GREMLIN Database
Q7LY08 - Uncharacterized protein
UniProt: Q7LY08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (315)
Sequences: 11560 (9523)
Seq/√Len: 536.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_T85_E5.5741.00
226_F296_I5.0641.00
76_T88_Y4.6051.00
10_T190_S3.7951.00
79_S85_E3.4961.00
12_S16_K3.2831.00
78_V82_Y3.2061.00
7_I193_I3.0201.00
279_P283_I2.8281.00
11_V197_I2.7581.00
11_V193_I2.7471.00
183_K186_E2.6771.00
79_S84_A2.6011.00
77_N81_K2.5111.00
313_S317_L2.5021.00
204_T224_L2.4881.00
80_L88_Y2.4801.00
227_L293_I2.4721.00
56_V59_N2.4211.00
232_L319_T2.4171.00
14_L191_L2.3581.00
240_I325_A2.3291.00
229_I316_F2.3051.00
7_I11_V2.3031.00
16_K19_L2.2451.00
75_V79_S2.2291.00
317_L321_V2.2121.00
8_L12_S2.2111.00
305_I309_P2.2011.00
233_L319_T2.0931.00
54_V63_A2.0641.00
13_A168_Y2.0451.00
114_E118_E2.0241.00
56_V60_Y1.9531.00
274_P285_V1.9221.00
230_A293_I1.8751.00
90_Y101_Y1.8661.00
57_E90_Y1.8391.00
236_G319_T1.8071.00
306_S309_P1.8061.00
318_F322_F1.8041.00
286_E292_V1.7911.00
230_A234_F1.7811.00
285_V291_S1.7791.00
199_T231_T1.6971.00
78_V81_K1.6651.00
286_E291_S1.6611.00
196_I228_V1.5921.00
314_I318_F1.5921.00
55_A76_T1.5821.00
139_T142_N1.5751.00
280_I283_I1.5621.00
69_T72_F1.5531.00
49_Y73_Q1.5381.00
196_I232_L1.5221.00
65_Y68_S1.5181.00
229_I319_T1.5001.00
75_V78_V1.4721.00
121_Y125_N1.4691.00
116_V120_Y1.4641.00
221_I225_G1.4571.00
208_I212_L1.4401.00
247_K250_I1.4391.00
168_Y191_L1.4351.00
203_T227_L1.4341.00
304_G307_P1.4181.00
113_L116_V1.4101.00
115_S119_Q1.3991.00
243_G329_L1.3991.00
85_E88_Y1.3911.00
166_A169_F1.3841.00
19_L22_R1.3841.00
110_V116_V1.3521.00
118_E122_Q1.3391.00
110_V114_E1.3391.00
15_V201_I1.3381.00
148_I151_I1.3351.00
324_Y328_R1.3321.00
229_I312_V1.3301.00
255_I258_N1.3191.00
7_I186_E1.3171.00
314_I317_L1.3151.00
233_L322_F1.3061.00
118_E121_Y1.2931.00
223_F226_F1.2901.00
282_R286_E1.2881.00
74_G78_V1.2761.00
74_G77_N1.2551.00
237_L260_L1.2391.00
16_K20_R1.2371.00
200_L228_V1.2351.00
90_Y99_T1.2291.00
37_L41_L1.2271.00
80_L85_E1.2151.00
288_Q291_S1.2101.00
233_L315_V1.2091.00
279_P282_R1.2051.00
63_A70_E1.2011.00
292_V314_I1.1941.00
299_D305_I1.1811.00
32_P42_V1.1791.00
79_S82_Y1.1791.00
150_G293_I1.1771.00
11_V190_S1.1751.00
63_A67_N1.1731.00
112_V116_V1.1681.00
305_I310_I1.1551.00
15_V197_I1.1511.00
53_T79_S1.1511.00
7_I189_I1.1501.00
226_F300_L1.1411.00
117_I120_Y1.1371.00
114_E117_I1.1351.00
103_S106_N1.1321.00
100_I103_S1.1311.00
111_P114_E1.1281.00
291_S295_T1.1261.00
64_K67_N1.1241.00
222_E300_L1.1201.00
186_E190_S1.1171.00
7_I190_S1.1151.00
63_A66_L1.1101.00
299_D303_Y1.1061.00
316_F320_I1.1051.00
312_V316_F1.1051.00
321_V325_A1.1031.00
240_I326_G1.1011.00
197_I201_I1.0941.00
185_Y189_I1.0851.00
151_I157_G1.0841.00
162_I253_S1.0841.00
283_I286_E1.0761.00
216_I220_G1.0761.00
188_V327_G1.0751.00
190_S194_Y1.0741.00
236_G323_L1.0681.00
274_P277_Y1.0631.00
153_S157_G1.0581.00
53_T88_Y1.0571.00
122_Q126_N1.0521.00
13_A17_D1.0511.00
13_A16_K1.0471.00
226_F312_V1.0391.00
152_I157_G1.0371.00
295_T299_D1.0341.00
76_T79_S1.0331.00
304_G309_P1.0321.00
185_Y327_G1.0301.00
145_I148_I1.0261.00
161_T165_S1.0131.00
96_S100_I1.0071.00
147_G152_I1.0031.00
110_V113_L1.0031.00
110_V124_V1.0021.00
110_V118_E0.9971.00
305_I308_N0.9971.00
265_M268_S0.9961.00
106_N109_F0.9931.00
70_E73_Q0.9911.00
173_I176_R0.9881.00
280_I284_F0.9871.00
283_I287_Y0.9861.00
278_P282_R0.9731.00
69_T73_Q0.9661.00
236_G322_F0.9661.00
162_I165_S0.9631.00
233_L318_F0.9621.00
77_N101_Y0.9591.00
8_L11_V0.9541.00
116_V121_Y0.9511.00
166_A253_S0.9451.00
113_L120_Y0.9451.00
66_L70_E0.9431.00
207_I227_L0.9411.00
33_I37_L0.9401.00
93_S96_S0.9391.00
100_I104_K0.9341.00
119_Q123_K0.9331.00
239_A326_G0.9331.00
261_V264_L0.9311.00
113_L117_I0.9301.00
262_F265_M0.9291.00
261_V265_M0.9251.00
293_I296_I0.9231.00
101_Y105_Q0.9201.00
15_V19_L0.9171.00
231_T235_G0.9161.00
240_I329_L0.9111.00
200_L204_T0.9101.00
289_P293_I0.9091.00
76_T87_D0.9081.00
188_V239_A0.9061.00
88_Y91_V0.9051.00
236_G326_G0.9051.00
87_D113_L0.9031.00
168_Y173_I0.9011.00
89_I100_I0.8941.00
36_T210_G0.8901.00
26_F30_V0.8881.00
56_V63_A0.8851.00
58_G91_V0.8791.00
277_Y280_I0.8791.00
170_R248_D0.8771.00
240_I322_F0.8771.00
103_S107_Q0.8701.00
11_V194_Y0.8691.00
104_K107_Q0.8691.00
35_I39_F0.8671.00
245_T256_V0.8661.00
155_S158_I0.8661.00
221_I224_L0.8651.00
32_P38_L0.8641.00
163_G166_A0.8641.00
99_T102_T0.8631.00
169_F174_I0.8611.00
67_N70_E0.8611.00
100_I106_N0.8601.00
32_P36_T0.8601.00
150_G290_L0.8551.00
277_Y282_R0.8541.00
119_Q122_Q0.8531.00
147_G158_I0.8531.00
208_I211_I0.8521.00
318_F321_V0.8511.00
222_E225_G0.8461.00
308_N311_L0.8461.00
18_N28_I0.8461.00
123_K126_N0.8441.00
88_Y101_Y0.8411.00
98_F101_Y0.8391.00
196_I235_G0.8371.00
147_G156_N0.8361.00
148_I152_I0.8351.00
323_L327_G0.8351.00
51_H73_Q0.8331.00
192_I235_G0.8281.00
278_P281_V0.8231.00
51_H86_H0.8171.00
238_G242_Y0.8171.00
21_N24_V0.8161.00
325_A329_L0.8141.00
116_V119_Q0.8111.00
245_T250_I0.8101.00
259_V263_P0.8101.00
221_I226_F0.8021.00
266_F272_F0.8001.00
128_Y134_Q0.7971.00
111_P115_S0.7931.00
292_V295_T0.7931.00
65_Y70_E0.7831.00
240_I244_L0.7831.00
178_A187_W0.7811.00
52_V89_I0.7801.00
121_Y124_V0.7801.00
241_I245_T0.7801.00
152_I156_N0.7791.00
303_Y306_S0.7771.00
193_I197_I0.7731.00
120_Y124_V0.7731.00
149_I157_G0.7641.00
112_V117_I0.7621.00
150_G153_S0.7601.00
145_I157_G0.7581.00
36_T39_F0.7571.00
307_P310_I0.7561.00
10_T182_L0.7541.00
192_I232_L0.7541.00
177_L187_W0.7531.00
52_V87_D0.7521.00
100_I105_Q0.7491.00
274_P282_R0.7491.00
15_V194_Y0.7461.00
238_G257_A0.7461.00
315_V318_F0.7451.00
68_S71_I0.7451.00
202_S206_V0.7441.00
182_L187_W0.7421.00
100_I107_Q0.7391.00
40_G43_F0.7391.00
150_G157_G0.7381.00
122_Q125_N0.7381.00
36_T40_G0.7381.00
192_I236_G0.7361.00
142_N150_G0.7361.00
113_L124_V0.7331.00
270_A294_I0.7331.00
96_S101_Y0.7321.00
243_G326_G0.7321.00
147_G150_G0.7231.00
39_F43_F0.7231.00
116_V125_N0.7181.00
110_V121_Y0.7171.00
76_T80_L0.7151.00
86_H91_V0.7121.00
229_I315_V0.7101.00
56_V91_V0.7091.00
11_V15_V0.7091.00
264_L288_Q0.7081.00
32_P35_I0.7081.00
192_I196_I0.7071.00
117_I121_Y0.7061.00
225_G229_I0.7041.00
154_L158_I0.7041.00
240_I243_G0.7021.00
140_Y143_Y0.7021.00
146_S151_I0.7011.00
319_T323_L0.7011.00
115_S118_E0.7001.00
146_S150_G0.6971.00
135_I142_N0.6901.00
261_V266_F0.6901.00
110_V119_Q0.6851.00
153_S156_N0.6851.00
306_S311_L0.6831.00
14_L18_N0.6811.00
9_L12_S0.6771.00
87_D90_Y0.6761.00
292_V318_F0.6751.00
139_T143_Y0.6731.00
204_T207_I0.6731.00
274_P291_S0.6711.00
52_V55_A0.6711.00
156_N159_L0.6701.00
22_R25_I0.6681.00
172_R175_E0.6681.00
141_Y145_I0.6671.00
155_S159_L0.6671.00
63_A72_F0.6651.00
55_A58_G0.6621.00
98_F102_T0.6601.00
303_Y309_P0.6561.00
10_T187_W0.6541.00
96_S103_S0.6511.00
264_L268_S0.6491.00
66_L117_I0.6471.00
113_L122_Q0.6461.00
41_L44_G0.6451.00
269_N273_P0.6441.00
237_L322_F0.6421.00
296_I299_D0.6401.00
313_S316_F0.6391.00
64_K69_T0.6341.00
167_S170_R0.6331.00
322_F326_G0.6321.00
55_A88_Y0.6321.00
289_P292_V0.6281.00
32_P39_F0.6281.00
96_S102_T0.6251.00
264_L290_L0.6251.00
65_Y69_T0.6241.00
152_I158_I0.6241.00
143_Y157_G0.6221.00
54_V57_E0.6201.00
207_I223_F0.6191.00
168_Y187_W0.6171.00
80_L83_A0.6161.00
256_V260_L0.6161.00
211_I214_G0.6161.00
62_L66_L0.6141.00
67_N71_I0.6131.00
236_G243_G0.6131.00
163_G248_D0.6121.00
166_A170_R0.6101.00
77_N88_Y0.6101.00
316_F319_T0.6071.00
136_S142_N0.6061.00
285_V288_Q0.6051.00
168_Y175_E0.6011.00
234_F238_G0.6001.00
65_Y127_T0.5991.00
154_L234_F0.5971.00
52_V57_E0.5951.00
110_V117_I0.5921.00
227_L297_I0.5911.00
187_W190_S0.5901.00
204_T208_I0.5890.99
36_T206_V0.5890.99
111_P118_E0.5880.99
169_F175_E0.5840.99
53_T58_G0.5830.99
167_S171_D0.5810.99
67_N73_Q0.5800.99
176_R180_S0.5800.99
18_N194_Y0.5790.99
151_I154_L0.5790.99
258_N262_F0.5770.99
296_I312_V0.5750.99
214_G219_I0.5750.99
111_P121_Y0.5750.99
286_E295_T0.5730.99
46_F49_Y0.5730.99
165_S168_Y0.5710.99
56_V61_G0.5710.99
174_I187_W0.5700.99
191_L195_V0.5700.99
151_I155_S0.5680.99
97_S100_I0.5670.99
17_D168_Y0.5650.99
188_V326_G0.5650.99
322_F325_A0.5640.99
168_Y172_R0.5630.99
224_L228_V0.5610.99
174_I188_V0.5610.99
144_L148_I0.5600.99
112_V124_V0.5600.99
205_A208_I0.5580.99
276_V279_P0.5560.99
156_N202_S0.5560.99
281_V285_V0.5550.99
145_I156_N0.5530.99
52_V56_V0.5530.99
104_K108_E0.5520.99
303_Y307_P0.5520.99
38_L41_L0.5510.99
33_I36_T0.5510.99
241_I257_A0.5490.99
162_I166_A0.5490.99
273_P277_Y0.5480.99
304_G308_N0.5470.99
143_Y148_I0.5470.99
127_T134_Q0.5470.99
76_T84_A0.5460.99
101_Y104_K0.5460.99
146_S153_S0.5440.99
110_V115_S0.5410.99
137_N142_N0.5400.99
110_V120_Y0.5370.99
151_I156_N0.5370.99
111_P116_V0.5370.99
142_N145_I0.5370.99
293_I297_I0.5360.99
62_L91_V0.5350.99
101_Y106_N0.5340.99
114_E120_Y0.5340.99
112_V118_E0.5330.99
77_N80_L0.5330.99
32_P253_S0.5330.99
14_L195_V0.5330.99
222_E226_F0.5330.99
36_T42_V0.5310.99
38_L42_V0.5300.99
216_I219_I0.5300.99
286_E289_P0.5280.99
105_Q109_F0.5280.99
96_S99_T0.5270.99
230_A242_Y0.5260.99
113_L118_E0.5250.99
65_Y73_Q0.5250.99
115_S122_Q0.5240.99
136_S140_Y0.5230.99
55_A60_Y0.5230.99
57_E61_G0.5210.99
95_G98_F0.5210.99
87_D100_I0.5200.99
299_D309_P0.5200.99
37_L209_L0.5200.99
53_T60_Y0.5200.99
91_V98_F0.5180.99
78_V84_A0.5150.99
262_F266_F0.5140.99
112_V120_Y0.5130.99
196_I200_L0.5110.99
138_Y147_G0.5090.99
232_L236_G0.5090.99
321_V324_Y0.5070.99
157_G238_G0.5070.99
66_L72_F0.5060.98
96_S105_Q0.5040.98
112_V121_Y0.5040.98
177_L191_L0.5020.98
148_I156_N0.5020.98
116_V124_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cniA 2 0.3125 97.4 0.848 Contact Map
2p0sA 2 0.3333 77.6 0.914 Contact Map
2rh1A 1 0.5506 10.3 0.949 Contact Map
2bs2C 2 0.1905 4.5 0.957 Contact Map
2zbkB 1 0.2232 2.9 0.961 Contact Map
2kncA 1 0.122 2.8 0.961 Contact Map
4knfA 3 0.122 2.3 0.962 Contact Map
2m8rA 1 0.1369 2.2 0.963 Contact Map
4grvA 1 0.5744 1.9 0.964 Contact Map
2mfrA 1 0.1339 1.9 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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