00
100_A234_T0.9901.00
76_M278_T0.9861.00
107_I248_V0.9851.00
152_E165_I0.9851.00
334_I338_V0.9841.00
337_K341_D0.9781.00
49_V282_K0.9771.00
83_L220_I0.9761.00
98_S131_A0.9741.00
79_E83_L0.9721.00
88_L249_F0.9671.00
241_G280_A0.9641.00
19_E24_W0.9631.00
196_E199_E0.9611.00
156_Y186_A0.9601.00
218_G224_Q0.9581.00
188_K192_K0.9571.00
161_S165_I0.9521.00
315_R327_D0.9511.00
166_T201_V0.9511.00
52_D59_E0.9421.00
105_L134_V0.9391.00
116_K169_T0.9381.00
176_P207_I0.9361.00
115_R168_D0.9331.00
171_A206_I0.9331.00
159_V163_K0.9321.00
308_L314_V0.9291.00
291_E294_Q0.9271.00
290_A293_A0.9231.00
163_K201_V0.9211.00
214_F284_A0.9151.00
191_V226_F0.9121.00
32_L366_D0.9101.00
197_V201_V0.9071.00
365_S368_E0.9041.00
14_K74_E0.9031.00
327_D352_T0.9011.00
119_A173_I0.8991.00
43_L280_A0.8981.00
185_P320_L0.8981.00
49_V52_D0.8981.00
56_K275_A0.8951.00
194_L205_L0.8901.00
120_F156_Y0.8851.00
107_I250_L0.8831.00
42_F238_A0.8831.00
284_A290_A0.8821.00
189_E193_S0.8811.00
104_A206_I0.8791.00
292_Q364_Q0.8781.00
120_F186_A0.8771.00
275_A279_A0.8751.00
163_K197_V0.8731.00
297_G301_M0.8721.00
56_K59_E0.8691.00
146_P150_P0.8661.00
111_I204_L0.8651.00
284_A289_I0.8621.00
306_E310_D0.8621.00
34_M362_I0.8621.00
243_F273_A0.8621.00
325_G353_T0.8611.00
83_L281_C0.8581.00
302_R305_K0.8561.00
43_L50_I0.8561.00
115_R150_P0.8551.00
32_L369_W0.8551.00
50_I276_A0.8551.00
133_S148_I0.8491.00
177_V320_L0.8451.00
225_H294_Q0.8441.00
163_K196_E0.8441.00
21_Q363_T0.8341.00
41_A241_G0.8311.00
26_E71_P0.8311.00
72_I275_A0.8251.00
290_A294_Q0.8231.00
108_A171_A0.8221.00
98_S128_S0.8211.00
199_E229_K0.8191.00
316_E327_D0.8171.00
212_T323_M0.8131.00
220_I290_A0.8111.00
116_K150_P0.8101.00
159_V197_V0.8051.00
85_P223_Y0.8041.00
289_I293_A0.8041.00
75_E79_E0.8011.00
177_V323_M0.8011.00
193_S197_V0.8001.00
49_V53_H0.7991.00
108_A204_L0.7991.00
362_I370_A0.7931.00
322_L362_I0.7871.00
72_I278_T0.7871.00
306_E375_R0.7861.00
303_I367_M0.7861.00
299_L302_R0.7831.00
310_D379_S0.7801.00
376_K380_E0.7801.00
110_K262_D0.7771.00
87_D233_L0.7761.00
295_K299_L0.7691.00
113_K168_D0.7631.00
223_Y228_I0.7611.00
356_F374_T0.7601.00
323_M357_L0.7591.00
318_R327_D0.7571.00
176_P191_V0.7561.00
32_L370_A0.7541.00
214_F281_C0.7531.00
121_K153_F0.7521.00
317_I324_I0.7501.00
307_K311_F0.7501.00
80_L249_F0.7501.00
198_T205_L0.7491.00
76_M274_A0.7461.00
221_W233_L0.7461.00
169_T203_A0.7451.00
179_G211_Q0.7421.00
94_L100_A0.7421.00
20_G361_L0.7421.00
81_D88_L0.7411.00
336_I348_K0.7411.00
172_V203_A0.7391.00
259_E262_D0.7381.00
202_N253_W0.7351.00
174_V205_L0.7341.00
335_A374_T0.7321.00
39_G357_L0.7321.00
72_I274_A0.7321.00
195_R228_I0.7281.00
72_I75_E0.7281.00
265_S268_G0.7281.00
220_I285_K0.7231.00
334_I337_K0.7221.00
335_A377_G0.7201.00
214_F235_A0.7161.00
306_E309_E0.7141.00
108_A232_I0.7121.00
296_K322_L0.7121.00
91_L247_A0.7111.00
192_K226_F0.7111.00
105_L173_I0.7111.00
120_F154_L0.7101.00
319_G324_I0.7101.00
217_T225_H0.7081.00
107_I258_I0.7061.00
70_T73_R0.7041.00
21_Q359_P0.7021.00
214_F220_I0.7011.00
69_D74_E0.7011.00
104_A232_I0.7011.00
328_L335_A0.6991.00
295_K298_E0.6961.00
88_L233_L0.6951.00
53_H276_A0.6941.00
251_P254_I0.6941.00
186_A189_E0.6901.00
177_V217_T0.6901.00
130_G148_I0.6891.00
253_W256_E0.6881.00
215_G284_A0.6851.00
293_A297_G0.6841.00
34_M344_V0.6811.00
365_S369_W0.6811.00
96_S99_E0.6771.00
101_V131_A0.6731.00
329_K332_P0.6711.00
32_L344_V0.6701.00
57_Q60_E0.6701.00
328_L378_I0.6691.00
95_N99_E0.6681.00
311_F378_I0.6671.00
106_K263_H0.6651.00
74_E78_K0.6651.00
235_A239_I0.6621.00
73_R77_I0.6611.00
62_S243_F0.6601.00
370_A373_A0.6571.00
214_F239_I0.6541.00
335_A339_L0.6541.00
72_I76_M0.6541.00
60_E71_P0.6541.00
15_I18_G0.6521.00
205_L228_I0.6511.00
54_L62_S0.6511.00
154_L161_S0.6511.00
297_G319_G0.6501.00
223_Y230_P0.6501.00
185_P319_G0.6481.00
35_H347_L0.6481.00
327_D353_T0.6471.00
206_I232_I0.6461.00
159_V162_L0.6431.00
298_E301_M0.6431.00
50_I241_G0.6421.00
14_K69_D0.6411.00
146_P149_G0.6411.00
29_N341_D0.6411.00
79_E281_C0.6411.00
254_I257_K0.6401.00
197_V200_K0.6391.00
347_L350_G0.6371.00
85_P224_Q0.6351.00
292_Q363_T0.6341.00
299_L367_M0.6341.00
158_N161_S0.6321.00
83_L221_W0.6321.00
53_H56_K0.6321.00
58_M272_L0.6301.00
339_L374_T0.6301.00
188_K226_F0.6301.00
337_K340_Q0.6301.00
199_E205_L0.6301.00
178_Q184_I0.6291.00
210_V234_T0.6291.00
60_E72_I0.6291.00
344_V369_W0.6271.00
21_Q362_I0.6271.00
362_I366_D0.6271.00
303_I307_K0.6251.00
313_I329_K0.6241.00
250_L255_S0.6241.00
236_G246_S0.6241.00
30_K373_A0.6231.00
57_Q72_I0.6231.00
188_K320_L0.6221.00
23_V345_L0.6211.00
114_R203_A0.6201.00
35_H345_L0.6191.00
354_I374_T0.6171.00
317_I326_I0.6161.00
107_I232_I0.6151.00
191_V207_I0.6121.00
178_Q181_G0.6121.00
87_D251_P0.6101.00
36_A359_P0.6101.00
84_K221_W0.6101.00
97_G210_V0.6091.00
293_A360_Y0.6081.00
84_K233_L0.6061.00
335_A354_I0.6061.00
373_A377_G0.6051.00
154_L162_L0.6051.00
179_G323_M0.6041.00
36_A357_L0.6031.00
111_I253_W0.6031.00
46_R58_M0.6021.00
85_P88_L0.6011.00
377_G380_E0.6001.00
103_L263_H0.5981.00
15_I68_F0.5961.00
371_S375_R0.5951.00
18_G61_I0.5951.00
296_K362_I0.5941.00
356_F370_A0.5921.00
43_L289_I0.5921.00
138_K142_E0.5921.00
51_I243_F0.5911.00
83_L219_K0.5901.00
152_E169_T0.5901.00
53_H282_K0.5871.00
199_E253_W0.5851.00
114_R168_D0.5841.00
176_P212_T0.5831.00
124_F127_R0.5821.00
326_I374_T0.5821.00
58_M276_A0.5801.00
48_K59_E0.5801.00
300_F371_S0.5801.00
314_V378_I0.5791.00
109_R129_M0.5771.00
120_F174_V0.5761.00
276_A279_A0.5751.00
19_E22_Y0.5751.00
336_I340_Q0.5741.00
294_Q297_G0.5721.00
42_F360_Y0.5721.00
76_M93_L0.5711.00
373_A376_K0.5701.00
330_V333_S0.5641.00
109_R146_P0.5641.00
232_I254_I0.5641.00
118_V154_L0.5631.00
115_R146_P0.5601.00
296_K363_T0.5601.00
87_D223_Y0.5591.00
293_A322_L0.5581.00
119_A151_V0.5571.00
136_W153_F0.5561.00
94_L99_E0.5551.00
138_K141_R0.5541.00
14_K71_P0.5531.00
18_G23_V0.5511.00
105_L130_G0.5511.00
300_F324_I0.5501.00
300_F367_M0.5501.00
299_L371_S0.5491.00
192_K195_R0.5491.00
76_M245_V0.5481.00
56_K279_A0.5461.00
214_F221_W0.5441.00
81_D249_F0.5431.00
32_L362_I0.5421.00
75_E78_K0.5421.00
13_I16_I0.5421.00
167_E201_V0.5401.00
318_R325_G0.5381.00
194_L203_A0.5381.00
307_K372_D0.5360.99
15_I61_I0.5350.99
42_F284_A0.5330.99
270_N273_A0.5320.99
318_R353_T0.5320.99
367_M371_S0.5310.99
374_T378_I0.5300.99
344_V377_G0.5300.99
256_E259_E0.5300.99
81_D89_D0.5300.99
233_L249_F0.5290.99
16_I19_E0.5290.99
287_E292_Q0.5280.99
57_Q61_I0.5280.99
220_I284_A0.5270.99
370_A374_T0.5240.99
188_K227_D0.5240.99
367_M370_A0.5220.99
368_E371_S0.5220.99
50_I280_A0.5210.99
211_Q323_M0.5190.99
285_K288_K0.5170.99
122_N181_G0.5170.99
204_L232_I0.5170.99
85_P89_D0.5160.99
174_V207_I0.5160.99
166_T169_T0.5150.99
162_L165_I0.5140.99
256_E260_E0.5140.99
281_C285_K0.5140.99
190_F194_L0.5130.99
236_G267_Y0.5130.99
307_K310_D0.5120.99
181_G184_I0.5120.99
58_M62_S0.5120.99
359_P362_I0.5090.99
81_D84_K0.5090.99
340_Q345_L0.5060.99
230_P233_L0.5040.99
156_Y178_Q0.5040.99
335_A378_I0.5020.99
186_A191_V0.5020.99
112_T170_A0.5020.99
326_I356_F0.5010.99
13_I340_Q0.5010.99
185_P226_F0.5010.99
68_F345_L0.5010.99
176_P223_Y0.5010.99
84_K235_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uoxA 3 1 100 0.348 Contact Map
4atqA 7 0.9845 100 0.361 Contact Map
3oksA 2 0.9794 100 0.364 Contact Map
4ffcA 4 0.9871 100 0.366 Contact Map
1z7dA 2 0.9175 100 0.366 Contact Map
4e3qA 3 0.9871 100 0.372 Contact Map
2epjA 2 0.9613 100 0.378 Contact Map
4a0gA 2 0.982 100 0.38 Contact Map
1sffA 3 0.9845 100 0.385 Contact Map
4nogA 2 0.9897 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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