GREMLIN Database
Q7LYL6 - Peptidyl-prolyl cis-trans isomerase
UniProt: Q7LYL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (185)
Sequences: 679 (477)
Seq/√Len: 35.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_A23_V5.8701.00
81_A89_K3.5021.00
50_L60_E3.3911.00
108_N111_L3.2111.00
15_K22_I3.0951.00
194_L197_V2.9651.00
61_E80_K2.8161.00
23_V58_G2.6611.00
66_F70_E2.6021.00
11_E27_N2.5721.00
9_Y47_L2.4671.00
66_F72_K2.3410.99
58_G76_I2.3010.99
48_V55_L2.2840.99
194_L198_E2.2100.99
185_S195_Y2.1930.99
18_D21_E2.1550.99
107_P111_L2.1240.99
196_L199_D1.9570.98
26_T59_L1.9220.98
174_G177_V1.9030.98
59_L91_K1.8940.97
154_N157_D1.8620.97
78_P86_D1.8380.97
199_D203_N1.8070.97
155_A158_K1.7310.96
194_L200_L1.6790.95
195_Y200_L1.6460.94
11_E26_T1.6360.94
197_V200_L1.6250.94
14_A58_G1.6230.94
51_G82_Y1.6020.93
62_A66_F1.5930.93
23_V60_E1.5650.93
48_V63_L1.5580.92
56_I76_I1.5400.92
197_V204_V1.5260.92
84_E87_N1.5160.91
123_S127_G1.5100.91
194_L199_D1.5100.91
186_V195_Y1.5050.91
7_F49_I1.4810.90
139_G165_R1.4580.90
62_A74_I1.4560.90
16_I21_E1.4440.89
12_Y25_T1.4330.89
4_N64_Y1.4070.88
195_Y198_E1.4020.88
184_K187_R1.3950.87
174_G181_D1.3760.87
58_G63_L1.3610.86
78_P81_A1.3440.85
71_E92_I1.3420.85
195_Y199_D1.3410.85
164_E178_E1.3390.85
9_Y150_K1.3100.84
73_T92_I1.3010.83
59_L93_V1.2950.83
13_T22_I1.2910.83
63_L66_F1.2790.82
165_R169_S1.2760.82
48_V56_I1.2660.82
154_N159_I1.2540.81
185_S192_K1.2330.80
168_S175_F1.2300.80
24_D91_K1.2080.79
199_D205_Y1.2020.78
66_F146_V1.1990.78
71_E94_P1.1980.78
13_T20_G1.1980.78
183_K199_D1.1870.77
131_L148_V1.1790.77
163_I199_D1.1480.75
178_E182_G1.1380.74
195_Y203_N1.1240.73
17_K75_E1.1180.73
194_L202_I1.1050.72
53_N60_E1.0940.71
164_E194_L1.0880.71
29_E61_E1.0770.70
196_L202_I1.0740.70
102_G105_A1.0670.69
77_P80_K1.0610.69
23_V84_E1.0610.69
16_I84_E1.0590.69
71_E147_K1.0570.69
175_F186_V1.0520.68
199_D204_V1.0320.67
29_E48_V1.0310.67
188_I197_V1.0280.66
169_S181_D1.0200.66
55_L189_T1.0160.66
182_G194_L1.0090.65
5_N89_K0.9980.64
81_A142_L0.9830.63
26_T45_P0.9810.63
20_G75_E0.9700.62
178_E185_S0.9640.61
12_Y26_T0.9630.61
193_D197_V0.9590.61
192_K195_Y0.9480.60
171_Y182_G0.9410.60
128_R139_G0.9340.59
120_V124_V0.9290.59
103_I109_R0.9260.58
61_E77_P0.9240.58
25_T29_E0.9130.57
163_I186_V0.9070.57
110_V113_L0.9030.56
56_I60_E0.9030.56
26_T91_K0.8980.56
103_I173_N0.8900.55
105_A112_R0.8880.55
176_N181_D0.8840.55
20_G69_N0.8820.55
55_L63_L0.8780.54
25_T46_R0.8720.54
78_P141_T0.8640.53
196_L203_N0.8590.53
58_G78_P0.8580.53
199_D202_I0.8580.53
7_F47_L0.8530.52
160_M180_D0.8500.52
10_I140_R0.8480.52
22_I68_L0.8460.51
157_D160_M0.8340.50
108_N112_R0.8300.50
14_A17_K0.8180.49
186_V194_L0.8170.49
127_G142_L0.8150.49
200_L204_V0.8110.48
14_A91_K0.8080.48
96_G99_R0.8050.48
119_A162_L0.8010.48
81_A88_S0.7980.47
57_K62_A0.7960.47
23_V78_P0.7740.45
71_E137_L0.7690.45
8_I48_V0.7670.45
124_V134_N0.7650.45
14_A56_I0.7630.44
23_V81_A0.7580.44
124_V128_R0.7560.44
78_P178_E0.7560.44
5_N53_N0.7520.43
192_K197_V0.7490.43
56_I64_Y0.7440.43
15_K75_E0.7410.43
187_R202_I0.7400.42
142_L149_V0.7390.42
135_H153_N0.7380.42
56_I74_I0.7350.42
96_G156_K0.7310.42
174_G193_D0.7290.42
50_L64_Y0.7180.41
67_N79_E0.7030.39
164_E192_K0.7020.39
81_A86_D0.7010.39
12_Y24_D0.6940.39
78_P88_S0.6910.38
193_D196_L0.6820.38
126_G138_A0.6800.37
68_L188_I0.6780.37
70_E164_E0.6780.37
130_V145_N0.6760.37
8_I50_L0.6740.37
83_G90_I0.6730.37
44_G149_V0.6700.37
15_K20_G0.6680.37
178_E181_D0.6680.37
64_Y77_P0.6650.36
102_G106_V0.6640.36
62_A70_E0.6640.36
70_E145_N0.6630.36
119_A128_R0.6630.36
60_E81_A0.6620.36
70_E126_G0.6620.36
107_P110_V0.6580.36
112_R151_V0.6540.35
102_G112_R0.6500.35
16_I87_N0.6500.35
186_V192_K0.6500.35
128_R132_D0.6490.35
139_G143_V0.6490.35
73_T90_I0.6480.35
107_P118_L0.6460.35
136_P149_V0.6440.35
142_L170_K0.6420.34
119_A131_L0.6400.34
110_V118_L0.6380.34
12_Y135_H0.6330.34
68_L159_I0.6320.34
21_E164_E0.6300.34
8_I148_V0.6290.33
164_E168_S0.6260.33
127_G167_F0.6260.33
12_Y90_I0.6250.33
131_L184_K0.6250.33
179_L183_K0.6220.33
27_N59_L0.6170.33
13_T81_A0.6160.32
164_E203_N0.6160.32
109_R113_L0.6140.32
176_N196_L0.6140.32
196_L200_L0.6110.32
93_V159_I0.6090.32
25_T51_G0.6080.32
63_L161_A0.6070.32
190_I196_L0.6050.32
8_I167_F0.6050.32
46_R55_L0.6040.32
200_L203_N0.6040.32
193_D200_L0.6020.31
23_V56_I0.6010.31
73_T122_R0.6000.31
58_G66_F0.5990.31
12_Y160_M0.5990.31
192_K198_E0.5960.31
67_N137_L0.5960.31
75_E90_I0.5950.31
136_P140_R0.5940.31
171_Y197_V0.5930.31
72_K148_V0.5900.31
178_E192_K0.5900.31
117_S150_K0.5850.30
93_V156_K0.5830.30
129_V141_T0.5810.30
47_L68_L0.5790.30
73_T161_A0.5730.29
21_E88_S0.5730.29
85_R133_L0.5720.29
24_D59_L0.5720.29
8_I63_L0.5720.29
79_E188_I0.5700.29
43_Y139_G0.5700.29
64_Y68_L0.5670.29
95_L176_N0.5660.29
131_L134_N0.5660.29
177_V181_D0.5650.29
80_K84_E0.5650.29
24_D53_N0.5580.28
6_D124_V0.5580.28
190_I200_L0.5570.28
50_L99_R0.5560.28
187_R191_P0.5550.28
127_G197_V0.5540.28
123_S164_E0.5530.28
104_T107_P0.5470.28
26_T29_E0.5460.27
160_M195_Y0.5450.27
169_S174_G0.5450.27
147_K153_N0.5440.27
105_A110_V0.5430.27
5_N124_V0.5390.27
174_G180_D0.5360.27
56_I81_A0.5330.27
72_K167_F0.5310.26
127_G195_Y0.5310.26
64_Y173_N0.5280.26
55_L71_E0.5230.26
123_S126_G0.5230.26
202_I205_Y0.5230.26
70_E146_V0.5230.26
89_K177_V0.5220.26
27_N94_P0.5220.26
134_N137_L0.5210.26
74_I118_L0.5200.26
190_I194_L0.5190.26
51_G79_E0.5170.26
68_L98_L0.5140.25
10_I77_P0.5090.25
53_N57_K0.5090.25
125_S147_K0.5060.25
142_L186_V0.5060.25
59_L63_L0.5050.25
84_E122_R0.5030.25
57_K89_K0.5000.24
87_N92_I0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3prbA 2 0.9532 100 0.412 Contact Map
4it4A 5 0.6894 100 0.489 Contact Map
1ix5A 1 0.6426 100 0.496 Contact Map
1kt0A 2 0.8298 100 0.51 Contact Map
3pr9A 1 0.6383 100 0.514 Contact Map
2if4A 1 0.8723 100 0.537 Contact Map
4dt4A 1 0.6043 100 0.574 Contact Map
2kr7A 1 0.6 99.9 0.579 Contact Map
2k8iA 1 0.7064 99.9 0.583 Contact Map
2kfwA 1 0.7191 99.9 0.587 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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