GREMLIN Database
Q7LYJ4 - Molybdenum cofactor biosynthesis protein E (MoaE)
UniProt: Q7LYJ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (212)
Sequences: 166 (130)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_V172_M5.9271.00
63_N75_D4.4680.99
8_Y21_E4.4330.99
192_I195_V3.0590.91
121_V184_I2.8700.88
125_V130_V2.8440.88
103_F182_M2.7910.87
189_K196_K2.7750.86
172_M178_V2.6650.84
113_S183_A2.5040.80
3_K24_E2.4270.78
113_S178_V2.3140.74
121_V178_V2.1540.68
51_S80_L1.9910.62
91_G169_I1.9710.61
61_L141_Y1.9700.61
172_M184_I1.9330.59
82_P86_G1.9330.59
13_K130_V1.9290.59
201_L205_S1.9060.58
37_L77_V1.8980.58
132_E171_S1.8730.57
158_N197_E1.8660.57
166_I169_I1.8630.56
129_R215_D1.7880.53
145_R148_E1.7120.50
81_P86_G1.7060.50
34_I60_I1.6760.48
117_Y170_D1.6150.46
139_E169_I1.6130.46
202_V206_T1.5540.43
3_K22_V1.5230.42
61_L122_K1.4730.40
18_K21_E1.4670.40
153_I181_I1.4670.40
5_K20_N1.4300.38
115_V195_V1.4300.38
113_S176_E1.4240.38
76_E82_P1.4210.38
20_N147_L1.4180.38
204_H219_Y1.4040.37
9_F78_A1.4020.37
38_G69_K1.3770.36
60_I161_I1.3750.36
125_V141_Y1.3720.36
34_I80_L1.3580.35
141_Y187_G1.3550.35
94_F166_I1.3480.35
35_E163_I1.3420.34
179_L202_V1.3400.34
26_E36_Q1.3390.34
51_S102_K1.3290.34
55_G58_V1.3240.34
128_H214_R1.3160.33
92_K213_I1.3090.33
16_T51_S1.2970.33
158_N198_T1.2890.32
194_A209_W1.2790.32
5_K22_V1.2740.32
78_A200_E1.2640.32
16_T55_G1.2630.31
83_P86_G1.2540.31
20_N98_E1.2490.31
72_K89_I1.2440.31
214_R219_Y1.2300.30
29_T40_I1.2130.30
6_V60_I1.2060.29
14_D116_V1.1950.29
121_V150_K1.1850.29
16_T163_I1.1630.28
60_I148_E1.1530.28
4_V51_S1.1500.27
16_T41_Y1.1480.27
13_K51_S1.1470.27
168_V187_G1.1440.27
102_K166_I1.1420.27
149_I200_E1.1390.27
179_L206_T1.1390.27
181_I195_V1.1380.27
9_F138_Y1.1330.27
6_V169_I1.1320.27
74_G77_V1.1300.27
103_F164_E1.1300.27
115_V191_A1.1030.26
93_K162_E1.1000.26
121_V173_K1.0980.26
3_K34_I1.0910.25
120_F200_E1.0890.25
77_V127_N1.0850.25
146_F165_I1.0810.25
122_K187_G1.0810.25
125_V202_V1.0790.25
84_S183_A1.0750.25
181_I199_L1.0680.25
149_I198_T1.0630.25
99_E150_K1.0630.25
91_G139_E1.0600.24
39_K144_K1.0550.24
24_E185_G1.0360.24
82_P85_G1.0330.24
148_E205_S1.0310.24
16_T25_T1.0280.23
78_A83_P1.0240.23
140_E200_E1.0200.23
39_K151_D1.0130.23
72_K174_P1.0130.23
117_Y207_G1.0000.23
153_I174_P0.9990.23
122_K141_Y0.9980.22
24_E28_E0.9900.22
129_R151_D0.9860.22
150_K163_I0.9860.22
56_I98_E0.9750.22
7_L146_F0.9720.22
4_V22_V0.9650.22
40_I47_N0.9570.21
63_N66_A0.9540.21
84_S133_L0.9520.21
143_R146_F0.9510.21
62_V65_S0.9420.21
78_A138_Y0.9420.21
75_D212_E0.9410.21
52_G70_N0.9360.21
128_H219_Y0.9350.21
214_R223_A0.9330.21
13_K71_I0.9330.21
170_D207_G0.9260.20
4_V77_V0.9090.20
172_M192_I0.9070.20
35_E116_V0.9070.20
46_V186_K0.9060.20
68_T151_D0.9000.20
135_Y208_I0.8980.20
169_I178_V0.8980.20
125_V208_I0.8970.20
89_I177_N0.8970.20
89_I143_R0.8940.20
185_G195_V0.8940.20
6_V77_V0.8860.19
38_G60_I0.8800.19
71_I213_I0.8790.19
174_P221_V0.8700.19
89_I169_I0.8700.19
49_L201_L0.8700.19
133_L149_I0.8690.19
165_I198_T0.8680.19
122_K125_V0.8660.19
95_D214_R0.8650.19
81_P84_S0.8610.19
74_G175_G0.8580.19
29_T146_F0.8550.18
99_E151_D0.8520.18
99_E164_E0.8520.18
24_E36_Q0.8510.18
18_K70_N0.8480.18
73_D171_S0.8440.18
75_D134_K0.8420.18
153_I198_T0.8410.18
76_E220_W0.8330.18
168_V199_L0.8310.18
160_L180_L0.8300.18
148_E211_L0.8290.18
14_D190_D0.8270.18
49_L137_A0.8250.18
51_S192_I0.8230.18
14_D211_L0.8210.18
35_E69_K0.8180.18
187_G209_W0.8170.17
63_N212_E0.8120.17
8_Y48_F0.8120.17
90_I148_E0.8110.17
72_K218_E0.8100.17
15_I63_N0.8100.17
121_V195_V0.8080.17
8_Y113_S0.8040.17
115_V192_I0.8010.17
37_L163_I0.8000.17
150_K172_M0.7930.17
22_V144_K0.7930.17
6_V23_L0.7930.17
99_E182_M0.7900.17
178_V185_G0.7860.17
111_A130_V0.7840.17
175_G212_E0.7840.17
24_E39_K0.7820.17
13_K23_L0.7810.17
138_Y220_W0.7770.17
23_L42_G0.7760.16
154_K160_L0.7730.16
113_S117_Y0.7700.16
4_V62_V0.7690.16
73_D151_D0.7660.16
50_K77_V0.7630.16
73_D144_K0.7630.16
199_L202_V0.7590.16
121_V192_I0.7570.16
27_C175_G0.7540.16
172_M195_V0.7540.16
33_F144_K0.7520.16
6_V74_G0.7510.16
168_V179_L0.7440.16
100_I116_V0.7440.16
202_V214_R0.7440.16
212_E216_D0.7390.16
29_T34_I0.7360.16
204_H215_D0.7350.16
115_V130_V0.7330.15
68_T101_R0.7310.15
6_V163_I0.7300.15
208_I221_V0.7290.15
92_K132_E0.7290.15
77_V159_D0.7260.15
201_L204_H0.7250.15
122_K209_W0.7230.15
166_I219_Y0.7210.15
9_F83_P0.7140.15
38_G121_V0.7110.15
147_L151_D0.7100.15
111_A120_F0.7080.15
62_V73_D0.7070.15
3_K27_C0.7050.15
123_G130_V0.7020.15
15_I148_E0.6940.15
59_S183_A0.6930.15
47_N64_G0.6930.15
60_I72_K0.6900.15
9_F220_W0.6880.15
3_K20_N0.6880.15
69_K193_D0.6870.14
74_G216_D0.6840.14
98_E102_K0.6830.14
12_I37_L0.6750.14
33_F193_D0.6700.14
187_G199_L0.6700.14
18_K41_Y0.6650.14
113_S170_D0.6610.14
11_F58_V0.6610.14
68_T92_K0.6480.14
88_L215_D0.6400.14
94_F132_E0.6400.14
181_I206_T0.6390.13
19_S92_K0.6370.13
164_E222_V0.6350.13
130_V214_R0.6340.13
151_D155_K0.6330.13
94_F99_E0.6310.13
77_V175_G0.6300.13
9_F76_E0.6260.13
68_T93_K0.6260.13
66_A207_G0.6250.13
129_R198_T0.6240.13
200_E204_H0.6200.13
24_E101_R0.6150.13
150_K176_E0.6140.13
103_F222_V0.6140.13
22_V97_L0.6110.13
28_E92_K0.6090.13
199_L209_W0.6080.13
4_V101_R0.6060.13
50_K68_T0.6010.13
79_L125_V0.6000.13
218_E224_G0.5990.13
134_K216_D0.5980.13
180_L222_V0.5980.13
9_F168_V0.5940.13
61_L125_V0.5930.13
108_P184_I0.5880.12
8_Y123_G0.5850.12
195_V199_L0.5830.12
14_D102_K0.5820.12
109_P190_D0.5820.12
131_F214_R0.5780.12
62_V71_I0.5760.12
126_D146_F0.5740.12
14_D58_V0.5730.12
14_D93_K0.5730.12
83_P168_V0.5710.12
61_L187_G0.5710.12
47_N94_F0.5710.12
26_E73_D0.5690.12
6_V36_Q0.5670.12
99_E223_A0.5660.12
11_F200_E0.5660.12
27_C190_D0.5660.12
24_E63_N0.5600.12
178_V187_G0.5590.12
28_E72_K0.5580.12
13_K125_V0.5500.12
51_S166_I0.5490.12
116_V177_N0.5440.12
178_V184_I0.5410.12
168_V193_D0.5370.12
25_T36_Q0.5360.12
175_G217_G0.5330.11
79_L108_P0.5320.11
63_N220_W0.5290.11
77_V121_V0.5250.11
178_V199_L0.5230.11
150_K154_K0.5230.11
6_V191_A0.5210.11
130_V159_D0.5210.11
20_N193_D0.5190.11
33_F92_K0.5190.11
163_I183_A0.5160.11
116_V151_D0.5160.11
11_F123_G0.5140.11
118_V146_F0.5120.11
138_Y168_V0.5100.11
84_S114_L0.5100.11
113_S172_M0.5080.11
12_I86_G0.5060.11
112_G188_R0.5010.11
112_G203_K0.5010.11
188_R203_K0.5010.11
119_G188_R0.5010.11
112_G119_G0.5010.11
119_G203_K0.5010.11
36_Q40_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wp4A 2 0.5584 100 0.443 Contact Map
2omdA 2 0.6147 100 0.478 Contact Map
2q5wE 2 0.5931 100 0.489 Contact Map
1fm0E 2 0.5974 100 0.502 Contact Map
4ap8A 2 0.5844 100 0.526 Contact Map
3rpfA 2 0.6104 100 0.545 Contact Map
2qjlA 1 0.3463 99.7 0.791 Contact Map
1vjkA 1 0.3333 99.7 0.793 Contact Map
1wgkA 1 0.3723 99.7 0.796 Contact Map
2k9xA 1 0.342 99.7 0.799 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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