GREMLIN Database
Q7LYK2 - Uncharacterized protein
UniProt: Q7LYK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 223 (205)
Sequences: 2058 (1733)
Seq/√Len: 121.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_S185_F3.3441.00
18_E57_K3.2751.00
18_E53_S3.2441.00
46_K49_E2.9761.00
17_Y43_P2.9431.00
25_L60_V2.9221.00
22_Y26_L2.8721.00
132_S136_K2.6671.00
17_Y46_K2.4521.00
135_I187_D2.4111.00
139_W218_L2.3491.00
59_L78_S2.3411.00
160_I163_S2.2721.00
137_V187_D2.2481.00
15_S53_S2.1281.00
16_V20_K2.1191.00
51_V60_V2.1071.00
28_L31_S2.0951.00
32_T35_E2.0921.00
51_V70_V2.0761.00
146_L150_L2.0341.00
22_Y75_P2.0301.00
21_V47_V2.0141.00
117_G120_I1.9621.00
24_T39_N1.9401.00
127_E131_K1.9131.00
129_V136_K1.9011.00
17_Y40_A1.8771.00
15_S18_E1.8751.00
97_V104_K1.8351.00
43_P46_K1.7921.00
100_Y104_K1.7651.00
14_F59_L1.7241.00
21_V50_V1.6871.00
17_Y42_I1.6781.00
21_V36_L1.6741.00
128_L189_V1.6571.00
147_I151_K1.6531.00
91_D94_I1.6471.00
83_R87_V1.6181.00
187_D212_E1.5821.00
101_W104_K1.5631.00
136_K185_F1.5581.00
34_K38_E1.5311.00
129_V150_L1.4771.00
205_R209_L1.4761.00
97_V101_W1.4471.00
36_L47_V1.4301.00
151_K154_K1.4261.00
24_T40_A1.4161.00
19_A23_L1.4031.00
61_R71_K1.4011.00
195_D199_I1.3971.00
17_Y50_V1.3961.00
44_Y48_Y1.3951.00
137_V212_E1.3851.00
10_R16_V1.3771.00
184_I212_E1.3591.00
129_V159_V1.3521.00
87_V91_D1.3431.00
76_S94_I1.3211.00
92_Y96_N1.3201.00
86_I89_E1.3191.00
28_L39_N1.3131.00
149_I152_K1.3091.00
160_I216_D1.3031.00
139_W162_S1.2951.00
40_A47_V1.2801.00
115_I201_V1.2761.00
17_Y49_E1.2480.99
30_N69_K1.2390.99
99_S102_S1.2390.99
124_M127_E1.2190.99
42_I47_V1.2160.99
96_N99_S1.2140.99
81_V85_K1.2070.99
27_N39_N1.2030.99
58_G117_G1.1940.99
130_D152_K1.1910.99
139_W179_K1.1650.99
31_S39_N1.1550.99
24_T36_L1.1430.99
21_V42_I1.1390.99
188_S203_S1.1360.99
124_M201_V1.1330.99
138_V183_I1.1160.99
142_L164_N1.1150.99
93_A104_K1.1100.99
113_L124_M1.1000.99
145_W149_I1.1000.99
138_V141_I1.0940.99
126_R149_I1.0940.99
35_E38_E1.0920.99
43_P50_V1.0860.99
34_K45_Q1.0820.98
152_K155_G1.0800.98
98_I101_W1.0690.98
55_E62_V1.0670.98
146_L149_I1.0640.98
96_N100_Y1.0610.98
33_M44_Y1.0440.98
112_S207_C1.0370.98
83_R93_A1.0310.98
133_N188_S1.0310.98
59_L82_Y1.0230.98
195_D198_E1.0170.98
136_K159_V1.0120.98
125_I129_V1.0070.98
118_K122_M1.0030.97
128_L191_V0.9970.97
126_R152_K0.9830.97
139_W214_H0.9810.97
40_A50_V0.9760.97
142_L181_K0.9700.97
47_V60_V0.9660.97
79_L82_Y0.9660.97
108_E134_K0.9590.97
26_L75_P0.9560.97
200_V207_C0.9530.97
143_P146_L0.9480.96
76_S98_I0.9480.96
94_I101_W0.9470.96
93_A96_N0.9420.96
43_P47_V0.9400.96
52_K56_D0.9390.96
115_I120_I0.9340.96
87_V94_I0.9300.96
143_P147_I0.9190.96
150_L159_V0.9120.96
125_I181_K0.9050.95
57_K85_K0.9050.95
33_M51_V0.8920.95
17_Y21_V0.8910.95
9_L19_A0.8870.95
129_V185_F0.8870.95
88_S92_Y0.8830.95
208_V212_E0.8830.95
128_L185_F0.8810.95
132_S186_D0.8740.94
162_S218_L0.8720.94
10_R19_A0.8640.94
194_N204_C0.8620.94
138_V159_V0.8600.94
215_F219_T0.8530.94
196_Q199_I0.8360.93
93_A97_V0.8330.93
24_T31_S0.8200.92
142_L174_Y0.8150.92
137_V184_I0.8050.92
173_K176_K0.8000.91
23_L103_E0.7850.91
45_Q49_E0.7840.91
62_V68_K0.7800.90
22_Y73_I0.7790.90
111_R203_S0.7760.90
32_T69_K0.7750.90
63_I71_K0.7730.90
25_L51_V0.7730.90
137_V216_D0.7720.90
63_I113_L0.7700.90
93_A100_Y0.7690.90
47_V214_H0.7680.90
78_S83_R0.7680.90
49_E52_K0.7670.90
18_E50_V0.7670.90
98_I104_K0.7660.90
37_S60_V0.7630.89
42_I46_K0.7630.89
82_Y86_I0.7630.89
115_I124_M0.7590.89
75_P101_W0.7580.89
23_L27_N0.7550.89
90_L94_I0.7510.89
139_W178_I0.7510.89
43_P49_E0.7500.89
52_K184_I0.7380.88
88_S91_D0.7360.88
111_R191_V0.7320.87
55_E60_V0.7320.87
91_D95_G0.7270.87
33_M48_Y0.7220.87
93_A101_W0.7180.86
180_S210_Q0.7160.86
181_K193_F0.7140.86
85_K88_S0.7080.86
42_I48_Y0.7020.85
156_N186_D0.7010.85
100_Y103_E0.7000.85
149_I207_C0.6990.85
41_E65_G0.6940.84
212_E216_D0.6900.84
46_K204_C0.6840.84
25_L36_L0.6820.83
184_I208_V0.6800.83
124_M128_L0.6790.83
202_D211_A0.6780.83
146_L159_V0.6770.83
143_P148_K0.6740.83
19_A48_Y0.6720.82
69_K191_V0.6710.82
83_R86_I0.6650.82
33_M70_V0.6640.82
125_I191_V0.6620.81
184_I190_L0.6570.81
102_S152_K0.6520.81
182_F214_H0.6500.80
52_K55_E0.6470.80
78_S114_H0.6410.79
131_K154_K0.6400.79
80_K117_G0.6380.79
139_W142_L0.6370.79
179_K214_H0.6340.79
32_T70_V0.6330.79
127_E185_F0.6310.78
53_S56_D0.6300.78
139_W182_F0.6280.78
148_K156_N0.6260.78
37_S45_Q0.6260.78
86_I90_L0.6250.78
166_L172_V0.6250.78
107_G184_I0.6240.78
135_I216_D0.6230.77
205_R208_V0.6220.77
75_P79_L0.6200.77
92_Y184_I0.6160.77
190_L194_N0.6160.77
160_I173_K0.6130.76
148_K152_K0.6080.76
80_K94_I0.6070.76
179_K210_Q0.6060.75
34_K44_Y0.6050.75
127_E130_D0.6040.75
14_F183_I0.6010.75
123_R126_R0.5980.75
202_D208_V0.5970.74
94_I100_Y0.5970.74
25_L33_M0.5920.74
80_K88_S0.5920.74
175_V178_I0.5920.74
88_S95_G0.5890.73
60_V70_V0.5830.73
34_K37_S0.5820.73
173_K219_T0.5800.72
137_V215_F0.5790.72
125_I183_I0.5790.72
14_F19_A0.5770.72
32_T44_Y0.5770.72
66_R123_R0.5760.72
21_V75_P0.5750.72
113_L203_S0.5730.71
185_F210_Q0.5720.71
52_K68_K0.5720.71
122_M145_W0.5720.71
21_V54_L0.5710.71
17_Y33_M0.5700.71
154_K165_N0.5640.70
185_F188_S0.5630.70
54_L89_E0.5630.70
72_L84_D0.5620.70
62_V67_P0.5610.70
211_A214_H0.5580.69
24_T27_N0.5580.69
136_K142_L0.5580.69
73_I78_S0.5580.69
17_Y48_Y0.5560.69
108_E127_E0.5560.69
11_K89_E0.5550.69
110_D204_C0.5540.69
37_S44_Y0.5540.69
149_I206_G0.5540.69
109_A183_I0.5520.69
97_V212_E0.5510.68
9_L13_G0.5510.68
82_Y184_I0.5500.68
191_V201_V0.5490.68
131_K189_V0.5460.68
25_L70_V0.5440.67
113_L201_V0.5390.67
28_L84_D0.5390.67
111_R204_C0.5370.66
94_I104_K0.5350.66
77_I91_D0.5340.66
11_K85_K0.5340.66
121_V138_V0.5330.66
31_S38_E0.5320.66
210_Q214_H0.5310.66
83_R136_K0.5300.65
129_V132_S0.5290.65
189_V203_S0.5270.65
175_V218_L0.5230.64
130_D149_I0.5230.64
112_S211_A0.5220.64
115_I163_S0.5180.64
204_C209_L0.5160.63
20_K42_I0.5160.63
159_V181_K0.5120.63
204_C207_C0.5120.63
158_T184_I0.5110.63
97_V100_Y0.5080.62
114_H201_V0.5080.62
34_K46_K0.5070.62
46_K50_V0.5060.62
126_R130_D0.5040.62
24_T95_G0.5040.62
128_L201_V0.5020.61
92_Y95_G0.5010.61
136_K183_I0.5000.61
88_S161_T0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qphA 2 0.9462 100 0.377 Contact Map
2f5tX 2 0.4888 99 0.763 Contact Map
1sfxA 3 0.4529 98.7 0.782 Contact Map
3r0aA 2 0.4709 98.7 0.788 Contact Map
1ku9A 2 0.5964 98.7 0.788 Contact Map
4nb5A 4 0.6233 98.6 0.795 Contact Map
1qgpA 1 0.3229 98.5 0.797 Contact Map
3g3zA 2 0.5561 98.5 0.798 Contact Map
1lj9A 2 0.583 98.5 0.8 Contact Map
3s2wA 3 0.5381 98.5 0.801 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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