GLCD1 - SULSO - GREMLIN Contacts

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GLCD1 - Glucose 1-dehydrogenase 1

UniProt:	Q7LYI9	Sequences: MKAIIVKPPNAGVQVKDVDEKKLDSYGKIKIRTIYNGICGTDREIVNGKLTLSTLPKGKDFLVLGHEAIGVVEESYHGFSQGDLVMPVNRRGCGICRNCLVGRPDFCETGEFGEAGIHKMDGFMREWWYDDPKYLVKIPKSIEDIGILAQPLADIEKSIEEILEVQKRVPVWTCDDGTLNCRKVLVVGTGPIGVLFTLLFRTYGLEVWMANRREPTEVEQTVIEETKTNYYNSSNGYDKLKDSVGKFDVIIDATGADVNILGNVIPLLGRNGVLGLFGFSTSGSVPLDYKTLQEIVHTNKTIIGLVNGQKPHFQQAVVHLASWKTLYPKAAKMLITKTVSINDEKELLKVLREKEHGEIKIRILWE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	366 (298)
Sequences:	51533 (34984)
Seq/√Len:	2026.6

ECOLI - AHR YGGP YBDR YAHK RSPB TDH YDJL YPHC FRMA IDND ADHP GATD YJJN YDJJ ACUI YCJQ QOR1 CURA
BACSU - YJMD ADHB ADHA YOGA YYCR TDH DHSO BDHA YHFP YFMJ
HALSA - Q9HMB6 Q9HP38 GLCDH Q9HR85 Q9HQS8
SULSO - GLCD1 GLCD2 GLCD3 Q97YT7 Q7LXK1 ADH Q97XR4 Q97VV5 Q97VW0 Q97ZV3 Q97YM2 Q97TZ4 Q97W06 Q97V32 Q97WA1 Q97VB8 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_I	143_E	3.117	1.00
32_R	73_E	3.077	1.00
34_I	71_V	3.005	1.00
343_D	346_E	2.876	1.00
30_K	73_E	2.700	1.00
7_K	16_K	2.654	1.00
80_S	83_D	2.598	1.00
84_L	138_I	2.529	1.00
83_D	137_K	2.454	1.00
29_I	135_L	2.409	1.00
20_E	127_W	2.406	1.00
189_T	209_M	2.390	1.00
183_K	206_E	2.369	1.00
179_L	182_R	2.347	1.00
201_R	229_N	2.338	1.00
32_R	71_V	2.296	1.00
339_V	350_V	2.293	1.00
144_D	338_T	2.292	1.00
68_A	123_F	2.280	1.00
32_R	127_W	2.250	1.00
7_K	14_Q	2.247	1.00
184_V	200_F	2.238	1.00
5_I	16_K	2.178	1.00
337_K	350_V	2.178	1.00
338_T	364_L	2.162	1.00
239_K	242_D	2.144	1.00
25_S	28_K	2.136	1.00
220_Q	224_E	2.092	1.00
160_E	203_Y	2.081	1.00
68_A	87_P	2.079	1.00
78_G	132_P	2.068	1.00
221_T	225_E	2.061	1.00
197_T	228_T	2.060	1.00
30_K	129_Y	2.009	1.00
141_S	321_A	1.997	1.00
73_E	127_W	1.983	1.00
47_N	352_R	1.982	1.00
318_V	322_S	1.962	1.00
349_K	353_E	1.912	1.00
69_I	143_E	1.887	1.00
202_T	324_K	1.877	1.00
340_S	343_D	1.866	1.00
152_L	195_L	1.851	1.00
84_L	143_E	1.839	1.00
185_L	210_A	1.807	1.00
160_E	315_Q	1.806	1.00
273_V	301_T	1.802	1.00
27_G	75_S	1.792	1.00
221_T	224_E	1.784	1.00
220_Q	231_Y	1.779	1.00
350_V	355_E	1.774	1.00
26_Y	75_S	1.772	1.00
248_D	269_G	1.770	1.00
185_L	247_F	1.742	1.00
208_W	247_F	1.724	1.00
138_I	143_E	1.710	1.00
346_E	349_K	1.686	1.00
211_N	220_Q	1.666	1.00
346_E	350_V	1.649	1.00
273_V	303_I	1.632	1.00
222_V	225_E	1.630	1.00
4_I	344_E	1.605	1.00
71_V	84_L	1.604	1.00
22_K	74_E	1.598	1.00
74_E	81_Q	1.598	1.00
339_V	347_L	1.586	1.00
187_V	264_V	1.583	1.00
30_K	127_W	1.581	1.00
124_M	348_L	1.550	1.00
268_L	274_L	1.527	1.00
79_F	83_D	1.520	1.00
212_R	234_S	1.518	1.00
345_K	349_K	1.516	1.00
230_Y	243_S	1.495	1.00
79_F	137_K	1.486	1.00
250_I	268_L	1.483	1.00
33_T	68_A	1.474	1.00
24_D	129_Y	1.471	1.00
268_L	272_G	1.470	1.00
236_G	239_K	1.469	1.00
27_G	131_D	1.464	1.00
30_K	74_E	1.460	1.00
28_K	131_D	1.456	1.00
268_L	300_K	1.444	1.00
138_I	146_G	1.421	1.00
182_R	273_V	1.415	1.00
28_K	129_Y	1.404	1.00
144_D	364_L	1.395	1.00
84_L	140_K	1.385	1.00
29_I	79_F	1.382	1.00
336_T	350_V	1.379	1.00
250_I	264_V	1.377	1.00
35_Y	144_D	1.376	1.00
24_D	30_K	1.373	1.00
206_E	230_Y	1.367	1.00
202_T	319_H	1.355	1.00
213_R	218_V	1.350	1.00
206_E	229_N	1.349	1.00
183_K	208_W	1.338	1.00
318_V	321_A	1.332	1.00
3_A	18_V	1.329	1.00
71_V	143_E	1.324	1.00
187_V	210_A	1.312	1.00
196_F	251_I	1.288	1.00
4_I	15_V	1.287	1.00
46_V	348_L	1.286	1.00
72_V	79_F	1.282	1.00
34_I	84_L	1.272	1.00
197_T	209_M	1.248	1.00
9_P	12_G	1.231	1.00
33_T	128_W	1.220	1.00
156_E	160_E	1.218	1.00
20_E	30_K	1.217	1.00
238_D	242_D	1.202	1.00
340_S	364_L	1.176	1.00
27_G	132_P	1.169	1.00
266_P	294_E	1.150	1.00
224_E	231_Y	1.146	1.00
310_K	314_Q	1.145	1.00
183_K	248_D	1.144	1.00
319_H	324_K	1.139	1.00
79_F	135_L	1.135	1.00
220_Q	233_S	1.125	1.00
182_R	248_D	1.123	1.00
315_Q	318_V	1.118	1.00
35_Y	364_L	1.117	1.00
5_I	18_V	1.114	1.00
130_D	135_L	1.111	1.00
225_E	333_M	1.107	1.00
165_V	205_L	1.104	1.00
239_K	243_S	1.094	1.00
326_L	333_M	1.093	1.00
198_L	326_L	1.081	1.00
157_K	312_H	1.079	1.00
73_E	81_Q	1.064	1.00
222_V	358_E	1.063	1.00
254_T	260_I	1.060	1.00
31_I	85_V	1.057	1.00
31_I	70_G	1.054	1.00
155_I	196_F	1.054	1.00
160_E	312_H	1.050	1.00
208_W	230_Y	1.043	1.00
35_Y	143_E	1.042	1.00
46_V	352_R	1.038	1.00
38_I	347_L	1.037	1.00
200_F	205_L	1.036	1.00
24_D	28_K	1.023	1.00
156_E	315_Q	1.020	1.00
15_V	342_N	1.020	1.00
4_I	341_I	1.019	1.00
36_N	124_M	1.013	1.00
237_Y	241_K	1.005	1.00
344_E	363_I	1.002	1.00
314_Q	318_V	0.987	1.00
76_Y	132_P	0.985	1.00
163_L	249_V	0.980	1.00
339_V	343_D	0.975	1.00
349_K	352_R	0.974	1.00
213_R	233_S	0.969	1.00
224_E	230_Y	0.963	1.00
152_L	316_A	0.962	1.00
263_N	266_P	0.956	1.00
315_Q	319_H	0.951	1.00
155_I	199_L	0.951	1.00
189_T	211_N	0.949	1.00
158_S	277_F	0.948	1.00
209_M	223_I	0.945	1.00
235_N	239_K	0.944	1.00
350_V	361_I	0.944	1.00
189_T	223_I	0.941	1.00
209_M	228_T	0.938	1.00
35_Y	362_R	0.937	1.00
43_R	351_L	0.933	1.00
182_R	249_V	0.931	1.00
219_E	358_E	0.929	1.00
158_S	251_I	0.926	1.00
164_E	179_L	0.924	1.00
262_G	266_P	0.920	1.00
124_M	344_E	0.916	1.00
197_T	207_V	0.914	1.00
237_Y	263_N	0.914	1.00
237_Y	266_P	0.906	1.00
189_T	197_T	0.906	1.00
145_I	326_L	0.895	1.00
208_W	232_N	0.895	1.00
34_I	69_I	0.894	1.00
252_D	255_G	0.894	1.00
36_N	123_F	0.892	1.00
86_M	317_V	0.891	1.00
39_C	67_E	0.887	1.00
194_V	222_V	0.887	1.00
185_L	267_L	0.885	1.00
142_I	146_G	0.880	1.00
294_E	298_T	0.870	1.00
295_I	302_I	0.867	1.00
311_P	315_Q	0.865	1.00
20_E	74_E	0.864	1.00
20_E	73_E	0.864	1.00
186_V	200_F	0.864	1.00
5_I	63_V	0.860	1.00
271_N	299_N	0.857	1.00
213_R	219_E	0.857	1.00
18_V	121_D	0.857	1.00
32_R	126_E	0.856	1.00
212_R	220_Q	0.853	1.00
187_V	250_I	0.850	1.00
77_H	132_P	0.848	1.00
3_A	63_V	0.844	1.00
62_L	121_D	0.844	1.00
7_K	12_G	0.844	1.00
211_N	231_Y	0.841	1.00
186_V	196_F	0.837	1.00
4_I	13_V	0.836	1.00
210_A	234_S	0.827	1.00
218_V	221_T	0.822	1.00
250_I	274_L	0.818	1.00
124_M	363_I	0.813	1.00
148_L	320_L	0.812	1.00
153_A	312_H	0.810	1.00
199_L	316_A	0.806	1.00
311_P	314_Q	0.803	1.00
37_G	67_E	0.803	1.00
319_H	322_S	0.802	1.00
290_K	294_E	0.802	1.00
38_I	351_L	0.797	1.00
183_K	247_F	0.796	1.00
203_Y	315_Q	0.796	1.00
136_V	314_Q	0.794	1.00
159_I	200_F	0.793	1.00
68_A	128_W	0.790	1.00
29_I	132_P	0.789	1.00
223_I	228_T	0.789	1.00
264_V	274_L	0.788	1.00
39_C	66_H	0.782	1.00
25_S	129_Y	0.780	1.00
80_S	137_K	0.778	1.00
200_F	207_V	0.770	1.00
140_K	321_A	0.765	1.00
253_A	277_F	0.762	1.00
123_F	128_W	0.760	1.00
155_I	195_L	0.760	1.00
22_K	30_K	0.760	1.00
184_V	205_L	0.756	1.00
18_V	63_V	0.755	1.00
339_V	361_I	0.754	1.00
15_V	341_I	0.754	1.00
240_L	247_F	0.752	1.00
337_K	346_E	0.748	1.00
211_N	223_I	0.747	1.00
187_V	260_I	0.740	1.00
199_L	319_H	0.732	1.00
335_I	338_T	0.728	1.00
39_C	42_D	0.723	1.00
41_T	66_H	0.721	1.00
205_L	249_V	0.718	1.00
208_W	243_S	0.715	1.00
24_D	74_E	0.715	1.00
230_Y	233_S	0.711	1.00
350_V	353_E	0.708	1.00
295_I	304_G	0.707	1.00
158_S	196_F	0.706	1.00
207_V	229_N	0.706	1.00
213_R	220_Q	0.703	1.00
317_V	321_A	0.699	1.00
43_R	352_R	0.696	1.00
276_L	302_I	0.694	1.00
237_Y	267_L	0.693	1.00
295_I	300_K	0.685	1.00
85_V	135_L	0.684	1.00
249_V	275_G	0.684	1.00
156_E	319_H	0.683	1.00
222_V	226_T	0.683	1.00
142_I	320_L	0.682	1.00
78_G	310_K	0.681	1.00
357_G	361_I	0.680	1.00
139_P	321_A	0.677	1.00
157_K	299_N	0.676	1.00
351_L	361_I	0.674	1.00
155_I	192_I	0.674	1.00
4_I	345_K	0.672	1.00
136_V	313_F	0.670	1.00
252_D	274_L	0.670	1.00
59_K	62_L	0.668	1.00
241_K	244_V	0.668	1.00
186_V	209_M	0.665	1.00
337_K	361_I	0.664	1.00
29_I	72_V	0.664	1.00
247_F	250_I	0.662	1.00
241_K	246_K	0.661	1.00
284_S	288_D	0.660	1.00
87_P	130_D	0.660	1.00
83_D	140_K	0.658	1.00
86_M	138_I	0.658	1.00
162_I	249_V	0.658	1.00
156_E	316_A	0.656	1.00
160_E	199_L	0.656	1.00
319_H	323_W	0.655	1.00
69_I	147_I	0.654	1.00
256_A	260_I	0.652	1.00
10_N	349_K	0.652	1.00
163_L	275_G	0.651	1.00
261_L	274_L	0.649	1.00
294_E	297_H	0.645	1.00
299_N	309_Q	0.645	1.00
33_T	36_N	0.643	1.00
154_D	192_I	0.643	1.00
69_I	138_I	0.642	1.00
27_G	133_K	0.642	1.00
39_C	151_P	0.641	1.00
270_R	298_T	0.640	1.00
44_E	49_K	0.639	1.00
225_E	326_L	0.638	1.00
198_L	226_T	0.636	1.00
155_I	159_I	0.635	1.00
262_G	294_E	0.634	1.00
66_H	150_Q	0.633	1.00
21_K	129_Y	0.632	1.00
132_P	135_L	0.630	1.00
262_G	284_S	0.629	1.00
35_Y	69_I	0.628	1.00
11_A	349_K	0.625	1.00
220_Q	223_I	0.623	1.00
67_E	150_Q	0.622	1.00
161_E	312_H	0.622	1.00
58_G	62_L	0.621	1.00
163_L	179_L	0.620	1.00
312_H	315_Q	0.619	1.00
69_I	84_L	0.616	1.00
165_V	249_V	0.616	1.00
238_D	241_K	0.614	1.00
180_N	204_G	0.614	1.00
6_V	12_G	0.614	1.00
339_V	363_I	0.614	1.00
257_D	262_G	0.613	1.00
350_V	357_G	0.613	1.00
39_C	150_Q	0.613	1.00
211_N	233_S	0.611	1.00
34_I	364_L	0.611	1.00
181_C	206_E	0.611	1.00
194_V	334_L	0.611	1.00
197_T	226_T	0.611	1.00
158_S	275_G	0.610	1.00
41_T	45_I	0.608	1.00
208_W	240_L	0.607	1.00
35_Y	338_T	0.606	1.00
84_L	141_S	0.605	1.00
151_P	195_L	0.602	1.00
156_E	312_H	0.602	1.00
165_V	182_R	0.600	1.00
163_L	273_V	0.599	1.00
196_F	277_F	0.599	1.00
157_K	161_E	0.598	1.00
222_V	334_L	0.597	1.00
249_V	273_V	0.597	1.00
231_Y	234_S	0.595	1.00
136_V	317_V	0.588	1.00
184_V	249_V	0.586	1.00
288_D	294_E	0.586	1.00
283_G	288_D	0.585	1.00
294_E	300_K	0.584	1.00
151_P	191_P	0.583	1.00
201_R	207_V	0.582	1.00
78_G	81_Q	0.581	1.00
31_I	135_L	0.580	1.00
247_F	267_L	0.578	1.00
65_G	124_M	0.578	1.00
45_I	50_L	0.578	1.00
43_R	47_N	0.576	1.00
185_L	250_I	0.570	1.00
136_V	310_K	0.569	1.00
150_Q	154_D	0.568	1.00
161_E	301_T	0.567	1.00
36_N	363_I	0.567	1.00
27_G	76_Y	0.565	1.00
199_L	203_Y	0.561	1.00
183_K	244_V	0.561	1.00
211_N	234_S	0.558	1.00
87_P	135_L	0.557	1.00
262_G	288_D	0.557	1.00
131_D	134_Y	0.555	1.00
88_V	136_V	0.555	1.00
38_I	124_M	0.555	1.00
313_F	317_V	0.555	1.00
348_L	352_R	0.555	1.00
40_G	44_E	0.555	1.00
77_H	80_S	0.554	1.00
31_I	87_P	0.550	1.00
79_F	132_P	0.550	1.00
154_D	277_F	0.550	1.00
159_I	199_L	0.547	1.00
41_T	44_E	0.544	1.00
165_V	179_L	0.544	1.00
21_K	127_W	0.542	1.00
39_C	360_K	0.541	1.00
211_N	219_E	0.540	1.00
305_L	308_G	0.539	1.00
337_K	358_E	0.539	1.00
19_D	22_K	0.538	1.00
300_K	304_G	0.538	1.00
228_T	231_Y	0.538	1.00
212_R	233_S	0.537	1.00
21_K	28_K	0.536	1.00
180_N	203_Y	0.534	1.00
197_T	223_I	0.530	1.00
12_G	345_K	0.529	1.00
262_G	286_P	0.529	1.00
186_V	197_T	0.529	1.00
337_K	343_D	0.529	1.00
347_L	363_I	0.529	1.00
13_V	348_L	0.527	1.00
162_I	275_G	0.526	1.00
194_V	226_T	0.525	1.00
21_K	30_K	0.523	1.00
201_R	228_T	0.523	1.00
250_I	267_L	0.522	1.00
240_L	244_V	0.522	1.00
78_G	137_K	0.522	1.00
223_I	231_Y	0.521	1.00
162_I	303_I	0.521	1.00
69_I	146_G	0.520	1.00
229_N	232_N	0.520	1.00
336_T	359_I	0.519	1.00
163_L	182_R	0.518	1.00
195_L	199_L	0.518	1.00
38_I	363_I	0.517	1.00
240_L	243_S	0.516	1.00
198_L	325_T	0.516	1.00
314_Q	317_V	0.512	1.00
137_K	140_K	0.511	1.00
323_W	326_L	0.511	1.00
232_N	236_G	0.509	1.00
143_E	146_G	0.509	1.00
159_I	196_F	0.509	1.00
20_E	129_Y	0.509	1.00
37_G	147_I	0.508	1.00
87_P	123_F	0.508	1.00
183_K	230_Y	0.508	1.00
305_L	309_Q	0.507	1.00
240_L	267_L	0.507	1.00
28_K	120_M	0.504	1.00
285_V	289_Y	0.504	1.00
219_E	355_E	0.503	1.00
358_E	361_I	0.503	1.00
183_K	246_K	0.502	1.00
151_P	360_K	0.501	1.00
158_S	305_L	0.501	1.00
40_G	190_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cdcA	3	0.9617	100	0.196	Contact Map
1vj0A	4	0.9071	100	0.21	Contact Map
4gi2A	2	0.9126	100	0.214	Contact Map
1h2bA	4	0.9016	100	0.215	Contact Map
4ilkA	2	0.8934	100	0.218	Contact Map
4ej6A	1	0.8934	100	0.219	Contact Map
4cpdA	2	0.8989	100	0.221	Contact Map
2b5wA	2	0.9262	100	0.222	Contact Map
1cdoA	2	0.9071	100	0.226	Contact Map
3widA	4	0.959	100	0.226	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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