GREMLIN Database
Q7LYK0 - Transposase ISC1217
UniProt: Q7LYK0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (300)
Sequences: 1062 (830)
Seq/√Len: 47.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_F205_G4.6561.00
145_I178_S3.4611.00
89_V172_L3.3601.00
36_L303_F3.2931.00
287_L307_K3.0751.00
91_D192_W2.7661.00
90_D274_R2.7621.00
166_K174_E2.7471.00
143_H178_S2.6271.00
90_D278_E2.5451.00
204_V271_W2.5041.00
89_V187_R2.4111.00
88_I132_K2.4111.00
128_V281_I2.4021.00
127_L193_Y2.2641.00
274_R278_E2.2041.00
142_I182_L2.1921.00
150_R154_E2.1501.00
222_V228_G2.1501.00
145_I174_E2.0631.00
143_H175_F2.0200.99
278_E285_K2.0110.99
91_D168_K2.0070.99
152_V155_E2.0010.99
239_I242_L1.9880.99
293_S299_R1.9740.99
130_G139_I1.9600.99
22_I30_K1.8990.99
91_D193_Y1.8930.99
224_E228_G1.8340.99
26_T30_K1.8170.99
240_K244_I1.8000.99
294_F299_R1.7990.99
222_V226_P1.7950.99
275_W278_E1.7920.99
220_V223_S1.7780.99
90_D285_K1.7660.99
70_A74_E1.7620.99
62_N65_D1.7460.99
36_L40_A1.7350.98
32_V59_T1.7300.98
147_Y165_F1.6660.98
193_Y274_R1.6390.98
22_I25_M1.6310.98
43_G46_A1.6120.97
91_D275_W1.6050.97
168_K193_Y1.6030.97
231_L234_Y1.6000.97
95_H117_H1.5820.97
86_L270_T1.5740.97
130_G281_I1.5710.97
296_T307_K1.5510.97
93_H121_E1.5430.97
243_V246_D1.5420.97
170_D173_L1.5410.97
63_N292_G1.5400.97
228_G232_V1.5220.96
129_I175_F1.5160.96
145_I301_S1.5140.96
115_R192_W1.5110.96
167_T170_D1.4920.96
220_V229_E1.4880.96
93_H114_C1.4740.96
260_L264_A1.4640.96
85_V131_V1.4610.95
203_T258_T1.4560.95
274_R285_K1.4460.95
206_E253_R1.4400.95
64_L306_L1.4180.95
102_M124_I1.4060.94
194_V205_G1.4060.94
158_R298_V1.3980.94
90_D275_W1.3960.94
89_V129_I1.3940.94
114_C121_E1.3930.94
193_Y285_K1.3620.93
275_W285_K1.3490.93
211_A256_F1.3460.93
221_P228_G1.3380.93
279_V283_E1.3270.92
45_N50_A1.3260.92
230_Y233_E1.3250.92
303_F310_S1.3220.92
37_L309_L1.3200.92
186_A270_T1.3110.92
48_E51_Q1.3040.92
109_A122_P1.2780.91
260_L263_T1.2740.91
295_L303_F1.2680.91
19_N23_L1.2610.90
152_V160_G1.2590.90
292_G300_N1.2550.90
92_T278_E1.2410.90
211_A254_Y1.2390.90
262_D265_E1.2380.90
297_W301_S1.2370.90
39_G49_I1.2300.89
188_V270_T1.2290.89
240_K245_D1.2290.89
260_L265_E1.2270.89
130_G280_L1.2210.89
276_D311_L1.2180.89
202_N258_T1.2130.89
204_V257_S1.2020.88
21_V25_M1.1950.88
93_H112_F1.1800.87
86_L188_V1.1750.87
224_E230_Y1.1730.87
222_V225_F1.1660.87
34_K38_L1.1650.87
195_N210_S1.1620.86
242_L267_I1.1560.86
108_G148_I1.1540.86
69_Q302_G1.1500.86
57_Y61_L1.1490.86
108_G288_G1.1460.86
145_I171_A1.1430.85
228_G231_L1.1350.85
58_E62_N1.1350.85
190_D278_E1.1320.85
207_L256_F1.1300.85
240_K243_V1.1270.85
220_V232_V1.1260.85
29_R67_A1.1250.85
154_E162_E1.1240.84
20_E25_M1.1220.84
205_G256_F1.1130.84
96_K109_A1.1110.84
22_I29_R1.1110.84
274_R281_I1.1100.84
112_F115_R1.1070.84
18_V34_K1.1050.83
200_Q214_V1.1050.83
147_Y168_K1.1030.83
226_P229_E1.1020.83
222_V229_E1.0990.83
224_E229_E1.0990.83
139_I276_D1.0960.83
94_D126_L1.0860.82
255_F271_W1.0860.82
92_T275_W1.0850.82
160_G163_V1.0760.82
141_V280_L1.0660.81
216_G219_S1.0660.81
239_I243_V1.0550.80
168_K192_W1.0520.80
201_G258_T1.0500.80
28_T33_A1.0500.80
242_L246_D1.0490.80
21_V24_S1.0460.80
114_C117_H1.0450.80
222_V227_Q1.0440.80
139_I280_L1.0430.80
242_L252_R1.0420.80
304_V307_K1.0390.79
141_V311_L1.0370.79
171_A175_F1.0360.79
167_T177_S1.0340.79
275_W314_V1.0330.79
128_V141_V1.0320.79
127_L172_L1.0180.78
125_Q168_K1.0170.78
227_Q231_L1.0170.78
77_K179_L1.0150.78
33_A37_L1.0080.77
90_D193_Y1.0080.77
126_L300_N1.0060.77
90_D277_I1.0050.77
127_L168_K1.0040.77
249_G257_S1.0040.77
285_K314_V1.0030.77
224_E227_Q1.0020.77
263_T266_D1.0000.77
199_L205_G1.0000.77
38_L41_V0.9940.76
141_V312_L0.9720.75
306_L310_S0.9700.75
114_C125_Q0.9660.74
26_T29_R0.9630.74
25_M29_R0.9630.74
238_P242_L0.9550.73
77_K200_Q0.9550.73
110_Q151_K0.9540.73
124_I300_N0.9530.73
221_P227_Q0.9460.73
88_I188_V0.9450.73
277_I285_K0.9400.72
115_R121_E0.9380.72
153_E156_L0.9380.72
63_N69_Q0.9380.72
124_I148_I0.9330.72
225_F228_G0.9320.72
243_V247_Y0.9320.72
63_N67_A0.9280.71
193_Y275_W0.9270.71
225_F230_Y0.9260.71
221_P226_P0.9220.71
112_F124_I0.9200.71
91_D277_I0.9170.70
150_R187_R0.9160.70
24_S71_K0.9140.70
281_I284_L0.9130.70
207_L278_E0.9090.70
222_V230_Y0.9080.70
36_L293_S0.9050.69
299_R303_F0.9050.69
281_I285_K0.8970.69
153_E162_E0.8960.69
46_A293_S0.8960.69
129_I187_R0.8950.68
73_I77_K0.8940.68
91_D281_I0.8900.68
220_V225_F0.8860.68
214_V219_S0.8830.67
97_L102_M0.8810.67
90_D168_K0.8800.67
189_F192_W0.8750.67
117_H121_E0.8720.66
21_V34_K0.8710.66
129_I176_L0.8710.66
129_I179_L0.8650.66
98_Y109_A0.8610.65
214_V218_R0.8580.65
127_L145_I0.8580.65
127_L171_A0.8580.65
76_V223_S0.8550.65
172_L187_R0.8540.65
112_F121_E0.8520.65
261_N264_A0.8520.65
112_F149_P0.8510.65
189_F194_V0.8510.65
94_D304_V0.8480.64
166_K177_S0.8470.64
126_L304_V0.8470.64
27_G31_D0.8430.64
92_T285_K0.8430.64
32_V35_R0.8400.63
58_E72_L0.8360.63
191_S207_L0.8360.63
101_A292_G0.8350.63
125_Q149_P0.8350.63
190_D274_R0.8310.63
48_E293_S0.8250.62
111_I122_P0.8180.61
92_T274_R0.8180.61
229_E232_V0.8180.61
75_V80_V0.8170.61
223_S228_G0.8160.61
23_L30_K0.8160.61
116_A290_E0.8130.61
152_V159_R0.8090.61
228_G234_Y0.7990.60
127_L147_Y0.7980.59
82_D136_N0.7940.59
98_Y295_L0.7920.59
152_V157_K0.7910.59
114_C275_W0.7900.59
284_L289_L0.7880.59
220_V228_G0.7860.58
158_R318_K0.7840.58
193_Y278_E0.7820.58
86_L272_E0.7810.58
94_D128_V0.7800.58
16_K19_N0.7770.57
271_W274_R0.7730.57
98_Y101_A0.7720.57
33_A36_L0.7720.57
25_M28_T0.7710.57
278_E281_I0.7700.57
192_W275_W0.7670.56
25_M30_K0.7610.56
21_V33_A0.7540.55
168_K172_L0.7520.55
90_D190_D0.7510.55
60_V63_N0.7450.54
40_A306_L0.7440.54
257_S293_S0.7380.54
102_M242_L0.7380.54
93_H120_F0.7330.53
16_K20_E0.7330.53
148_I159_R0.7320.53
278_E314_V0.7310.53
89_V176_L0.7300.53
127_L274_R0.7280.53
277_I287_L0.7220.52
153_E161_E0.7180.52
226_P234_Y0.7140.51
115_R120_F0.7110.51
221_P232_V0.7110.51
94_D303_F0.7080.51
39_G60_V0.7030.50
181_G214_V0.7020.50
227_Q230_Y0.7000.50
288_G291_G0.6990.50
220_V224_E0.6990.50
159_R163_V0.6980.50
18_V37_L0.6980.50
60_V142_I0.6970.49
68_A84_P0.6930.49
92_T289_L0.6920.49
18_V21_V0.6910.49
156_L162_E0.6850.48
32_V63_N0.6850.48
122_P149_P0.6840.48
93_H125_Q0.6790.48
102_M300_N0.6750.47
114_C120_F0.6710.47
92_T304_V0.6700.47
97_L121_E0.6690.47
194_V198_T0.6680.47
275_W281_I0.6670.46
241_L244_I0.6650.46
119_R200_Q0.6650.46
17_A20_E0.6630.46
20_E24_S0.6620.46
69_Q305_A0.6620.46
150_R217_G0.6610.46
44_R291_G0.6600.46
93_H115_R0.6600.46
191_S208_K0.6600.46
62_N67_A0.6590.46
112_F125_Q0.6590.46
45_N118_K0.6590.46
68_A302_G0.6580.46
111_I121_E0.6570.45
17_A31_D0.6560.45
172_L194_V0.6550.45
95_H121_E0.6520.45
127_L289_L0.6500.45
17_A313_V0.6500.45
148_I152_V0.6490.45
188_V273_N0.6490.45
279_V282_R0.6460.44
124_I303_F0.6460.44
132_K273_N0.6450.44
95_H114_C0.6440.44
264_A273_N0.6430.44
289_L304_V0.6420.44
252_R309_L0.6410.44
39_G288_G0.6400.44
99_A176_L0.6330.43
44_R98_Y0.6320.43
223_S232_V0.6320.43
26_T32_V0.6300.43
21_V27_G0.6280.43
102_M297_W0.6260.42
199_L256_F0.6240.42
26_T33_A0.6190.42
207_L211_A0.6180.42
234_Y318_K0.6180.42
189_F208_K0.6170.42
203_T268_I0.6170.42
43_G142_I0.6160.41
21_V213_V0.6140.41
23_L188_V0.6130.41
67_A302_G0.6090.41
123_A271_W0.6050.40
28_T31_D0.6020.40
135_V138_Q0.6010.40
300_N304_V0.6010.40
296_T308_A0.6000.40
29_R296_T0.6000.40
39_G108_G0.5990.40
276_D280_L0.5960.39
136_N268_I0.5960.39
19_N34_K0.5940.39
153_E159_R0.5930.39
21_V182_L0.5890.39
76_V79_L0.5880.39
168_K171_A0.5870.39
292_G303_F0.5860.39
88_I276_D0.5810.38
101_A256_F0.5800.38
84_P232_V0.5800.38
32_V62_N0.5790.38
65_D299_R0.5790.38
142_I216_G0.5770.38
302_G305_A0.5770.38
221_P224_E0.5740.37
131_V189_F0.5720.37
91_D191_S0.5720.37
18_V33_A0.5690.37
210_S250_Y0.5690.37
111_I120_F0.5670.37
241_L254_Y0.5650.37
316_Y322_G0.5650.37
19_N22_I0.5630.36
44_R48_E0.5630.36
42_V286_A0.5630.36
64_L302_G0.5630.36
45_N311_L0.5580.36
22_I176_L0.5580.36
275_W282_R0.5580.36
99_A109_A0.5550.36
18_V24_S0.5550.36
190_D281_I0.5540.36
48_E283_E0.5520.35
159_R162_E0.5520.35
241_L251_G0.5510.35
223_S230_Y0.5510.35
111_I253_R0.5500.35
185_K219_S0.5450.35
34_K176_L0.5450.35
54_E218_R0.5430.35
299_R306_L0.5430.35
18_V22_I0.5400.34
46_A113_Y0.5390.34
220_V226_P0.5370.34
36_L85_V0.5350.34
240_K257_S0.5350.34
274_R287_L0.5340.34
102_M126_L0.5330.34
31_D68_A0.5320.34
298_V302_G0.5310.33
203_T249_G0.5300.33
173_L234_Y0.5300.33
96_K113_Y0.5290.33
114_C290_E0.5280.33
90_D130_G0.5270.33
91_D128_V0.5270.33
228_G233_E0.5270.33
74_E173_L0.5260.33
72_L75_V0.5260.33
184_V201_G0.5260.33
87_L144_I0.5250.33
226_P230_Y0.5240.33
299_R302_G0.5240.33
57_Y275_W0.5210.33
197_R251_G0.5190.32
208_K212_R0.5190.32
45_N69_Q0.5180.32
113_Y183_N0.5180.32
114_C123_A0.5160.32
78_K210_S0.5150.32
181_G207_L0.5150.32
121_E200_Q0.5140.32
180_S264_A0.5110.32
69_Q98_Y0.5110.32
29_R58_E0.5110.32
89_V175_F0.5110.32
127_L187_R0.5090.32
50_A312_L0.5090.32
114_C141_V0.5080.31
29_R33_A0.5050.31
240_K247_Y0.5040.31
225_F229_E0.5040.31
83_H156_L0.5030.31
292_G299_R0.5020.31
299_R311_L0.5000.31
91_D287_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9237 99.9 0.714 Contact Map
2kkoA 2 0.3023 15.4 0.966 Contact Map
3qfiA 1 0.2571 13.6 0.967 Contact Map
3owqA 1 0.2345 11.8 0.968 Contact Map
2j49A 1 0.2288 9.6 0.97 Contact Map
3hdeA 2 0.2797 8.3 0.97 Contact Map
1qgpA 1 0.2034 8 0.97 Contact Map
3hdfA 1 0.2684 6.5 0.972 Contact Map
1r1tA 2 0.2768 6.4 0.972 Contact Map
2zkzA 2 0.2514 6.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.