Q7LYK0 - SULSO - GREMLIN Contacts

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Q7LYK0 - Transposase ISC1217

UniProt:	Q7LYK0	Sequences: MTKELTREEYYKALEKAVNEVILSMTGTRKDVAKRLLLGAVVGRNATEIAQEAEMDYETVLNNLDKAAQAKLIEVVKKLVGDHPVLLIVDDTHDHKLYARAMPVSRNGAQIFYCRAHKRFEPAIQLLVIGVKDLVNNQIYVIHIIAYIPRKVEEELKRRGEEVKFKTKIDALLEFLSSLSGLNVKARVFDSWYVNSRTLQGNTVGELKSSARVVEGGRSVPVSEFPQGEYLVEYLGTPIKLLVIDDYKGYGRRYFFSTDLNDTAEDIITTWENRWDIEVLIRELKALGLEGGSFLTWVRNSGFVALKALSLLVVQYFKYSTGLMLGAKRLARLIKSIYREAGGIKKLFKRRRKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	354 (300)
Sequences:	1062 (830)
Seq/√Len:	47.9

SULSO - Q7LYK0 Q7LX51 Q97VQ0 Q97XR1 Q97ZD8 Q97Y34 Q97XK5 Q97YE4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
189_F	205_G	4.656	1.00
145_I	178_S	3.461	1.00
89_V	172_L	3.360	1.00
36_L	303_F	3.293	1.00
287_L	307_K	3.075	1.00
91_D	192_W	2.766	1.00
90_D	274_R	2.762	1.00
166_K	174_E	2.747	1.00
143_H	178_S	2.627	1.00
90_D	278_E	2.545	1.00
204_V	271_W	2.504	1.00
89_V	187_R	2.411	1.00
88_I	132_K	2.411	1.00
128_V	281_I	2.402	1.00
127_L	193_Y	2.264	1.00
274_R	278_E	2.204	1.00
142_I	182_L	2.192	1.00
150_R	154_E	2.150	1.00
222_V	228_G	2.150	1.00
145_I	174_E	2.063	1.00
143_H	175_F	2.020	0.99
278_E	285_K	2.011	0.99
91_D	168_K	2.007	0.99
152_V	155_E	2.001	0.99
239_I	242_L	1.988	0.99
293_S	299_R	1.974	0.99
130_G	139_I	1.960	0.99
22_I	30_K	1.899	0.99
91_D	193_Y	1.893	0.99
224_E	228_G	1.834	0.99
26_T	30_K	1.817	0.99
240_K	244_I	1.800	0.99
294_F	299_R	1.799	0.99
222_V	226_P	1.795	0.99
275_W	278_E	1.792	0.99
220_V	223_S	1.778	0.99
90_D	285_K	1.766	0.99
70_A	74_E	1.762	0.99
62_N	65_D	1.746	0.99
36_L	40_A	1.735	0.98
32_V	59_T	1.730	0.98
147_Y	165_F	1.666	0.98
193_Y	274_R	1.639	0.98
22_I	25_M	1.631	0.98
43_G	46_A	1.612	0.97
91_D	275_W	1.605	0.97
168_K	193_Y	1.603	0.97
231_L	234_Y	1.600	0.97
95_H	117_H	1.582	0.97
86_L	270_T	1.574	0.97
130_G	281_I	1.571	0.97
296_T	307_K	1.551	0.97
93_H	121_E	1.543	0.97
243_V	246_D	1.542	0.97
170_D	173_L	1.541	0.97
63_N	292_G	1.540	0.97
228_G	232_V	1.522	0.96
129_I	175_F	1.516	0.96
145_I	301_S	1.514	0.96
115_R	192_W	1.511	0.96
167_T	170_D	1.492	0.96
220_V	229_E	1.488	0.96
93_H	114_C	1.474	0.96
260_L	264_A	1.464	0.96
85_V	131_V	1.461	0.95
203_T	258_T	1.456	0.95
274_R	285_K	1.446	0.95
206_E	253_R	1.440	0.95
64_L	306_L	1.418	0.95
102_M	124_I	1.406	0.94
194_V	205_G	1.406	0.94
158_R	298_V	1.398	0.94
90_D	275_W	1.396	0.94
89_V	129_I	1.394	0.94
114_C	121_E	1.393	0.94
193_Y	285_K	1.362	0.93
275_W	285_K	1.349	0.93
211_A	256_F	1.346	0.93
221_P	228_G	1.338	0.93
279_V	283_E	1.327	0.92
45_N	50_A	1.326	0.92
230_Y	233_E	1.325	0.92
303_F	310_S	1.322	0.92
37_L	309_L	1.320	0.92
186_A	270_T	1.311	0.92
48_E	51_Q	1.304	0.92
109_A	122_P	1.278	0.91
260_L	263_T	1.274	0.91
295_L	303_F	1.268	0.91
19_N	23_L	1.261	0.90
152_V	160_G	1.259	0.90
292_G	300_N	1.255	0.90
92_T	278_E	1.241	0.90
211_A	254_Y	1.239	0.90
262_D	265_E	1.238	0.90
297_W	301_S	1.237	0.90
39_G	49_I	1.230	0.89
188_V	270_T	1.229	0.89
240_K	245_D	1.229	0.89
260_L	265_E	1.227	0.89
130_G	280_L	1.221	0.89
276_D	311_L	1.218	0.89
202_N	258_T	1.213	0.89
204_V	257_S	1.202	0.88
21_V	25_M	1.195	0.88
93_H	112_F	1.180	0.87
86_L	188_V	1.175	0.87
224_E	230_Y	1.173	0.87
222_V	225_F	1.166	0.87
34_K	38_L	1.165	0.87
195_N	210_S	1.162	0.86
242_L	267_I	1.156	0.86
108_G	148_I	1.154	0.86
69_Q	302_G	1.150	0.86
57_Y	61_L	1.149	0.86
108_G	288_G	1.146	0.86
145_I	171_A	1.143	0.85
228_G	231_L	1.135	0.85
58_E	62_N	1.135	0.85
190_D	278_E	1.132	0.85
207_L	256_F	1.130	0.85
240_K	243_V	1.127	0.85
220_V	232_V	1.126	0.85
29_R	67_A	1.125	0.85
154_E	162_E	1.124	0.84
20_E	25_M	1.122	0.84
205_G	256_F	1.113	0.84
96_K	109_A	1.111	0.84
22_I	29_R	1.111	0.84
274_R	281_I	1.110	0.84
112_F	115_R	1.107	0.84
18_V	34_K	1.105	0.83
200_Q	214_V	1.105	0.83
147_Y	168_K	1.103	0.83
226_P	229_E	1.102	0.83
222_V	229_E	1.099	0.83
224_E	229_E	1.099	0.83
139_I	276_D	1.096	0.83
94_D	126_L	1.086	0.82
255_F	271_W	1.086	0.82
92_T	275_W	1.085	0.82
160_G	163_V	1.076	0.82
141_V	280_L	1.066	0.81
216_G	219_S	1.066	0.81
239_I	243_V	1.055	0.80
168_K	192_W	1.052	0.80
201_G	258_T	1.050	0.80
28_T	33_A	1.050	0.80
242_L	246_D	1.049	0.80
21_V	24_S	1.046	0.80
114_C	117_H	1.045	0.80
222_V	227_Q	1.044	0.80
139_I	280_L	1.043	0.80
242_L	252_R	1.042	0.80
304_V	307_K	1.039	0.79
141_V	311_L	1.037	0.79
171_A	175_F	1.036	0.79
167_T	177_S	1.034	0.79
275_W	314_V	1.033	0.79
128_V	141_V	1.032	0.79
127_L	172_L	1.018	0.78
125_Q	168_K	1.017	0.78
227_Q	231_L	1.017	0.78
77_K	179_L	1.015	0.78
33_A	37_L	1.008	0.77
90_D	193_Y	1.008	0.77
126_L	300_N	1.006	0.77
90_D	277_I	1.005	0.77
127_L	168_K	1.004	0.77
249_G	257_S	1.004	0.77
285_K	314_V	1.003	0.77
224_E	227_Q	1.002	0.77
263_T	266_D	1.000	0.77
199_L	205_G	1.000	0.77
38_L	41_V	0.994	0.76
141_V	312_L	0.972	0.75
306_L	310_S	0.970	0.75
114_C	125_Q	0.966	0.74
26_T	29_R	0.963	0.74
25_M	29_R	0.963	0.74
238_P	242_L	0.955	0.73
77_K	200_Q	0.955	0.73
110_Q	151_K	0.954	0.73
124_I	300_N	0.953	0.73
221_P	227_Q	0.946	0.73
88_I	188_V	0.945	0.73
277_I	285_K	0.940	0.72
115_R	121_E	0.938	0.72
153_E	156_L	0.938	0.72
63_N	69_Q	0.938	0.72
124_I	148_I	0.933	0.72
225_F	228_G	0.932	0.72
243_V	247_Y	0.932	0.72
63_N	67_A	0.928	0.71
193_Y	275_W	0.927	0.71
225_F	230_Y	0.926	0.71
221_P	226_P	0.922	0.71
112_F	124_I	0.920	0.71
91_D	277_I	0.917	0.70
150_R	187_R	0.916	0.70
24_S	71_K	0.914	0.70
281_I	284_L	0.913	0.70
207_L	278_E	0.909	0.70
222_V	230_Y	0.908	0.70
36_L	293_S	0.905	0.69
299_R	303_F	0.905	0.69
281_I	285_K	0.897	0.69
153_E	162_E	0.896	0.69
46_A	293_S	0.896	0.69
129_I	187_R	0.895	0.68
73_I	77_K	0.894	0.68
91_D	281_I	0.890	0.68
220_V	225_F	0.886	0.68
214_V	219_S	0.883	0.67
97_L	102_M	0.881	0.67
90_D	168_K	0.880	0.67
189_F	192_W	0.875	0.67
117_H	121_E	0.872	0.66
21_V	34_K	0.871	0.66
129_I	176_L	0.871	0.66
129_I	179_L	0.865	0.66
98_Y	109_A	0.861	0.65
214_V	218_R	0.858	0.65
127_L	145_I	0.858	0.65
127_L	171_A	0.858	0.65
76_V	223_S	0.855	0.65
172_L	187_R	0.854	0.65
112_F	121_E	0.852	0.65
261_N	264_A	0.852	0.65
112_F	149_P	0.851	0.65
189_F	194_V	0.851	0.65
94_D	304_V	0.848	0.64
166_K	177_S	0.847	0.64
126_L	304_V	0.847	0.64
27_G	31_D	0.843	0.64
92_T	285_K	0.843	0.64
32_V	35_R	0.840	0.63
58_E	72_L	0.836	0.63
191_S	207_L	0.836	0.63
101_A	292_G	0.835	0.63
125_Q	149_P	0.835	0.63
190_D	274_R	0.831	0.63
48_E	293_S	0.825	0.62
111_I	122_P	0.818	0.61
92_T	274_R	0.818	0.61
229_E	232_V	0.818	0.61
75_V	80_V	0.817	0.61
223_S	228_G	0.816	0.61
23_L	30_K	0.816	0.61
116_A	290_E	0.813	0.61
152_V	159_R	0.809	0.61
228_G	234_Y	0.799	0.60
127_L	147_Y	0.798	0.59
82_D	136_N	0.794	0.59
98_Y	295_L	0.792	0.59
152_V	157_K	0.791	0.59
114_C	275_W	0.790	0.59
284_L	289_L	0.788	0.59
220_V	228_G	0.786	0.58
158_R	318_K	0.784	0.58
193_Y	278_E	0.782	0.58
86_L	272_E	0.781	0.58
94_D	128_V	0.780	0.58
16_K	19_N	0.777	0.57
271_W	274_R	0.773	0.57
98_Y	101_A	0.772	0.57
33_A	36_L	0.772	0.57
25_M	28_T	0.771	0.57
278_E	281_I	0.770	0.57
192_W	275_W	0.767	0.56
25_M	30_K	0.761	0.56
21_V	33_A	0.754	0.55
168_K	172_L	0.752	0.55
90_D	190_D	0.751	0.55
60_V	63_N	0.745	0.54
40_A	306_L	0.744	0.54
257_S	293_S	0.738	0.54
102_M	242_L	0.738	0.54
93_H	120_F	0.733	0.53
16_K	20_E	0.733	0.53
148_I	159_R	0.732	0.53
278_E	314_V	0.731	0.53
89_V	176_L	0.730	0.53
127_L	274_R	0.728	0.53
277_I	287_L	0.722	0.52
153_E	161_E	0.718	0.52
226_P	234_Y	0.714	0.51
115_R	120_F	0.711	0.51
221_P	232_V	0.711	0.51
94_D	303_F	0.708	0.51
39_G	60_V	0.703	0.50
181_G	214_V	0.702	0.50
227_Q	230_Y	0.700	0.50
288_G	291_G	0.699	0.50
220_V	224_E	0.699	0.50
159_R	163_V	0.698	0.50
18_V	37_L	0.698	0.50
60_V	142_I	0.697	0.49
68_A	84_P	0.693	0.49
92_T	289_L	0.692	0.49
18_V	21_V	0.691	0.49
156_L	162_E	0.685	0.48
32_V	63_N	0.685	0.48
122_P	149_P	0.684	0.48
93_H	125_Q	0.679	0.48
102_M	300_N	0.675	0.47
114_C	120_F	0.671	0.47
92_T	304_V	0.670	0.47
97_L	121_E	0.669	0.47
194_V	198_T	0.668	0.47
275_W	281_I	0.667	0.46
241_L	244_I	0.665	0.46
119_R	200_Q	0.665	0.46
17_A	20_E	0.663	0.46
20_E	24_S	0.662	0.46
69_Q	305_A	0.662	0.46
150_R	217_G	0.661	0.46
44_R	291_G	0.660	0.46
93_H	115_R	0.660	0.46
191_S	208_K	0.660	0.46
62_N	67_A	0.659	0.46
112_F	125_Q	0.659	0.46
45_N	118_K	0.659	0.46
68_A	302_G	0.658	0.46
111_I	121_E	0.657	0.45
17_A	31_D	0.656	0.45
172_L	194_V	0.655	0.45
95_H	121_E	0.652	0.45
127_L	289_L	0.650	0.45
17_A	313_V	0.650	0.45
148_I	152_V	0.649	0.45
188_V	273_N	0.649	0.45
279_V	282_R	0.646	0.44
124_I	303_F	0.646	0.44
132_K	273_N	0.645	0.44
95_H	114_C	0.644	0.44
264_A	273_N	0.643	0.44
289_L	304_V	0.642	0.44
252_R	309_L	0.641	0.44
39_G	288_G	0.640	0.44
99_A	176_L	0.633	0.43
44_R	98_Y	0.632	0.43
223_S	232_V	0.632	0.43
26_T	32_V	0.630	0.43
21_V	27_G	0.628	0.43
102_M	297_W	0.626	0.42
199_L	256_F	0.624	0.42
26_T	33_A	0.619	0.42
207_L	211_A	0.618	0.42
234_Y	318_K	0.618	0.42
189_F	208_K	0.617	0.42
203_T	268_I	0.617	0.42
43_G	142_I	0.616	0.41
21_V	213_V	0.614	0.41
23_L	188_V	0.613	0.41
67_A	302_G	0.609	0.41
123_A	271_W	0.605	0.40
28_T	31_D	0.602	0.40
135_V	138_Q	0.601	0.40
300_N	304_V	0.601	0.40
296_T	308_A	0.600	0.40
29_R	296_T	0.600	0.40
39_G	108_G	0.599	0.40
276_D	280_L	0.596	0.39
136_N	268_I	0.596	0.39
19_N	34_K	0.594	0.39
153_E	159_R	0.593	0.39
21_V	182_L	0.589	0.39
76_V	79_L	0.588	0.39
168_K	171_A	0.587	0.39
292_G	303_F	0.586	0.39
88_I	276_D	0.581	0.38
101_A	256_F	0.580	0.38
84_P	232_V	0.580	0.38
32_V	62_N	0.579	0.38
65_D	299_R	0.579	0.38
142_I	216_G	0.577	0.38
302_G	305_A	0.577	0.38
221_P	224_E	0.574	0.37
131_V	189_F	0.572	0.37
91_D	191_S	0.572	0.37
18_V	33_A	0.569	0.37
210_S	250_Y	0.569	0.37
111_I	120_F	0.567	0.37
241_L	254_Y	0.565	0.37
316_Y	322_G	0.565	0.37
19_N	22_I	0.563	0.36
44_R	48_E	0.563	0.36
42_V	286_A	0.563	0.36
64_L	302_G	0.563	0.36
45_N	311_L	0.558	0.36
22_I	176_L	0.558	0.36
275_W	282_R	0.558	0.36
99_A	109_A	0.555	0.36
18_V	24_S	0.555	0.36
190_D	281_I	0.554	0.36
48_E	283_E	0.552	0.35
159_R	162_E	0.552	0.35
241_L	251_G	0.551	0.35
223_S	230_Y	0.551	0.35
111_I	253_R	0.550	0.35
185_K	219_S	0.545	0.35
34_K	176_L	0.545	0.35
54_E	218_R	0.543	0.35
299_R	306_L	0.543	0.35
18_V	22_I	0.540	0.34
46_A	113_Y	0.539	0.34
220_V	226_P	0.537	0.34
36_L	85_V	0.535	0.34
240_K	257_S	0.535	0.34
274_R	287_L	0.534	0.34
102_M	126_L	0.533	0.34
31_D	68_A	0.532	0.34
298_V	302_G	0.531	0.33
203_T	249_G	0.530	0.33
173_L	234_Y	0.530	0.33
96_K	113_Y	0.529	0.33
114_C	290_E	0.528	0.33
90_D	130_G	0.527	0.33
91_D	128_V	0.527	0.33
228_G	233_E	0.527	0.33
74_E	173_L	0.526	0.33
72_L	75_V	0.526	0.33
184_V	201_G	0.526	0.33
87_L	144_I	0.525	0.33
226_P	230_Y	0.524	0.33
299_R	302_G	0.524	0.33
57_Y	275_W	0.521	0.33
197_R	251_G	0.519	0.32
208_K	212_R	0.519	0.32
45_N	69_Q	0.518	0.32
113_Y	183_N	0.518	0.32
114_C	123_A	0.516	0.32
78_K	210_S	0.515	0.32
181_G	207_L	0.515	0.32
121_E	200_Q	0.514	0.32
180_S	264_A	0.511	0.32
69_Q	98_Y	0.511	0.32
29_R	58_E	0.511	0.32
89_V	175_F	0.511	0.32
127_L	187_R	0.509	0.32
50_A	312_L	0.509	0.32
114_C	141_V	0.508	0.31
29_R	33_A	0.505	0.31
240_K	247_Y	0.504	0.31
225_F	229_E	0.504	0.31
83_H	156_L	0.503	0.31
292_G	299_R	0.502	0.31
299_R	311_L	0.500	0.31
91_D	287_L	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.9237	99.9	0.714	Contact Map
2kkoA	2	0.3023	15.4	0.966	Contact Map
3qfiA	1	0.2571	13.6	0.967	Contact Map
3owqA	1	0.2345	11.8	0.968	Contact Map
2j49A	1	0.2288	9.6	0.97	Contact Map
3hdeA	2	0.2797	8.3	0.97	Contact Map
1qgpA	1	0.2034	8	0.97	Contact Map
3hdfA	1	0.2684	6.5	0.972	Contact Map
1r1tA	2	0.2768	6.4	0.972	Contact Map
2zkzA	2	0.2514	6.3	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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