GREMLIN Database
Q7LYK3 - Uncharacterized protein
UniProt: Q7LYK3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (204)
Sequences: 9766 (6729)
Seq/√Len: 471.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_T121_S4.1561.00
26_E53_A3.9041.00
96_N170_K3.3061.00
99_E106_K3.1401.00
176_D206_K2.9871.00
101_K106_K2.9351.00
109_V120_I2.8401.00
99_E108_K2.8131.00
108_K125_Y2.7631.00
57_D68_A2.7491.00
56_I122_V2.6041.00
54_Y80_Y2.4691.00
107_I124_I2.4281.00
83_E95_K2.4271.00
80_Y94_V2.3561.00
28_F54_Y2.3251.00
26_E51_K2.3171.00
44_A52_I2.3001.00
78_N92_E2.1741.00
41_I74_L2.0491.00
30_V140_L1.9311.00
80_Y92_E1.9131.00
166_Y217_K1.8391.00
42_E46_D1.8191.00
54_Y78_N1.8131.00
137_W177_Y1.7791.00
30_V58_T1.7741.00
85_S118_D1.7661.00
109_V122_V1.7161.00
38_D42_E1.6991.00
92_E98_E1.6551.00
70_K74_L1.6541.00
43_L47_L1.6321.00
72_A91_V1.6291.00
82_H111_H1.5861.00
165_Y169_A1.5631.00
121_S139_I1.5601.00
161_E217_K1.5521.00
20_G27_L1.5501.00
138_A181_Y1.5481.00
204_F208_F1.5451.00
176_D203_G1.5451.00
95_K98_E1.5401.00
41_I75_T1.5151.00
218_D222_N1.5121.00
222_N226_E1.4711.00
58_T142_G1.4631.00
41_I45_R1.4571.00
43_L46_D1.4571.00
172_K195_S1.4571.00
28_F56_I1.4381.00
190_C193_G1.4251.00
123_L139_I1.4051.00
96_N111_H1.3861.00
114_G167_S1.3841.00
20_G50_M1.3741.00
110_L170_K1.3711.00
82_H120_I1.3691.00
18_V43_L1.3391.00
68_A79_V1.3331.00
45_R74_L1.3321.00
219_E222_N1.3241.00
27_L50_M1.3131.00
112_T167_S1.2901.00
119_S142_G1.2821.00
108_K123_L1.2781.00
124_I127_R1.2751.00
42_E45_R1.2741.00
139_I174_L1.2711.00
70_K73_S1.2671.00
220_F224_I1.2591.00
159_N163_N1.2531.00
16_T40_I1.2351.00
169_A198_P1.1721.00
105_V124_I1.1721.00
157_G160_A1.1721.00
121_S144_T1.1581.00
156_G159_N1.1481.00
97_G108_K1.1431.00
39_E43_L1.1291.00
153_I160_A1.1111.00
100_I107_I1.1001.00
17_Y181_Y1.0921.00
221_V225_R1.0851.00
72_A79_V1.0831.00
47_L50_M1.0811.00
148_G191_G1.0811.00
40_I44_A1.0761.00
37_V70_K1.0701.00
94_V109_V1.0641.00
102_A105_V1.0521.00
144_T171_L1.0521.00
38_D70_K1.0401.00
15_A198_P1.0331.00
19_F30_V1.0321.00
55_I77_A1.0101.00
117_P163_N1.0101.00
23_Q104_N1.0101.00
105_V127_R1.0091.00
29_V52_I1.0081.00
147_V208_F1.0021.00
170_K173_E0.9911.00
195_S199_S0.9801.00
110_L123_L0.9771.00
169_A172_K0.9701.00
200_S204_F0.9641.00
28_F102_A0.9631.00
78_N91_V0.9511.00
112_T119_S0.9501.00
10_K16_T0.9491.00
101_K104_N0.9441.00
163_N166_Y0.9431.00
158_E161_E0.9321.00
201_T204_F0.9311.00
18_V29_V0.9281.00
62_A66_S0.9281.00
56_I107_I0.9271.00
37_V67_G0.9171.00
37_V41_I0.9071.00
14_C183_A0.9051.00
200_S205_E0.9051.00
123_L137_W0.9011.00
106_K125_Y0.9011.00
202_I206_K0.8971.00
99_E125_Y0.8941.00
29_V32_P0.8891.00
222_N225_R0.8831.00
27_L52_I0.8791.00
26_E54_Y0.8771.00
87_V90_K0.8711.00
111_H120_I0.8631.00
25_G50_M0.8621.00
139_I180_I0.8611.00
107_I122_V0.8611.00
84_L111_H0.8571.00
84_L87_V0.8561.00
127_R138_A0.8551.00
217_K221_V0.8431.00
123_L174_L0.8351.00
83_E93_R0.8341.00
144_T167_S0.8331.00
69_K73_S0.8261.00
141_T180_I0.8241.00
54_Y92_E0.8171.00
52_I77_A0.8111.00
153_I164_L0.8081.00
37_V40_I0.8061.00
172_K198_P0.8021.00
123_L178_V0.8001.00
16_T33_K0.7991.00
223_R227_V0.7991.00
119_S144_T0.7911.00
69_K72_A0.7911.00
53_A78_N0.7881.00
117_P157_G0.7821.00
56_I100_I0.7801.00
121_S171_L0.7771.00
201_T205_E0.7731.00
206_K209_N0.7711.00
215_N218_D0.7711.00
166_Y170_K0.7701.00
81_Y85_S0.7631.00
65_L68_A0.7621.00
52_I75_T0.7581.00
40_I43_L0.7551.00
60_T85_S0.7541.00
20_G23_Q0.7531.00
86_Q90_K0.7501.00
161_E166_Y0.7491.00
203_G207_R0.7441.00
218_D221_V0.7431.00
112_T144_T0.7371.00
169_A173_E0.7341.00
28_F107_I0.7331.00
20_G47_L0.7321.00
168_L212_F0.7301.00
32_P55_I0.7281.00
156_G160_A0.7261.00
113_P167_S0.7231.00
39_E42_E0.7211.00
144_T164_L0.7211.00
60_T118_D0.7191.00
82_H85_S0.7181.00
169_A202_I0.7161.00
20_G24_A0.7161.00
143_D184_H0.7161.00
55_I71_L0.7151.00
94_V120_I0.7121.00
38_D41_I0.7091.00
180_I202_I0.7091.00
24_A104_N0.7061.00
10_K13_G0.7041.00
20_G43_L0.6991.00
161_E218_D0.6991.00
206_K210_S0.6931.00
81_Y89_F0.6901.00
125_Y137_W0.6871.00
17_Y140_L0.6861.00
18_V27_L0.6861.00
108_K174_L0.6841.00
94_V100_I0.6791.00
127_R137_W0.6771.00
29_V71_L0.6721.00
146_F151_G0.6711.00
17_Y183_A0.6621.00
180_I188_S0.6581.00
68_A72_A0.6551.00
55_I79_V0.6541.00
191_G194_I0.6521.00
61_H64_H0.6491.00
114_G153_I0.6401.00
147_V200_S0.6391.00
194_I198_P0.6381.00
172_K206_K0.6351.00
219_E223_R0.6351.00
148_G151_G0.6321.00
25_G48_G0.6290.99
148_G187_G0.6270.99
25_G103_G0.6270.99
111_H170_K0.6270.99
23_Q26_E0.6270.99
224_I227_V0.6190.99
15_A185_T0.6180.99
217_K220_F0.6160.99
179_E199_S0.6160.99
141_T182_P0.6140.99
85_S88_K0.6120.99
19_F124_I0.6110.99
175_P192_I0.6100.99
124_I140_L0.6090.99
205_E209_N0.6080.99
18_V50_M0.6080.99
25_G51_K0.6060.99
20_G25_G0.6050.99
96_N109_V0.6040.99
161_E221_V0.6030.99
160_A164_L0.6010.99
116_T119_S0.6010.99
86_Q93_R0.5990.99
35_E70_K0.5990.99
41_I44_A0.5970.99
150_L197_K0.5950.99
90_K93_R0.5920.99
45_R48_G0.5910.99
112_T171_L0.5870.99
110_L121_S0.5870.99
29_V44_A0.5840.99
18_V52_I0.5840.99
97_G170_K0.5820.99
31_D59_H0.5800.99
140_L181_Y0.5790.99
60_T116_T0.5760.99
83_E86_Q0.5710.99
169_A214_I0.5700.99
34_Y65_L0.5690.99
19_F28_F0.5690.99
214_I223_R0.5680.99
94_V122_V0.5650.99
211_L223_R0.5650.99
32_P68_A0.5640.99
225_R228_K0.5630.99
106_K126_D0.5620.99
143_D146_F0.5590.99
145_L180_I0.5590.99
121_S141_T0.5590.99
63_D184_H0.5570.99
218_D223_R0.5490.99
57_D65_L0.5480.99
35_E67_G0.5450.99
137_W175_P0.5410.98
86_Q89_F0.5410.98
138_A179_E0.5380.98
110_L139_I0.5360.98
14_C33_K0.5360.98
126_D137_W0.5360.98
27_L53_A0.5360.98
145_L194_I0.5350.98
221_V224_I0.5340.98
211_L227_V0.5340.98
37_V74_L0.5330.98
33_K39_E0.5300.98
179_E189_V0.5290.98
80_Y98_E0.5280.98
175_P178_V0.5260.98
102_A107_I0.5260.98
223_R226_E0.5260.98
141_T183_A0.5260.98
24_A103_G0.5250.98
223_R228_K0.5250.98
165_Y214_I0.5250.98
172_K215_N0.5220.98
59_H143_D0.5190.98
210_S214_I0.5190.98
98_E109_V0.5190.98
113_P144_T0.5170.98
71_L75_T0.5170.98
167_S171_L0.5150.98
127_R181_Y0.5110.98
172_K212_F0.5090.98
10_K33_K0.5080.98
72_A76_N0.5080.98
15_A183_A0.5040.98
215_N223_R0.5030.98
96_N110_L0.5020.98
210_S213_R0.5020.98
84_L95_K0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tp9A 2 0.9798 100 0.296 Contact Map
3r2uA 4 0.9798 100 0.301 Contact Map
4efzA 2 0.9757 100 0.301 Contact Map
4yslA 2 0.9514 100 0.311 Contact Map
2zo4A 1 0.9028 100 0.336 Contact Map
4ysbA 2 0.9069 100 0.346 Contact Map
4ad9A 4 0.9271 100 0.35 Contact Map
2gcuA 3 0.9352 100 0.356 Contact Map
2p18A 1 0.9231 100 0.358 Contact Map
1qh5A 1 0.915 100 0.361 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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