GREMLIN Database
Q7LYJ9 - Uncharacterized protein
UniProt: Q7LYJ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (278)
Sequences: 3754 (2250)
Seq/√Len: 135.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_K75_E10.0111.00
160_K163_F5.7231.00
255_Q258_Y3.6401.00
83_I87_F3.3451.00
258_Y262_S3.0051.00
41_I236_V2.9731.00
247_N250_P2.9321.00
56_E60_R2.9301.00
31_S35_E2.8711.00
236_V240_M2.7761.00
168_V236_V2.6371.00
28_G183_V2.5631.00
258_Y264_H2.5611.00
107_G272_I2.5351.00
200_S288_W2.5271.00
161_L164_T2.4051.00
246_G249_D2.3791.00
164_T240_M2.3011.00
114_N117_F2.2811.00
252_D255_Q2.2511.00
174_S177_F2.2471.00
136_E140_K2.2271.00
122_F272_I2.1951.00
108_C111_I2.1191.00
166_Q170_Y2.1131.00
67_K72_L2.0431.00
61_L72_L2.0131.00
80_R84_L1.9841.00
105_A115_P1.9751.00
246_G250_P1.9371.00
56_E221_G1.9261.00
68_G71_E1.9061.00
36_Y174_S1.8811.00
104_I122_F1.8691.00
59_G220_I1.8371.00
52_F225_L1.8361.00
218_S222_I1.8331.00
159_P164_T1.8291.00
163_F167_D1.8101.00
153_A241_I1.7971.00
87_F91_L1.7621.00
161_L165_G1.7521.00
27_L253_P1.7321.00
36_Y177_F1.7241.00
167_D170_Y1.6951.00
222_I226_L1.6951.00
14_W227_G1.6791.00
78_S81_I1.6531.00
17_L21_A1.6331.00
155_I159_P1.6321.00
6_S222_I1.6271.00
45_M232_E1.6061.00
240_M243_T1.5901.00
64_I217_T1.5881.00
140_K143_V1.5861.00
47_L188_V1.5801.00
187_A190_T1.5791.00
136_E139_E1.5621.00
108_C118_G1.5291.00
139_E143_V1.4761.00
263_V266_I1.4751.00
139_E205_K1.4741.00
190_T193_C1.4681.00
265_Y269_I1.4621.00
29_G235_I1.4521.00
162_S165_G1.4421.00
146_S277_L1.4311.00
44_V239_E1.4181.00
125_L276_F1.4171.00
139_E146_S1.4161.00
73_I85_S1.4071.00
108_C272_I1.4021.00
154_L240_M1.3901.00
165_G169_F1.3851.00
283_S287_A1.3491.00
79_T83_I1.3421.00
168_V171_F1.3381.00
113_V117_F1.3071.00
255_Q259_N1.3041.00
50_P185_V1.3011.00
19_A281_V1.2791.00
232_E236_V1.2791.00
74_R82_S1.2751.00
36_Y176_N1.2621.00
238_S243_T1.2541.00
145_I273_S1.2311.00
56_E217_T1.2281.00
20_D231_T1.2261.00
153_A157_V1.2241.00
152_S156_M1.2171.00
117_F120_I1.2161.00
101_Y123_F1.2121.00
55_Q70_G1.2041.00
194_M281_V1.1981.00
88_P93_D1.1900.99
100_E103_G1.1810.99
88_P92_V1.1790.99
57_A61_L1.1790.99
30_L253_P1.1750.99
125_L128_L1.1720.99
229_I233_L1.1720.99
231_T235_I1.1690.99
23_A275_G1.1670.99
96_T100_E1.1580.99
26_I270_T1.1560.99
137_I140_K1.1490.99
68_G203_A1.1310.99
116_L120_I1.1300.99
173_T181_I1.1270.99
32_T184_N1.1260.99
128_L132_T1.1250.99
160_K164_T1.1100.99
244_S247_N1.1020.99
65_A72_L1.0850.99
166_Q172_S1.0840.99
32_T180_F1.0610.99
25_S29_G1.0590.99
162_S166_Q1.0530.99
239_E243_T1.0500.99
100_E187_A1.0490.99
15_I281_V1.0450.99
217_T221_G1.0440.99
202_T205_K1.0390.99
22_D25_S1.0250.98
109_Y251_I1.0240.98
113_V118_G1.0150.98
111_I265_Y1.0130.98
58_S62_G1.0070.98
153_A156_M1.0000.98
254_A264_H0.9960.98
100_E278_T0.9920.98
235_I239_E0.9920.98
37_G246_G0.9920.98
102_A105_A0.9840.98
63_A213_N0.9810.98
48_S229_I0.9610.98
165_G168_V0.9400.97
159_P240_M0.9280.97
226_L229_I0.9260.97
21_A230_I0.9250.97
265_Y268_G0.9210.97
194_M198_Q0.9170.97
72_L75_E0.9170.97
238_S242_G0.9160.97
49_L53_I0.9150.97
18_L146_S0.9120.97
237_L240_M0.9030.97
35_E176_N0.9010.97
119_L123_F0.8990.97
113_V121_V0.8980.97
262_S265_Y0.8930.96
29_G238_S0.8880.96
158_G161_L0.8870.96
273_S277_L0.8870.96
51_I188_V0.8810.96
19_A195_L0.8690.96
143_V147_V0.8670.96
19_A26_I0.8660.96
139_E142_L0.8650.96
237_L244_S0.8570.95
20_D193_C0.8560.95
216_K224_T0.8540.95
101_Y118_G0.8530.95
151_L233_L0.8510.95
109_Y115_P0.8500.95
52_F229_I0.8490.95
112_G117_F0.8450.95
154_L237_L0.8410.95
124_I128_L0.8400.95
172_S177_F0.8380.95
270_T274_A0.8360.95
38_Y167_D0.8330.95
93_D286_S0.8320.95
86_I90_F0.8300.95
151_L237_L0.8270.94
19_A192_P0.8250.94
71_E203_A0.8240.94
67_K71_E0.8200.94
190_T195_L0.8190.94
15_I18_L0.8170.94
148_I152_S0.8170.94
155_I158_G0.8160.94
192_P195_L0.8150.94
67_K76_H0.8110.94
166_Q171_F0.8110.94
223_E227_G0.8100.94
55_Q190_T0.8050.94
189_V192_P0.8040.94
237_L241_I0.7990.93
55_Q192_P0.7960.93
144_V265_Y0.7950.93
136_E142_L0.7950.93
20_D25_S0.7940.93
55_Q188_V0.7930.93
13_A107_G0.7910.93
36_Y180_F0.7900.93
110_L265_Y0.7880.93
234_I238_S0.7830.93
152_S155_I0.7820.93
163_F166_Q0.7790.93
256_L270_T0.7780.92
83_I91_L0.7750.92
96_T99_S0.7750.92
103_G159_P0.7740.92
150_L253_P0.7740.92
147_V236_V0.7720.92
275_G278_T0.7670.92
51_I228_A0.7630.92
232_E235_I0.7620.92
228_A234_I0.7610.92
86_I93_D0.7570.91
151_L155_I0.7540.91
231_T237_L0.7540.91
108_C113_V0.7530.91
18_L22_D0.7530.91
220_I224_T0.7520.91
12_P223_E0.7510.91
29_G96_T0.7500.91
77_Y81_I0.7470.91
189_V271_L0.7430.91
167_D174_S0.7420.91
55_Q189_V0.7420.91
21_A277_L0.7410.91
213_N217_T0.7400.90
44_V184_N0.7370.90
117_F165_G0.7350.90
251_I254_A0.7350.90
135_Y139_E0.7340.90
142_L280_I0.7330.90
35_E148_I0.7320.90
160_K165_G0.7310.90
135_Y288_W0.7300.90
230_I234_I0.7280.90
22_D29_G0.7270.90
22_D100_E0.7270.90
25_S187_A0.7260.90
193_C199_S0.7230.89
22_D96_T0.7200.89
20_D51_I0.7160.89
45_M168_V0.7160.89
21_A29_G0.7150.89
59_G198_Q0.7140.89
214_S218_S0.7100.89
70_G196_V0.7070.88
57_A60_R0.7040.88
144_V152_S0.7040.88
251_I255_Q0.7030.88
94_F97_Y0.7020.88
235_I243_T0.7010.88
224_T228_A0.6990.88
97_Y100_E0.6980.88
237_L243_T0.6940.87
237_L247_N0.6900.87
48_S232_E0.6890.87
58_S199_S0.6880.87
40_L178_L0.6840.87
240_M244_S0.6810.86
90_F94_F0.6800.86
84_L88_P0.6800.86
193_C196_V0.6800.86
27_L99_S0.6800.86
17_L223_E0.6780.86
38_Y160_K0.6760.86
62_G199_S0.6760.86
16_A194_M0.6750.86
238_S257_L0.6750.86
232_E243_T0.6740.86
97_Y102_A0.6730.86
154_L161_L0.6710.86
192_P200_S0.6690.85
235_I238_S0.6680.85
89_I92_V0.6680.85
37_G249_D0.6680.85
237_L242_G0.6620.85
32_T44_V0.6610.85
182_A281_V0.6590.85
114_N124_I0.6570.84
124_I162_S0.6560.84
217_T220_I0.6540.84
11_G223_E0.6510.84
205_K223_E0.6490.84
107_G268_G0.6440.83
39_K43_F0.6420.83
58_S69_I0.6420.83
24_A58_S0.6370.83
54_I131_L0.6360.83
142_L146_S0.6360.83
31_S245_I0.6360.83
89_I93_D0.6330.82
30_L238_S0.6320.82
15_I194_M0.6310.82
23_A198_Q0.6310.82
60_R274_A0.6300.82
64_I203_A0.6290.82
26_I238_S0.6270.82
19_A194_M0.6270.82
190_T235_I0.6260.82
69_I199_S0.6250.81
69_I85_S0.6250.81
6_S10_F0.6250.81
37_G243_T0.6240.81
150_L157_V0.6230.81
121_V125_L0.6220.81
149_L266_I0.6190.81
25_S190_T0.6190.81
173_T177_F0.6170.81
62_G69_I0.6170.81
15_I19_A0.6150.80
166_Q169_F0.6150.80
143_V146_S0.6130.80
118_G121_V0.6100.80
63_A220_I0.6100.80
244_S249_D0.6090.80
162_S169_F0.6070.80
183_V188_V0.6070.80
212_D233_L0.6060.79
30_L122_F0.6050.79
206_Y213_N0.6040.79
136_E146_S0.6010.79
44_V241_I0.5980.79
49_L52_F0.5960.78
104_I123_F0.5960.78
238_S241_I0.5960.78
20_D194_M0.5960.78
47_L180_F0.5950.78
31_S253_P0.5950.78
216_K219_W0.5940.78
128_L200_S0.5930.78
132_T138_T0.5920.78
16_A195_L0.5910.78
279_L282_V0.5910.78
60_R217_T0.5910.78
16_A224_T0.5890.77
42_W220_I0.5890.77
233_L240_M0.5860.77
100_E193_C0.5840.77
284_L288_W0.5820.77
126_H279_L0.5820.77
20_D198_Q0.5820.77
151_L157_V0.5810.77
94_F202_T0.5800.76
80_R83_I0.5800.76
24_A206_Y0.5800.76
13_A227_G0.5780.76
253_P267_F0.5770.76
21_A150_L0.5770.76
180_F185_V0.5760.76
48_S52_F0.5760.76
69_I196_V0.5750.76
121_V124_I0.5740.76
59_G66_G0.5720.75
127_V266_I0.5720.75
175_K250_P0.5650.75
10_F14_W0.5600.74
85_S88_P0.5590.74
194_M197_Y0.5590.74
97_Y279_L0.5560.73
190_T198_Q0.5550.73
27_L31_S0.5550.73
86_I282_V0.5540.73
20_D190_T0.5540.73
197_Y201_A0.5530.73
119_L122_F0.5520.73
13_A17_L0.5510.73
236_V239_E0.5500.73
30_L188_V0.5500.73
154_L157_V0.5420.71
163_F175_K0.5420.71
124_I166_Q0.5410.71
104_I107_G0.5410.71
226_L249_D0.5400.71
38_Y139_E0.5390.71
225_L229_I0.5390.71
62_G203_A0.5390.71
91_L136_E0.5380.71
154_L241_I0.5380.71
175_K179_F0.5380.71
23_A103_G0.5380.71
26_I281_V0.5370.71
141_Y147_V0.5360.71
111_I121_V0.5350.71
16_A19_A0.5330.70
153_A259_N0.5330.70
17_L63_A0.5310.70
55_Q196_V0.5310.70
84_L87_F0.5310.70
187_A192_P0.5310.70
148_I255_Q0.5300.70
211_I214_S0.5300.70
34_E243_T0.5280.70
212_D216_K0.5280.70
201_A204_I0.5270.69
103_G275_G0.5260.69
25_S235_I0.5250.69
230_I237_L0.5230.69
10_F165_G0.5220.69
23_A99_S0.5200.68
173_T176_N0.5190.68
34_E37_G0.5190.68
48_S231_T0.5170.68
179_F185_V0.5170.68
144_V172_S0.5160.68
249_D259_N0.5160.68
212_D218_S0.5150.68
103_G107_G0.5150.68
26_I187_A0.5130.67
35_E39_K0.5130.67
117_F124_I0.5130.67
216_K220_I0.5100.67
150_L257_L0.5100.67
134_N137_I0.5090.67
156_M259_N0.5090.67
44_V48_S0.5090.67
22_D278_T0.5080.67
148_I162_S0.5060.66
100_E192_P0.5050.66
73_I77_Y0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wgvA 2 0.9384 100 0.199 Contact Map
3dh4A 3 0.9247 98.8 0.84 Contact Map
2xq2A 2 0.9281 98.3 0.865 Contact Map
3l1lA 2 0.9007 97.2 0.893 Contact Map
4djkA 2 0.8836 96.8 0.9 Contact Map
3giaA 1 0.9349 96.7 0.901 Contact Map
2jlnA 1 0.9623 96.6 0.903 Contact Map
4us3A 1 0.9521 87.7 0.93 Contact Map
2a65A 2 0.9658 84.7 0.933 Contact Map
4xp4A 1 0.9315 49.3 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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