Q7LYJ4 - SULSO - GREMLIN Contacts

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Q7LYJ4 - Molybdenum cofactor biosynthesis protein E (MoaE)

UniProt:	Q7LYJ4	Sequences: MKKVKVLYFAFIKDITHKSNEVLETECETVDCFIEQLGKIYGSELVNFLKSGINGIKVSILVNGSASTKNIKDGDEVALLPPPSGGDLIIGKKFDLLEEIRKFREKAPPEAGSLVVYVGFVKGIVDNHRVFELKYEAYEEYTRKRFLEIKDEIKKKYNDLIEIEIIHVIDSMKPGENVLLIMAIGKGRKDAIDAVKETLELVKHSTGIWKLEIRDDGEYWVVAGNTRVKKQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	231 (212)
Sequences:	166 (130)
Seq/√Len:	8.9

ECOLI - MOAE
BACSU - MOAE
SULSO - Q7LYJ4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
121_V	172_M	5.927	1.00
63_N	75_D	4.468	0.99
8_Y	21_E	4.433	0.99
192_I	195_V	3.059	0.91
121_V	184_I	2.870	0.88
125_V	130_V	2.844	0.88
103_F	182_M	2.791	0.87
189_K	196_K	2.775	0.86
172_M	178_V	2.665	0.84
113_S	183_A	2.504	0.80
3_K	24_E	2.427	0.78
113_S	178_V	2.314	0.74
121_V	178_V	2.154	0.68
51_S	80_L	1.991	0.62
91_G	169_I	1.971	0.61
61_L	141_Y	1.970	0.61
172_M	184_I	1.933	0.59
82_P	86_G	1.933	0.59
13_K	130_V	1.929	0.59
201_L	205_S	1.906	0.58
37_L	77_V	1.898	0.58
132_E	171_S	1.873	0.57
158_N	197_E	1.866	0.57
166_I	169_I	1.863	0.56
129_R	215_D	1.788	0.53
145_R	148_E	1.712	0.50
81_P	86_G	1.706	0.50
34_I	60_I	1.676	0.48
117_Y	170_D	1.615	0.46
139_E	169_I	1.613	0.46
202_V	206_T	1.554	0.43
3_K	22_V	1.523	0.42
61_L	122_K	1.473	0.40
18_K	21_E	1.467	0.40
153_I	181_I	1.467	0.40
5_K	20_N	1.430	0.38
115_V	195_V	1.430	0.38
113_S	176_E	1.424	0.38
76_E	82_P	1.421	0.38
20_N	147_L	1.418	0.38
204_H	219_Y	1.404	0.37
9_F	78_A	1.402	0.37
38_G	69_K	1.377	0.36
60_I	161_I	1.375	0.36
125_V	141_Y	1.372	0.36
34_I	80_L	1.358	0.35
141_Y	187_G	1.355	0.35
94_F	166_I	1.348	0.35
35_E	163_I	1.342	0.34
179_L	202_V	1.340	0.34
26_E	36_Q	1.339	0.34
51_S	102_K	1.329	0.34
55_G	58_V	1.324	0.34
128_H	214_R	1.316	0.33
92_K	213_I	1.309	0.33
16_T	51_S	1.297	0.33
158_N	198_T	1.289	0.32
194_A	209_W	1.279	0.32
5_K	22_V	1.274	0.32
78_A	200_E	1.264	0.32
16_T	55_G	1.263	0.31
83_P	86_G	1.254	0.31
20_N	98_E	1.249	0.31
72_K	89_I	1.244	0.31
214_R	219_Y	1.230	0.30
29_T	40_I	1.213	0.30
6_V	60_I	1.206	0.29
14_D	116_V	1.195	0.29
121_V	150_K	1.185	0.29
16_T	163_I	1.163	0.28
60_I	148_E	1.153	0.28
4_V	51_S	1.150	0.27
16_T	41_Y	1.148	0.27
13_K	51_S	1.147	0.27
168_V	187_G	1.144	0.27
102_K	166_I	1.142	0.27
149_I	200_E	1.139	0.27
179_L	206_T	1.139	0.27
181_I	195_V	1.138	0.27
9_F	138_Y	1.133	0.27
6_V	169_I	1.132	0.27
74_G	77_V	1.130	0.27
103_F	164_E	1.130	0.27
115_V	191_A	1.103	0.26
93_K	162_E	1.100	0.26
121_V	173_K	1.098	0.26
3_K	34_I	1.091	0.25
120_F	200_E	1.089	0.25
77_V	127_N	1.085	0.25
146_F	165_I	1.081	0.25
122_K	187_G	1.081	0.25
125_V	202_V	1.079	0.25
84_S	183_A	1.075	0.25
181_I	199_L	1.068	0.25
149_I	198_T	1.063	0.25
99_E	150_K	1.063	0.25
91_G	139_E	1.060	0.24
39_K	144_K	1.055	0.24
24_E	185_G	1.036	0.24
82_P	85_G	1.033	0.24
148_E	205_S	1.031	0.24
16_T	25_T	1.028	0.23
78_A	83_P	1.024	0.23
140_E	200_E	1.020	0.23
39_K	151_D	1.013	0.23
72_K	174_P	1.013	0.23
117_Y	207_G	1.000	0.23
153_I	174_P	0.999	0.23
122_K	141_Y	0.998	0.22
24_E	28_E	0.990	0.22
129_R	151_D	0.986	0.22
150_K	163_I	0.986	0.22
56_I	98_E	0.975	0.22
7_L	146_F	0.972	0.22
4_V	22_V	0.965	0.22
40_I	47_N	0.957	0.21
63_N	66_A	0.954	0.21
84_S	133_L	0.952	0.21
143_R	146_F	0.951	0.21
62_V	65_S	0.942	0.21
78_A	138_Y	0.942	0.21
75_D	212_E	0.941	0.21
52_G	70_N	0.936	0.21
128_H	219_Y	0.935	0.21
214_R	223_A	0.933	0.21
13_K	71_I	0.933	0.21
170_D	207_G	0.926	0.20
4_V	77_V	0.909	0.20
172_M	192_I	0.907	0.20
35_E	116_V	0.907	0.20
46_V	186_K	0.906	0.20
68_T	151_D	0.900	0.20
135_Y	208_I	0.898	0.20
169_I	178_V	0.898	0.20
125_V	208_I	0.897	0.20
89_I	177_N	0.897	0.20
89_I	143_R	0.894	0.20
185_G	195_V	0.894	0.20
6_V	77_V	0.886	0.19
38_G	60_I	0.880	0.19
71_I	213_I	0.879	0.19
174_P	221_V	0.870	0.19
89_I	169_I	0.870	0.19
49_L	201_L	0.870	0.19
133_L	149_I	0.869	0.19
165_I	198_T	0.868	0.19
122_K	125_V	0.866	0.19
95_D	214_R	0.865	0.19
81_P	84_S	0.861	0.19
74_G	175_G	0.858	0.19
29_T	146_F	0.855	0.18
99_E	151_D	0.852	0.18
99_E	164_E	0.852	0.18
24_E	36_Q	0.851	0.18
18_K	70_N	0.848	0.18
73_D	171_S	0.844	0.18
75_D	134_K	0.842	0.18
153_I	198_T	0.841	0.18
76_E	220_W	0.833	0.18
168_V	199_L	0.831	0.18
160_L	180_L	0.830	0.18
148_E	211_L	0.829	0.18
14_D	190_D	0.827	0.18
49_L	137_A	0.825	0.18
51_S	192_I	0.823	0.18
14_D	211_L	0.821	0.18
35_E	69_K	0.818	0.18
187_G	209_W	0.817	0.17
63_N	212_E	0.812	0.17
8_Y	48_F	0.812	0.17
90_I	148_E	0.811	0.17
72_K	218_E	0.810	0.17
15_I	63_N	0.810	0.17
121_V	195_V	0.808	0.17
8_Y	113_S	0.804	0.17
115_V	192_I	0.801	0.17
37_L	163_I	0.800	0.17
150_K	172_M	0.793	0.17
22_V	144_K	0.793	0.17
6_V	23_L	0.793	0.17
99_E	182_M	0.790	0.17
178_V	185_G	0.786	0.17
111_A	130_V	0.784	0.17
175_G	212_E	0.784	0.17
24_E	39_K	0.782	0.17
13_K	23_L	0.781	0.17
138_Y	220_W	0.777	0.17
23_L	42_G	0.776	0.16
154_K	160_L	0.773	0.16
113_S	117_Y	0.770	0.16
4_V	62_V	0.769	0.16
73_D	151_D	0.766	0.16
50_K	77_V	0.763	0.16
73_D	144_K	0.763	0.16
199_L	202_V	0.759	0.16
121_V	192_I	0.757	0.16
27_C	175_G	0.754	0.16
172_M	195_V	0.754	0.16
33_F	144_K	0.752	0.16
6_V	74_G	0.751	0.16
168_V	179_L	0.744	0.16
100_I	116_V	0.744	0.16
202_V	214_R	0.744	0.16
212_E	216_D	0.739	0.16
29_T	34_I	0.736	0.16
204_H	215_D	0.735	0.16
115_V	130_V	0.733	0.15
68_T	101_R	0.731	0.15
6_V	163_I	0.730	0.15
208_I	221_V	0.729	0.15
92_K	132_E	0.729	0.15
77_V	159_D	0.726	0.15
201_L	204_H	0.725	0.15
122_K	209_W	0.723	0.15
166_I	219_Y	0.721	0.15
9_F	83_P	0.714	0.15
38_G	121_V	0.711	0.15
147_L	151_D	0.710	0.15
111_A	120_F	0.708	0.15
62_V	73_D	0.707	0.15
3_K	27_C	0.705	0.15
123_G	130_V	0.702	0.15
15_I	148_E	0.694	0.15
59_S	183_A	0.693	0.15
47_N	64_G	0.693	0.15
60_I	72_K	0.690	0.15
9_F	220_W	0.688	0.15
3_K	20_N	0.688	0.15
69_K	193_D	0.687	0.14
74_G	216_D	0.684	0.14
98_E	102_K	0.683	0.14
12_I	37_L	0.675	0.14
33_F	193_D	0.670	0.14
187_G	199_L	0.670	0.14
18_K	41_Y	0.665	0.14
113_S	170_D	0.661	0.14
11_F	58_V	0.661	0.14
68_T	92_K	0.648	0.14
88_L	215_D	0.640	0.14
94_F	132_E	0.640	0.14
181_I	206_T	0.639	0.13
19_S	92_K	0.637	0.13
164_E	222_V	0.635	0.13
130_V	214_R	0.634	0.13
151_D	155_K	0.633	0.13
94_F	99_E	0.631	0.13
77_V	175_G	0.630	0.13
9_F	76_E	0.626	0.13
68_T	93_K	0.626	0.13
66_A	207_G	0.625	0.13
129_R	198_T	0.624	0.13
200_E	204_H	0.620	0.13
24_E	101_R	0.615	0.13
150_K	176_E	0.614	0.13
103_F	222_V	0.614	0.13
22_V	97_L	0.611	0.13
28_E	92_K	0.609	0.13
199_L	209_W	0.608	0.13
4_V	101_R	0.606	0.13
50_K	68_T	0.601	0.13
79_L	125_V	0.600	0.13
218_E	224_G	0.599	0.13
134_K	216_D	0.598	0.13
180_L	222_V	0.598	0.13
9_F	168_V	0.594	0.13
61_L	125_V	0.593	0.13
108_P	184_I	0.588	0.12
8_Y	123_G	0.585	0.12
195_V	199_L	0.583	0.12
14_D	102_K	0.582	0.12
109_P	190_D	0.582	0.12
131_F	214_R	0.578	0.12
62_V	71_I	0.576	0.12
126_D	146_F	0.574	0.12
14_D	58_V	0.573	0.12
14_D	93_K	0.573	0.12
83_P	168_V	0.571	0.12
61_L	187_G	0.571	0.12
47_N	94_F	0.571	0.12
26_E	73_D	0.569	0.12
6_V	36_Q	0.567	0.12
99_E	223_A	0.566	0.12
11_F	200_E	0.566	0.12
27_C	190_D	0.566	0.12
24_E	63_N	0.560	0.12
178_V	187_G	0.559	0.12
28_E	72_K	0.558	0.12
13_K	125_V	0.550	0.12
51_S	166_I	0.549	0.12
116_V	177_N	0.544	0.12
178_V	184_I	0.541	0.12
168_V	193_D	0.537	0.12
25_T	36_Q	0.536	0.12
175_G	217_G	0.533	0.11
79_L	108_P	0.532	0.11
63_N	220_W	0.529	0.11
77_V	121_V	0.525	0.11
178_V	199_L	0.523	0.11
150_K	154_K	0.523	0.11
6_V	191_A	0.521	0.11
130_V	159_D	0.521	0.11
20_N	193_D	0.519	0.11
33_F	92_K	0.519	0.11
163_I	183_A	0.516	0.11
116_V	151_D	0.516	0.11
11_F	123_G	0.514	0.11
118_V	146_F	0.512	0.11
138_Y	168_V	0.510	0.11
84_S	114_L	0.510	0.11
113_S	172_M	0.508	0.11
12_I	86_G	0.506	0.11
112_G	188_R	0.501	0.11
112_G	203_K	0.501	0.11
188_R	203_K	0.501	0.11
119_G	188_R	0.501	0.11
112_G	119_G	0.501	0.11
119_G	203_K	0.501	0.11
36_Q	40_I	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wp4A	2	0.5584	100	0.443	Contact Map
2omdA	2	0.6147	100	0.478	Contact Map
2q5wE	2	0.5931	100	0.489	Contact Map
1fm0E	2	0.5974	100	0.502	Contact Map
4ap8A	2	0.5844	100	0.526	Contact Map
3rpfA	2	0.6104	100	0.545	Contact Map
2qjlA	1	0.3463	99.7	0.791	Contact Map
1vjkA	1	0.3333	99.7	0.793	Contact Map
1wgkA	1	0.3723	99.7	0.796	Contact Map
2k9xA	1	0.342	99.7	0.799	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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