GREMLIN Database
GLCD1 - Glucose 1-dehydrogenase 1
UniProt: Q7LYI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (298)
Sequences: 51533 (34984)
Seq/√Len: 2026.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_I143_E3.1171.00
32_R73_E3.0771.00
34_I71_V3.0051.00
343_D346_E2.8761.00
30_K73_E2.7001.00
7_K16_K2.6541.00
80_S83_D2.5981.00
84_L138_I2.5291.00
83_D137_K2.4541.00
29_I135_L2.4091.00
20_E127_W2.4061.00
189_T209_M2.3901.00
183_K206_E2.3691.00
179_L182_R2.3471.00
201_R229_N2.3381.00
32_R71_V2.2961.00
339_V350_V2.2931.00
144_D338_T2.2921.00
68_A123_F2.2801.00
32_R127_W2.2501.00
7_K14_Q2.2471.00
184_V200_F2.2381.00
5_I16_K2.1781.00
337_K350_V2.1781.00
338_T364_L2.1621.00
239_K242_D2.1441.00
25_S28_K2.1361.00
220_Q224_E2.0921.00
160_E203_Y2.0811.00
68_A87_P2.0791.00
78_G132_P2.0681.00
221_T225_E2.0611.00
197_T228_T2.0601.00
30_K129_Y2.0091.00
141_S321_A1.9971.00
73_E127_W1.9831.00
47_N352_R1.9821.00
318_V322_S1.9621.00
349_K353_E1.9121.00
69_I143_E1.8871.00
202_T324_K1.8771.00
340_S343_D1.8661.00
152_L195_L1.8511.00
84_L143_E1.8391.00
185_L210_A1.8071.00
160_E315_Q1.8061.00
273_V301_T1.8021.00
27_G75_S1.7921.00
221_T224_E1.7841.00
220_Q231_Y1.7791.00
350_V355_E1.7741.00
26_Y75_S1.7721.00
248_D269_G1.7701.00
185_L247_F1.7421.00
208_W247_F1.7241.00
138_I143_E1.7101.00
346_E349_K1.6861.00
211_N220_Q1.6661.00
346_E350_V1.6491.00
273_V303_I1.6321.00
222_V225_E1.6301.00
4_I344_E1.6051.00
71_V84_L1.6041.00
22_K74_E1.5981.00
74_E81_Q1.5981.00
339_V347_L1.5861.00
187_V264_V1.5831.00
30_K127_W1.5811.00
124_M348_L1.5501.00
268_L274_L1.5271.00
79_F83_D1.5201.00
212_R234_S1.5181.00
345_K349_K1.5161.00
230_Y243_S1.4951.00
79_F137_K1.4861.00
250_I268_L1.4831.00
33_T68_A1.4741.00
24_D129_Y1.4711.00
268_L272_G1.4701.00
236_G239_K1.4691.00
27_G131_D1.4641.00
30_K74_E1.4601.00
28_K131_D1.4561.00
268_L300_K1.4441.00
138_I146_G1.4211.00
182_R273_V1.4151.00
28_K129_Y1.4041.00
144_D364_L1.3951.00
84_L140_K1.3851.00
29_I79_F1.3821.00
336_T350_V1.3791.00
250_I264_V1.3771.00
35_Y144_D1.3761.00
24_D30_K1.3731.00
206_E230_Y1.3671.00
202_T319_H1.3551.00
213_R218_V1.3501.00
206_E229_N1.3491.00
183_K208_W1.3381.00
318_V321_A1.3321.00
3_A18_V1.3291.00
71_V143_E1.3241.00
187_V210_A1.3121.00
196_F251_I1.2881.00
4_I15_V1.2871.00
46_V348_L1.2861.00
72_V79_F1.2821.00
34_I84_L1.2721.00
197_T209_M1.2481.00
9_P12_G1.2311.00
33_T128_W1.2201.00
156_E160_E1.2181.00
20_E30_K1.2171.00
238_D242_D1.2021.00
340_S364_L1.1761.00
27_G132_P1.1691.00
266_P294_E1.1501.00
224_E231_Y1.1461.00
310_K314_Q1.1451.00
183_K248_D1.1441.00
319_H324_K1.1391.00
79_F135_L1.1351.00
220_Q233_S1.1251.00
182_R248_D1.1231.00
315_Q318_V1.1181.00
35_Y364_L1.1171.00
5_I18_V1.1141.00
130_D135_L1.1111.00
225_E333_M1.1071.00
165_V205_L1.1041.00
239_K243_S1.0941.00
326_L333_M1.0931.00
198_L326_L1.0811.00
157_K312_H1.0791.00
73_E81_Q1.0641.00
222_V358_E1.0631.00
254_T260_I1.0601.00
31_I85_V1.0571.00
31_I70_G1.0541.00
155_I196_F1.0541.00
160_E312_H1.0501.00
208_W230_Y1.0431.00
35_Y143_E1.0421.00
46_V352_R1.0381.00
38_I347_L1.0371.00
200_F205_L1.0361.00
24_D28_K1.0231.00
156_E315_Q1.0201.00
15_V342_N1.0201.00
4_I341_I1.0191.00
36_N124_M1.0131.00
237_Y241_K1.0051.00
344_E363_I1.0021.00
314_Q318_V0.9871.00
76_Y132_P0.9851.00
163_L249_V0.9801.00
339_V343_D0.9751.00
349_K352_R0.9741.00
213_R233_S0.9691.00
224_E230_Y0.9631.00
152_L316_A0.9621.00
263_N266_P0.9561.00
315_Q319_H0.9511.00
155_I199_L0.9511.00
189_T211_N0.9491.00
158_S277_F0.9481.00
209_M223_I0.9451.00
235_N239_K0.9441.00
350_V361_I0.9441.00
189_T223_I0.9411.00
209_M228_T0.9381.00
35_Y362_R0.9371.00
43_R351_L0.9331.00
182_R249_V0.9311.00
219_E358_E0.9291.00
158_S251_I0.9261.00
164_E179_L0.9241.00
262_G266_P0.9201.00
124_M344_E0.9161.00
197_T207_V0.9141.00
237_Y263_N0.9141.00
237_Y266_P0.9061.00
189_T197_T0.9061.00
145_I326_L0.8951.00
208_W232_N0.8951.00
34_I69_I0.8941.00
252_D255_G0.8941.00
36_N123_F0.8921.00
86_M317_V0.8911.00
39_C67_E0.8871.00
194_V222_V0.8871.00
185_L267_L0.8851.00
142_I146_G0.8801.00
294_E298_T0.8701.00
295_I302_I0.8671.00
311_P315_Q0.8651.00
20_E74_E0.8641.00
20_E73_E0.8641.00
186_V200_F0.8641.00
5_I63_V0.8601.00
271_N299_N0.8571.00
213_R219_E0.8571.00
18_V121_D0.8571.00
32_R126_E0.8561.00
212_R220_Q0.8531.00
187_V250_I0.8501.00
77_H132_P0.8481.00
3_A63_V0.8441.00
62_L121_D0.8441.00
7_K12_G0.8441.00
211_N231_Y0.8411.00
186_V196_F0.8371.00
4_I13_V0.8361.00
210_A234_S0.8271.00
218_V221_T0.8221.00
250_I274_L0.8181.00
124_M363_I0.8131.00
148_L320_L0.8121.00
153_A312_H0.8101.00
199_L316_A0.8061.00
311_P314_Q0.8031.00
37_G67_E0.8031.00
319_H322_S0.8021.00
290_K294_E0.8021.00
38_I351_L0.7971.00
183_K247_F0.7961.00
203_Y315_Q0.7961.00
136_V314_Q0.7941.00
159_I200_F0.7931.00
68_A128_W0.7901.00
29_I132_P0.7891.00
223_I228_T0.7891.00
264_V274_L0.7881.00
39_C66_H0.7821.00
25_S129_Y0.7801.00
80_S137_K0.7781.00
200_F207_V0.7701.00
140_K321_A0.7651.00
253_A277_F0.7621.00
123_F128_W0.7601.00
155_I195_L0.7601.00
22_K30_K0.7601.00
184_V205_L0.7561.00
18_V63_V0.7551.00
339_V361_I0.7541.00
15_V341_I0.7541.00
240_L247_F0.7521.00
337_K346_E0.7481.00
211_N223_I0.7471.00
187_V260_I0.7401.00
199_L319_H0.7321.00
335_I338_T0.7281.00
39_C42_D0.7231.00
41_T66_H0.7211.00
205_L249_V0.7181.00
208_W243_S0.7151.00
24_D74_E0.7151.00
230_Y233_S0.7111.00
350_V353_E0.7081.00
295_I304_G0.7071.00
158_S196_F0.7061.00
207_V229_N0.7061.00
213_R220_Q0.7031.00
317_V321_A0.6991.00
43_R352_R0.6961.00
276_L302_I0.6941.00
237_Y267_L0.6931.00
295_I300_K0.6851.00
85_V135_L0.6841.00
249_V275_G0.6841.00
156_E319_H0.6831.00
222_V226_T0.6831.00
142_I320_L0.6821.00
78_G310_K0.6811.00
357_G361_I0.6801.00
139_P321_A0.6771.00
157_K299_N0.6761.00
351_L361_I0.6741.00
155_I192_I0.6741.00
4_I345_K0.6721.00
136_V313_F0.6701.00
252_D274_L0.6701.00
59_K62_L0.6681.00
241_K244_V0.6681.00
186_V209_M0.6651.00
337_K361_I0.6641.00
29_I72_V0.6641.00
247_F250_I0.6621.00
241_K246_K0.6611.00
284_S288_D0.6601.00
87_P130_D0.6601.00
83_D140_K0.6581.00
86_M138_I0.6581.00
162_I249_V0.6581.00
156_E316_A0.6561.00
160_E199_L0.6561.00
319_H323_W0.6551.00
69_I147_I0.6541.00
256_A260_I0.6521.00
10_N349_K0.6521.00
163_L275_G0.6511.00
261_L274_L0.6491.00
294_E297_H0.6451.00
299_N309_Q0.6451.00
33_T36_N0.6431.00
154_D192_I0.6431.00
69_I138_I0.6421.00
27_G133_K0.6421.00
39_C151_P0.6411.00
270_R298_T0.6401.00
44_E49_K0.6391.00
225_E326_L0.6381.00
198_L226_T0.6361.00
155_I159_I0.6351.00
262_G294_E0.6341.00
66_H150_Q0.6331.00
21_K129_Y0.6321.00
132_P135_L0.6301.00
262_G284_S0.6291.00
35_Y69_I0.6281.00
11_A349_K0.6251.00
220_Q223_I0.6231.00
67_E150_Q0.6221.00
161_E312_H0.6221.00
58_G62_L0.6211.00
163_L179_L0.6201.00
312_H315_Q0.6191.00
69_I84_L0.6161.00
165_V249_V0.6161.00
238_D241_K0.6141.00
180_N204_G0.6141.00
6_V12_G0.6141.00
339_V363_I0.6141.00
257_D262_G0.6131.00
350_V357_G0.6131.00
39_C150_Q0.6131.00
211_N233_S0.6111.00
34_I364_L0.6111.00
181_C206_E0.6111.00
194_V334_L0.6111.00
197_T226_T0.6111.00
158_S275_G0.6101.00
41_T45_I0.6081.00
208_W240_L0.6071.00
35_Y338_T0.6061.00
84_L141_S0.6051.00
151_P195_L0.6021.00
156_E312_H0.6021.00
165_V182_R0.6001.00
163_L273_V0.5991.00
196_F277_F0.5991.00
157_K161_E0.5981.00
222_V334_L0.5971.00
249_V273_V0.5971.00
231_Y234_S0.5951.00
136_V317_V0.5881.00
184_V249_V0.5861.00
288_D294_E0.5861.00
283_G288_D0.5851.00
294_E300_K0.5841.00
151_P191_P0.5831.00
201_R207_V0.5821.00
78_G81_Q0.5811.00
31_I135_L0.5801.00
247_F267_L0.5781.00
65_G124_M0.5781.00
45_I50_L0.5781.00
43_R47_N0.5761.00
185_L250_I0.5701.00
136_V310_K0.5691.00
150_Q154_D0.5681.00
161_E301_T0.5671.00
36_N363_I0.5671.00
27_G76_Y0.5651.00
199_L203_Y0.5611.00
183_K244_V0.5611.00
211_N234_S0.5581.00
87_P135_L0.5571.00
262_G288_D0.5571.00
131_D134_Y0.5551.00
88_V136_V0.5551.00
38_I124_M0.5551.00
313_F317_V0.5551.00
348_L352_R0.5551.00
40_G44_E0.5551.00
77_H80_S0.5541.00
31_I87_P0.5501.00
79_F132_P0.5501.00
154_D277_F0.5501.00
159_I199_L0.5471.00
41_T44_E0.5441.00
165_V179_L0.5441.00
21_K127_W0.5421.00
39_C360_K0.5411.00
211_N219_E0.5401.00
305_L308_G0.5391.00
337_K358_E0.5391.00
19_D22_K0.5381.00
300_K304_G0.5381.00
228_T231_Y0.5381.00
212_R233_S0.5371.00
21_K28_K0.5361.00
180_N203_Y0.5341.00
197_T223_I0.5301.00
12_G345_K0.5291.00
262_G286_P0.5291.00
186_V197_T0.5291.00
337_K343_D0.5291.00
347_L363_I0.5291.00
13_V348_L0.5271.00
162_I275_G0.5261.00
194_V226_T0.5251.00
21_K30_K0.5231.00
201_R228_T0.5231.00
250_I267_L0.5221.00
240_L244_V0.5221.00
78_G137_K0.5221.00
223_I231_Y0.5211.00
162_I303_I0.5211.00
69_I146_G0.5201.00
229_N232_N0.5201.00
336_T359_I0.5191.00
163_L182_R0.5181.00
195_L199_L0.5181.00
38_I363_I0.5171.00
240_L243_S0.5161.00
198_L325_T0.5161.00
314_Q317_V0.5121.00
137_K140_K0.5111.00
323_W326_L0.5111.00
232_N236_G0.5091.00
143_E146_G0.5091.00
159_I196_F0.5091.00
20_E129_Y0.5091.00
37_G147_I0.5081.00
87_P123_F0.5081.00
183_K230_Y0.5081.00
305_L309_Q0.5071.00
240_L267_L0.5071.00
28_K120_M0.5041.00
285_V289_Y0.5041.00
219_E355_E0.5031.00
358_E361_I0.5031.00
183_K246_K0.5021.00
151_P360_K0.5011.00
158_S305_L0.5011.00
40_G190_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cdcA 3 0.9617 100 0.196 Contact Map
1vj0A 4 0.9071 100 0.21 Contact Map
4gi2A 2 0.9126 100 0.214 Contact Map
1h2bA 4 0.9016 100 0.215 Contact Map
4ilkA 2 0.8934 100 0.218 Contact Map
4ej6A 1 0.8934 100 0.219 Contact Map
4cpdA 2 0.8989 100 0.221 Contact Map
2b5wA 2 0.9262 100 0.222 Contact Map
1cdoA 2 0.9071 100 0.226 Contact Map
3widA 4 0.959 100 0.226 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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