Q7LYK3 - SULSO - GREMLIN Contacts

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Q7LYK3 - Uncharacterized protein

UniProt:	Q7LYK3	Sequences: MMIFRQIISKSGGCATYVFGCTQAGELFVVDPKYEMVDEIIELARDLGDMKIAYIIDTHTHADHLSGAKKLASLTNANVYYHELSQVKFKVERVKNGEEIKAGNVKIKVLHTPGHTPDSISVLIYDRRRDESWNEPWAILTGDTLFVGGLGRIDIGGENAEENLYYSLAKLKELPDYVEIYPAHTAGSVCGIGISGKPSSTIGFEKRFNSLFRINNKDEFVNRIREVKMPKPKEFDDYIRKNLEGVI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	247 (204)
Sequences:	9766 (6729)
Seq/√Len:	471.1

ECOLI - YCBL GLO2
BACSU - YRKH PKSB YQGX YQJP YYBB YFLN YOBT
HALSA - O54647 Q9HRG5 Q9HSD1 O54661 Q9HS22 Q9HNJ2 Q9HQ50 Q9HNJ9 Q9HSH2
SULSO - Q7LYK3 Q97VU4 Q97U88 Q97VU0 Q97UV2 Q97YZ2 Q97WC2 Q97UR2 Q97XZ1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
112_T	121_S	4.156	1.00
26_E	53_A	3.904	1.00
96_N	170_K	3.306	1.00
99_E	106_K	3.140	1.00
176_D	206_K	2.987	1.00
101_K	106_K	2.935	1.00
109_V	120_I	2.840	1.00
99_E	108_K	2.813	1.00
108_K	125_Y	2.763	1.00
57_D	68_A	2.749	1.00
56_I	122_V	2.604	1.00
54_Y	80_Y	2.469	1.00
107_I	124_I	2.428	1.00
83_E	95_K	2.427	1.00
80_Y	94_V	2.356	1.00
28_F	54_Y	2.325	1.00
26_E	51_K	2.317	1.00
44_A	52_I	2.300	1.00
78_N	92_E	2.174	1.00
41_I	74_L	2.049	1.00
30_V	140_L	1.931	1.00
80_Y	92_E	1.913	1.00
166_Y	217_K	1.839	1.00
42_E	46_D	1.819	1.00
54_Y	78_N	1.813	1.00
137_W	177_Y	1.779	1.00
30_V	58_T	1.774	1.00
85_S	118_D	1.766	1.00
109_V	122_V	1.716	1.00
38_D	42_E	1.699	1.00
92_E	98_E	1.655	1.00
70_K	74_L	1.654	1.00
43_L	47_L	1.632	1.00
72_A	91_V	1.629	1.00
82_H	111_H	1.586	1.00
165_Y	169_A	1.563	1.00
121_S	139_I	1.560	1.00
161_E	217_K	1.552	1.00
20_G	27_L	1.550	1.00
138_A	181_Y	1.548	1.00
204_F	208_F	1.545	1.00
176_D	203_G	1.545	1.00
95_K	98_E	1.540	1.00
41_I	75_T	1.515	1.00
218_D	222_N	1.512	1.00
222_N	226_E	1.471	1.00
58_T	142_G	1.463	1.00
41_I	45_R	1.457	1.00
43_L	46_D	1.457	1.00
172_K	195_S	1.457	1.00
28_F	56_I	1.438	1.00
190_C	193_G	1.425	1.00
123_L	139_I	1.405	1.00
96_N	111_H	1.386	1.00
114_G	167_S	1.384	1.00
20_G	50_M	1.374	1.00
110_L	170_K	1.371	1.00
82_H	120_I	1.369	1.00
18_V	43_L	1.339	1.00
68_A	79_V	1.333	1.00
45_R	74_L	1.332	1.00
219_E	222_N	1.324	1.00
27_L	50_M	1.313	1.00
112_T	167_S	1.290	1.00
119_S	142_G	1.282	1.00
108_K	123_L	1.278	1.00
124_I	127_R	1.275	1.00
42_E	45_R	1.274	1.00
139_I	174_L	1.271	1.00
70_K	73_S	1.267	1.00
220_F	224_I	1.259	1.00
159_N	163_N	1.253	1.00
16_T	40_I	1.235	1.00
169_A	198_P	1.172	1.00
105_V	124_I	1.172	1.00
157_G	160_A	1.172	1.00
121_S	144_T	1.158	1.00
156_G	159_N	1.148	1.00
97_G	108_K	1.143	1.00
39_E	43_L	1.129	1.00
153_I	160_A	1.111	1.00
100_I	107_I	1.100	1.00
17_Y	181_Y	1.092	1.00
221_V	225_R	1.085	1.00
72_A	79_V	1.083	1.00
47_L	50_M	1.081	1.00
148_G	191_G	1.081	1.00
40_I	44_A	1.076	1.00
37_V	70_K	1.070	1.00
94_V	109_V	1.064	1.00
102_A	105_V	1.052	1.00
144_T	171_L	1.052	1.00
38_D	70_K	1.040	1.00
15_A	198_P	1.033	1.00
19_F	30_V	1.032	1.00
55_I	77_A	1.010	1.00
117_P	163_N	1.010	1.00
23_Q	104_N	1.010	1.00
105_V	127_R	1.009	1.00
29_V	52_I	1.008	1.00
147_V	208_F	1.002	1.00
170_K	173_E	0.991	1.00
195_S	199_S	0.980	1.00
110_L	123_L	0.977	1.00
169_A	172_K	0.970	1.00
200_S	204_F	0.964	1.00
28_F	102_A	0.963	1.00
78_N	91_V	0.951	1.00
112_T	119_S	0.950	1.00
10_K	16_T	0.949	1.00
101_K	104_N	0.944	1.00
163_N	166_Y	0.943	1.00
158_E	161_E	0.932	1.00
201_T	204_F	0.931	1.00
18_V	29_V	0.928	1.00
62_A	66_S	0.928	1.00
56_I	107_I	0.927	1.00
37_V	67_G	0.917	1.00
37_V	41_I	0.907	1.00
14_C	183_A	0.905	1.00
200_S	205_E	0.905	1.00
123_L	137_W	0.901	1.00
106_K	125_Y	0.901	1.00
202_I	206_K	0.897	1.00
99_E	125_Y	0.894	1.00
29_V	32_P	0.889	1.00
222_N	225_R	0.883	1.00
27_L	52_I	0.879	1.00
26_E	54_Y	0.877	1.00
87_V	90_K	0.871	1.00
111_H	120_I	0.863	1.00
25_G	50_M	0.862	1.00
139_I	180_I	0.861	1.00
107_I	122_V	0.861	1.00
84_L	111_H	0.857	1.00
84_L	87_V	0.856	1.00
127_R	138_A	0.855	1.00
217_K	221_V	0.843	1.00
123_L	174_L	0.835	1.00
83_E	93_R	0.834	1.00
144_T	167_S	0.833	1.00
69_K	73_S	0.826	1.00
141_T	180_I	0.824	1.00
54_Y	92_E	0.817	1.00
52_I	77_A	0.811	1.00
153_I	164_L	0.808	1.00
37_V	40_I	0.806	1.00
172_K	198_P	0.802	1.00
123_L	178_V	0.800	1.00
16_T	33_K	0.799	1.00
223_R	227_V	0.799	1.00
119_S	144_T	0.791	1.00
69_K	72_A	0.791	1.00
53_A	78_N	0.788	1.00
117_P	157_G	0.782	1.00
56_I	100_I	0.780	1.00
121_S	171_L	0.777	1.00
201_T	205_E	0.773	1.00
206_K	209_N	0.771	1.00
215_N	218_D	0.771	1.00
166_Y	170_K	0.770	1.00
81_Y	85_S	0.763	1.00
65_L	68_A	0.762	1.00
52_I	75_T	0.758	1.00
40_I	43_L	0.755	1.00
60_T	85_S	0.754	1.00
20_G	23_Q	0.753	1.00
86_Q	90_K	0.750	1.00
161_E	166_Y	0.749	1.00
203_G	207_R	0.744	1.00
218_D	221_V	0.743	1.00
112_T	144_T	0.737	1.00
169_A	173_E	0.734	1.00
28_F	107_I	0.733	1.00
20_G	47_L	0.732	1.00
168_L	212_F	0.730	1.00
32_P	55_I	0.728	1.00
156_G	160_A	0.726	1.00
113_P	167_S	0.723	1.00
39_E	42_E	0.721	1.00
144_T	164_L	0.721	1.00
60_T	118_D	0.719	1.00
82_H	85_S	0.718	1.00
169_A	202_I	0.716	1.00
20_G	24_A	0.716	1.00
143_D	184_H	0.716	1.00
55_I	71_L	0.715	1.00
94_V	120_I	0.712	1.00
38_D	41_I	0.709	1.00
180_I	202_I	0.709	1.00
24_A	104_N	0.706	1.00
10_K	13_G	0.704	1.00
20_G	43_L	0.699	1.00
161_E	218_D	0.699	1.00
206_K	210_S	0.693	1.00
81_Y	89_F	0.690	1.00
125_Y	137_W	0.687	1.00
17_Y	140_L	0.686	1.00
18_V	27_L	0.686	1.00
108_K	174_L	0.684	1.00
94_V	100_I	0.679	1.00
127_R	137_W	0.677	1.00
29_V	71_L	0.672	1.00
146_F	151_G	0.671	1.00
17_Y	183_A	0.662	1.00
180_I	188_S	0.658	1.00
68_A	72_A	0.655	1.00
55_I	79_V	0.654	1.00
191_G	194_I	0.652	1.00
61_H	64_H	0.649	1.00
114_G	153_I	0.640	1.00
147_V	200_S	0.639	1.00
194_I	198_P	0.638	1.00
172_K	206_K	0.635	1.00
219_E	223_R	0.635	1.00
148_G	151_G	0.632	1.00
25_G	48_G	0.629	0.99
148_G	187_G	0.627	0.99
25_G	103_G	0.627	0.99
111_H	170_K	0.627	0.99
23_Q	26_E	0.627	0.99
224_I	227_V	0.619	0.99
15_A	185_T	0.618	0.99
217_K	220_F	0.616	0.99
179_E	199_S	0.616	0.99
141_T	182_P	0.614	0.99
85_S	88_K	0.612	0.99
19_F	124_I	0.611	0.99
175_P	192_I	0.610	0.99
124_I	140_L	0.609	0.99
205_E	209_N	0.608	0.99
18_V	50_M	0.608	0.99
25_G	51_K	0.606	0.99
20_G	25_G	0.605	0.99
96_N	109_V	0.604	0.99
161_E	221_V	0.603	0.99
160_A	164_L	0.601	0.99
116_T	119_S	0.601	0.99
86_Q	93_R	0.599	0.99
35_E	70_K	0.599	0.99
41_I	44_A	0.597	0.99
150_L	197_K	0.595	0.99
90_K	93_R	0.592	0.99
45_R	48_G	0.591	0.99
112_T	171_L	0.587	0.99
110_L	121_S	0.587	0.99
29_V	44_A	0.584	0.99
18_V	52_I	0.584	0.99
97_G	170_K	0.582	0.99
31_D	59_H	0.580	0.99
140_L	181_Y	0.579	0.99
60_T	116_T	0.576	0.99
83_E	86_Q	0.571	0.99
169_A	214_I	0.570	0.99
34_Y	65_L	0.569	0.99
19_F	28_F	0.569	0.99
214_I	223_R	0.568	0.99
94_V	122_V	0.565	0.99
211_L	223_R	0.565	0.99
32_P	68_A	0.564	0.99
225_R	228_K	0.563	0.99
106_K	126_D	0.562	0.99
143_D	146_F	0.559	0.99
145_L	180_I	0.559	0.99
121_S	141_T	0.559	0.99
63_D	184_H	0.557	0.99
218_D	223_R	0.549	0.99
57_D	65_L	0.548	0.99
35_E	67_G	0.545	0.99
137_W	175_P	0.541	0.98
86_Q	89_F	0.541	0.98
138_A	179_E	0.538	0.98
110_L	139_I	0.536	0.98
14_C	33_K	0.536	0.98
126_D	137_W	0.536	0.98
27_L	53_A	0.536	0.98
145_L	194_I	0.535	0.98
221_V	224_I	0.534	0.98
211_L	227_V	0.534	0.98
37_V	74_L	0.533	0.98
33_K	39_E	0.530	0.98
179_E	189_V	0.529	0.98
80_Y	98_E	0.528	0.98
175_P	178_V	0.526	0.98
102_A	107_I	0.526	0.98
223_R	226_E	0.526	0.98
141_T	183_A	0.526	0.98
24_A	103_G	0.525	0.98
223_R	228_K	0.525	0.98
165_Y	214_I	0.525	0.98
172_K	215_N	0.522	0.98
59_H	143_D	0.519	0.98
210_S	214_I	0.519	0.98
98_E	109_V	0.519	0.98
113_P	144_T	0.517	0.98
71_L	75_T	0.517	0.98
167_S	171_L	0.515	0.98
127_R	181_Y	0.511	0.98
172_K	212_F	0.509	0.98
10_K	33_K	0.508	0.98
72_A	76_N	0.508	0.98
15_A	183_A	0.504	0.98
215_N	223_R	0.503	0.98
96_N	110_L	0.502	0.98
210_S	213_R	0.502	0.98
84_L	95_K	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tp9A	2	0.9798	100	0.296	Contact Map
3r2uA	4	0.9798	100	0.301	Contact Map
4efzA	2	0.9757	100	0.301	Contact Map
4yslA	2	0.9514	100	0.311	Contact Map
2zo4A	1	0.9028	100	0.336	Contact Map
4ysbA	2	0.9069	100	0.346	Contact Map
4ad9A	4	0.9271	100	0.35	Contact Map
2gcuA	3	0.9352	100	0.356	Contact Map
2p18A	1	0.9231	100	0.358	Contact Map
1qh5A	1	0.915	100	0.361	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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