Q7LY08 - SULSO - GREMLIN Contacts

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Q7LY08 - Uncharacterized protein

UniProt:	Q7LY08	Sequences: MRTMNRILLTVSALVKDNLRNRFVIFWIIVFPIIITLLFGLVFGGFSSYFHVTVAVEGNYGLAKYLNSTEIFQGVTNVSLKYAAEHDYIYVISNGSSFTIYTSKQNQEFVPVLESVIEQYYQKVNNTYDFTVLQISNYTYYNYLISGIIGIISLSNGILSTIGVSASYFRDRIIERLATSPLKSYEWVISLIIYVIIITLISTTAVIILGILFGFIPIIGIEFLGFLVIATLLFGGLGAIIYGLTPKDKIFLSEIVANVLVFPLMFLSNAFFPPNVYPPIVRIFVEYQPLSVIITIIRDLIVYGISPNPILVSIVFLFTIVFLYAGGRLLRLREIS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	336 (315)
Sequences:	11560 (9523)
Seq/√Len:	536.6

ECOLI - YHHJ YBHS YBHR YADH
BACSU - YFIM YFIN NATB YHAP
HALSA - Q9HRJ5
SULSO - Q7LY08 Q97W41 Q97WP5 Q97VH7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_T	85_E	5.574	1.00
226_F	296_I	5.064	1.00
76_T	88_Y	4.605	1.00
10_T	190_S	3.795	1.00
79_S	85_E	3.496	1.00
12_S	16_K	3.283	1.00
78_V	82_Y	3.206	1.00
7_I	193_I	3.020	1.00
279_P	283_I	2.828	1.00
11_V	197_I	2.758	1.00
11_V	193_I	2.747	1.00
183_K	186_E	2.677	1.00
79_S	84_A	2.601	1.00
77_N	81_K	2.511	1.00
313_S	317_L	2.502	1.00
204_T	224_L	2.488	1.00
80_L	88_Y	2.480	1.00
227_L	293_I	2.472	1.00
56_V	59_N	2.421	1.00
232_L	319_T	2.417	1.00
14_L	191_L	2.358	1.00
240_I	325_A	2.329	1.00
229_I	316_F	2.305	1.00
7_I	11_V	2.303	1.00
16_K	19_L	2.245	1.00
75_V	79_S	2.229	1.00
317_L	321_V	2.212	1.00
8_L	12_S	2.211	1.00
305_I	309_P	2.201	1.00
233_L	319_T	2.093	1.00
54_V	63_A	2.064	1.00
13_A	168_Y	2.045	1.00
114_E	118_E	2.024	1.00
56_V	60_Y	1.953	1.00
274_P	285_V	1.922	1.00
230_A	293_I	1.875	1.00
90_Y	101_Y	1.866	1.00
57_E	90_Y	1.839	1.00
236_G	319_T	1.807	1.00
306_S	309_P	1.806	1.00
318_F	322_F	1.804	1.00
286_E	292_V	1.791	1.00
230_A	234_F	1.781	1.00
285_V	291_S	1.779	1.00
199_T	231_T	1.697	1.00
78_V	81_K	1.665	1.00
286_E	291_S	1.661	1.00
196_I	228_V	1.592	1.00
314_I	318_F	1.592	1.00
55_A	76_T	1.582	1.00
139_T	142_N	1.575	1.00
280_I	283_I	1.562	1.00
69_T	72_F	1.553	1.00
49_Y	73_Q	1.538	1.00
196_I	232_L	1.522	1.00
65_Y	68_S	1.518	1.00
229_I	319_T	1.500	1.00
75_V	78_V	1.472	1.00
121_Y	125_N	1.469	1.00
116_V	120_Y	1.464	1.00
221_I	225_G	1.457	1.00
208_I	212_L	1.440	1.00
247_K	250_I	1.439	1.00
168_Y	191_L	1.435	1.00
203_T	227_L	1.434	1.00
304_G	307_P	1.418	1.00
113_L	116_V	1.410	1.00
115_S	119_Q	1.399	1.00
243_G	329_L	1.399	1.00
85_E	88_Y	1.391	1.00
166_A	169_F	1.384	1.00
19_L	22_R	1.384	1.00
110_V	116_V	1.352	1.00
118_E	122_Q	1.339	1.00
110_V	114_E	1.339	1.00
15_V	201_I	1.338	1.00
148_I	151_I	1.335	1.00
324_Y	328_R	1.332	1.00
229_I	312_V	1.330	1.00
255_I	258_N	1.319	1.00
7_I	186_E	1.317	1.00
314_I	317_L	1.315	1.00
233_L	322_F	1.306	1.00
118_E	121_Y	1.293	1.00
223_F	226_F	1.290	1.00
282_R	286_E	1.288	1.00
74_G	78_V	1.276	1.00
74_G	77_N	1.255	1.00
237_L	260_L	1.239	1.00
16_K	20_R	1.237	1.00
200_L	228_V	1.235	1.00
90_Y	99_T	1.229	1.00
37_L	41_L	1.227	1.00
80_L	85_E	1.215	1.00
288_Q	291_S	1.210	1.00
233_L	315_V	1.209	1.00
279_P	282_R	1.205	1.00
63_A	70_E	1.201	1.00
292_V	314_I	1.194	1.00
299_D	305_I	1.181	1.00
32_P	42_V	1.179	1.00
79_S	82_Y	1.179	1.00
150_G	293_I	1.177	1.00
11_V	190_S	1.175	1.00
63_A	67_N	1.173	1.00
112_V	116_V	1.168	1.00
305_I	310_I	1.155	1.00
15_V	197_I	1.151	1.00
53_T	79_S	1.151	1.00
7_I	189_I	1.150	1.00
226_F	300_L	1.141	1.00
117_I	120_Y	1.137	1.00
114_E	117_I	1.135	1.00
103_S	106_N	1.132	1.00
100_I	103_S	1.131	1.00
111_P	114_E	1.128	1.00
291_S	295_T	1.126	1.00
64_K	67_N	1.124	1.00
222_E	300_L	1.120	1.00
186_E	190_S	1.117	1.00
7_I	190_S	1.115	1.00
63_A	66_L	1.110	1.00
299_D	303_Y	1.106	1.00
316_F	320_I	1.105	1.00
312_V	316_F	1.105	1.00
321_V	325_A	1.103	1.00
240_I	326_G	1.101	1.00
197_I	201_I	1.094	1.00
185_Y	189_I	1.085	1.00
151_I	157_G	1.084	1.00
162_I	253_S	1.084	1.00
283_I	286_E	1.076	1.00
216_I	220_G	1.076	1.00
188_V	327_G	1.075	1.00
190_S	194_Y	1.074	1.00
236_G	323_L	1.068	1.00
274_P	277_Y	1.063	1.00
153_S	157_G	1.058	1.00
53_T	88_Y	1.057	1.00
122_Q	126_N	1.052	1.00
13_A	17_D	1.051	1.00
13_A	16_K	1.047	1.00
226_F	312_V	1.039	1.00
152_I	157_G	1.037	1.00
295_T	299_D	1.034	1.00
76_T	79_S	1.033	1.00
304_G	309_P	1.032	1.00
185_Y	327_G	1.030	1.00
145_I	148_I	1.026	1.00
161_T	165_S	1.013	1.00
96_S	100_I	1.007	1.00
147_G	152_I	1.003	1.00
110_V	113_L	1.003	1.00
110_V	124_V	1.002	1.00
110_V	118_E	0.997	1.00
305_I	308_N	0.997	1.00
265_M	268_S	0.996	1.00
106_N	109_F	0.993	1.00
70_E	73_Q	0.991	1.00
173_I	176_R	0.988	1.00
280_I	284_F	0.987	1.00
283_I	287_Y	0.986	1.00
278_P	282_R	0.973	1.00
69_T	73_Q	0.966	1.00
236_G	322_F	0.966	1.00
162_I	165_S	0.963	1.00
233_L	318_F	0.962	1.00
77_N	101_Y	0.959	1.00
8_L	11_V	0.954	1.00
116_V	121_Y	0.951	1.00
166_A	253_S	0.945	1.00
113_L	120_Y	0.945	1.00
66_L	70_E	0.943	1.00
207_I	227_L	0.941	1.00
33_I	37_L	0.940	1.00
93_S	96_S	0.939	1.00
100_I	104_K	0.934	1.00
119_Q	123_K	0.933	1.00
239_A	326_G	0.933	1.00
261_V	264_L	0.931	1.00
113_L	117_I	0.930	1.00
262_F	265_M	0.929	1.00
261_V	265_M	0.925	1.00
293_I	296_I	0.923	1.00
101_Y	105_Q	0.920	1.00
15_V	19_L	0.917	1.00
231_T	235_G	0.916	1.00
240_I	329_L	0.911	1.00
200_L	204_T	0.910	1.00
289_P	293_I	0.909	1.00
76_T	87_D	0.908	1.00
188_V	239_A	0.906	1.00
88_Y	91_V	0.905	1.00
236_G	326_G	0.905	1.00
87_D	113_L	0.903	1.00
168_Y	173_I	0.901	1.00
89_I	100_I	0.894	1.00
36_T	210_G	0.890	1.00
26_F	30_V	0.888	1.00
56_V	63_A	0.885	1.00
58_G	91_V	0.879	1.00
277_Y	280_I	0.879	1.00
170_R	248_D	0.877	1.00
240_I	322_F	0.877	1.00
103_S	107_Q	0.870	1.00
11_V	194_Y	0.869	1.00
104_K	107_Q	0.869	1.00
35_I	39_F	0.867	1.00
245_T	256_V	0.866	1.00
155_S	158_I	0.866	1.00
221_I	224_L	0.865	1.00
32_P	38_L	0.864	1.00
163_G	166_A	0.864	1.00
99_T	102_T	0.863	1.00
169_F	174_I	0.861	1.00
67_N	70_E	0.861	1.00
100_I	106_N	0.860	1.00
32_P	36_T	0.860	1.00
150_G	290_L	0.855	1.00
277_Y	282_R	0.854	1.00
119_Q	122_Q	0.853	1.00
147_G	158_I	0.853	1.00
208_I	211_I	0.852	1.00
318_F	321_V	0.851	1.00
222_E	225_G	0.846	1.00
308_N	311_L	0.846	1.00
18_N	28_I	0.846	1.00
123_K	126_N	0.844	1.00
88_Y	101_Y	0.841	1.00
98_F	101_Y	0.839	1.00
196_I	235_G	0.837	1.00
147_G	156_N	0.836	1.00
148_I	152_I	0.835	1.00
323_L	327_G	0.835	1.00
51_H	73_Q	0.833	1.00
192_I	235_G	0.828	1.00
278_P	281_V	0.823	1.00
51_H	86_H	0.817	1.00
238_G	242_Y	0.817	1.00
21_N	24_V	0.816	1.00
325_A	329_L	0.814	1.00
116_V	119_Q	0.811	1.00
245_T	250_I	0.810	1.00
259_V	263_P	0.810	1.00
221_I	226_F	0.802	1.00
266_F	272_F	0.800	1.00
128_Y	134_Q	0.797	1.00
111_P	115_S	0.793	1.00
292_V	295_T	0.793	1.00
65_Y	70_E	0.783	1.00
240_I	244_L	0.783	1.00
178_A	187_W	0.781	1.00
52_V	89_I	0.780	1.00
121_Y	124_V	0.780	1.00
241_I	245_T	0.780	1.00
152_I	156_N	0.779	1.00
303_Y	306_S	0.777	1.00
193_I	197_I	0.773	1.00
120_Y	124_V	0.773	1.00
149_I	157_G	0.764	1.00
112_V	117_I	0.762	1.00
150_G	153_S	0.760	1.00
145_I	157_G	0.758	1.00
36_T	39_F	0.757	1.00
307_P	310_I	0.756	1.00
10_T	182_L	0.754	1.00
192_I	232_L	0.754	1.00
177_L	187_W	0.753	1.00
52_V	87_D	0.752	1.00
100_I	105_Q	0.749	1.00
274_P	282_R	0.749	1.00
15_V	194_Y	0.746	1.00
238_G	257_A	0.746	1.00
315_V	318_F	0.745	1.00
68_S	71_I	0.745	1.00
202_S	206_V	0.744	1.00
182_L	187_W	0.742	1.00
100_I	107_Q	0.739	1.00
40_G	43_F	0.739	1.00
150_G	157_G	0.738	1.00
122_Q	125_N	0.738	1.00
36_T	40_G	0.738	1.00
192_I	236_G	0.736	1.00
142_N	150_G	0.736	1.00
113_L	124_V	0.733	1.00
270_A	294_I	0.733	1.00
96_S	101_Y	0.732	1.00
243_G	326_G	0.732	1.00
147_G	150_G	0.723	1.00
39_F	43_F	0.723	1.00
116_V	125_N	0.718	1.00
110_V	121_Y	0.717	1.00
76_T	80_L	0.715	1.00
86_H	91_V	0.712	1.00
229_I	315_V	0.710	1.00
56_V	91_V	0.709	1.00
11_V	15_V	0.709	1.00
264_L	288_Q	0.708	1.00
32_P	35_I	0.708	1.00
192_I	196_I	0.707	1.00
117_I	121_Y	0.706	1.00
225_G	229_I	0.704	1.00
154_L	158_I	0.704	1.00
240_I	243_G	0.702	1.00
140_Y	143_Y	0.702	1.00
146_S	151_I	0.701	1.00
319_T	323_L	0.701	1.00
115_S	118_E	0.700	1.00
146_S	150_G	0.697	1.00
135_I	142_N	0.690	1.00
261_V	266_F	0.690	1.00
110_V	119_Q	0.685	1.00
153_S	156_N	0.685	1.00
306_S	311_L	0.683	1.00
14_L	18_N	0.681	1.00
9_L	12_S	0.677	1.00
87_D	90_Y	0.676	1.00
292_V	318_F	0.675	1.00
139_T	143_Y	0.673	1.00
204_T	207_I	0.673	1.00
274_P	291_S	0.671	1.00
52_V	55_A	0.671	1.00
156_N	159_L	0.670	1.00
22_R	25_I	0.668	1.00
172_R	175_E	0.668	1.00
141_Y	145_I	0.667	1.00
155_S	159_L	0.667	1.00
63_A	72_F	0.665	1.00
55_A	58_G	0.662	1.00
98_F	102_T	0.660	1.00
303_Y	309_P	0.656	1.00
10_T	187_W	0.654	1.00
96_S	103_S	0.651	1.00
264_L	268_S	0.649	1.00
66_L	117_I	0.647	1.00
113_L	122_Q	0.646	1.00
41_L	44_G	0.645	1.00
269_N	273_P	0.644	1.00
237_L	322_F	0.642	1.00
296_I	299_D	0.640	1.00
313_S	316_F	0.639	1.00
64_K	69_T	0.634	1.00
167_S	170_R	0.633	1.00
322_F	326_G	0.632	1.00
55_A	88_Y	0.632	1.00
289_P	292_V	0.628	1.00
32_P	39_F	0.628	1.00
96_S	102_T	0.625	1.00
264_L	290_L	0.625	1.00
65_Y	69_T	0.624	1.00
152_I	158_I	0.624	1.00
143_Y	157_G	0.622	1.00
54_V	57_E	0.620	1.00
207_I	223_F	0.619	1.00
168_Y	187_W	0.617	1.00
80_L	83_A	0.616	1.00
256_V	260_L	0.616	1.00
211_I	214_G	0.616	1.00
62_L	66_L	0.614	1.00
67_N	71_I	0.613	1.00
236_G	243_G	0.613	1.00
163_G	248_D	0.612	1.00
166_A	170_R	0.610	1.00
77_N	88_Y	0.610	1.00
316_F	319_T	0.607	1.00
136_S	142_N	0.606	1.00
285_V	288_Q	0.605	1.00
168_Y	175_E	0.601	1.00
234_F	238_G	0.600	1.00
65_Y	127_T	0.599	1.00
154_L	234_F	0.597	1.00
52_V	57_E	0.595	1.00
110_V	117_I	0.592	1.00
227_L	297_I	0.591	1.00
187_W	190_S	0.590	1.00
204_T	208_I	0.589	0.99
36_T	206_V	0.589	0.99
111_P	118_E	0.588	0.99
169_F	175_E	0.584	0.99
53_T	58_G	0.583	0.99
167_S	171_D	0.581	0.99
67_N	73_Q	0.580	0.99
176_R	180_S	0.580	0.99
18_N	194_Y	0.579	0.99
151_I	154_L	0.579	0.99
258_N	262_F	0.577	0.99
296_I	312_V	0.575	0.99
214_G	219_I	0.575	0.99
111_P	121_Y	0.575	0.99
286_E	295_T	0.573	0.99
46_F	49_Y	0.573	0.99
165_S	168_Y	0.571	0.99
56_V	61_G	0.571	0.99
174_I	187_W	0.570	0.99
191_L	195_V	0.570	0.99
151_I	155_S	0.568	0.99
97_S	100_I	0.567	0.99
17_D	168_Y	0.565	0.99
188_V	326_G	0.565	0.99
322_F	325_A	0.564	0.99
168_Y	172_R	0.563	0.99
224_L	228_V	0.561	0.99
174_I	188_V	0.561	0.99
144_L	148_I	0.560	0.99
112_V	124_V	0.560	0.99
205_A	208_I	0.558	0.99
276_V	279_P	0.556	0.99
156_N	202_S	0.556	0.99
281_V	285_V	0.555	0.99
145_I	156_N	0.553	0.99
52_V	56_V	0.553	0.99
104_K	108_E	0.552	0.99
303_Y	307_P	0.552	0.99
38_L	41_L	0.551	0.99
33_I	36_T	0.551	0.99
241_I	257_A	0.549	0.99
162_I	166_A	0.549	0.99
273_P	277_Y	0.548	0.99
304_G	308_N	0.547	0.99
143_Y	148_I	0.547	0.99
127_T	134_Q	0.547	0.99
76_T	84_A	0.546	0.99
101_Y	104_K	0.546	0.99
146_S	153_S	0.544	0.99
110_V	115_S	0.541	0.99
137_N	142_N	0.540	0.99
110_V	120_Y	0.537	0.99
151_I	156_N	0.537	0.99
111_P	116_V	0.537	0.99
142_N	145_I	0.537	0.99
293_I	297_I	0.536	0.99
62_L	91_V	0.535	0.99
101_Y	106_N	0.534	0.99
114_E	120_Y	0.534	0.99
112_V	118_E	0.533	0.99
77_N	80_L	0.533	0.99
32_P	253_S	0.533	0.99
14_L	195_V	0.533	0.99
222_E	226_F	0.533	0.99
36_T	42_V	0.531	0.99
38_L	42_V	0.530	0.99
216_I	219_I	0.530	0.99
286_E	289_P	0.528	0.99
105_Q	109_F	0.528	0.99
96_S	99_T	0.527	0.99
230_A	242_Y	0.526	0.99
113_L	118_E	0.525	0.99
65_Y	73_Q	0.525	0.99
115_S	122_Q	0.524	0.99
136_S	140_Y	0.523	0.99
55_A	60_Y	0.523	0.99
57_E	61_G	0.521	0.99
95_G	98_F	0.521	0.99
87_D	100_I	0.520	0.99
299_D	309_P	0.520	0.99
37_L	209_L	0.520	0.99
53_T	60_Y	0.520	0.99
91_V	98_F	0.518	0.99
78_V	84_A	0.515	0.99
262_F	266_F	0.514	0.99
112_V	120_Y	0.513	0.99
196_I	200_L	0.511	0.99
138_Y	147_G	0.509	0.99
232_L	236_G	0.509	0.99
321_V	324_Y	0.507	0.99
157_G	238_G	0.507	0.99
66_L	72_F	0.506	0.98
96_S	105_Q	0.504	0.98
112_V	121_Y	0.504	0.98
177_L	191_L	0.502	0.98
148_I	156_N	0.502	0.98
116_V	124_V	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cniA	2	0.3125	97.4	0.848	Contact Map
2p0sA	2	0.3333	77.6	0.914	Contact Map
2rh1A	1	0.5506	10.3	0.949	Contact Map
2bs2C	2	0.1905	4.5	0.957	Contact Map
2zbkB	1	0.2232	2.9	0.961	Contact Map
2kncA	1	0.122	2.8	0.961	Contact Map
4knfA	3	0.122	2.3	0.962	Contact Map
2m8rA	1	0.1369	2.2	0.963	Contact Map
4grvA	1	0.5744	1.9	0.964	Contact Map
2mfrA	1	0.1339	1.9	0.964	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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